DNA Replication
DNA
Replication Is Governed by a Set of Fundamental
Rules
DNA Is
Synthesized by DNA Polymerases
Polymerization
Is a Thermodynamically Favorable Reaction
DNA
Polymerases Are Very Accurate
E. coli
Has at Least Three DNA Polymerases
DNA
Replication Requires Many Enzymes and Protein
Factors
Replication
of the E. coli Chromosome Proceeds in Stages
Replication
in Enkaryotic Cells Is More Complex
DNA Repair
Mutations
Are Linked to Cancer
All Cells
Have Multiple DNA Repair Systems
When DNA
Damage Is Extensive, Repair Becomes Error-Prone
DNA Recombination
Homologous
Genetic Recombination Has Multiple Funetions
Recombination
Requires Specific Enzymes
Homologous
Recombination Is an Important Pathway for DNA
Repair
Site-Specific
Recombination Results in Precise DNA
Rearrangements
Immunoglobulin
Genes Are Assembled by Recombination
T'ransposable
Genetic Elements Move from One Location to
Another
Summary
Further Reading
Problems
