> ...........................UUUCCGG....................UUGAUC CUGCCGGAGGCCACU..GCUAU.CGGGGUCCGACUA....AGCCAU.GCGAGUCAAGGG. ........G......CU..C........................................ ...............C................UUC......................... ............G.......G....................................... .......G............A..........GC........................... .......................................................ACC.G GCGC.....ACGGCUCA....GUAACAC.GUG.GC.UAACC..................U ........................................A................CC. .C.....UCG................................................GG .AG.GGGGAUAA.C.CU.CG...........GG.AA.ACUG.A................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... .............CCAUAGGGGAG.................................... ............................................................ ................................................GAGGUCU..... ............................................................ ............................................................ ....................Gg...................................... .AACGAUCCCUCCCCGAAA................................G........ ..U..........................UC............................. ............................................................ .......................C......GG............................ ......CGCCC................................................. ..............................G............................. ..............................................A............. .GGAUGGGG.....UUG.CGG....................................... .AGG..................AUUAGGU...AG.UUGGUGG.GGUAACGGC..CCACCA AG.CCGACGA..UCCGUAC..GG.....GCCCUGAG.AGGG..GGAGC..CCG...G..A GAUGGAC.ACUGAGACACG.GGUCCAG...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUC.....CG...CAAUGCACGAA.AG................UGC...GAC....G.GG GGGAC.....CCCGAGUGCC...........AU....C.CC.........AAC.GGGAUG ............................................................ ............................................................ ............................................................ ............................................................ ....GCU.....U..............UUCCG...GAGUG.........UAAACAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CUCCG..G.GAA..U .......AAGGG.................CUGG........................... ............GCAAG.UCC.G.UGCCAGCAGCCGCGGUAAUACCGGCGGCCCAAGUGG UGGCCAC...............UGUUAUUGGGCCU..AAAGCGU...CCGUAG....... .......CC.GG.............C....CCAGUAAGUCUC.......UG......... ............................CUUAAAU........CCUGC.GGCUCAA.C.C ...GC....A..G.G........G...........C........U...GGC......... ........................AG.....................AG..A..UACUGC UGG...............G.CU....UGG..GA..C....CG.............GG... AGAGGCC..GG..GGGUACCC......CA.....................GGGGUAGCGG UG..AAAUGCGUU.GAUC.CCU.GGG.GGACCACCUG.UGGCGAA............GGC GCCCG.G.CUGGA..ACGGG..UCCGACGGU....GAG.GGACGAAGGCCAGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCUGUAAACUCUGCG....GAC.......... ....UAGGU........................G.......UC....GC.Guc..G.... ................GCUUC.................Gggccg........AC...... .....................G.....................C................ .....G.GU........GCCG.......AAGGGAAGC..CGU..........UAAG..UC C.............GCCGCCUGGGGAGUACGGUCGCAAGACUGAAACUUAA...AGGAAU UGGCGGGGGAGCACU.ACA.ACG..GGUGGAGCCUGC.GGUUUAAUUGGAU.UCAACGCC G.GGCAUCUCA.CCAGGGG....C........GACGGCAGGAUGAAGGCCAGGUUGACGA CCUUGCCAGA.....CGC....................G..................... ...................CC........................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGUGCAUGGCCGUCGUCAGCUCGUACCGUGAGGCGU CCUGUUAAGUCAG.GUAACGAGCGAGACCCGUGC...CCCAUG......U....UGCA.. .AC.C...............UccUCCUCC..GG.G.AG......G...A.....GGG..C A.CUCAUGGG............GG.ACCGCC.G..G.CGC.U.AA..GCC.G........ ...GAGGA.A.GGUGC.GGGCAACGAC..AG..GUCCGCAUGCCCCGAAUCC.CCUG.GG CUACAC.GCGGGCUACAAU.GGC.CG..GG.ACAA.UG................GG.... ....A.A.G..............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGCGAAU......CCC.......CU.AAAC.C..CG.G.U.C GU.A....GUCCGGAUCGAGGGCUGUAACUCGCCCUCGUGAAGC.CGGAAUCCGUAGUAA UCGCGCCUCA..CCAU.G.GCGCGG.....UGAAUGCGUCCCUGCUCCUUGC..ACACAC CGCCCGUCACGCCACCCGAauugagcc................................. ..........................CAAGUU....GA...................A.. ...GCC........................CUG.........U.........CCG..... ..............CaA...AG.GGCAGGGUCCAAACUU..................... .........................................................GUU C.......................AGCA.AGG...GGGG..................... ............................................................ ............................................................ ........................................................... > ...........................AUUCCGG....................UUGAUC CCGCCGGAGGUCACU..GCUAUU.GGGGUUCGACUA....AGCCAU.GCGAGUCUA.... ..................U........G................................ ............................................G.........CUUCGG C........................................................... .................C............AU............................ ...........................................................G GCGG.....ACGGCUCA....UUAUCAC.GUG.GU.UAACU..................U ........................................A................CC. .C....................UC.....A......A......................G c.G.GAGGAUAA.C.CUU.G...........GG.AA.ACUG.A................. ...............G............................................ .............................................G.............. ................................................AUAAUACU.... .............CCAUAGGaaaa.................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .AA.........G...GUUUGG.......A..AUAAUCU.UU.................. ............................................................ ..........UUCUGA.AAGCAUAugCGCUUGAGNAua...................... ............................................................ ............................................................ ............................................................ ......GGA.....CUG.CGc....................................... .UCG..................AUUAGGU...AG.UUGGUGG.GGUAAUGGC..CCACCA AG.CCUACGA..UCGaUAC..GG.....GCCUUGAG.AGAG..GGAGC..CCG...G..A GAUGGGG.ACUGAGACACG.GCCCCAG...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUC.....CG...CAAUGCACGAA.AG................UGC...GAC....G.GG GGGAC.....CCCAAGUGCC...........UAuguaacuca...............UAG ............................................................ ............................................................ ............................................................ ............................................................ ....GCU.....U..............UU...AguaAGUG.........UAAAUAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CUUA.A..AGAA..U .......AAGGG.................CUGG........................... ............GCAAG.UUCgG.UGCCAGCAGCCGCGGUAACACCGaCGGCCCAAGUGG UGACCAC...............UCUUAUUGGGUCU..AAAGCGU...CCGUAG....... .......CC.GGU.................UU.............AGUAAG.UC.C.... .........U..........UGU.......UUAA.......AUCC.UCUGGCUUAA.C.C .........A..G.A........G.........NAC........U...GGC......... ........................AG...G..................G..A..UACUGC UAGA................CU....UGG..GA..C....CG.............GG... AGAGG..ACAA..GGGUACUC......CAA.....................GGGUAGCGG UGG..AAUGUGUU.GAUC.CUU.GG.AGGACCACCU.AUGGCGAA............GGC AcuUG.U.CUGGA..ACGGG..UCCGACGGU....GAG.GGACNNAAGCCAGGGGCGCGA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCCGUAAACUUUGCG....AAC.......... ....UAGGU........................G.......UUAGGUAggcucuguGC.. .....................C.........UAU........C................. ......................U..................................... .A.....GU........GCCG.......AAGGGAAGC..CGU..........UAAG..UU C.............GCCACCUGGGGAGUACGGUCGCAAGACUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.ACG..GGUGGAGNCUGC.GGUUUAAUUGGAU.UCAACGCC G.GGCAUCUCA.CCAGGaG....C........GACAGCAUUAUGAUGaCCAGGUUGACGA CCUUGucugaa.....GC....................G..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGNGCAUGGCCAUCGUCAGCUCGUACCGcGAGGCGU CCUGUUAAGUCAG.GUAACGAGCGAGACCCGUGC...CCUAUG......U....UGCU.. .AGuuuc................UUCUCCGG..Aggnac................AG..C A.CUCAUAGGA............G.ACCGnu.G..G.CGC.U.AA..GuC..A....... ...GAGGA.A.GGAGC.GGGCAACGAU..AG..GUCCGCAUGCCCCGAAUC.UCCUG.GG CUACAC.GCGGGCUACAAU.GGCU.G..GG.ACAA.UG................GG.... ....A.U.G..............CU........A........CCCUGAAAAGGGa..... ..................CGCAAAU......CUC.......CU.AAAC.C..CU.G.U.C GU.A....GUUCGGAUCGUGGGCUGUAACUCGCCCACGUGAAGC.UGGAAUCCGUAGUAA UCGCAGUUCAU..AAU.A.CUGCGG.....UGAAUGUGUCCCUGCUCCUUGC..ACACAC CGCCCGUCACACCAUCCGA......GU.............................UGGG ........UUGAGGUGAGGUUUUGG..CCUUcggc......................UAA GA.......................................................... ............................................................ ...............................................UCGAACCUGGGUU C.......................AGCN.AGGA...GGG.......G.UAACAA.GGAA. ..............................C..................CUGnnnnnnGA U............CACCUCC........................................ ........................................................... > ac.UCC...............GUUUGAUCCU.GG.......................... ....CGGAGGCCACU..GCUAUg.GGGGUCCGACUA....AGCCAU.GCAAGUC.....G AAC.....G........GG......................................... .Ccuugnu.................................................... ............................................................ ...................NAC...................................... ........................................................GU.G GCG.....AACGGCUCA....GUAACAC.GUG.GAC.AACC..................U ........................................A................CC. .C.....UGg................................................GG .UNC.GGGAUAA.C.CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... ...................................GGAU.AGGC................ .......GA...........GGUCUNCugga............................. ............................................................ ............ANNGGGCCUCGCCGAAAGG.....UCUUUUGACCG........CCC.. .......................C....................NNN............. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...AUGGGU.....CUG.CGGC...................................... ..CG..................AUUAGGU...AG.UUGGUAG.GGUAACGGC..CUACCA AG.CCUACGA..UCGGUAC..GG.....G..UUGUG.AGAGCAAGAGC..CnG...G..A GACGGGGC.CUGAGACAAGNcccnna....GC..CCUACGGGNNGCAGCAGGCGCGAAAA CUC.....CG...CAAUGCNnGAA.AGC................GC...GAC....G.GG GGGAC.....CCCCAGuncgcucg.................................... ....................................U.........A...A......... ............................................................ ....................N......GNGA...................Gc........ ............................................................ ....GCU.....U..............UUCCG...GAGUG.........UAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CUCCG..G.GAA..U .......AAGGG.................CUGG........................... ............GCAANC.CC.GGUGCCAGCCGCCGCGGUAACACCGGCAGCCCGAGUGG UGGCCGCG...............UUUAUUGGGCCU..AAAGCGU...Cnguagcc..... ....NGUCC.GGU.................AAG.............UCUCc......... ..........G..........GUG.......AAAG.......CC.NNG.AGCUCAA.C.. ..UG......C...G........GGAGUNNCNG........................... .........................G.....................AG..A..UACUGC CNNnc..........UNNG............G..GC....AG.............GG... AGAGGCC..GG..AGGUACUC......CC.....................GGGGUAGGGG UG..AAAUCCUGUAg.A.UCCG.GG.NNGACCACCUG.UNGCGAA............GGC GUCCG.G.CUGGA..ACGGGC..CCGACGGU....GAG.GGACGAAAGCCAGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCCGUAAACGAUGCG....GAC.......... ....UUGGU........................G.......UU....G.GG.....G... .C..............................AA........C........CUCGA.... .....G..............UUGC.........CC........C................ .A.....GU........GCCG.......AAGGGAAGC..CGU..........UAAG..UC C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.ACGC..GUGGAGCNUG.UGGUUUAAUUGGAU.UCAACGCC G.GACACCUCA.CCGGGGG....CNACGGN........AGGAUGAUGGCCAGGUUGAUGA CCUUGCCUGA.....CG....................AG..................... ...................CC........................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGCCGUCAGCUCGUACCGUGAGGCGU CCUGUUAAGUCAG.GCAACGAGCGAGACCCGCGC...CCCUAG......U....UGC..C AGCngu.......CCC.....G.U.........A.NNG......G...ACG.CCGGG..C A.CACUAGGG............GG.ACCGCCA...G.CG.AU.AA..GC.UG........ ...GAGGA.A.GGUGC.GGGnGACGGU..AG..GUCCGUAUGCCCCGAAACC.CCCG.GG CUACAC.GCGGGCUACAAU.GGC.CG..GG.ACAA.UG................GG.... ....U.AN...............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGGUAAU......CCC.....A..U.AAA..C..CCggcn.. GU.A....GUUCGGAUCGAGGGCUGCAACUCGCCCUCGUGAAGC.UGGAAUGCGUAGUAA UCGCGGGUCA..C.UA.UCCCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCACGCCACCCAAAc......GGGGUUCGGAUGAGGCgnnuc............ ......................UGG..CCAUN....GU...................C.. ...GA.AUCCgggcccc........................................... ............................................................ ............................................................ ......................................G.......G.UAACAA.GGAA. ..............................C..................CUG......GA U............CACCUCCU....................................... ........................................................... > .AAUCC...............GUUUGAUCCU.GG.......................... ....CGGAGGCCACU..GCUUUU.GGGGUUCGAUUA....AGCCAU.GCAAGUC.....G AAC.....G.......A.A......................................... ........U......C................A.....................CUUCGG ..........U.........G....................................... .......G...........UUC...................................... ........................................................GU.G GCG.....AACGGCUCA....GUAACAC.GUG.GA.UAAUC..................U ........................................A................CC. .C.....U..............U......A............................GG .A.CUGGGAUAAC..CCU.G...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.............. ................................................AUAAUACC.... ...................................GGAU.AG............UUAGG. ............................................................ ................................................AguUCCUGGAAU GGu......................................................... ............................................................ ..........................CUUC.............................. .............................UUUUUA.......AAUG.............. ...............UU........................................... ............................................................ ............................CAGG............................ ......CGCCUA................................................ ............................................................ ..............................................A............. .GGAUGGAU.....CUG.CGGC...................................... ..AG..................AUUAGGU...AG.UUGGUGG.GGUAAUGGC..CCACCA AG.CCUUUGA..UCUGUAC..GG.....G..UUGUG.AGAGCAAGAGC..CCG...G..A GAUGGAAC.CUGAGACAAGGUucu.AG...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUC.....CG...CAAUGCACGAA.AG................UGC...GAC....G.GG GGGAC.....CCCAAGUGCC...........A...CUCUU..........AAC.GGGGUG ............................................................ ............................................................ ............................................................ ............................................................ ....GCU.....U..............UU...UUUGAGUG.........UAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CUUU...GAGAA..U .......AAGAG.................CUGG........................... ............GCAAG.ACC.GGUGCCAGCCGCCGCGGUAACACCGGCAGCUCAAGUGG UGGCCAU...............UUUUAUUGGGCCU..AAAGCGU.U.C.GUAG....... .......CC.GG.............C....UUG.............AUAAG.UCUC.... .........UG..........GUG.......AAA.......UCCC.A.UAGCUUAA.C.. ..UG.........UG........GGnauugCUG........................... .........................G.....................AG..A..UACUAU UAG...............G.CU....UGA..G..GC....CG.............GG... AGAGG..UUAG..GGGUACUC......CCA.....................GGGUAGGGG UG..AAAUCCUAUA.AUC.CUG.GG.AGGACCACCUG.UGGCGAA............GGC GCCU.AA.CUGGA..ACGGAC..CUGACGGU....GAGU.AACGAAAGCCAGGGGCGCGA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCCGUAAACGAUGCG....GAC.......... ....UUGGU........................G.......UU....G.G..AaUG.... ................GCUUC.................GAGCUgcU.............. ..................................C........C................ .A.....GU........GCCG.......AAGGGAAGC..UGU..........UAAG..UC C.............GCCGCCUGGGAAGUACGGUCGCAAGACUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.ACGC..GUGGAGCNUGC.GGUUUAAUUGGAU.UCAACGCC G.GACAUCUCA.CCAGGGG....C........GACAGCAGAAUGAUGGCCAGGUUGACGA CCUUGCUUGA.....C...A.................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGCCGUCAGCUCGUACCGUGAGGCGU CCUGUUAAGUCAG.GCAACGAGCGAGACCCACGC...CCUUAG......U....UAC..C .AG.C.G...GA...........UCCUCC..GG.G.AU............G.CCGGG..C A.CACUAAGGN.............NACCGCCA...G.UG.AU.AAA..C.UG........ ...GAGGA.A.GGAGU.GGACGACGGU..AG..GUCNGUAUGCCCCGAAUCC.CCUG.GG CAACAC.GCGGGCUACAAU.GGCU.AU..G.ACAA.UG................GG.... ....U.UC...............CG........A........Cacu.....G.AAA.G.. ......G........UGAAGGUAAU......CUC.......CU.AAACA....UAG.U.C UU.A....GUUCGGAUCGAGGGCUGUAACCCGCCCUCGUGAAGC.UGGAAUGCGUAGUAA UCGCGUGUCAUA...A.UCGCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCACGCCACCCAAAaagGGU......UUGGAUGAGGCCu............... ............................................................ ............................................................ ...........................................................C .A.....GUCGUU....GGU......................UGGGGUCGAAUCUGGGUU C.......................UUU...........G.......G.UAACAA.GGAA. ..............................C..................CUG......GA U............CACCUCCU....................................... ........................................................... > ..........................AUUCU.GG....................UUGAUC CUGCCAGAGGUCACU..GCUAU.CGGGGUUCGAUUA....AGCCAU.GCGAGUC.....G ...........................................AG....A.......... ................................G......Gguucagac...........C CUC...................................................GG.... ............................................................ ............................................................ .CGg.....ACUGCUCA....GUAACAC.GUG.GA.UAAUC..................U .G.......................................................CC. .C.....U..............A......U............................GG .UG.GAGGAUAA.C.CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.............. ................................................AUAAUACU.... .............CCAUAAGUCAgg.AG...UACUGGAA.UG............UCucc. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .........................................U.................. ............................................................ ..........AACUGA.AAGuugC......GG............................ ......CGCCAU................................................ ............................................................ ..............................................A............. .GGAUGaAU.....CUG.CGGC...................................... ..CG..................AUUAGGU...AG.UUGUUGG.GGUAACGGC..CCAACA AG.CCcgUAA..UCGGUAC..GG.....G..UUGUGG.GAGCAAGAGC..CCG...G..A GAUGGAA.UCUGAGACACGAU.UCCAG...GC..CCUACGGnNNGCAGCAGGCGCGAAAA CUUUACAAUG...CA.....GG.................AAACUGU...GAUAA..G.GG A..AC.....CCCGAGUGCC........................................ .....CguacaCGCG.................GGCU.........GU............. ...................................................CCcg..G.. ............................................................ ............................................................ ......UGUUUAA............................................... ............................................................ ............................................................ ............................................................ ...................AACACAUc................................. ............................................................ ..................................................G.G...AAGA .......AAGGG.................CCGG........................... ............GCAAG.ACC.GGUGCCAGCCGCCGCGGUAAUACCGGCNnCUCGAGUGG UGACCAC...............UUUUAUUGGGCUU..AAAGCGU.U.C.GUAG....... .......Cuu.GA.................UU.............UUUAAG.UCUC.... .........U..........UGGG.......AAA.......UCUC.AC.GGCUUAA.C.. ..UG.........UG.........................AGGCGUCu............ .......................AAG.....................AG..A..UACUGG GAAU................CU....AGG..GA..C....CG.............GG... AGAGG..UAAG..AGGUACUU......CA.....................GGGGUAGAAG UG..AAAUUCUGUA.AUC.CUU.GAG.GGACCACCG.AUGGCGAA............GGC AUCU.UA.CCAGA..ACGGcuu..CGACAGU....GAG.GAACGAAAGCUGGGGGAGCGA ACGGGAUUAGAUACCCCGGUAGUCCCA.GCCGUAAACUAUGCG....CGU.......... ....UAGGU........................G.......U...G..CC.......... ...................UGU.A.......A.CU.................ACGA.... .....G..............UUaccGG................................. .....G.GU........GCCG.......AAGUGAAAACGUG............AAAC..G U.............GCCGCCUGGGAAGUACGGUCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.ACG..GGUGGAGCCUGC.GGUUUAAUUGGAC.UCAACGCC G.GGCAgCUCA.CCGG............AUAgGACAGCGGAAUGAUAGcCGGGCUGAAGA CCUUGCUUGA.....Cc....................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGUCGUCAGUUCGUACUGUGAAGCAU CCUGUUUAGUCAG.GCAACGAGCGAGACCCACGC...CAACAG......U....UGCU.. .AG.C....A..........UG.UUCUCCGG..A.AUG.A........U.....GAGG.. A.CACUGUUG............GG.ACCGCCU.CUGC..UAA.A...G..AG........ ...GAGGA.A.GGAAUGGGCA.ACGGU..AG..GUCAGCAUGCCCCGAAUU.AUCCG.GG CUACAC.GCGGGCUACAAU.GGU.CA..GG.ACAA.UG................GG.... ....A.AA...............CGgca................CUGAAAAG.UGUA... ......G........UC.....AAU......CUC.......CU.AAAC.CUGUC.....C cA.A....GUUCGGAUUGUGGGCUGCAACUCGCCCACAUGAAGC.UGGAAUCCGUAGUAA UCGCGUUUCAA..AAU.A.GCGCGG.....UGAAUAAGUCCCUGCUCCUUGC..ACACAC CGCCCGUCAAACCAUCUUAGUgaGGU......UUGGAUGAGGC................. ..............UGUGGUUAACUGCCAc.............................. ............................................................ ............................................................ ............................................................ ..........................................AGUCG.AAUCUA.GGUUU Cgc.........AAG..........GAGGGUUaagnnguaacaaggaauCUG......GA U............CACCUCCU....................................... ........................................................... > ...............................................AUUCUGNUUGAUC CUGCCAGAGGCCACU..GCUAU.CGGGGUUUGACUA....AGCCAU.GCGAGUC.....G ...........................................AG....A.......... ................................G......G...UG.........CAAGaC CUC...................................................GG.... ............................................................ ............................................................ .CG.....UACUGCUCA....GUAACAC.GUG.GAC.AAUC..................U .G.......................................................CC. .C.....U....................GA......A......................G .AG.GAGGAUAAU..CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.G............ .................................................UAAUACU.... .............CCAUAGuucgugcug....ACUGGAA.UG............UUAUGC GAA......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ..............CGAAA................................G........ ..A..........................UC............................. ............................................................ .......................C......Gu............................ ......CGCU.....UC........................................... ...............................A............................ ..................GG.......A.......U........................ GA.....GU.....CUG.CGGC...................................... ..CG..................AUUAGGU...AG.UUGUUGG.GGUAACGGC..CCAACA AG.CCUGucA..UCGGUAC..GG.....G..UUGUGG.GAGCAAGAGC..CCG...G..A GAUGGAU.UCUGAGACACGAA.UCCAG...GC..CCUACGGGGCGCAGCAGGCGCGAAAA CUUUACc........AUGCGGGCA.ACC................GU...GAUAA..G.GA A..AC.....CCCGAGUGCC...........AGcacagG..................... ....C..........................UGGCU.........GU............. ...................................................CCaccaG.. ............................................................ ............................................................ ......UGUAAAU............................................... ............................................................ ............................................................ ............................................................ ...................AACUg.................................... ............................................................ .................................................GU.G...AAGA .......AAGGG.................CCGG........................... ............GCAAG.ACC.GGUGCCAGCCGCCGCGGUAAUACCGGCGGCUCGAGUGG UGGCCGC...............UAUUACUGGGCUU..AAAGGGU...CCGUAG....... .......C.UGGA.................UA.............UACAAG.UCCC.... .........U..........UGAG.......AAA.......UCCgc.C.GGCUUAA.C.C ...G........GUG........GG.........CG........UucAG........... .........................G...G..................G..A..AACUGU AUUU................CU....AGG..GA..C....CG.............GG... AGAGG..UGAG..AGGUACUG......CC.....................GGGGUAGGAG UG..AAAUCCUGUA.AUC.CCG.GUG.GGACCACCU.AUGGCGAA............GGC AUCUC.A.CCAGA..ACGGG..UCCGACAGU....GAG.GGACGAAAGCUGGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCCA.GCUGUAAACGAUGCG....CGU.......... ....UAGGU........................G.......U...GUcagug........ .................................A........C........CACGU.... .....G..............UC.........AC......................U...G ....AG.GU........GCCG.......AAGGGAAAC..CGUGAAA..........C..G C.............GCCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.ACG..GGUGGAGCCUGC.GGUUUAAUcGGAC.UCAACGCC G.GAAAUCUCA.CCGG............AUAAGACAGCUGAAUGAUAGucgGGAUGAAGA CUcUACUUGA.....C...U.................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGUCGUCAGUUCGUACUGUGAAGCAU CCUGUUUAGUCAG.GCAACGAGCGAGACCCACGCga...GCAG......U....UGC..C .AG.C....U..........UG.ACCUUCGGG.U.U.G.A........U.....GGGG.. A.CACUGcUC............GG.ACCGCCU.CUGC..UAA.A...G.G.G........ ...GAGGA.A.GGAAUGGGCA.ACGGU..AG..GUCAGCAUGCCCCGAAUU.AUCCG.GG CUACAC.GCGGGCUACAAU.GGA.CA..GG.ACAA.UG................GG.... ....U.UU...............CG........A........CACC.....G.AGA.G.. ......G........UGAggAUAAU......CUC.......CU.AAAC.CUGUC.....C GA.A....GUUCGGAUUGCGGGuUGUAACUCACCCGCAUGAAGC.UGGAAUCCGUAGUAA UCGCGUUUCAA.C.AU.A.GCGCGG.....UGAAUAUGUCCCUGCUCCUUGC..ACACAC CGCCCGUCAAACCACCCGA......GUGaggucuu........................G ........AUGAGGAugUA........UCAUU....GA...................UAU GU.......................................................... ............................................................ ...............................................UCGAAUCUGGGUU U.......................UGCA.AGG...GGGGUUAAGUCG.UAACAA.GGUAG CCG.UAGGGGAAUC............UGCG.....G.............CUG......GA U............CACCUCCU....................................... ........................................................... > ttctGG.................TTGATCCT............................. ..GCCAGAGGCCAttgctatcagggtttGA..CTAAGCCATGCG.A.GT....C.....G AGaggtgtaagacctcggca..................................TACT.. ............................................................ ............................................................ ............................................................ ............................................................ ............GCTCA....GTAACAC.GTG.GtT.AACCT.................. .G.......................................................CC. .CTaaggtggagaatact.......................................... ...............CC.CG...........GG.AA.ACTG.G................. ...............G............................................ .............................................G.CTAATgCTCCATA gtGGAT...................................................... ........................................ATGtc............... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................................................CTGGAATGg tatatcct.................................................... ........................................CG.................. ................AAA......................................... ............................................................ ...................G.......AT.......CcgtcgccttA............. .GGATGGnn.....CTG.CGTC...................................... ..CG..................ATTAGG.TTGTT...GGCGG.GGTAACGGC..CCACCA AG.CCNtttATC..GGTAC..GG.....GTTGT..GG.GAGCAAGAtC..CCG...G..A GATGGATT.CTGAGACATGAA.TCCAG...GC..CCTACGGGGCGCAGCAGGCGCGcAAA CTTTACAAT........GCGagcaat.C................GTGAT...AA..G.GA A..AC.....CCtGAGTGCCtgtcgat...........G..................... ....C..........................AGGCN.........GttcatatatctaaA TCATATGt.................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................................................G...AAGA .......AAGGG.................CAGG........................... ............GCAAG.ACCn.GTGCCAGCCGCCGCGGTAATACCGGCtgctcgagtga ...TGGCNNCt............ATTAC..TGGGTTTAAAGCGT...CCGTAG....... .......Cttgactgttaggtctctt.................................. .....................GGG.......AAATCTtcgc.........GCTCAA.Cgt gaaggcgtctaagagatacc........................................ ..........................................................GG CAGN................CTT....GGA..A..Ct....G.............GG... AGAGGT..AAaccgtacttCG.............................GGGGTAGGAG TG..AAATCTTGTAAT.C.Ctc.GAG.GGACGACCt.ATGGCGAA............GGC AGtTT.A.CCAGN..ACAgcttcgaca..GT....GAG.GGACNNAAGCTGGGGGAGCAA ACGGGATTAGATACCCCGGTAGTCCCA.GCCGTAAACaatgtgcgtTAGGTGT....... ...............................................Gtcggt....... ................................AA........C........CACGtgtta ctgat....................................................... .......GC........GCCG.......AAGAGAAAtcgt..GAAA..........C..G Ca.............CCACCTGGGAAGTACGGTCGCAAGGCTGAAACTTAA...AGGAAT TGGCGGGNNAGCAC.CACA.ACa..GGTGGAGCCTGCGGTTTAATTG.GNN.NNAACGCC G.GACAtCTCA.CCGG............AtAAGACAGCtgaatgattgtcaatCTGAAGG T.....TTTACATGact....................AG..................... ...................CT........................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGTGCATGGCCGTCGTCAGTTCGTACTGTGAAGCAT CCTGTTAAGTCAG.GCAACGAGCGAGACCCACGC...CGacaaTT..........GC..C .AG.C....Agcatctccggatggct....GG...NGACAttgt................ ........CG............GG.ACCGCCtctgct...NA.A...G.G.G........ ...GAGGA.A.GGAAtGGGCA.ACGGT..AG..GTCAGCATGCCCCGAATTat.CCG.GG CTACAC.GCGGGCTACAAT.GGA.CG..GG.ACAAT.G................GGTaa. .......................CA........A........CACC.....G.AAA.G.. ......Gtgcagt........CAAT......CTCcg.........AA..C..CCCG..CC CTTA....GTTaGGATTGCgggtTGCAACTCACCCGCATGAAtCT.GGAATCtGTAGTAA TCGCGTTTCAcTAT...A.GCGCGGT.....GAATACGTCCCTnCTCCTTGC..ACACAC CGCCCGNCAAACCAtccta......................................... ............................................................ ....GT........G.GGG............TtTGGATGAGtccctngtctttgccgg.. ............................................................ G......GTCGAAtctaggt................T....................... .CCGT.......................GAGGagg......................... ............................................................ ............................................................ ........................................................... > ............................................................ .................GCTATCGGtgttcgcCTAAGCCATGCG.A.GT....C...... ...............................ATatgttcttcgtgaacatggcgTACT.. ............................................................ ............................................................ ............................................................ ............................................................ ............GCTCA....GTAACAC.GTG.GAT.AACCT.................. .G.......................................................CC. .CTTGGgtctggc............................................... ........ATAA.C.CC.CG...........GG.AA.ACTG.G................. ...............G............................................ .............................................Gataatt.CC..... ..GGAT...................................................... ........................................AAcgcat............. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..............................................ATATGCTGGAATGc tttatgcgtaaaatggATTCGT...................................... ............................................................ .....CCGCCC.....A........................................... ...............................AG........................... ..................GAT....................................... GGGT..........CTG.CGGC...................................... ..CT..................ATCAGG.TAGT...AGtgggtgtaatgtacctact... AG.CCTACaAC..GGGTAC..GG.....GTTGT..G.AGAGCAAGAGC..CCG...G..A GATGGATT.CTGAGACATGAA.TCCAG...GC..CCTACGGGGCGCAnnAGGCGCGAAAA CTTTACAAT........GCGGGAA.ACC................GTGAT...AA..G.GG GACAC.....C.GA......Gtgctagc................................ ...........................................................A TCATATGctggctgtccaggtgTGTAAACTacacctgtt..................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .......................................................AGC.. .......AAGGG.................CCGG........................... ............GCAAG.ACC.GGTGCCAGCCGCCGCGGTAACACCGGCGGCCCGAGTGG TGatcgtg...............ATTA..TTGGGTcTAAAGGGT...CCGTAG....... .......CC.GGT.................TT......GGTCA.......GT.Cct.... ..........CC.........GGG.......AAATCTgat.......A..GCTCAA.CTa ttaggctttcg.....................GG.......................... ..........................G.....................G..AT..ACTGC CAGA................CTT....GGA..A..C....CG.............GG... AGAGGT..AAGaggtact..A......CA.....................GGGGTAGGAG TG..AAATCTTGTAAT.C.CCtgt.G.GGACCACCtG.TGGCGAA............GGC GtcTT.A.CCAGA..ACGGGTt..CGACGGT....GAG.GGACGAAAGCTGGGGGCACGA ACCGGATTAGATACCCGGGTAGTCCCA.GCCGTAAACGATGCtCGCTAGGTGTCaggcat ggc......................................................... .........................................................GCG ACCGTGTCTG.................................................. ...............GTGCCGC.......AGGGAAGC..CGTG..........AAGC..G A.............GCCACCTGGGAAGTACGGCCGCAAGGCTGAAACTTAA...AGGAAT TGGCGGGGGAGCACA.ACA.ACG..GGTGGAGCCTGCGGTTTAATTG.GAcT.CAACGCC G.GACAACTCA.CCGGGGa....C........GACAGCAAtatgtaggtCAGGCTGAAGA CCttacctgaatc.........................G..................... ...................CT........................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGTGCATGGCCGTCGcCAGTTCGTACTGTGAAGCAT CCTGTTAAGTCAG.GCAACGAGCGAGACCCGtgcccact...GTT..........AC..C .AG.C....ATatcctccgggatgatgggt.............................. A.CTCTGTGG............GG.ACCGCC.G..GT.GT.T.AAA.T.C.G........ ...GAGGA.A.GGTGc.GGGCCACGGT..AG..GTCAGTATGCCCCGAATTt.CCCG.GG CTACAC.GCGGGCTACAAT.GAAt.G..GG.ACAAT.G................GGTccc tcccct........................................GAAAAGGGctgg.. .....................TAAT......CTC........AC.AAA.C..CCAT...C CTTA....GTTCGGATCGAGGGCTGtAACTCGCCCTCGTGAAGCT.GGAATCCGTAGTAA TCGCGTTTCAaTAT...A.GCGCGGT.....GAATACGTCCCTGCTCCTTGC..ACACAC CGCCCGTCAAACCACCCGA......GTg................................ ............................................................ ............................................................ ............................................................ ............A....GGTATGGgtgagggcacgaacatcgtgtcgtgttcgaacctgt gcttt....................GCA.AGG...GGGGTTAAGTCGT.AAC........ ............................................................ ............................................................ ........................................................... > ..........................AUUCU.GG....................UUGAUC CUGCCAGAGGUuACU..GCUAU.CGaGGUUCGACUA....AGCCAU.GCGAGUC.....G ...........................................A................ .......AUG.............................................UAGC. .................A......A.................UAC.......AUGG.... ............................................................ ............................................................ .CG.....AACUGCUCA....GUAACAC.GUG.GAC.AACC..................U .G.......................................................CC. .C.....U..............U......A............................GG .UU.GGGUAUAAA..CC.CG...........GG.AA.ACUG.G................. ...............GUAUAAUAC.................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .......................CCGAUAGG.....UCUCGAUUG............... ............................................................ ............................................................ ....................................................CUGG..AA UGcaucgagau....UUAAAGC.......UC............................. ............................................................ .......................C......GG............................ ......CGCCUA................................................ ............................................................ ..............................................A............. .GGAUGGGU.....CUG.CGGC...................................... ..C..................UAUCAGGU...AG.UAGU..G.GGUGUAGcguaCCUACU AG.CCUACGAC..GGGUAC..GG.....G..UUGUG.AGAGCAAGAGC..CCG...G..A GAUGGAU.UCUGAGACACGAA.UCCAG...GC..CCUACGGGGUGCAGCAGGCGCGAAAA CUUUACAAUG...CU.....GGC.................AACAGC...GAUAA..G.GG A..AC.....CuCGAGUGCC...........AGguuac...................... AAAUC..........................UGGCU.........GU............. ...................................................CG....... ............................................................ ............................................................ ..............................AG............AUGCCUAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CAUU.UC.AUAGC.. .......AAGGG.................CCGG........................... ............GCAAG.ACC.GGUGCCAGCCGCCGCGGUAACACCGGCGGCUCGAGUGG UaaccgU...............UAUUAUUGGGUCU..AAAGGGUC...UGUAG....... .......CC.GG.............C....CGG.............AUAAG.UCUC.... .........U..........UGAG.......AAA.......UCUG.GC.AGCUUAA.C.. ..UG.........Ucaggc........UUUCAG........................... .........................G.....................AG..A..UACUGU CUG...............G.CUC....GA..G..GC....CG.............GG... AGAGG..UGAG..AGGUACUU......CA.....................GGGGUAGGGG UG..AAAUCuUGUA.AUC.CUU.GA.AGGACCACCAG.UGGCGAA............GGC GUCUC.A.CCAGA..ACGGAC..CUGACGGca....AG.GGACGAAAGCUAGGGGCACGA ACCGGAUUAGAUACCCGGGUAGUCCUA.GCCGUAAACGAUAC....UCGC.......... ....UAGGU........................G.......UC....G.G.......... ..........................................C........CACGGUGCG ACCGUUG..............U.....................C................ .....G.GU........GCCG.......UAGGGAAGC..CGUG..........AAGC..G A.............GCCACCUGGGAAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.ACG..GGUGGAGCUUGC.GGUUUAAUUGGAU.UCAACGCC G.GAAAUCUUA.CCGGGac....C........GACAGCAAUAUGAAGGCCAGGCUGAAGA CUUUGCCGGAu........U.................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGUGCAUGGCCGUCGUCAGUUCGUACUGUGAAGCAU CCUGUUAAGUCAG.GCAACGAGCGAGACCCACGC...CCACAG......U....UGC..C AGCguacuCU....CUGGA............G.Ugac..................GGG.. UACACUGUGG............GG.ACCGCC.GCUGC..UAA.A...G.C.G........ ...GAGGA.A.GGAAUGGGCA.ACGGU..AG..GUCAGUAUGCCCCGAAUA.UCCCG.GG CUACAC.GCGAGCUACAAU.GGUU.G..G.UACAA.UG................GG.... ....U.AU...............Cu........A........CCCC.....G.AAA.G.. ......GG........GAcggGAAU......CUC.......CU.AAAA.C..CA..AU.C UU.A....GUUCGGAUUGAGGGCUGCAACUCGCCCUCAUGAAGC.UGGAAUCCGUAGUAA UCGCGUUUCAA.C.Aga.A.CGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCAAACCACCCGA......GU.............................AGGG ........Ucugaaug.......................A.................... ....G.A.......GC.............GCU.....U....U.........C....... ..........U.....U...UG.G.................AG.....GC........Gu ucgAAUU.UGGGC..............................................U U.......................UGCA.AGG...GGGGUUAAGUCG.UAACAA.GGUAG CCG.UAGGGGAAUC............UGCG.....G.............CUG......GA U............CACCUCCUA...................................... ........................................................... > ...........................AUUCCGG....................UUGAUC CUGCCGGAGGCCAuU..GCUAU.CGGAgucCGAUUU....AGCCAU.GCUAGU.....UG UGC.....G........GG.............................UUUAGAcC.... .CG............CAGCGGaa..................................... ............................................................ ............................................................ ............................................................ ...........AGCUCA....GUAACAC.GUG.GCC.AAgC..................U ........................................A................CC. .C.....UGUG....................G............................ ..AC.GGGAAUAC.UCU.CG...........GG.AA.ACUG.A................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... .............C......................GAU.AacgcuuU............ GCUCC....................................................... ......................................................U..... .......................G.................................... ............................................................ ............GA.......AGGGGCAAagccggaaac..................... ............................................................ ....................GC.......UC............................. ............................................................ .......................C......GG............................ ......CGCCAC................................................ ............................................................ ..............................................A............. .GGAUGCGG.....CUG.CGG....................................... .UCG..................AUUAGGU...AG.ACGGUGG.GGUAACGGC..CCACCG UG.CCcAUAA..UCGGUAC..GG.....G..UUGUG.AGAGCAAGAGC..CCG...G..A GACGGAA.UCUGAGACAAGAuuCCG.G...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUuuacac........UGUACGAA.AG................UGC...GAUAA..G.GG GACUC.....C.GA......GUGUGAAGgc.............................. .AUAG..........................AG.C......................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................CUUCACUUUUGU.............................. ............................................................ .......Ac...................................ACCGU.A..AGguggu gc................ACGAAUAAGGaCUGG........................... ............GCAAG.ACC.GGUGCCAGCCGCCGCGGUAAUACCGGCAGuCCGAGUGa uggccga...............UCUUAUUGGGCCU..AAAGCGU...CCGUAG....... .......C.UGG.............C....UGAACAAGUCcg.................. .........U..........UGGG.......AAA.......UCUG..........U.C.C ...GC....U....U..................AACGGgcAGGCGUCc............ ...............AG........C...G..................G..A..AACUGU UCA...............G.CU....UGG..GA..C....CG.............GA... AGAccug..AG..GGGUACgU......CU.....................GGGGUAGGAG UG..AAAUCCUGUA.AUC.CUG.GAc.GGACCGCCGG.UGGCGAAA............GC GCcucagg..AGA..ACGGA..UCCGACAGU....GAG.GGACGAAAGCUAGGGUCUCGA ACCGGAUUAGAUACCCGGGUAGUCCUA.GCUGUAAACGAUGUC....CGC.......... ....UAGGU........................G.......U...G.GC.Gc..AG.... ................GCUAC.................GAGCCU................ ............GC.......G.....................C................ .U.....GU........GCCG.......UAGGGAAGC..CGAG..........AAGC..G GA.............CCGCCUGGGAAGUACGUCuGCAAGGAUGAAACUUAA...AGGAAU UGGCGGGGGAGCACU.ACA.AC.C.GGAGGAGCCUG.AGGUUUAAUUGGAC.UCAACGCC G.GACAUCUCA.CCAGccccgacaguagUAAUGACggu...........CAGGUUGAUGA CCUUACCcgaggc........................UA..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGCCGUCAGCUCGUACCGUGAGGCGU CCUGUUAAGUCAG.GCAACGAGCGAGACCCGCacu...CCUAA......U....UGC..C .AG.C.G...GU...........ACCCUUugggU.A........G..CU.....GGGU.. A.CAUUAGGU............GG.ACUGCC.GCUGCc..AA.A...G.C.G........ ...GAGGA.A.GGAAcGGGCA.ACGGU..AG..GUCAGUAUGCCCCGAAUG.GGCUG.GG CAACAC.GCGGGCUACAAU.GGU.CGA..G.ACAA.UG................GG.... ....A.A.G..............CC........A........CUCC.....G.AGA.G.. ......G........AGGCGCUAAU......CUC.......CU.AAACU...CG..AU.C GU.A....GUUCGGAUUGAGGGCUGAAACUCGCCCUCAUGAAGC.UGGAUUCGGUAGUAA UCGCGUGUCAG.C.AG..CGCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCAAAUCACCCGA......GUGGGGUUCGGAUGAGGCCggcaugcgC...UGG. ..UC.....A..............AAUCUGgg............................ ................................C.........U.........CCG..... ..............C.A...AG.GG.................G.....GA.......... ............................................................ .......................................UUAAGUCG.UAACAA.GGUAG CCG.UAGGGGAAUC............UGCG.....G.............CUG......GA U............CACCUCCU....................................... ........................................................... > ..........................AUUCU.GG....................UUGAUC CCGgcggcGGCCACU..GCUAU.CAaGUUCCGACUA....AGCCAU.GCGAGUCAAGGG. ........G......CCGU..................AAG.................... .........G.....C................A.....................C..... ..C...................................................GG.... ............................................................ ............................................................ .CG.....UACcGCUCA....GUAACAC.GcG.GA.UAAUC..................U ........................................A................CC. .C.....UCG................................................GG .AA.GGGCAUAA.C.CU.CG...........GG.AA.ACUG.A................. ...............G............................................ .............................................G.C............ .................................................UAAUUCC.... .............C.UAUAGCCAUUCAG...AACUGGAA.UG............UUUGG. ............................................................ ................................................A........... ............................................................ ............................................................ ............................................................ .................UG..........................G.............. ...............UGAAAGC.......UC............................. ............................................................ .......................C......GG............................ ......CGCCC................................................. ..............................GG............................ ..................GG.......A.......U........................ GA.....GU.....CUG.CGGC...................................... ..C..................UAUCAGGU...AG.UAGGUGGU.GUAACGGA..CCACCU AG.CCUAAGAC..GGGUAC..GG.....GCCCUGggaggg...GUAGC..CCG...G..A GAUGGAC.UCUGAGACACUA.GUCCAG...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUG.....UG...CAAUGCGCGCA.AGC................GC...GACACGGG.GA GCUUGAg..............................................UGUCUUG ............................................................ ............................................................ ............................................................ ............................................................ ....GCA.....A..............AAGCCAAGACUUuucuuAUGCCUAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CAUA.A.G.GAA..U .......AAGGG.................CUGG........................... ............GuAAG.ACG.GGUGCCAGCCGCCGCGGUAACACCCGCAGCUCAAGUGG UGGUCACUUuuacuga...............GCCU..AAAGCGU.U.C.GUAG....... .......CC.GG.............C....UU.............UGU............ ....................................................AAAU.C.. ..U..C....C...A........GG.........UAAAUUCU..A...G........... ......................CGC...UuaacguuagaucuccuggAG..AG..ACUGU AAA...............G.CU....UGG..GA..C....CG.............GG... UGGGG..UUGA..AcGUACUUU......CA.....................GGGUAGGGG U..AAAAUCCUGUA.AUC.CUG.GA.AGGACGACCGG.UAGCGAA............GGC GUUC.AACU.AGA..ACGGA..UCCGACGGU....GAG.GAACGAAGGCUAGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCUA.GCUGUAAACUCUGCC....CAC.......... ....UUGGU........................G.......UU....GCC.......... ...................Uu....................................... UCCGUUGAGGGGAG.......G.....................C................ .A.....GU........GCCGG.......AGCG.AAG.GUGU..........UAAG..UG .............GGCCGCUUGGGGAGUAUGGUCGCAAGACUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CGCA.ACG..GGAGGAAUGUGC.GGUUUAAUUGGAU.UCAACGCC G.GAAAACUCA.CCGGGAGCGACCUg............UGGAUGAg.............. .......AGU.....C...A.................AC.C................... ...UGA...CG................AG.UUUacucgauagcAGGA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGUGCAUGGCCGUCGUCAGCUCGUACCGUAGGGCGU UCACUUAAGUGUGA.UAACGAGCGAGACCCCCA...UCUCcaauugcaauuaccUACG.. ............................CGGG...UAG......G...Ua.....AG..C A.CUUUGGAGA............G.ACCGCCA...G.CGC.U.AA..GC.UG........ ...GAGGA.A.GGAG.GGGUCGACGGC..AG..GUCAGUACGCCCCGAAUC.UCCCG.GG CUACAC.GCGCAUUACAAA.GGG.CA..GG.ACAA.UGC................G.... ....U.U.G..............CA........A........CCUC.....G.AAA.G.. ......GG........GAAGCUAAU......CGCc.........AAAC.CUGUC.....C GU.A....GUUaGGAUUGAGGGCUGUAACUCGCCCUCAUGAAuC.UGGAUUCCGUAGUAA UCGCGGGUCAAC...A.ACCCGCGG.....UGAAUAUGCCCCUGCUCCUUGC..ACACAC CGCCUGUCAAACCAUCCGA......GCUGGUGUUGGAUGAGGGUuagcucgagaggguua gcUC.....A..............AAUCUGAU....GU...................CA. ....G.U.......G.A............G.............................. ............................................................ ............................................................ .........................G......A...GGGUUAAGUCA.UAACAA.GGUAU CuG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCC........................................ ........................................................... > AC...........................UCCGG....................UcGAUC CUGCCGGcGGUCACU..GCUAU.CAgGUUCCGACUA....AGCCAU.GCAAGUCAUGGG. ........G......CCGU..................AAG.................... .........G.....C................A.....................C..... ..C...................................................GG.... ............................................................ ............................................................ .CG.....AACAGCUCA....GUAACAC.GUG.GA.UAAUU..................U ........................................A................CC. .C....................UC.....Aggcg.......................... ....GGGCAUAA.C.CU.CG...........GG.AA.ACUG.A................. ...............G............................................ .............................................G.C............ .................................................UAAUUCC.... .............CCAUAG....UCAUUACaAACUGGAA.UGG....UUGUAAug..... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...A.........UGA.AAGCUU..................................... ...CU..GCAcC................................................ .............................UGA............................ ..................GG.......A.......UA....................... .A.....GU.....CUG.CGGC...................................... ..C..................UAUCAGGU...AG.UAGGUGGU.GUAAAGGA..CCACCU AG.CCUAAGAC..GGGUAC..GG.....GCCCUGAa.AGGG..GGAGC..CCG...G..A GAUGGAC.UCUGAGACAAcA.GUCCAG...GC..CCUACGGGGCGCAGCAGGCGCGAAAA CUG.....UG...CAAUGCGCGAA.AGC................GC...GACACGGG.GA GC.....CU....GAGUGCC...........UU...GA.C.........UUUUUGUCAAG ............................................................ ............................................................ ............................................................ ............................................................ ....GCU.....U..............UUCUG............AUGCCUAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CAUC.A.G.GAA..U .......AAGGG.................CUGG........................... ............GCAAG.ACG.GGUGCCAGCCGCCGCGGUAACACCCGCAGCUCGAGUGG UGAuCAC...............UUUUAUUGaGUCU..AAAGCGU.U.C.GUA........ ......ACC.GG..................UC.............UUAUAaaUCUUC... ....................AGA.......UAAA.......U..........UCUU.C.C ...GC....U....U..................AACGGa..................... ..................AGAACUUCUGA..................AG..AG..ACUGU AAGA................CU....UGG..GA..C....CG.............GG... UGAGG..UUGAau..GUACUUU......CA.....................GGGUAGGGG U..AAAAUCCUGUA.AUC.CUGa.A.AGGACGACCGG.UGGCGAAA............GC GUUC.AACU.AGA..ACGGA..UCCGACGGU....GAG.GGACGAAGGCUAGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCUA.GCUGUAAACGCUGCC....CAC.......... ....UUGGU........................G.......UU....GCuuc........ ............................................................ UCCGUUGAGGGGGG.......G.....................C................ .A.....GU........GCCG.......UAGCG.AAG.GUGU..........UAAG..UG .............GGucaCUUGGGGAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CGCA.ACG..GGAGGAGCGUGC.GGUUUAAUUGGAU.UCAACGCC G.GAAAACUCA.CCGGGAGCGACCUUCGGA........UGagg................. ........GU.....C...A.................AC.C................... ...UGA...CG................AAUUUAcccgauaga.AGGA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGUGCAUGGCCGUCGUCAGCUCGUACCGUAGGGCGU UCACUUAAGUGUGA.UAACGAGCaAGACCCCCA...UCUCUAA......U....UGC..C .AGAC....UGucuuugcgggca.....................G...A......GG..C A.CUUUAGAG............GG.ACCGCCA...G.CGC.U.AA..GC.UG........ ...GAGGA.A.GGAG.GGGUCGACGGC..AG..GUCAGUACGCCCCGAAUC.UCCCG.GG CUACAC.GCGCGCUACAAA.GGA.CG..GG.ACAA.UGA................G.... ....U.U.G..............CA........A........CCUC.....G.AAA.G.. ......GG........GAAGCUAAC......CUC......G...AAAC.C..CG..UU.C GU.A....GUCaggacUGAGGGCUGUAACUCGCCCUCAcgaauG.UGGAUUCCGUAGUAA UCGUAGGUCAAC...Agc.CUACGG.....UGAAUAUGCCCCUGCUCCUUGC..ACACAC CGCCCGUCAAACCAUCCGA......GCUGGUGUUGGAUGAGGGUccguccucuggaUGG. .......AUU.Cg...........AAUCUGAU....GU...................CA. ....G.U.......G.A............G.............................. ............................................................ ............................................................ .........................G......A...GGGUUAAGUCG.UAACAA.GGUAU CCG.UAGGGGAACC............UGCG.....GA.............UG......GA U............CACCUCC........................................ ........................................................... > ..........................AUUCU.GG....................UUGAUC CUGCCAGAGGCCgCU..GCUAU.CcggcUGGGACUA....AGCCAU.GCGAGUCAAGGG. ........G......CUugua....................................... ..............UC.......................C.................... ..CUUC......GGG.....G..........................AUgca........ ....................A..........GC........................... .......................................................ACC.G GCGG.....ACGGCUCA....GUAACAC.GUG.GAC.AACC..................U .G.......................................................CC. .C.....UCG................................................GG .UG.GGGGAUAA.C.CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... .............CCAUAGGGGAugg.G...UACUGGAA.UG............UC.... ......................CC.................................... .......................................A.................... ............................................................ ......................UCUCCg................................ ............................................................ ............................................................ ............................................................ ......................AAAGCGCUUA............................ ...............................G............................ ......CGCCC................................................. ..............................G............................. ..............................................A............. .GGAUGGGU.....CUG.CGGC...................................... ..GG..................AUUAGGU...UG.UUGGUGG.GGUAACGGC..CCACCA AG.CCGAAGA..UCCGUAC..GG.....GCCAUGAG.AGUG..GGAGC..CCG...G..A GAUGGACC.CUGAGACACG.GGUCCAG...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUC.....CG...CAAUGCGGGAA.ACC................GC...GAC....G.GG GUCAgccg.....GAGUGC...UCGcgcaucg............................ ...........CGCG.................GGCU.........GU............. ...................................................CGGGG.... ............................................................ ............................................................ .............................................UGCCUAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CACCccac..AGC.. .......AAGGG.................CCGG........................... ............GCAAGGccgguGG..CAGCCGCCGCGGUAAUACCGGCGGCCCGAGUGG cGGCCAC...............UUUUAUUGGGCCU..AAAGCGU...CCGUAG....... .......CC.GGGC.................UG.............GUAAG.UC.C.... .........UCC.........GGG.......AAA.......UCUG.GC.GGCUUAA.C.C ...G.........UCA........G.........AC........U...G........... ......................CcgG..AG..................G..A..UACUGC CAgc................CU....AGG..GA..C....CG.............GG... AGAGGCC..GG..GGGUAUUC......CC.....................GGAGUAGGGG UG..AAAUCCUGUA.AUC.CCG.GG.AGGACCACCUG.UGGCGAA............GGC GCCCG.G.CUGGA..ACGGG..UCCGACGGU....GAG.GGACGAAGGCCAGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCUGUAAACGAUGCG....GAC.......... ....UAGGU........................G.......UCACC....G........A ...............AGCUAC.................GAGCU................. .....................U.....................C................ .....G.GU........GGUGCCGG....AGGGAAGC..CGU..........UAAG..UC C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCACU.ACA.ACG..GGUGGAGCCUGC.GGUUUAAUUGGAU.UCAACGCC G.GGAAgCUUA.CCGGGGG............AGACAGCGGGAUGAAGGUCGGGCUGAAGA CCUUACCAGA.....C...U.................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGUGCAUGGCCGCCGUCAGUUCGUACUGUGAAGCAU CCUGUUAAGUCAG.GCAACGAGCGAGACCCGCGC...CCCCAG......U....UGC..C .AG.C.G...GU...........UCCCUUCGGG.G.AA............G.CCGGG..C A.CACUGGGG............GG.ACUGCC.G..G.CGC.U.AA..GCC.G........ ...GAGGA.A.GGUGC.GGGCAACGGC..AG..GUCCGUAUGCCCCGAAUCC.CCCG.GG CUACAC.GCGGGCUACAAU.GGC.CG..GG.ACAA.UG................GG.... ....U.AC...............CG........A........CCCC.....G.AAA.G.. ......GG........GUAGGUAAU......CCC.......CU.AAAC.C..CG.G.U.C UA.Acc....UGGGAUCGAGGGCUGCAACUCGCCCUCGUGAACC.UGGAAUCCGUAGUAA UCGCGCCUCAA..AAU.G.GCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCAAGCCACCCGA......GUGGGccaggggc...................... ........GAGG.............G.................................. ...GG.U.......GG.C............C.....CU....AGGCCA............ ...........................................C.....CUucgagccc. ...................AG......................GG...U........... CC.................GC.......GAGG...GGGGCUAAGUCG.UAACAA.GGUAG CCG.UAGGGGAAUC............UGCG.....G.............CUG......GA U............CACCUCCU....................................... ........................................................... > tcc.GG.................TTGATCCT............................. ..GCCGGAGGCCACtgctatgggggtccGA..CTAAGCCATGCG.A.GT....C...... ...............................AT........................... .......................................GGG...............GCG CCttgcgc.................................................... ...............................GC........................... .......................................................ACC.G GCGG.....ACGGCTCA....GTAACAC.GTc.GGT.AACCTA................. .........................................................CC. .CT.....CG................................................GG .AG.GGGGATAA.C.CC.CG...........GG.AA.ACTG.G................. ...............G............................................ .............................................G.CTAATCCCCCATA GG........CCTGAGGtaCTGGAAGGtcctcag.......................... ............................................................ ............................................................ ............................................................ ......................GCCGAAAGGGtctct....................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .................................G.......................... ....ACCGCCC................................................. ..............................G............................. ..............................................A............. .GGATGGGccg.....G.CGGC...................................... ..CG..................ATTAGG.TAGTT...GGTGG.GGTAACGGC..CCACCA AG.CCGAAGATC..GGTAC..GG.....GCCAtgagagt.G..GGAGC..CCG...G..A GATGGAC.ACTGAGACACG.GGTCCAG...GC..CCTACGGGGCGCAGCAGGCGCGAAAC CTCCGCAAT........GCGGGCA.ACC................GC...GAC....G.GG GGGAC.....CCCCAGTGCCGtggcatcgccA...CGG.CTT.........TTccggagt g........................................................... ............................................................ ............................................................ ............................................................ ................T.................................AAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CtCCG..G.GAAT.. .......AAGGgct.................GG........................... ............GCAAGGacggtGG..CAGCCGCCGCGGTAATACCGGCGGCCCGAGTGG TGgccgct...............ATTA..TTGGGCcTAAAGCGT...CCGTAG....... .......CC.GGGCcc.................G......T.......AAGT.CCctggc .......................G.......AAAT.......CCC.AC.GGCTCAA.C.C ...G..T.......G........GggcttgctGG.......................... ..........................G.....................G..AT..ACTGC gggcctt....................GG..GA..C....CG.............GG... AGAGGCC..GG..GGGtacccct...........................GGGGTAGGGG TG..AAATCCtaTAAT.C.CCA.GGG.GGACCGCCAG.TGGCGAA............GGC GCCCG.G.CtGGA..ACGGGT..CCGACGGT....GAG.GGACGAAGGCCAGGGGAGCGA ACCGGATTAGATACCCGGGTAGTCCTG.GCTGTAAAgGATGCGGGCTAGGTGTCGGacga gcttcgagctcgtc.............................................. .........................................................C.. .........G.................................................. ...............GTGCCG.......AAGGGAAGC..CGTT..........AAGC..C C.............GCCGCCTGGGGAGTACGGCCGCAAGGCTGAAACTTAA...AGGAAT TGGCGGGGGAGCACt.ACA.AGG..GGTGGAGCGTGCGGTTTAATTG.GAtT.CAACGCC G.GGAACCTCA.CCGGGGG....C........GACGGCAGGATGAAGGCCAGGCTGAAGG TCTTGCCGGA.....CAC....................G..................... ...................CC........................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGTGCATGGCCGCCGTCAGCTCGTaCCGTGAGGcgt ccaCTTAAGTGtg.GTAACGAGCGAGACCCGCGC...CCCCAGTT..........GC..C .AGtcctccccgct................GGG.G.AG......G...A......GG..C A.CTCTGGGG............GG.ACCGCC.G..G.CG.AT.AA..GCC.G........ ...GAGGA.A.GGAGC.GGGCGACGGT..AG..GTCAGTATGCCCCGAAACC.CCCG.GG CTACAC.GCGCGCTACAAT.GGG.CG..GG.ACAAT.G................GG.... ....AT.C...............CG........A........CCCC.....G.AAA.G.. ......GG........GAAGGGAAT......CCCct........AAAC.C..CGC...CC CC.A....GTTCGGATCGCGGGCTGCAAatCGCCCGCGTGAAGCT.GGAATCCCTAGTAc CCGCGTGTCAtcatcgcgcgac.........GAATACGTCCCTGCTCCTTGC..ACACAC CGCCCGTCACtCCACCCGA......GCGGGGtc........................... ............................................................ .................................TGGATGAGgcctgatctc......CCT TC........GG.........Gga.................................... .................GGTCGGGTCgagtctGGGCT....................... .CCGT.......................GAGG...GGGGAGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TacggctcGATCACCTCCaatcgccgga...... ............................................................ ........................................................... > AC...........................UCCGG....................UUGAUC CUGCCGGAGGCCAC..CGCUAU.CGGGGUCCGACUA....AGCCAU.GCAAGUC.....G AGG.....GcCGCC.............................................. .............................C..G......GcaauggG............. ......................................................GG..C. ..............GGC........................................... ........................................................CC.G GCGG.....ACGGCUCA....GUAACAC.GUG.GG.UAACC..................U ........................................A................CC. .C.....UCG................................................GG .A.CGGGGAUAA.C.CC.CG...........GCGAAAG.UG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... .............C......................GAU.AGGC................ .......Ggggc...........GG................................... ....................................................CCUGGAAC GGUCCUc..............CGCCGAAAGGGCccgggccc................... ............................................................ ............................................................ ............................................................ ..................AUGC...................................... ............................................................ ..........................CGCccggG.......................... ....UCCGCCC................................................. ..............................G............................. ..............................................A............. .GGAUGGG.....CCUG.CGGC...................................... ..CG..................AUUAGGU...AG.UUGGCGG.GGUAACGGC..CCGCCA AG.CCGAUAA..UCGGUAC..GG.....GCG..GUG.AGAGCCGGAGC..CCG...G..A GACGGGG.ACUGAGACAAGGccCCG.G...GC..CCUACGGGGCGCAGCAGGCGCGAAAC CUC.....CG...CAAUGCGGGCA.ACC................GC...GAC....G.GG GGGAC.....CCCGAGUGCCGuc..................................... ............................................................ ............................................................ ...........................GGG.............................. ............................................................ ....GCA.....AagccccGGCGGCUGUACCggg...GUG.........UAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCccgG.G...UAGA .......AAGCGG.................CGG........................... ............GCAAG.ACC.GcUGCCAGCCGCCGCGGUAAUAgcggcgccgCAAGUGG UGGCCGC...............UUUUAUUGGGCCU..AAAGGGG...CCGUAG....... .......CC.GGU.................CCC.............GUggguccc..... ...............CGCC....G.......AAAG.......CCC.GC.GGCUUAA.C.C ...G......CgG.GAGUCGgc..........................G........... .........................G...G..................G..A..AACUGC GGGA................CU....UGG..GA..C....CG.............GG... AGAGGCC..GG..AGGUACCC......CC.....................GGGGUAGGGG UG..AAAUCCUGUc.AUC.CCG.GGG.GGACCGCCAG.UGGCGAA............GGC GUCCG.G.CUGGA..ACGGG..UCCGACGGU....GAG.GGCCGAAAGCCGGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCCG.GCUGUAAACGAUGCG....GAC.......... ....UAGGU........................G.......UU....G.GG.....G... .Cgg......................................C........CACGA.... .....Gcc..............GC.........CC........C................ .A.....GU........GCCG.......UAGGGAAGC..CGU..........UAAG..UC C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.AC.C.GGUGGAGCCUGC.GGUUUAAUUGGAU.UCAACGCC G.GAAACCUUA.CCGGGGG....C........GACAGCAGGAUGAAGGCCAGGUUGACGA CCUUGCCGGA.....CG....................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGCCGUCAGCUCGUGCCGUGAGGUGU CCUGUUAAGUCAG.GUAACGAGCGAGACCCCCGC...CCGCAG......U....UGC..C .AG.C.G...GGcCCC.....G.U.........A.Agggg.........CG.CCGGG..C A.CUCUGcggggauc.............GCC.GCCG....UUAAGGCG.Gaugaaa.... ............GUG.GGGGCGACGGC..AG..GUCCGUAUGCCCCGAAACC.CCCG.GG CUACAC.GCGGGCUACAAU.GGCG.G..GG.ACAA.UG................GG.... ....A.UC...............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGGAAAU......CCC.......CU.AAAC.C..Cc.G.U.C GU.A....GUUCGGAUUGCGGGCUGCAACUCGCCCGCAUGAAGG.UGGAAUCGGUAGUAA CCGUGccUCAG..AAU.Gg.CACGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCACGCCACCCGA......GCccc......................CC...GGG G.........GC.............Aagcccccg.......................... ................................G.........U.........CCG..... ..............C.A...AG.GGCUGGG............G.....GCgagcccc... .....................CGGGGG................................. .........................G.UGAGG...GGGGCGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCC........................................ ........................................................... > AC...........................UCCGG....................UUGAUC CUGCCGGACCCGAC..CGCUAU.CGGGGUGGGGCUA....ACCCAU.GGAAGUCUAGGAG cc.......................GGG................................ ............................................G.........CUACGG C........................................................... .................Cg............GC........................... .......................................................UCC.G GCGG.....ACGGCUCA....GUAgCAC.GUG.GC.UAACC..................U ........................................A................CC. .C.....UCG................................................GG .AG.GGGGAUAA.C.CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.............. ................................................AUAAACCC.... .............CCAUAGGcgcggac................................. ............................................................ ...................................................ACCUGGAAU GGguccgCGCUGAAAGGGCCACGGuac................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ................CAUGCUUA.........CcgugG..................... .....CCGCCC................................................. ..............................G............................. ..............................................A............. .GGAUGGGG.....CUG.CGcC...................................... ..C..................UAUCAGGU...AG.UUGGCGG.GGUAACGGC..CCGCCA AG.CCGAUAAC..GGGUgGGGGCC.........GUG.AGAGC..GGGAG..CCC...CGA GAUGGGC.ACUGAGACAAGGG.CCCAG...GC..CCUACGGGGUGCACCAGGgGCGAAAC UUC.....CG...CAAUGCGGGAA.ACC................GU...GAC....G.GA GUCAC.....CCCGAGUGCC...........A...Cccgaaga............GGGUG ............................................................ ............................................................ ............................................................ ............................................................ ....GCU.....U..............UUGCCcggu............CUAAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCG.G..GCGAA..U .......AAGCGGG.................GG........................... ............GCAAGcu..UGGUGUCAGCCGCCGCGGUAAUACCAaCCCCGCGAGUGG UCGGGACG...............UUUAUUGGGCCU..AAAGCGU...CCGUAG....... .......CC.GG.............C....CCG.............GUAAG.UC.C.... .........................CUCCUUAAAG.......CCC.AC.GGCUCAA.C.C ...G.........UG........GG.........Agcg...................... .......................GAG...G..................G..A..UACUGC CGG...............G.CU....AGG..G..GG....CG.............GG... AGAGGCC..GG..GGGUACUC......CU.....................GGGGUAGGGG CG..AAAUCCUAUA.AUC.CCA.GG.AGGACCACCAG.UGGCGAA............GGC GCCCG.G.CUagc..ACGCGC..CCGACGGU....GAG.GGACGAAAGCUGGGGGAGCAA AGGGGAUUAGAUACCCCCGUAGUCCCA.GCUGUAAACGAUGCG....GGC.......... ....UAGGU........................G.......UU....G.G..AcgG.... ................GCUUC.................GAGCCcgU.............. ..................................C........C................ .A.....GU........GCCG.......UAGGGAAGC..CGU..........UAAGC..C C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.AGG..GGUGAAGCUUGC.GGUUUAAUUGGAG.UCAACGCC G.GAAACCUUA.CCGGGGG....C........GACAGCAGGAUGAAGGCCAGGCUGACGA CCUUGCCAGA.....CG....................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGUCGCCgGCUCGUGCCGUGAGGUGU CCUGUUAAGUCAG.GGAACGAGCGAGACCCCCGC...CCCUAG......U....UGCU.. .AC.CCag................CCCUUCGGG.Gcu..............G..GGG..C A.CUCUAGGG............GG.ACUGCC.G..G.CG.AU.AA..GCC.G........ ...GAGGA.A.GGUG.GGGGCUACGGC..AG..GUCAGUAUGCCCCGAAACC.CCCG.GG CUACAC.GCGAGCUGCAAU.GGCG.G..GG.ACA.GCG................GG.... ....U.UC...............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGGUAAU......CCC.....U..U.AAA..C..CCCG..CC UC.A....GUAGGaAUCGAGGGCUGCAACUCGCCCUCGUGAACG.UGGAAUCCCUAGUAA CCGCGUGUCACC...A.ACGCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCGCUCCACCCGA......G...GG.........................AGGC C.........U.............AG.................................. ..............GUG.........................AGGCCU............ ...........................................C.....CU.......GC ....C..GACGA....GGuggga......................GGUCGAACCUGGGCC UCC.......................CA.AGG...GGGGAGAAGUCG.UAACAA.GGUGG CCG.UAGGGGAACC............UGCG.....G.............CCG......GA U............CACCUCC........................................ ........................................................... > ............................................................ ......GACCCGAC..CGCTATCGGggtagggCTAAGCCATGCG.A.GT....C.....G CN........CGCC.............................................. .............................C..G......GGG...............GCG CCc............................GG........................... ...............................G............................ .......................................................AGC.G GCGC.....ACGGCTCA....GTAACAC.GTGcC.C.AACCTA................. .........................................................CC. .CT.....CG................................................GG .AG.GGGGACAc.C.CC.CG...........GG.AA.ACTG.G................. ...............G............................................ .............................................G.CcAATCCCCCATA GGggaggggcg........CTGGAAGGcCCCCT....................CCC.... .............CCAAAGGGat..................................... ............................................................ ............................................................ ..................................................GG........ ............................................................ ......................CGGCCgatccgccgcca..................... ............................................................ ............................................................ .....................T...................................... ............................................................ .....CCGCCC................................................. ..............................G............................. ..............................................A............. .GGATGGGggc.....A.CGGC...................................... ..CC..................ATCAGG.TAGTT...GGCGG.GtTAAAGGC..CCGCCA AG.CCGAAGAC..GGGTAGGGGcg.......GT..G.AGAGCCGc.GAG..CCC...CGA GAtcGGC.ACTGAGACAAGGG.CCgagg......CCTACGGGGtGCAGCAGGCGCGAAta CTCCGCAAT........GCGGGCA.ACC................GC...GAC....G.GG GCtAC.....CCCGAGTGCCGGGCGAAG...AgccCGG.CTT.........TTgccc... ............................................................ ............................................................ ............................................................ ............................................................ ............GGTCT.................................AAAAAG.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCG.G..GAGAAT.. .......AAGCGGG.................GG........................... ............GCAAGtctggtgt..CAGCCGCCGCGGTAATACCagctCCGCGAGTGG Tcggggtgt...............TTAC..TGGGCTTAAAGCG.C..CCGTAG....... .......CC.GG.............C....CCG.............GCAAGT.CGctcc. ............T..........G.......AAAT.......CCC.AG.GGCccaacC.C T...........G.G........GGcgggggg............................ .............................C..................G..AT..ACTGC CGG...............G.C.T...AGG..G..GG....CG.............GG... AGAGGCC..GccggtactcCG.............................GGGGTAGGGG CG..AAATCCGTTAAT.C.CC.CGG.AGGACCACCAG.TGGCGAAA............GC GGgcgg..CCAGA..ACGCGC..CCGACGGT....GAG.GGGCGAAAGCCGGGGGAGCAA AGGGGATTAGATACCCCtGTAGTCCCG.GCCGTAAACGATGCGGGCTAGCT........G Tcggccgggcttagggcccggc...................................... ............................................................ ................................CGGT........................ .....G.G...........CG.......AAGGGAAAC..CGTT..........AAGC..C C.............GCCGCCTGGGGAGTACGGCCGCAAGGCTGAAACTTAA...AGGAAT TGGCGGGGGgGCAC.CACA.AGG..GGTGaagcttgcGGCTTAATTG.GAgT.CAACGCC G.GAAACCTCA.CCcGGGG....C........GACAGCAGGATGAAGGCCAGGCTAACGA CCTTGCCGGA.....CG....................AG..................... ...................CT........................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGTGCATGGCCGTCGTCAGCTCGTGCCGTGAGGTGT CCGGTTAAGTCCG.GCAACGAGCGAGACCCCCAC...CCCTAGTT..........GCT.. .AC.CccgtcctacgggacgG..............................G..GGG..C A.CACtAGGG............GG.ACTGCC.G..G.CG..T.AA..GCC.G........ ...GAGGA.A.GGAG.GGGGCCACGGC..AG..GTCAGTATGCCCCGAAACC.CCGG.GG CTGCAC.GCGAGCtgCAAT.GGCG.G..GG.ACA.GCG................GG.... ....AT.C...............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGGCAAT......CCC.GT.......AAA..C..CCCG..CC Ccagtag.....GGATCGAGGGCTGCAACTCGCCCTCGTGAAcGT.GGAATCCCTAGTAA CCGCGTGTCACC...A.ACGCGCGGT.....GAATACGTCCCTGCcCCTTGC..ACACAC CGCCCGTCGCACCACCCGA......G...GG.........................AGcc ctctgc...................................................... ................G.........................AGGCCCCttgccgacgag gt........................................G.....GGG.......GG ACGA..............GCAGG.........GGGCT....................... .CC.......................CA.AGG...GGGGTGAA................. ............................................................ ............................................................ ........................................................... > AC...........................UCCGG....................UUGAUC CUGCCGGgCCCGAC..CGCUAU.CGGGGUGGGACUA....AGCCAU.GGGAGUC.....G UGC.....G..................................CC............... .CCcgg...........ACG.........C..G......GGG...............GC. ............................................................ ............................................................ ........................................................GC.G GCGG.....ACGGCUGA....GUAACAC.GUG.GCC.AACC..................U ........................................A................CC. .C.....UCG................................................GG .A.CGGGGAUAA.C.CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... .............C......................GAU.AGGC................ .......GA...........GGgGG................................... ....................................................CCUGGAAC GGguc.............CCUCGCCGAAAGGGCgcgcggag................... ............................................................ ............................................................ ........CCUCCCCGcgc......................................... ............................................................ ............................................................ ......................................G..................... .....CCGCCC................................................. ..............................G............................. ..............................................A............. .GGAUGGGG.....CUG.CGGC...................................... ..CC..................AUCAGGU...AG.UUGGCGG.GGUAACGGC..CCGCCA AG.CCGAUAAC..GGGUAGGGGCC.........GUG.AGAGC..GGGAGn..CC...CCA GAUGGGC.ACUGAGACAAGGG.CCCAG...GC..CCUACGGGGCGCACCAGGCGCGAAAC CUC.....CG...CAAUGCGGGCA.ACC................GU...GAC....G.GG GUCAC.....CCCGAGUGCCGcc..................................... ............................................................ ............................................................ ............................................................ ......................................................GA.... ...UAA.............GGCGGCUGUUCCCCGC......................... ......................................UGUAGGAA.............. .........................................................GGC G........................................................... ............................................................ ............................................................ ...............................................G.G..G.GA..GU .......AAGCGGG.................GG........................... ............GCAAG..UCUGGUGUCAGCCGCCGCGGUAAUACCAGCCCCGCGAGcGG UCGGGAUG...............AUUACUGGGCCU..AAAGCG.C..CCGUAG....... .......CC.GG.............C....CCG.............GUAAG.UC.C.... .........................CccccUAAAG.......CCC.CG.GGCUCAA.C.C .....C......G.G........GGAGUGGg.................G........... .........................G...G..................G..A..UACUGC CGG...............G.CU....AGG..G..GG....CG.............GG... AGAGGCC..GA..GGGUACUC......CC.....................GGGGUAGGGG CG..AAAUCCGAUA.AUC.CCG.GG.AGGACCACCAG.UGGCGAA............GGC GCUCG.G.CUGGA..ACGCGC..CCGACGGU....GAG.GGGCGAAAGCCGGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCCG.GCUGUAAACGAUGCG....GGC.......... ....UAGGU........................G.......UU....G.GGcgg...... ........................................GCUU................ ............G.............GAGCccgCC........C................ .A.....GU........GCCGC.......AGGGAAGC..CGU..........UAAGC..C C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUUAA...AGGAAU UGGCGGGGNAGCAC.CACA.AGG..GGUGGAGCCUGC.GGCUUAAUUGGAG.UCAACGCC G.GGAAUCUUA.CCGGGGG....C........GACAGCAGGAUGACGGCCAGGCUGACGA CCUUGCCcGA.....CAC....................G..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGUCGCCAGCUCGUGCCGUGAGGUGU CCGGUUAAGUCCG.GCAACGAGCGAGACCCCCAC...CCCUAG......U....UGCU.. .AC.CCCGgggccacccc..G..............................G..GGG..C A.CACUAGGG............GG.ACUGCC.G...NCG.UcCAAG.G.C.G........ ...GAGGA.A.GGAG.GGGGCCACGGC..AG..GUCAGCAUGCCCCGAAUCC.CCCG.GG CUGCAC.GCGGGCUACAAU.GGCG.G..GG.ACA.GCG................GG.... ....A.UC...............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGGCAAU......CCC.....U..U.AAA..C..CCCG..CC GC.A....GUUGGGAUCGAGGGCUGCAACUCGCCCUCGUGAACG.CGGAAUCCCUAGUAA CCGCGCGUuagC...A.UCGCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCGCUCCACCCGA......GCGGGG............................. ........GAGG.............G.................................. ..............GUG.........................AGGCCCCGU......CCC .UC........Gccagggc......................................... ...........................................GGGGUCGAACCUcuccc CC.................GC.......GAGG...GGGGAGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCU....................................... ........................................................... > AC...........................UCCGG....................UUGAUC CUGCCGGUCCCGAC..CGCUAU.CGGGGUGGGGCUA....AGCCAU.GGGAGUC.....G CA........CGCuccg......................................C.... .CG............CUGCGGG.....................GCG.............. ............................................................ ...............................U............................ ...........................................................G GCGG.....ACGGCUGA....GUAACAC.GUG.GC.UAACC..................U ........................................A................CC. .C.....UCG................................................GG .AG.GGGGAUAA.CA.C.CG...........GG.AA.ACUG.G................. ................U........................................... .............................................G.C............ .................................................UAAUCCC.... .............CCAUAGGGGAG.................................... ............................................................ ................................................GAGGccU..... .......................G.................................... ............................................................ ............GA.......AGGGUU................................. ........CCUCCCCGAAA................................Gggugug.. ....................GC.......AGG............................ .........................GGUUaacgc.......................... ..................UGCUA..................................... ...CACCGCCC................................................. ..............................G............................. ..............................................A............. .GGAUGGGG.....CUA.CGGC...................................... ..CC..................AUUAGGU...UG.UUGGCGG.GGUAACGGC..CCGCCA AG.CCGAUAA..UGGGUAGGGGCC.........GUG.AGAGC..GGGAG..CCC...CCA GAUGGGC.ACUGAGACAAGGG.CCCAG...GC..CCUACGGGGCGCACCAGGCGCGAAAC CUC.....CG...CAAUGCGGGAA.ACC................GU...GAC....G.GG GCCAC.....CCCGAGUGCC........................................ .....CCC............................U.........U...ACG....... ............................................................ ...........................GGG.............................. ............................................................ ....GCU.....U..............UUCCCCGC......................... ......................................UGUAGGAA.............. .........................................................GGC G........................................................... ............................................................ ............................................................ ...............................................G.G..G.GAA..U .......AAGCGGG.................GG........................... ............GCAAG..UCUGGUGUCAGCCGCCGCGGUAAUACCAGCCCCGCGAGUGG UCGGGACG...............AUUAUUGGGCCU..AAAGCG.C..CCGUAG....... .......CC.GG.............C....CCG.............GCAAGucC.C.... .........................CUCCUAAAUU........CC.CG.GGCUCAA.C.C .....C......G.G........GGAcugg.................AG........... .........................G...G..................G..A..UACUGC CGG...............G.CU....AGG..G..GG....UG.............GG... AGAGGCC..GA..GGGUACUC......CC.....................GGGGUAGGGG CG..AAAUCCUAUA.AUC.CCG.GG.AGGACCACCAG.UGGCGAA............GGC GCUCG.G.CUGGA..ACACGC..CCGACGGU....GAG.GGGCGAAAGCCGGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCCG.GCUGUAAACGAUGCG....GGC.......... ....UAGGU........................G.......UU....G.GG......... ......................UG........GGCUUAGAGCC........CA....... .................................CC........C................ .A.....GU........GCCGC.......AGGGAAGC..CGU..........UAAGC..C C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUCAA...AGGAAU UGGCGGGGGAGCAC.CACA.AGG..GGUGGAGCCUGC.GGUUCAAUUGGAG.UCAACGCC G.GGAAUCUCA.CCGGGGG............AGACAGCAGGAUGACGGCCAGGUUaaagg CCUUGCCUGA.....CGC....................G..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGUCGCCAGCUCGUGCUGUGAAGUGU CCGGUUAAGUCCG.GAAACGAGCGAGACCCCCAC...CCCUAG......U....UGCU.. .AC.CCGGGGCUAC.......................G......G..CUccG..GGG..C A.CACUAGGG............GG.ACUGCC.GCCG....UUUAAG.G.C.G........ ...GAGGA.A.GGAG.GGGGCCACGGC..AG..GUCAGCAUGCCCCGAAcCC.CCCG.GG CUACAC.GCGGGCUACAAU.GGCG.G..GG.ACA.GCG................GG.... ....A.UC...............CG........A........CCCC.....G.AAA.G.. ......GG........GGAGGCAAU......CCC.....UC...AAA..C..CCCG..CC Gug.....GUUGGGAUCGAGGGCUGCAACUCGCCCUCGUGAACG.AGGAAUCCCUAGUAA CCGCGCGUCAAC...A.UCGCGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCGCUCCACCCGA......G...GG............................. ........GAGG.............G.................................. ...GG.A.......GUG.........................AGGCCCgg..CC...CCU UGgguc..................G.................G.....GUC.......GA .....AC.UCCc..............................................CC UCC.......................CUGAGG...GGGGAGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCU....................................... ........................................................... > aagggugugguuagcuuccuacccccaAAUCCGG....................UUGAUC CUGCCGGACCCGAC..CGCUAU.CGGGGUGGGGCUA....AGCCAU.GGGAGUC.....G UAC.....G......CU..C........................................ ...............CcggGCAA................GGGaGCG.............. ............................................................ ...............................U............................ ...........................................................G GCGG.....ACGGCUGA....GUAACAC.GUG.GC.UAACC..................U ........................................A................CC. .C.....UGAG....................G............................ ..AgggAGAUAA.C.CC.CG...........GG.AA.ACUG.G................. ...............G............................................ .............................................G.............. ................................................AUAAUCucc... ...............................C.....AU.AGGC................ .......GA...........GGAg.................................... ...................................................UCCUGGAAC GGuuccuCGCUGAAAGGcucaugggcuauuccccGCUCAU.................... ............................................................ ............................................................ ....................................................GA...... ............................................................ ............................................................ ...............................G............................ ......CGCCUC................................................ ............................................................ ..............................................A............. .GGAUGGGG.....CUG.CGGC...................................... ..CC..................AUCAGGU...AG.UUGGgGG.GGUAAGGGC..CCcCCA AG.CCUAUAAC..GGGUAGGGGCC.........GUG.AGAGC..GGGAG..CCC...CCA GUUGGGC.ACUGAGACAAGGG.CCCAG...G...CCUACGGGGCGCACCAGGCGCGAAAC GUC.....CC...CAAUGCGCGgaagcgugagggc......................... GCCAC.....CCCGAGUGC...UCcc.................................. ............................................................ ............................................................ ............................................................ ........................................................GUAA GGGAGCU.....U..............UUCCCCGC......................... ......................................UcuacaAA.............. .........................................................GGC G........................................................... ............................................................ ............................................................ ...............................................G.G..G.GAA..U .......AAGCGGG.................GG........................... ............GCAAG..UCUGGUGUCAGCCGCCGCGGUAAUACCAGCCCCGCGAGUGG UCGGGAC...............UCUUACUGGGCCU..AAAGCG.C..CCGUAG....... .......CC.GG.............C....CCG.....................AC.... .........A..........AGUCACUCCUUAAAG.......ACC.CC.GGCUCAA.C.C ...G........G.G........GGaauggg.G........................... .........................G.....................UG..A..UACUGU CGG...............G.CU....AGG..G..GG....CG.............GG... AGAGGCC..AG..CGGUACUC......CC.....................GGAGUAGGGG CG..AAAUCCUcA.GAUC.UCG.GG.AGGACCACCAG.UGGCGAAA............GC GGCUgg.CU.AGA..ACGCGC..CCGACGGU....GAG.GGGCGAAAGCCGGGGcAGCAA AAGGGAUUAGAUACCCCUGUAGUCCCG.GCUGUAAACAAUGC....AGGC.......... ....UAGGU........................G.......UCAC............... ...............A......UG........GGCUUAGAGCC........CA....... .......................................................U...G ....UG.GU........GCCGC.......AGGGAAGC..CGU..........UAAGC..C U.............GCCGCCUGGGGAGUACGGUCGCAAGACUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.AGG..GGUGGAACCUGC.GGCUCAAUUGGAG.UCAACGCC .UGGAAUCUUA.CuaGGGG............AGACcGCAGGAUGACGGCCAGGCUAACGA CCUUGCCUGA.....C...Ucgc..................................... ............................................GGA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.AGGUGCAUGGCCGUCGCCAGCUCGUGUUGUGAAAUGU CCUGUUAAGUCAG.GCAACGAGCGAGACCCCCAC...CACUAG......U....UGgU.. .A.UCC..............UGg.UCUCCGG...................G.CCGGGAcC A.CACUAGUG............GG.ACUGCC.G..G.CG.UA.A...GCC.G........ ...GAGGAg..GGAG.GGGGCCACGGC..AG..GUCAGCAUGCCCCGAAACC.CCUG.GG CCGCAC.GCGGGUUACAAU.GGCA.G..GG.ACA.GCG................GGa... ....U.UC...............CG........A........CCCC.....G.AAA.G.. ......GG........GAAGGUAAU......CCC.....U..U.AAA..C..CCuG..CC GC.A....GUUGGGAUCGAGGGCUGAAACUCGCCCUCGUGAACG.AGGAAUCCCUAGUAA CCGCAGAUCAA.C.AA.U.CUGCGG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCGCUCCACCCGA......GU.............................AGG. .......AGAGG.............G.................................. ..............GUG.........................AGGCCCCuugCC.....U .U........UG.........G.G.................UG.....GGG.......GG UCGA..............GCUucucuc................................. C.......................UGCA.AGG...GGGGAGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCauaguuacaaacuccccc....................... ........................................................... > gAAUCC...............GUUUGAUCCU.GacggaccugacugcUAUCAGAUUGAU. ................................ACUA....AGCCAU.GUUAGUCAU.... ............................................................ ............................................................ ...........UGUAGUA......A.................UAC.......AAGG.... ............................................................ ............................................................ .CAG.....ACGGCUCA....GUAACGC.GUA.GUC.AACC..................U ........................................Aa................C. ......UU..............A......U............................GG .A.CGGGGAUAA.C.CU.CG...........GG.AA.ACUG.A................. ...............GAAUAAUA..................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .U.....................CCGAUAGG.....UCAU.................... ............................................................ ............................................................ ....GAUGC.........................................C......... ..U.........G...GAAUGG.......U..UUAUgac..................... ............UCAAAUGAUU....................UAU............... ............................................................ ......CGccgU................................................ ............................................................ ..............................................A............. .GGAUGGGA.....CUG.CGag...................................... ..C..................UAUCAGCU...UG.UUGGUGA.GGUAAUGGC..CCACCA AGG.CUA..UuacagcuacGGGC...U....CUGAG.AGG..AGUAGC..CCG...G..A GAUGGGU.ACUGAGACAAGGA.CCCAG...GC..CCUAuGGGGCGCAGCAGGCGag.... .AAAACUUUG...CAAUGCGCGAA.AGCucgacaagguuAAUCUGAgugGU.UC...C.U GCUAAA...................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............GGA............................ACCUU.U..UGUU..A gucG...UAGAACCAcaaACGAAUAAGGggUGG........................... ............GCAAG.UUCUGGUGUCAGCCGCCGCGGUAAAACCAGCacCUCAAGUGG UcaGGAUG...............AUUAUUGGGCCU..AAAGCaU...CCGUAG....... .......CCugu..................UCUGUAAGUuuuc................. ............................................................ .......................GG.........UUAAAUCU..Augcgcucaacguaua ggcugccggAAAUACUGCAGAACUAgg................................. ...............................GA..G....UG.............GG... AGAGG..UAGA..CGGUACUCggua...........................GGAAGGGG U..AAAAUCCUUUgaucua..UC.G.AUGACCACCUG.UGGCGAA............GGC GGUC.UA.CCAGA..ACAcg..UUCGACGGU....GAG.GGAUGAAAGCUGGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCCA.GCUGUAAACGAUGC....AAAC.......... ....UCGAU........................G......AU.......GCG........ .......................U.......UGGCUUAUUGCUA................ ............GC.......G.....................C................ .A.....GU........GUCGC.......AGGGAAGC..CGU..........UAAG..UU U.............GCCGCCUGGGAAGUACGUACGCAAGUAUGAAACUUAA...AGGAAU UGGCGGGGGAGCAC.CACA.AGG..GGUGAAGCCUGC.GGUUCAAUUGGAG.UCAACGCC .UGAAACCUUA.CCCGGAG............AGACAGCAGAAUGAAGGUCaaGCUGAAGA CUUUACCAGA.....C...A.................AG..................... ...................C....U....................GA............. ........G................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................AGG.UGGUGCAUGGCCGUCGCCAGCUCGUGCCGUGAGAUGU CCUGUUAAGUCAG.GUAACGAGCGAGAuCCCUGC...CUCUAG......U....UGC..C .A..CUAUUACAccCUGGU............G.U.A.G.U........A.....GGG..C ga.AUUAGGG............GG.ACCGCC.GCAGu..UAA.U...G.C.G........ ...GAGGA.A.GGAA.GGGGCCACGGC..AG..GUCAGUAUGCCCCGAAAC.UCUGG.GG CCACAC.GCGGGCUGCAAU.GGUA.GC..G.ACAA.UGA................G.... ....U.Uc...............CA........AA........AUC.....GAA.A.GA. ...............UGGAGGUAAU......CCC.....U..A.AACg....CU..A.CC AC.A....GUUGUGAUUGAGGGCUGCAACUCGCCCUCAUGAAC.AUGGAAUCCCUAGUAA CCGCGUGUCAUU...A.UCGCGCAG.....UGAAUACGUCCCUGCUCCUUGC..ACACAC CGCCCGUCG................................................... .................UU........UCAUU....GA...................A.. ...GU.UU.......G.C............CU.....U....Uagcgaggugaugucuaa UUGGCAUUAUCgAAC.U...UG.GG.................GUA.....A.......G. ............................................................ .....................UGACA......A...GGGAAAAGUCG.UAACAA.GGUGA CCG.UAGGGGAACC............UGCG.....GU.............CG......GA U............CACCUCCUU...................................... ........................................................... > nuuccC.........UGAAGAGUUUGAUCCU.GG.......................... ....CUCAGc.GCGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G UGC.....G..................................CAg.............. .........GCUCGCUCcC...U......CUGG......G...AgcgggugcUG...... ............................................................ ............................................................ .......................................................AGC.G GCA.....AACGGGUGA....GUAACAC.GUG.GG.UAACC..................U ........................................A................CC. .C.....CC....................A............................GG .AG.GGGGAUAA.C.CC.CG...........GG.AA.ACCG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............CCAUAAAGCcgCCCGCCAC.....UA.AGGC................ .......GA...........GGcggCC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......AAAGGGG...Gccucug..................................... ............................................................ ....................................................GGCUCUGC ccaagcuccc..GCCU............................................ ..............................GG............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..CC..................AUCAGGU...AG.UUGGUGG.GGUAACGGC..CCACCA AG.CCUAUGAC..GGGUAGCCGGCC.........UG.AGAG..GGUGG..CCG...GCCA CAGCGGG.ACUGAGACACG.GCCCGcac...C..CCUACGGGGGGCAGCAGUGGGGAAUC GUG.....GG...CAAUGGGCGAA.AGC................CU...GAC.C...C.C GCGAC.GCCGC.GU......GGGGGAAG...AA...GC.CC.........UgC.GGGGUG UAAACC..........................C.CU.........GU............. ...................................................CGGGGGGGA CGAAGGG.............ACU.....G............................... ...UGG................................................G..... .....................................................UUA.... ...............A..................UAGCCC.................... ............................................................ ............ACA...G.UC...................................... .............................U.............................. ............................................................ .......U..GACGGU............................ACCCC........... .CAGAGGAAGGGAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUCCCGAG..CGUUGCgcgaAGUCACUGGGCGU..AAAGCGU...CCGCAGccggu.. ........C.GG.................GUA.............AGCG.....G.G... .........A..........UGUC.......AAAG.......CCC.AC.GGCUCAA.C.C ...G.........UG........G.........AA......UG.....G........... ......................CAUCCC.........................GAACUGC CCGA................CU....UGA..G..GC....AcgcccG............. ...GGC..AGG..CGGAAUUC......CC.....................GGGGUAGCGG UG..AAAUGCGUA.GAUC.UCG.GG.AGGAACACCG.AAGGGGAAGC............C AGCC.UG.CUGG..GGCUGUC..CUGACGGUC....AG.GGACGAAAGCCGGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCCG.GCCGUAAACcAUGGG....CGC.......... ....UAGGGc.................................................. ....................................UUGU..C........CC....... ....................UUuggggcaggc............................ ..................UCGC.......AGC..UAACGCGU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGGCGCAAGCCUGAAACUCAA...AGGAAU UGGCGGGGG.CCC.GCACA.AC.C.GGUGGAGCGUc.UGGUUCAAUUCGAU.GCUAACCG .AAGAACCUUA.CCCGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C.....C...................G.........GGGAG ACuccgcgaAAG...........................CGG............AG.UUG UGGA........................................A............... ..................................GUcucugaCU................ ....UCCCC................................................... ...................................CCG...................... ........................................................G... ...............CA.CAGG.UGGUGCAUGGCCGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...CCCUAG......U....UGCU.. .AC.CCCGagaggg........................................GAG..C A.CUCUAGGG............GG.ACCGCC.G..G.CG.AU.AA..GCC.G........ ...GAGGA.A.GGGG.GGGAUGACGUC..AG..GUCAGUAUGCCCUUUAUGC.CCGG.GG CCACACAg.GCGCUACAGU.GGC.CG..GG.ACAA.UG................GG.... ....A.A.G..............CG........A........CCCC.....GC.AA.G.. ......GG........GGAGCUAAU......CCC.....AG...AAAC.C..CG.G.U.C AUggug.....CGGAUUGGGGGCUGAAACUCGCCCCCAUGAAGC.CGGAAUCGGUAGUAA CGGgGUAUCAG.Cgaugucc..CCG.....UGAAUACGUUCUCGGGCCUUGC..ACACAC CGCCCGUCACGCCACGGAA......GU..........................C...GG. .......UCcggc...........................................C... ...GG.AAGUCCccG.A............GCU.....A....A.........CCGGccc. ............................................................ ...UUUU.UGGGCcggGGGCAGG.........GGCCGAUGGCcGGG.............. CCG.................GCGACU.........GGGGCGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGC............................... ............................................................ ........................................................... > ....UA.......UAUGGAGGGUUUGAUCCU.GG.......................... ....CUCAG.GGUGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AGC.....G........GGGGaaa.................................... .............CUC.......................C.................... ..CUUC......GGG.....G..........................AG........... ..............GAguacc....................................... ............C..........................................AGC.G GCGG.....ACGGGUGA....GUAACAC.GUG.GG.UAACC..................U .G.......................................................CC. .C.....UC....................C............................GG .AG.GGGGAUAAC..CAG.GGGAAACC.............C.U................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............CCAUA.......................................... ............................................................ ............................................................ .............................................CGCUccAUCA..... .............ACGCAAGU....................................... .......................UG...G............................... ..........................................U..G.....G........ ..A.........G...GAAAGGGG.................................... .............................CGUUU.G....CCC................. ............................................................ ............................................................ ............CGCCG.............GA............................ ........................................................GGAG GGG..........CCCG.CGGC...................................... ..CC..................AUCAGGU...AG.UUGGUGG.GGUAACGGC..CCACCA AG.CCGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGUGG..UCG...GCCA CAGGGGC.ACUGAGACACG.GGCCCC..AC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UUG.....G...ACAAUGGGGGAA.ACC................CU...GA.UC...C.A GCGAC.GCCGC.GU......GCGGGACG...AA...GC.CC.........UUC.GGGGUG UAAACC..........................G.CU.........GUGGcg......... ............................................................ .....................G...................................... ....GGGAA.....G..................AAU........................ ..AAGGU..................................................... ............................................................ ............................................................ ............................................................ ..................................................AGGGAGGAAA UgcccuaCCG.................................................. .......AU.GACGGU............................ACCCCg...C..UAGA .......AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGGGCAAG..CGUUACCCGGAUUUACUGGGCGU..AAAGGGG.G.C.GUAGG...... ........C.GG.............C....CUG.............GUGUG.UCG.G... .........A..........UGUG.......AAA.......UCCC.AC.GGCUCAA.C.C ...G.........UG........GG.........GC........U...G........... ......................CAUC...C..................G..A..AACUAC CAG...............G.CU....UGG..G..GG....CG.............GU... AGAGGG..AGA..CGGAACUG......CC.....................GGUGUAGGGG UG..AAAUCCGUA.GAU.AUCG.GC.AGGAACGCCGG.UGGGGAAGC............C GGucuc.C.UGG..GCCGACC..CCGACGCU....GAG.GCCCGAAAGCCAGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCUGUAAACGAUGCC....CAC.......... ....UAGGU........................G.......U...G.G.GG.....G... ....................G....GU........AAUC.................CC.. .....................U.....................C................ ...C...GU........GCUG.......AAGC..UAACGCGU..........UAAG..UG .............GGCCGCCUGGGGAGUACGCCCGCAAGGGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCGUG.UGGUUUAAUUGGAU.GCUAAGCC .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C.....C...................G.........GUG.. ..........GUACCuc........................................... ............................................................ .....................................CCCG.AAAGGGGUagggacc... ...........C..........AGU................................... ......CCUUC..G..........GGA.CUgggagCCG...................... ........................................................G... ...............CA.CAGG.UGGUGCACGGCCGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...CCCUAG......U....UGC..C .AG.C.G...GU...........UC.....G...................G.CCGGG..C A.CUCUAGGG............GG.ACUGCC.G..G.CG.A.CgA..GCC.G........ ...GAGGA.A.GGAG.GGGAUGACGUC..AG..GUacucgUGCCCCUUAUGC.CCUG.GG CGACACA.CGCGCUACAAU.GGG.CG..G.UACAA.UG................GG.... ....U.U.G..............CG........A........CCCC.....GC.GA.G.. ......GG........GGAGCCAAU......CCC.......CA.AAG..C..C..GC.CC UC.A....GUUCGGAUCGCAGGCUGCAACCCGCCUGCGUGAAGC.CGGAAUCGCUAGUAA UCGCGGAUCAG.CCAU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGCCACCCGA......GU..........................C...GGG G.........GC.............UCCCGAA....GA...................CAC cuac.............C............C.....CA....A.........CC...CGA .A........AG.........G.G.................AG.....GGG.......GG GU.....GUCGA....GGGAGAAccu.................................. ..................GGC.......GAGG...GGGGCGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > gg.......................................................... ............CUAACGCUGG.CGG..CGUGUCUU....AGCCAU.GCAAGUC.....G AGC.....G........GGCCugu.................................... ...................GGG.....................GCG.............. ............................................................ ...............................AccugcA...................... .........GGUC..........................................AGC.G GCGG.....ACGGCgGA....GUAACAC.GUA.GC.UAACC..................U ........................................A................CC. .C.....CC....................U............................GG .A.CGGGGAUAA.C.CA.C...........C.CGAAAG.GG.U................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............C......................GAUG.................... ....................................UagucCC................. ............................................................ ............................................................ .............................................U.............. .....................A..................UCU................. ...................................................G.......A GAU.........G...GUAG........................................ ............................................................ .....................................GGAUGAAAGGUGGGCCucugcgg aagcaagcucauGCCA............................................ ..............................GG............................ ..................GG.......AG............................... .....GGGG.....CUG.CGGC...................................... ..C..................UAUCAGGU...A.KUUGGUGG.GGUAAAGGC..CCACCA AG.CCUAUGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..ACCG...GCCc gagGGAC.ACUGAGACACG.GGUCCC..AC..U.CCUACGGGAGGCAGCAGGCuAGAAAA UUG.....GG...CAAUGGGGGAA.ACC................CU...GAC.C...C.A GuGAC.GCCGC.GU......GCAGGAAG...AA...GC.CC.........UUC.GGGGUG UAAAC..........................UG.CU.........GU............. ...................................................CGUGCGGGA CGAAGGG.............UCc..................................... .................................AUA........................ ..KGCGaac................................................... ............................................................ ...........................A.............................G.U C.UAUGGgc................................................... ............................................................ ............................................................ .......UU.GACGGU............................ACCCC.A.G.GA.... G..G...AAGCCCAK............................................. ............GCUAACCUC.G.UGCCAGCAGCCGCGGUAAUACS.............G GGuGGGCGAG..CGUUGCCCGGAAUUACUGGGUUU..AAAGGGG.G..UGUAGG...... ........C.GGU.................CCG.............GAGAG.UCA.GG.. ....................UGUG.......UAA.......UCC.AACC.GCUCAA.CGg uu.....................GG.........GC........U...G........... ......................CACC.....................UG..A..UACUUC CGG...............G.CU....AGA..G..GG....CG.............GU... AGAGG..AGAG..CGGAACUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AGGAACGCCGG.UGGCGAA............GGC GGCUC.U.CUGG..GCUGUUC..CUGACGCU....GAG.GCCCGAAAGCUGGGGGAGCGA AAGGGAUUAGAUACCCCUGUAGUCCCA.GCCGUAAACGAUGGG....CAC.......... ....UAGGU........................G.......UUccccc.GCG........ .......................A.......UGG.......................... ...........................................................G GA.....GU........GCCG.......ACGGGAAAC..CAU..........UAAG..UG CC.............CCACCUGGGGAGUACGCCCGCAAGGGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCGCG.UGGUUUAAUUCGAC.GCUAAGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....U....................G.........GUG.. ..........GUACCCugg......................................... ............................................................ ............................................................ .........U.GGAAACA.......................................... .......C..................U.....GGgggacuccccguugaggggaGAG... ..................CC...................................AG... ...............CA.CAGG.UGCUGCACGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...CCUUAG......U....UGC..C .A..CAg..............CAUCCAUgagg.U...G......G..CU.....GGG..C A.CUCUAAGG............GG.ACUGCC.GCCG....AUg.AG.G.C.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCGUgUGGCCUUUAUG.UCCAG.GG CUACACA.CGCGCUACAAU.GGGU.G..G.UACAA.UG................GGCu.. ....U.U.G..............CG........A........CCCC.....GC.GA.G.. ......GG........GAAGCGAAU......CCC.....AG...RAAA.C..CAC...CC CC.A....GUUGGGAUUGGGGUCUGCAACCCGACCCCAUGAAG.ACGGAAUCGCUAGUAA UCGCCUAUCAG.C.AU.Gg.GGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGCCAUGGGA......G..........................CC...GGG G.........GC.............ACCUGAA....GU...................C.. ...GC.U.......GG.C............C.....CAacccU.........CCG..... ..........A.....A...AG.G.................AG.....GGA.......GG GAGGC..GCCUA....GGGUGAA.........................AC.......... .C.................GGUGACU.........GGGGCG................... ............................................................ ............................................................ ........................................................... > ......................UUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCCUA....AUGCAU.GCAAGUC.....G AGC.....G........GGC........U...................AC.......... ...................................................AAUCUUCGG ..........AUU...........................................G... ...........U.....AGC..................UU.................... .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUA.GG.UAAUC................... ........................................UA................C. .CC..........................UUG....A......................G .AG.GAGGACAACC..U.C...........AGG.AA.ACUG.A................. ...............G............................................ .............................................G.C............ .................................................UAAACCuuc.. ......................................A.UAC...GUUCa......... ....C....................................................... ......................................................U..... .......................G.................................... ............................................................ ............GU.......AGGGAUACUGg........U................... ............................................................ ............................................................ ............................................................ ......................................GAAGAAAGAguuaccguugagg uagCU..GCUG................................................. ..............................AA............................ ..................GG.......A.......U........................ GAG..........CCUG.CGGC...................................... ..CC..................AUCAGGU...AG.UUGGUGA.GGUAACGGCU..CACCA AG.CCGAAGAC..GGGUAACCGG...U....CUGAG.AGG..A..UG..UCCG...GUCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGCAGGGAAUC UUG.....G...UCAAUGGGCGAA.AGC................CU...GAC.C...C.A GCGAC.GCCGC.GU......GGAGGAAG...AA...GU.CC.........UUC.GGGGCG UAAAC..........................UC.CU.........Ggacu.......... ......................................................GGGGGA CGAGU....................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .......AAGGACGGU............................ACCCC.A.G...UAGA .......AAGGGAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAAAC.............GU AGGUCCCGAG..CGUUGUUCGGAUUCACUGGGUGU..AAAGGG.CG.C.GUAGG...... .........UGGU.................UGUcug.............UG.UCUC.... .........A..........UGUG.......AAA.......ACUC.AG.GGCUCAA.C.. ..U..C........U........G.........AgauUGCG................... .........................................................UGG GAAA................CU....AGGcagcuagaggACG.............GU... AGAGGG..GAG..UGGAAUUC......CC.....................GGUGUAGCGG U..AAAAUGCGUA.GAU.AUCG.GG.AGGAACACCGG.UGGCGAA............GGC GGCUC.U.CUGG..GCCGAUC..CUGACGCU....GAG.GCGCGAAAGCUAGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCUA.GCCGUAAACGAUCcc....UGC.......... ....UAGGU........................G.......UU....G.GG.....G... ....................G....GU........AAAGA..C........CC....... ....................UU.....................C................ .A.....GU........GCCG.......AAGCC..AACGCGA..........UAAGC..A UC.............CCACCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGGCGGGGGU.CC.GCACA.AG.C.GGCGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GUUUGA.....C...A.................UG..................... ...................C....A....................G.........GUG.. ..........GUA............................................... ............................................................ .................................GGAACCUG.AAAGGGGGA......... ..CGACCC...............A.................................... .............ACCGUAAGGGAGG............................GAG... ..................CC...................................AG... ...............CA.CAGG.UGUUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU CGGCUUAAGUGCC.GUAACGAGCGCAACCCUCA...UCCCUAA......U....UGCUcC .UGAC....AGG........U..A.........A.AAG......GguCA.....GAG..C A.CAAUAGGGA............G.ACCGCuggcgaagagc........C..A....... ...GAGGA.A.GGGGA.GGAUGACGUC..A..AGUCAGCAUGGCCUUUAUGC.CCUG.GG CUACACA.CAUGCUACAAU.GCAG.G..G.UACAA.CG................GG.... ....A.A.G..............CG........AA........GCC.....GC.GA.G.. ......G........UGGAGCAAAU......CCC.......CA.AAA.GC..CC...UGC UC.A....GUUCGGAUCGCAcGCUGAAAUUCGCgUGCGUGAAG.UCGGAGUCGCUAGUAA CCGUGGAUCAG.C.AA.G.CCGCGG.....UGAAUACGUUCUCGGGCCUUGC..ACACAC CGCCCGUCAAGCCACCCGA......GU..........................C...GGG ........U.UC.............ACCAGAA....GG...................C.. .............................GGU.....A....A.........CCG..... ..........A.....AG..AG.GGc.................................C G......GACGAC....GGUGU......................GC.............. CU.................GGUAAGG......A...GGGCUAAGUCG.UAACAA.GGUAG CUG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUccuu................................... ........................................................... > taat........................................................ ......................................GCATGCAA.GT....C.....G AGC.....G..................................CAttctccggaat.... ............................................................ ....................................................G....... ............................................................ ........................................................AGTG GCGC.....ACGGCTGA....GGAACAC.GTGAc.T.AACCTA................. .........................................................CC. .CCggt.....................................................G T.G.GGGGATAA.Cgg.G.T............CGAAAG.A.CtC................ ............................................................ .............................................G.CTAATCCC..... ..GCATAC.................................................... ..............................................GATTCACt...... .TCGGT...................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..A............AGAAAGT...................................... ............................................................ ..........................CGCAAGGC.......................... .......GCActgggcggggg....................................... ............................................................ ............................................................ ..............TCG.CGTCC..................................... ...C..................ATTAGG.Tgattggtgta....GTAATGGCG..CACCA AG.CCGATGAT..GGGTctCTGGTCT.......GAG.AGG..A..CG..ACCA...Gaca gATTGGG.ACTGAGACACG.GCCC..AAACT...CCTACGGGGGGCAGCAACAAGGAATT TTcGNCAAT........GGACGCA.AGC................CT...GAC.C....GA GCAAGgG.CGC.GT......GGAGGATG...A...CGG.CTct..........TGGGT.. ............................................................ ......................TGTAAACTCCTT................TTGGGGGGGA CGA......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .........................TA.A...TGACG.G....TACCCTccgaatcagg. ...........CCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGGCCAAG..CGTTGTCCGGAATTAC..TGGGCGTAAAGCGT.Gg..GTAGGTGGtcg atgatgtgccgcgt................................GAAAGCGCCggagt aatgccGGCGAGGtcgcggtAGACACAtt............................... ............................................................ ............................................................ ..GA................C.T...AGA..Ggctc...................G.C.. AGAGG..AACG..TGGAATTCCCGG..........T.................GTAGtGG TG..AAATGCGTA.GATAT.CG.GG.AGGAACACCAG.TGGCGcaagcggcgttctgGGC GAGAC......................CTGACACTGAgccacgac.GGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCAGTAAACGATGCataccAGGTGT....... ...............................................G.GGAtggcgttt cgcgtc...................................................... .....GTTCC.................................................. ...............GTGCCGC.......AGCTt..ACGCGATcagta..........T. ..............GCCGCCTGGGGActACGAGCGCAAGCTTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.CA.GCGGAGCGTGTGGTTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCTAGT.......................................... .....CTTGACAT.........................Agcactgcaag........... ............................................................ ............................................................ .........CTT................................................ ............................................................ ............................................................ .......C.................................................... .......................................GGAAatgaagtcgccttcgag ggtgtgcT........A.CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTGTGAggtgttacaagtgtcacc...... ............................................................ ........TCA............G.ACTGCC.GTtgtcagc....A..AC.G........ ...GAGGA.A.GGCG.GGGATGACGTCAA....GTCCgCATGGCCCTTACG.ACtAG.GG CGACACA.CACGCTACAAT.GGCT.G..GgagaatgcgccgcgaccaggtaactGGC... ......A.G..............CG........AAt................C.GA.GA. ...............ACAccag...................................T.C AC.A....GTTCAGATTGGGGGCTGCAACTCGCCCCCATGAAGG.CGGAGTTGCTAGTAA TCGCCGGTCAG.CCAT.A.CGGCGGT.....GAATcagtACCCGGGCCTTGTt..CACAC CGCCCGTCACGTCATGGAA......GTg.............................GG. .......AAA.C.............ACCTGAA....GTCCGTG................. .......G........G.............CT.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GC G......GCCGA....GGGT.......................GGGG............. .CTcgtt.........................ACTGGGACGAAGTCGctttCAA.GGTAG nccttccCCNG.AAG..........Gtg................................ ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCCUA....AUGCAU.GCAAGUC.....G AACR........................................................ ..........................................................C. .................A......ACAGGCGUGCCuggcug................... .....................C...................................... ........................................................GU.G GCG.....AACGGCUGA....GGAACAC.GUG.GG.UGACC..................U G.........................................................C. .CC....C....................G..G....A......................G .UG.GGGGAUACC..CCG............U.CGAAAG.A.C.................. ...............G............................................ .............................................Ggac........... ...................................................AAUCC.... .............C.N....................CAU.AC.................. ....................G.CUCga................................. ............................................................ ............................................................ ............................................................ ............................................................ .................C...........................G.....G........ ..A.........G...GAAAGC...................................... ............................................................ ..........................CGCAGG............................ ......CGCu....CN............................................ ..............................GG............................ ..................GG.......AG............................... .....G.........UG.CGGC...................................... ..CC..................AUCAGGU...AG.UUGGUGU.GGUAACGGCG..CACCA AG.CCAAUGAC..GGGUACCCGG...U....CUGAG.AGG..A..CG..ACCG...GgCA GACUGGG.ACUGAGACACG.GCCC..AGAC..Ug.CUACGGGAGGCAGCAGCAAGGRAAU UU.....NCC...CAAUGGGCGCA.AGC................CU...GA....GG.GA GCAAC.GCCGC.GU......GGAGGACG...A...CGG.CC.........CUA..GGUUG UAAAC..........................KC.CUU.........U............. ...................................................C........ ....................A......GG............................... ...UGG................................................G..... .....................................................ACG.... ............................................................ ..................A....UG................................... ............................................................ ............................................................ ........................................................C... .......U..GACGGU............................ACCAC..C.AGAA... ...Gc...AGCCCC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAGACA.............G AGGGGGCAAG..CGUUGUCCGGAGUUACUGGGCGU..AAAGGG.CG.C.GCAGG...... ........C.GGUGggcugcgucggCG....C.............UGAAAGCGCCucgcu uaacggGGCGAGGcgCGCC....G.......AUAcgaguccACUC.G.AGGCAA...... ............................................................ ............................................................ .......................................................G.C.. AGAGGG..UGG..CGGAAUUU......Cg.....................GGUGGAGCGG UG..AAAUGCGUA.GAG.AUU.CGG.AGGAACGCCGG.UGGGGAAGC............C GGCC.A.CCUGG..GCUUUAC..CUGACGCU....GcG.GCGCGAcAGCGUGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCA.CGCCGUAAACGAUGCCgg............... ............................................................ ...................................................CUCGGCGuc ............................................................ ....UG.G...........CGC.......A.CG.UUG.GUGUgcugggugccUUANC..U NAcgcgguaagccGGCCGCCUGGGGACUACGAGCGCAAGCUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GCGGAGCGUG.UGGUUUAAUUCGAC.GCAACACG .AAGAACCUUA.CCCGGAc......................................... ............................................................ ............................................................ ....................U.....UNAC.........................A.U.G ............GUGcug.......................................... ..........................................CA................ ....UCCCCU.GGAAACAGGGgcgccugnc.............................. .................................GA...................GGCG.. ....................C..AC................................... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCcCGUGUCGUGAGAUGU UGGGUUNAGUCCC.GCAACGAGCGCAACCCGugucg...GUAG......U....UACA.. ..............................GG...UGUCUac.................. ........CGA............G.ACUGCC.C..G.UG.Acc..G.G.C.G........ ...GAGGA.A.GGCGC.GGAUGACGUC..A..AGUCAGCAUGGCCCUUACG.UCCGG.GG CGACACA.CANGCUAnAAU.GGC.CAC..G.ACAA.UGC................GUUGC ........................C........AA........GCC.....GC.AA.G.. ......G........UGGAGCUAAU......CUC.......CU.AAACg.U..G.G.U.C UN.A....GUgCAGAUCGGGGGCUGCAACUnGCCCCCGUGAAGG.CGGAGUUGCUAGUAA CCGCGUAUCAG.CCAU.G.GCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGGGA......GUG.............................Gcc aaug......................CUUGAA....GU...................CC. ....G.U.......G.U............GCU.....A....A.........CC...CCA guc.......GG.........G.G.................AG.....GCA.......GC G......GCCGU....GGGCAGG.........GGCCG....................... .....................CGACU.........GGGGAc................... ............................................................ ............................................................ ........................................................... > gggG..........AUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GGgGAACGCUGG.CGG..CGUGCCUA....AUGCAU.GCAAGUC.....G GAC.....G........G.......................................... .....GA.NGCACGCNC........................................... ........................UCUGGCGUGCCgac...................... .....................C...................................... ........................................................GU.G GCGG.....ACGGGUG....CGUAACAC.GUG.GGG.......................A ........................................A................CC. .C....................UCCCgGG.......U......................G C.G.GGGGAUAA.C.CCG.GGGAAAC.............UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............CCAUA.......................................... ............................................................ ............................................................ .............................................CGCUUGG........ ............................................................ ......................CUG...Gc.............................. ............................................................ ............................................................ ............................................................ .............................................GGUGGGCCggc.... ............................................................ ........................CAAGGAAA............................ ..................GGcgcaggcgacuGUGCU........................ GUGcucggagggcCCUG.CGGC...................................... ..C..................UAUCAGCU...AG.AcGGUAG.GGUAACGGC..CUACCg UGG.CGAUGAC..GGGUAGCUGG...U....CUGAG.AGG..A..UGG..CCA...GCCA CACGGGC.ACUGAGACACG.GGCCC..GAC..U.CCUACGGGAGGCAGCAGCAGGGAAUC UUC.....CG...CAAUGGGGGCA.ACC................CU...GAC....G.GA GCGAC.GCCGC.GU......GCGGGAGG...AA...GC.CC.........UUC.GGGGUG UAAACC..........................G.CU.........GUuc........... .....................................................GGGGGGA CGAUcgagc................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..........GACGGU............................ACCCU..CG.GA.... Gc.....AAGUCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAGAC.............GU AGGGGGCGAG..CGUUACCCGGAGUCACUGGGCGU..AAAGGG.CG..UGUAGG...... ........C.GG.............C....UGGguacgccgc...............G.. ....................UGUG.......AAAG.......UCC.CC.GGCUCAA.C.C ...G........G.G........G.........AGGGU...................... ......................CGcgcggg.........................ACGGC CUG...............G.CUC....GA..G..GG....CG.............GG... AGAGGC..GGG..UGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCG.GG.AGGAACGCCGG.UGGCGAA............GGC GGCCC.GC.UGGC..CCGUAC..CUGACGCU....GAG.GCGCGAAGGCGUGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCA.CGCAGUAAACGAUGCG....GGCg......... .....AGGU........................G.......U...G.G.G..U...G... ....................G..UG.......UUGA.....CC........CC....... ....................AU.....................C................ ...C...GU........GCCGGc.......GCC..AACGCAG..........UAAGC..C C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GCGGAGCGUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C.....CACC............................... ..........................................GAACCUGG.......... ............................................................ .....CUGAAAGGC................UGGGGUGCCCGguG................ .....................................................A...... ......G.................GGAGCGgu.....G...................... ........................................................G... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGgg...GUCAG......U....UACG.. ............................CGGG...UGUCUgaccc............... .......................G.ACUGCC.G..G..GGAAAgC...CC.G........ ...GAGGA.A.GGAG.GGGAUGACGUC..A..AGUCAGCAUGGCCCUGACGC.CCUG.GG CGACACA.CACGCUACAGU.GaC.CG..GG.ACA.GUG................GGC... ......A.G..............CG........AA........G................ .......GGGCGACCUGGAGCCAAU......CCC.G.......CAAAC.C..CG.G.U.C GUg.....GUGGGGAUCGCAGGCUGCAACCCGCCUGCGUGAACG.CGGAGUUGCUAGUAA CCGCCGGUCAG.CCAU.A.CGGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCACGAAA......G..........................C...UGGC ........U.UC.............ACCUGAA....G...................CU.. ...GG.U.......GG.............GC.....CA....A.........CCGGcgca c.......................GCUGGG............G.....GCA.......GC ....C..GUCGA....GGGUG......................GGG.............. CU.................GGUGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GNnnngg..................UG......GA U............CACCUCCUUUCU................................... ........................................................... > ..................AGGGUUUGAUCAU.GG.......................... ....CUCAG.GAUGAACGUUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAC.....G.......A.A........GAC.............................. ............................................................ ...........UGUAGUA......A.................UAC.......U....... ...............G.UCUU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACGC.GUG.GG.UGACC..................U G.........................................................C. .CC....C....................GA......A......................G .UG.UGGGAUAAC.A.............GUU.CGAAAG.G.AU................. ................U........................................... .............................................G.C............ .................................................UAAUAC..... ..................................UGCAU.AA.UA............... .....................................UC..................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...CAAG..................................................... .................AGAUU....................AGA............... ............................................................ ............................................................ ......................CGCU...UUU............................ ..................GG.......A.......UUAAAGGaguaauucGCUUCGGGAG GGG..........CCCG.CGUC...................................... ..CC..................AUCAGCU...AG.UUGGUAA.GGUAAUGGCU..UACCA AGG.CGAUGAC..GGGUAGGGGACC.........UG.AGAG..GGUGG..CCCC...CCA CAAUGGA.ACUGAAACACG.GUCC..AUAC..A.CCUACGGGUGGCAGCAGUAGGGAAUA UU.....AG...U.AAUGGGCGAA.AGC................CU...GA.ACU....A GCAAC.GCCGC.GU......GUGCGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................A.CUU.........U...U......... ............................................................ ....................U......GAGA...................GGAUGAG... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......GAAGGACGGU............................ACUCU..C.AGAA..U .......AAGUCUC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAACAC.............GU AGGAGGCAAA..CGUUAUCCGGAUUUACUGGGCGU..AAAGCG.CG..UGUAGG...... .........UGGU.................UUG.............GUAAG.UAG.GG.. ..........C..........GUG.......AAAG.......CUC.C.UGGCUCAA.C.. ..U...........G........GGAGAGGACG........................... ........................U...UC..................U..A..AACUGC CAA...............G.CU....UGA..G..G....AUG.............GU... AGAGGG..AGG..UGGAAUUC......CG.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUC.CGG.AGGAACACCAG.UGGCGAA............GGC GGCC.U.CCUGGA..CCACUC..CUGACACUC....AGA.CGCGAAAGCUAGGGUAGCAA ACGGGAUUAGAGACCCCGGUAGUCCUA.GCCCUAAACGAUGU....AGAC.......... ....UUGG.....................................C....G........U C.........GGugGU......UU.......AAU........C.G......CC....... ....................AU.....................C................ ......GGU........GUCG.......UAGC..UAACGCGU..........UAAG..UC UA.............CCGCCUGGGGACUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGUC.CCC.GCACA.AG.CA.GCGGAGCGUG.UGGUUUAAUUCGAU.GCUACACG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UA.............G....... ........................A....................G.........GUAG. ............................................................ ............................................................ ...........................................UAGGGAAGCGAAAGCGG ACCGACCC...............U............................U....... .....CG.................GG............................GGAGCC ....................................................UC...U.. ................A.CAGG.UGUUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UCGGUUAAGUCCGC.UAACGAGCGCAACCCUCG...AUGugugu.....U....AACA.. .AGUG....................................................... ...UCACAcG............G.UACUGCC.G...AUAUUA.A...GUC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGCAUGaCCUUUAUA.UCCAG.GG CUACACA.CACGCUACAAU.GGC.CA..G.UACAA.UG................GG.... ....U.U.G..............CC........AA........GCC.....GC.GA.G.. ......G........CGGAGCCAAU......CCU....AA..A.AAGCU......GG.CC UC.A....GUUCAGAUUGCAGUCUGCAACUCGACUGCGUGAAG.UUGGAGUUGCUAGUAA CCGCAGGUCAG.CAAU.A.CUGCGG.....UGAAUACGUUCCCGGGGAUUGU..ACACAC CGCCCGUCAAGUCAUGGAA......G..........................C...UGGC ........A.AC.............ACCUGAA....G...................CC.. ...GG.UAU........C............CU.....A....A.........CC...CGA .A........AG.........G.G.................AG.....GGA.......GC .U.....GUCGAA....GGUG......................GGG...U.......... .C.................GGUGACU.........GGGACUAAGUCG.UAACAA.GGUAG GUG.UA.CCGG.AAG..........GUGCGC..................CUG......GA U............CACCUCCUUUAU................................... ........................................................... > ............................................................ ..........GAUGAACGUUGG.CGG..CGUGCCUGaga....UAU.GCAAGUC.....G AGC.....GAccccgc............................................ ................C........................................... ........................UCUGGCGGG........................... ...............................G............................ .......................................................AGC.G GCG.....AACGGCUGA....GUAACAC.GUA.GG.AA.CC..................U .G.......................................................CC. .CCU..AA....................GUC............................G .AG.GA..UAGu...CCG............U.CGAAAG.GC.G................. ...............G............................................ ..............................................AG............ .................................................UAAUACU.... .............CG.AUgguu..CCCGCCUC.....Uggcg.................. ............................................................ ............................................................ ............................................................ ............................................................ ...................GGA..................UA.................. ..................................A.......A..G.....G........ ..Au........................................................ ............................................................ ............................................................ ........CU.....AA........................................... ...............................CC........................... ..................GUCCGCU..U.......A........................ GGGAgGGG.....CCUG.CGGC...................................... ..C..................UAUCAGGU...AG.UUGGUAG.GGUAACGGC..CUACCA AG.CCGAUGAC..GGGUAGCUGGCC.........UuAUGAG..GGUGG..UCA...GCCA GAGGGGG.ACUGAGACACG.GCCCCC..AC..U.CCUACGGGAGGCAGCAAUCAGGAAUC GUC.....GG...CAAUGGGCGAA.AGC................CU...GAC.C....GC GCGAC.GCCGC.GU......GCGGGAAG...AA...GCU.C.........UUC.GGAGUG UAAACC..........................G.CU.........GUGGuagg....... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................................................G.GA.... G..G...AAGCCCC..................Gccuuuggcgggguugacaguacccuac uagaaaggggccGCUAACUgC.G.UGCCAGAAGCgUCGGUAAUAC.............GU GGGcccCAAA..CGUUAUCCGGUGUUAUUGGGCGU..AAAGGGUCG..UGUAGG...... ........C.GU.............C....CCG.....................UC.... .........A..........AGU.......UUUAccucaaagaC.UA.UGGCUCAA.C.C .........A...UA........Ggaagggg............................. ........................U...A..................AA..A..AACUGA C........................................................... ........GGGA.UAGAAUUC......CCUcaagggggacgggaacuugcGGAGGAGCAG UG..AAAUGCGUU.GAU.ACCGcag..GGAACACCAG.UGGCGAA............GGC GCgucccuucgag....GGA..AUUGACGCU....GAGA.CACGAAAGCUAGGGGAGCGA AgCAGAUUAGAGACCUGCGUAGUCCUA.GCCGUAAACGCAugu................. ............................................................ .........................................................C.. .....................UGCUAGCUGUGCUUuuccucgccucaucggcgggguuag gca.....U........GGCG.......AAGGUAACC..CGU..........UAAGC..A GA.............CCGCCUGGGGACUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGGCGGGGAGG.CA.CACA.AC.CA.GUGGAACAUG.UGGUUCAAUUCGAGACG.AACCG .AAGAACCUCA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....U....A...C.......................... ...........CG.......U.....UC................................ ............................................................ ....................................ACCCG.AAAGG.......AAA... ......C...............UU............................U....... .....CG.................GG............................GAUCcg caaggaugG............U.................................AG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUUCCGUGAGGAGU gCCCUUAAGUGGgA.CAACGAGCGCAACCCCCG...UCCUGUG......U....U..... ....................AG.A.........A.AUGU..............Ca..... ......CAGGA............G.ACAGCC.C...CGCcUAUUGGCG.G.G........ ...GAGGA.A.GGAG.GGGUAGACGUC..A..AGUCAGCAUGGCCCUUAUGC.CCUG.GG CUACACA.CAUG................U.UACAA.UG................GG.... ....A.A.GgacagcgggcuuugCC........A........CACC.....G.UAA.G.. ......G........UGGAGCGAAU......CCC.....UC...AAA..C..CU..U.CC CCaA....GUUGGGAUUGAGGUCUGCAACUCGACCUCAUGAACG.CGGAAUUGGUAGUAA UCGCGGAUCAGuC.AU.G.CCGCGG.....UGAAUACGUUCUuGCCUCUUGC..ACACAC CGCCCGUCAAGCCAACAAAGUcgggGA.............................UGG. .......UU.G.............AACccc......G...................CC.. ...GG.U.......GG.C.......................................... ............................................................ ............................................................ ...............................G...GGGGAGAUcauucccgg........ .CG.AUGGGGguu............................................... ............................................................ ........................................................... > uu.G..........UUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GGUGAACGCUGG.CGG..CGUGCCUA....AGACAU.GCAAGUC.....G UGC.....G........GGCCgc...GG..............................GG UU....U.Uacuccg............................................. ............................................................ .....................................U...................... .........GGUC..........................................AGC.G GCGG.....ACGGGUGA....GUAACGC.GUG.GG.UGACC..................U ........................................A................CC. .C.........................GGA......A......................G .AG.GGGGACAA.C.CCG.GGGAAAC.............UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAUCCC.... .............CCAUg....................UG..GACCCGC........... ......................C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UU.GGGGugU............................................ ..........................GUCCAAAGGG....C................... ..........................................UUUGCC............ ............................................................ ......................CGCUUC...C............................ ..................GG.......A.......U........................ GGG..........CCCG.CGUC...................................... ..CC..................AUCAGCU...AG.UUGGUGG.GGUAAUGGC..CCACCA AGG.CGACGAC..GGGUAGCCGG...U....CUGAG.AGG..A..UGG..CCG...GCCA CAGGGGC.ACUGAGACACG.GGCCCC..AC..U.CCUACGGGAGGCAGCAGUUAGGAAUC UUC.....CG...CAAUGGGCGCA.AGC................CU...GAC....G.GA GCGAC.GCCGCu.U......GGAGGAAG...AA...GC.CC.........UUC.GGGGUG UAAAC..........................UC.CU.........GAa....C....... ............................................................ ............................CCG............................. ............................................................ ............................................................ ............................................................ ....................................GGACGAAAccc............. ............................................................ ............................................................ ............................................CCGACGAGgggAC... .......U..GACGGU............................ACCG.G..G.GUA..A .......UAGCGCC..................G........................... ............GCCAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGCGCGAG..CGUUACCCGGAUUCACUGGGCGU..AAAGGG.CG..UGUAGG...... ........C.GG.............C....CUG.............GggcG.UCCC.... .........A..........UGUG.......AAAG.......ACC.AC.GGCUCAA.C.C ...G.........UG........GG.........Gg.AGCG................... .........................................................UGG GAUA................CgcucaggcuagacGG....UG.............GG... AGAGGG..UGG..UGGAAUUC......CC.....................GGAGUAGCGG UG..AAAUGCGCA.GAU.ACCG.GG.AGGAACGCCG.AUGGCGAA............GGC AGCC.A.CCUGGU..CCACccG..UGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACCGGAUUAGAUACCCGGGUAGUCCA.CGCCCUAAACGAUGCG....CGC.......... ....UAGGU................................................... ......................................C..................... .UCUGGG..............U.....................C................ .UC.....CUGggg...GCCG.......AAGC..UAACGCGU..........UAAGC..G C.............GCCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....CCUUGA.....C...A.................UG..................... ...................C....U....AG..........................G.. ..........GAACCC............................................ ..........................................GGGUGAAAGC........ .............C................UGGGGUGCCCGc.G................ .....................................................A...... ......G.................GGAGCCC............................. .....................U.................................AG... ...............CA.CAGG.UGCUGCAUGGCCGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCCGC...CGUUAG......U....UGC..C .AG.C.G...GU...........UC.....G...................G.CCGGG..C A.CUCUAACG............GG.ACUGCC.C..GCG...A.AA..GCG.G........ ...GAGGA.A.GGAG.GGGACGACGUC..UG..GUCAGCAUGGCCCUUACG.GCCUG.GG CGACACA.CGUGCUACAAU.GCC.C.....UACAA.AGC................GAUGC ........................C........Acccggcaac................. ......GG........GGAGCUAAU......CGC....AA..A.AAGg..U....GGG.C CC.A....GUUCGGAUUGGGGUCUGCAACCCGACCCCAUGAAGC.CGGAAUCGCUAGUAA UCGCGGAUCAG.CCAU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGCCAUGGGA......G..........................CG...GGC ........UC..............UACCCGAA....GU...................C.. ...GCcgg......G.A............GC.....CU....A.........C....... .............................G............G.....GCA.......GG ....C..GCCGA....GGGUAgggcc.................................. ..C.................GUGACU.........GGGGCGAAGUCG.UAACAA.GGUAG CUG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ............................................................ .......AG.GGUGAACGCUGG.CGG..CGUGCUUA....AGACAU.GCAAGUC.....G AAC.....G........G.......................................... ...............C.......................C.................... ..CAGCUUGC.U.GG.....G....................................... ..................C.............AG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUGA.C.UGACC..................U ........................................A................CC. .C.....C...................G.AAG....Uucu.................... ......GAAUAAC..CUG.G............CGAAAG.UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAUAC..... ..................................AGGAUG.................... ....................................U....................... ...........................................GC............... ............................................................ ..............................................A............. .GUAUCGCUG..U...........GGC................................. ............................................................ ............................................................ ..........................GAUACU............................ ............................................................ .......GCA.....AA........................................... ...............................Gguuu........................ ...................ACCGCU..U.......U........................ GGGAUGGGG.....UUG.CGU....................................... .UCC..................AUCAGCU...AG.AUGGUGG.GGUAAAGGC..CUACCA UGG.CGACGAC..GGAUAGCCGGCC.........UG.AGAG..GGUGG..CCG...GCCA CAGGGGC.ACUGAGACACG.GGUCCC..AC..U.CCUACGGGAGGCAGCAGUUAGGAAUC UUC.....C...ACAAUGGGCGAA.AGC................CU...GA.U...G.GA GCGAC.GCCGC.GU......GAGGGAUG...A...CGGU..........UUUC.GGAUUG UAAACC..........................U.CU.........G....AA........ ............................................................ ......................U.....C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AA................................... ............................................................ ...................................GGGCCUUUAUGGcA........... .......................G...................................A .......U..GACGGU............................ACCU.G...AGUA..A .......UAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAG..CGUUACCCGGAAUCACUGGGCGU..AAAGGG.CG..UGUAcgcgggau guuaAGUCC.GG..................UC.............UUAAAG.AC...... ............................................CG.C.AGCUCAA.C.. ..UG......C...G........GGAGUGGAC............................ ............................UG..................G..A..UACUGG CAcucuggacc............................UC.............UGG... AGAGG..UAG..CUGGAAUUU......CU.....................GGUGUAGCGG UGG..AAUGCGUA.GAU.ACCA.GA.AGGAACACCA.AUGGCGAA............GGC AGGU.UA.CUGGA..CAGAAgG..UGACGCU....GAG.GCGCGAAAGUGUGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCA.CACCCUAAACGAUGU....ACGuuggcagaucg caggAUGCU........................G......UGAu................ ............................................................ ...........................U..........U..................... ..................GCG.......AAGC..UAACGCGA..........UAAAC..G UA.............CCGCCUGGGAAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAG............................................ ...ACCUUGA.....C...A.................UC.C................... ...ACA......GA................................AC............ ....................GC.....C......G....CGG.................. ....AAgcgcggc................................GG............. ...................................UG....................... .....CCC...............U............................U....... .....CG.................GG............................GA.... .................ACUG..U........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUGC...CUUUAG......U....UGC..C .AG.CA...U..........U..U.........A.A.G.U........U.....GGG..C A.CUCUAGAG............GG.ACUGCCUG....UG..A.AA..GC.AG........ ...GAGGA.A.GGCG.GGGAUGACGUC..U..AGUCAGCAUGGUCCUUACG.GUCUG.GG CUACACA.CGUGCUACAAU.GGC.CA..G.UACAA.CGC................GcAGC AAACU.U.G..............CG........A......G..A................ .......GUGAGcg........AAU......CGC....UA..A.AAGCU......GG.CC UC.A....GUUCAGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UUGGAAUCGCUAGUAA UCGUGGGUCAG.C.AU.A.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................AGA. ........UUGC.............Agc.............................U.. ..............................GA.....A....A.........CCG..... ..............C.Ugggagccgca..............AG.....GCA.......GG ....C..GUC...........................UAGGCUGUGGUU........... ..U.................AUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG GUG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA ............................................................ ........................................................... > g........................................................... ...........GCGAACGCUAG.CGG..CGUGCCUGc....GACAU.GCAAGUC.....G AGC.....G........GGGG.......................G....A.......... ................................G......G...AG.........CUUCGG CuccgaA..............C.........................C............ .......................................U.................... .......................................................AGC.G GCG.....AACGGuCGA....GUAACAC.GUAA.GC.AACC..................U .G.......................................................CC. .C.....C...................G.AAG....A....................... C..C.GGGAUAAC.A.............GCU.CGAAAG.GG.C................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAUG.................... ....................................U....................... ...........................................GCCc............. ............................................................ ............................................................ ....ACGCAG..A...........GGCAUCUCUgc........G.UGAGUAAAAC.CCGC AAGGG....................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................................................GCUUCGGGAG GGG..........CUUG.CGGC...................................... ..CC..................AUCAGCU...AG.UUGGUAG.GGUAACGGC..CUACCA AGG.CGGCGAC..GGGUAGCUGG...U....CUGAG.AGG..A..CGG..CCA...GCCg GACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUCGGGAguc cUG.....C...ACAAUGGGGGAA.ACC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GCGGGAUG...AA...GU.CC.........UUC.GGGACG UAAACC..........................G.CUU.........U...U......... ....................................................GUCC.... ............................................................ ....G........GG..................AA...................G..... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................AAGU...............................UC... .......U..GACGGU............................ACCG.GA..CGAA..U .......AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAAAC.............GU AGGGGGCGAG..CGUUGCCCGGAUUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GG.............C....UGC.............GUAAG.Uggggag. .............................UUAAAG.......CCC.UC.GGCUCAA.C.C ...G.........AG........G.........AA......A..U...G........... ......................CUCC.....................UC..A..AACUGC GCG...............G.CU....UGA..GU..G....U.............AGG... AGAGGG..GAG..UGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUU.GAU.AUCG.GG.AGGAACACCGG.UGGCGAA............GGC GGCUC..CCUGGC..CUACC..ACUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCGA ACGGGAUUAGAUACCCCGGUAGUCCA.CGCCGUAAACGAUGAG....CGC.......... ....UAGGU........................G.......UU....G.GCgguc..... ...............................U.CGA.....CC........CCg...... ..................................C........C................ .A.....GU........GCCG.......UAGC..UAACGCAU..........UAAGC..G CU.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGAUUAAUUCGAU.ACUAACCG .AAGAACCUUA.CCCAG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A.CAcgcaag.......................... ............................................................ ............................................................ ............................................................ ......CCCU.GGAAACAGGGcc.....CUCC............................ .......................AGG............................GUAAcc uggacgu...............................................GUG... ...............CA.CAGC.UGUUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCGCGC...CCCAUG......U....UGC..C AA..C.G...GGUC......................AU............G.CCGGG..C A.CUCUUGGG............GG.ACUGCC.C..GGGU.....AAC.CG.G........ ...GAGGA.A.GGAGC.GGAUGACGUC..A..AGUCgGCAUGGCGCUUACGC.CUGG.GG CCUCACA.CAUGCUACAAU.GGG.CG...CAACAA.AG................GG.... ....U.UC...............CG........AU........GCC.....GC.GA.G.. ......G........CGGAGGCAAU......CCC.....A..A.AAAUa...C..GC.CC UC.A....GUUCAGAUCGCAGGCUGCAACUCGCCUGCGUGAAGC.CGGAAUCGCUAGUAA CCGCAGAUCAG.CUAU.G.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACCUGA......GU..........................C...GUC .........UGC.............ACCUGAA....GU...................CC. ....G.U.......GG.C............C.....CA....A.........CC...CGC .A........AG.........G.G.................AG.....GGA.......GC G......GCCGA....GGGUGCGGGGG................................. .........................GCA.AGG...GGGacu................... ............................................................ ............................................................ ........................................................... > ............................................................ ...............ACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUCcg.... .AC.....G.......U.G...AA................AG................G. ................................G......G...AG.........CAAUCC cccgg....................................................... ....................................UAGG.................... ........................................................GU.G GCA.....AACGGGUGA....GUAAGACA.UG.GG.UGAUC..................U .G.......................................................CC. .C.....U....................GG......A......................G .AU.GGGGAUAUC..CCU............C.CGAAAG.GG.G................. ...............G............................................ .............................................Ggc............ ..................................................AAUACC.... ...................................GAAU.AG............UAUCCG guuccg.............................UGAAGGGGAcc.............. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..........GGG...GAAAGGGA.......G............................ .........................GCCUCUGgU.......................... ...............ACAAGCUU..................................... ...C..CGCUc.....C........................................... ...............................U............................ ..................GG.......A.......U........................ GAG..........CCCAU.GGC...................................... ..CC..................AUCAGCU...AG.UUGGUAG.GGUAAAGGC..CUACCA AGG.CGACGAC..GGGUAGCUGG...U....CUGAG.AGG..A..CA..ACCA...GCCA CACUGGC.ACUGAGACACG.GGCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....C...NCAAUGGGGGCA.ACC................CU...GAC....GC.A GCAACA.CCGC.GU......GUGGGAAG...AA...GG.C.........UUUC.GGGUUG UAAACC..........................A.CUU.........U...UGC....... ............................................................ ............................CCG............................. ............................................................ ............................................................ ............................................................ ....................................GGACGAAAAGGgaug......... ......UCAGAACAC............................................. ............................GgcauuUC........................ .......................G...................................A .......U..GACGGU............................ACCG.G..GAGAA..U .......AAGCCAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAGACA.............G AGGUGGCAAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGAGUC...UGUAGG...... .........UGGU.................UUG.............UCAAG.UCUU.... .........UG..........GUG.......AAAG.......NCC.G.UGGCUUAA.C.C .........A...UG........GGaaun............................... ......................CCA...A..................AG..AG..ACUGG CAGA................CU....NGA..G..GC....UG.............GG... AGAGNG..AAG..CGGAAUUU......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCA.GA.AGGAAAGCCGg.UGUCGAA............GNC GGCU.U.CCUGGA..ACAGNC..CUGACACU....GAGA.GACGAAAGCGUGGGGAGCAc ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGGG....UAC.......... ....UAAGU........................G.......U.......GG.....GA.. ....................G....GGUUAAA..........C........C........ .........................................UCC................ ...C...GU........GCCGC.......AGCC..AACGCAG..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGUGCAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C.....C...................Gc............. .........................................G............AG.UAG ..................G....A.AACUGAA............................ .AGG......................................................GG ACCGACCggUUC..........AGU................................... ......CC.................................................... .......................................GGAAGCg..........GA.. ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUcAGUCCC.GCAACGAGCGCAACCCUCGC...CCUCUG......U....UGC..C AU..C.G...GGUC......................AA............G.CCGGG..C A.CUCUGAGG............GG.ACUGCCAGC....G..ACAA..G.UUG........ ...GAGGA.A.GGAGA.GGAUGACGUC..A..AGUCAUCAUGGCCCUUAUGC.CCAG.GG CCACACA.CGUGCAACAAU.GGC.CG..G.UACA.GAC................GG.... ....A.A.G..............CG........A......G..ACC.....G.AGA.G.. ......G........UGGAGCAAAU......CCG.....AG...AAA.GC..C..GGU.C CC.A....GUUCGGAUUGAGGUCUGCAACUCGACCUCAUGAAG.UCGGAAUCGCUAGUAA UCGCGUAUCAG.C.A.CGA.CGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......GU..........................C...UG. ........UUG.............UNCCUGAA....GU...................C.. .............................GGUGcccCA....A.........CCGGA..A .AC..................G.G.................AG.....GGA.......GC ....C..GNCCAA....GGU......................AUGG.............. CC.................GGUAAUU.........GGGG..................... ............................................................ ............................................................ ........................................................... > ............................................................ ............CGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G GAC.....G........GACUUAUg...................UCUGAA........G. ................................G......G...U................ .................A......ACUGGAgggug.......UAA.............G. ..............................UUAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUA.GA.UAACC..................U ........................................A................CC. .C.....U..............U......A......A......................G .AG.GGGGACAAC.A.CA.GGGAAAC.............U.UG................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.................. ....................G....................................... ............................................................ .................GCCACGG.................................... ............................................................ ............GU.......UGGGAUACUUg............................ .................UG..........................G.............. ...............UAAAAGGGU.......G............................ .........................GCgac.............................. ............................................................ ............................................................ ............................................................ ...................ACCGCU..U.......A........................ GGGAUGGGU.....CUG.CGGC...................................... ..C..................UAUCAGGU...AG.UUGGUGG.GGUAAUGGC..CUACCA AG.CCUAAGAC..GGGUAACCGG...A....CUGAG.AGG..U..UGG..ACG...GUCA CACUGGA.ACUGAGAUACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....C...ACAAUGGGCGGA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GGAGGAAG...AA...GG.CC.........UUC.GGGUUG UAAAC..........................UC.CUU.........U...UA........ ............................................................ ......................U.....Ag.............................. ............................................................ ............................................................ ............................................................ ..............................G...................GG.....GCA A.....Ugg................................................... UGAU........................................................ ............................................................ .............GGU............................ACCCU.A..UGAA..U .......AAGCCAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAGACA.............G AGGAGGCGAG..CGUUGUUCGGAAUUACUGGGCUU..AAAGGGN.G..NGUAGG...... ........C.GGU.................UA.............UACAAG.UCU.G... .........UG..........GUGg.......AA.......UCUC.A.UGGCUUAA.C.C .........A..G.G........GG.........GC........U...G........... ......................Cc.G..UG..................G..A..AACUGU AUGA................CU....UGA..GU......UGG.............UG... AGGGG..AAGG..SGGAAUAU......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCA.GG.UAGAAgGCCUG.UGGCGAA............GGC GGCC.UU.CUGGCg..CUUA..ACUGACGCU....GAG.GCGCGAAAGCG.......... .............................CCCUAAACGGUGGG....CaU.......... ....UAGGU........................G.......U...G.G.GG........U CU.......................................................... ..........GUAAgggC...U.....................C................ .U.....GU........GCCG.......AAGGGAAAC..CAU..........UAAa..UG CC.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UGU.................... ........UAGUGGUAA........................................... ..................G............................AGG.......... ............................................................ .....CUGAAAGGC................UGaugaccu..................... ........UGGGGUAACC.......................................... .......................UGG............................GGAGC. ...............................................UA..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UCCUCUG......U....UGC..C cugc........................................G...A.....GGGG.. AUCUCUGAGGA.............AACUGCCAGC....G..ACAA..GC.UG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUAUA.UCCAG.GG CUACACA.CGUGCUACAAU.GGCU.G...CUACA.GAG................GGGg.. ........G..............CG........AU........AC.....UG.UGA.G.. ......G........UGGAGCGAAU......CCC.G......A.AAA.G...CA.G.U.C UC.A....GUUGGGAUCGGAGUCUGCAACUCGACUCCGUGAACG.CGGAAUCGCUAGUAA UCGCGGAUCAG.CAAU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......GU..........................C...UG. ........UUG.............UACCCGAA....GU...................U.. ...GG.U.......G.A............GCU.....A....A.........CC.....U GC........A.....AG.........GGG............G.....GCA.......GC ....C.A.ACGAA....GGU......................AUGG.............. CC.................GGUAAUU.........GG....................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.ACGAACGCUGG.CAG..CGUGGAUG....AGGCAU.GCAAGUC.....G AAC.....G........GUCUUCggccga............................... .......................................................UAGC. .................A......A.................UAUUggcCGAU....... ...............G.AC.............AG....U..................... ...........................................................G GCGG.....AAGGGCGA....GUAAUGC.GAGA.GCAAg.C..................U .G.......................................................CC. .C.....CCCG....................G....A....................... C..C.GGGACAA.Cg.U.C...........UGG.AA.ACGG.AC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.UC.................. ....................GA.....AGC.............................. ...........................................GG............... AA.....................CCGAAUGG.....UUccguc................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .......................................UUGAAAGGC............ ....................................................GGggaccc gcgagggcccguCGCCG.............GA............................ ........................................................GGAG Gcgcucccgug................................................. ..CC..................AUCAGCU...AG.UUGGUGA.GGUAACGGCU..CACCA AGG.CCUacggcuagg....UGG...A....CUGAG.AGG..U..UGG..UCAcccg... CACUGGG.ACUGAGACACU.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUCGAGGAUC AU.....UCG...CAAUGGGGGAA.ACC................CU...GAC....GA.U GCGAC.GCUGC.GU......GGAGGAUG...AA...GG.CC.........CUC.GGGUCG UAAAC..........................UC.CU.........GU............. ...................................................C........ ....................A.U.....Gcgggg.......................... ............................................................ ............................................................ ............................................................ ............................................................ ............CAAGGGCGccugcgccaacagCGCA................UGGcgcU UGAU........................................................ ............................................................ .............GGU............................ACCGC.A..AGA.... G..G...AAGCCAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AGGUGGCGAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGCGU.G.C.GUAGG...... ........C.GGU.................CGC.............GUGUG.UCG.G... .........A..........UGUG.......AAA.......UCCC.GG.GGCUCAc.C.C .....C....C...G........G.........AAG........U...G........... ......................CAUC...C..................G..A..AACUGC GCG...............G.CUG....GA..G..GC....CG.............GG... AuGGG..UGA..CUGGAACACA......U.....................GGUGUAGCGG UG..AAAUGCGUU.GAU.AUCAU.G.UGGAACACCGG.AGGCGAA............GGC GAGUC.A.CUGGA..ACGGA..UCUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGC....ACAuuugccg.... ..........................................U....G.GG.....G... ....................G....GA........AUUGA..C........CCcccc... ..........................................................CG ....UG.G...........CGC.......AGCg..AACGCGA..........UAAA..UG U.............GCCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGAAAU UGACGGGGG.CCC.GCACA.AG.C.GGAGGAGCAUG.UGGCUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAG........................................... ....GCUUGA.....C...A.................UGUG................... .............................A...C.......................... ...................UGCACGGc............C...................G ............GUGAAAGCC...GGC...................C............. ............................................................ ............................................................ ..............................UCCUUCGAGGGU.................. ........G............U.........................C...A........ ...............CA.CAGG.UGCUGCAUGGCCGUCGUCAGUUCGUGCCGUGAGGUGU UUGGUUAAGUCCAC.CAACGAACGCAACCCCUGCG...UCCAG......U....UGC..C AU..C.G...GGUC......................AU............G.CCGGGA.. A.CUCUGGAC............GG.ACCGCCccuucaaa.........CG.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGUAUGGCCCUUACGC.CUAG.GG CcGCACA.CGUGCUACAAU.GGC.CG..G.UACA.GAG................GG.... ....AC..G..............CG........A......G..ACC.....GC.GA.G.. ......G........UGGAGCAAAC......CCC.....C....AAAA.C..C..GG.CC CC.A....GUUCAGAUUGGAGUCUGCAACCCGACUCCAUGAAG.UUGGAUUCGCUAGUAA CGGCGCAUCAG.CAUUCGG.CGCCG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCAUGAAA......G..........................CC...GUC .........UGC.............ACCCGAA....G...................CC.. ...GG.U.......GC.............GC.....CA....A.........CUCG..CA gg....................AG.................AG.....GCA.......GC ....C..GUCUAA....GGUGU......................GGG............. .U.................GGUGAUU.........GGGAUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.ACGAACGCUGG.CAG..CGUGGAUG....AGGCAU.GCAAGUC.....G AAC.....G.......A.G...AA................U................... ..UCCGGGUG.............................................UAGC. .................A......A.................UAC.......AUcU.... ..........GGGAGG.AC.............AG....U..................... ...........................................................G GCG.....AAAGGGUGU....GUAACAC.GUG.GGC.AAUC..................U .G.......................................................CC. ......UCC....................G......A......................G .UU.GGGGAUAAC.U.C.CG............CGAAAG.CG.G................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GAAU..................... .......GU...........GGUCUUCCUggcgcaUGUUGGGGAGAUCAAAGGC...... ...................GG......................GG............... AA.....................CCGUAAGG.....UCC..................... ...........UGUCGCUUG........................................ .................GAG........................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...........................AG............................... GAG..........CUCG.CGUC...................................... ..C..................UAUCAGCU...UG.UUGGUGA.GGUAACGGCU..CACCA AGG.CUU..AC..GGGUAGCUGG...U....CUGAG.AGG..A..UGG..UCA...GCCA CACUGGG.ACUGAGACACU.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUCGAGGAUC AU.....UUG...CAAUGGGCGAA.AGC................CU...GACA....A.U GCGAC.GCUGC.GU......GGAGGAUG...AA...GG.CC.........UUC.GGGUCG UAAAC..........................UC.CU.........GU............. ...................................................CGUU..... .............................C.............................. ....GGGAACAAUUccuggagggugaauaccccUUC........................ ............................................................ ................................AGAUUGA..............UAGUA.. ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCG.GA..AAA.... G..G...AAGCCAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AAGUGGCAAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGGGU.G.C.GUAGG...... ........C.GGU.................UUC.............GUAUG.UCG.G... .........AC..........GUG.......AAA.......UCCC.A.UUGCUUAA.CG. .........A...UG........G.........AAC........U...G........... ......................CGU...UC..................G..A..AACUGC GGGA................CU....UGA..GU..G....C.............AGG... AGAGG..AGAG..CGGAAUUCU......U.....................GGUGUAGCGG UG..AAAUGCGUU.GAU.AUCAA.G.AAGAACACCGG.UGGCGAA............GGC GGCUC.U.CUGGA..AUGUU..ACUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGGUGC....ACAC.......... ....UUGGU........................G.......U...G.G.GG........A g........................................................... ........................AU.......UAGACUCUUCC................ ...C...GU........GCCGG.......AGC..UAACGCGU..........UAAG..UG U.............GCCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGAAAU UGACGGGGG.CCC.GCACA.AG.C.GGAGGAGCAUG.UGGCUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A....A...C.......................... ...................UGCACGuccc............................... ............GUGAAAGCG...Gga................................. ............................................................ ............................................................ .............................UUCCUUCGAGGGU.................. ........G............U.................................UG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGUUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAACGCAACCCCUG...UAUUUAG......U....UGC..C .A..C...CA....CAGGU............G.A.U.G.AgccuG...U.....GAG..C A.CUCUAAAUA............G.ACUGCC.C..G.UG.AU.AA..GCG.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGUAUGGCCUUUAUGC.CCUG.GG CUGCACA.CGUGCUACAAA.GGU.CG..G.UACA.GAG................GG.... ....A.A.G..............CG........AU........GCC.....GC.GA.G.. ......G........UGGAGCAAAU......CCC.......CA.AAAA.C..C..GG.CC CC.A....GUUCAGAUUGAAGGCUGAAACUCGCCUUCAUGAAG.UCGGAUUCGCUAGUAA UGGCGCAUCAG.C.UACGG.CGCCG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCAUGAAA......G..........................CC...GUC .........UGC.............ACCCaac....GU...................C.. ...GC.U.......G.UA............C.....CA....A.........CC...CGC .A........AG.........G.G.................AG.....GAAGGU...... .......GCCUAA....GGUGU......................GGG............. .U.................GGUGAUU.........GGGAUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.ACGAACGCUGG.CGG..CGUGGAUA....AGACAU.GCAAGUC.....G AGC.....G........GUCAccaucuuG............................... ....C...................................................AGC. .................A......A.................U..GU........A.... ..........GGGUGG................UG....AU.................... .......................................................AGC.G GCGC.....ACGGGUGA....GUAACGC.GUG.GG.UUACC..................U ........................................A................CC. .C....................Ug.....A......A......................G .A.CUGGGAUAAuc..C.CG............CGAAAG.C..G................. ...............G............................................ .............................................GAC............ .................................................UAAUACC.... ...................................GGAUG.................... ....................................U....................... ...........................................GG............... UUucucgaggAAA....GCCUCGG.................................... ............................................................ ............GA.......A..................Au.................. ............................................................ ...............U.AAAGC.......UGG............................ .........................GGACCGAAA.GGC...................... ......CUGG.................................................. ......CGCU.....UC........................................... ...............................A............................ ..................GG.......A.......U........................ GGG..........CCCG.CGUC...................................... ..C..................UAUCAGCU...AG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CUAAGAC..GGGUAGCUGG...U....CUGAG.AGG..A..CG..ACCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..A.CCUACGGGUGGCAGCAGUCGAGAAUU UU.....UC...ACAAUGGGCGAA.AGC................CU...GA.U...G.GA GCGAC.GCCGC.GU......GGGGGAUG...AA...GGGcuucggc...........CUG UAAACC..........................C.CU.........GU............. ...................................................C........ ....................A......GccaCG........................... ............................................................ ............................................................ ............................................................ .......ACCAAAgucccU....UGCC................................. ..UAA....................................................... .........C.................................................. .........................................AA................. ......GU..GAGGGA............................UCUGA.U.G.GUAgug gCAGAGGAAGGGAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAGACA.............G AGGUCCCGAG..CGUUGUUCGGAUUCACUGGGCGU..AAAGGGU.G.C.GUAGG...... ........C.GGU.................UGG.............GUAAG.UC.CG... .........AC..........GUG.......AAA.......UCCC.G.UGGCUUAA.C.C .........AC...G........G.........AA......U..U...G........... ......................CGU...UG..................G..A..AACUAU ccA...............G.CUC....GAggGU......UGG.............AG... AGGGG..A....CUGGAAUUCU......C.....................GGUGUAGCAG UG..AAAUGCGUA.GAU.AUCGA.G.AAGAACACCGG.UGGCGAA............GGC GAGUC..CCUGGA..CAACUC..CUGACGCU....GAG.GCACGAAAGCUAGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCGUAAACGGUGC....ACGU.......... ....UUGcua...............................U...G.G.G..U...G... ....................GA.A.......U.CGA.....CC........CC....... ....................AU.....................C................ ...C...GU........GGCG.......AAGC..UAACGCGU..........UAAAC..G U.............GCCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGAAAU UGACGGGGG.CC.UGCACA.AG.C.GGUGGAGUAUG.UGGCUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....CCUUGA.....C...A.................UG..................... ...................C....A.C............................GUG.. ..........GUA............................................... ............................................................ .................................GGAGCCCG.AAAGGGUAACGA...... ........................................C.C................. ..............CCGCA....AGG............................GGAGC. ......................................................GUG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCUUCguG...UCCUG......U....UGCU.. .AC.C...............Agaccaaaaaau...............CU.....GGG..C A.CUCUGGACA............G.ACUGCCU..CAUUUAAA.U...G..AG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGgAUGGCCCUUAUG.GCCAG.GG CUGCACA.CGUACUACAAU.GCC.CG..G.UACAA.UG................GG.... ....A.U.G..............CA........AU........ACC.....G.UAA.G.. ......G........UGGAGCAAAU......CCC.......CA.AAAA.C..C..GGG.C CC.A....GUUCAGAUUGUcGUCUGCAACUCGACGGCAUGAAGC.CGGAAUCGCUAGUAA UGGCGCAUCAG.C.UACGG.CGCCG.....UGAAUACGUUCCCAGGCCUUGU..ACACAC CGCCCGUCACAUCACGAAA......G..........................CC...GGC ........U.G.............UACCCGAA....GU...................C.. ...GC.U.......G.A............GC.....CA....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GG ....C..GCCGAA....GGU......................AUGG.............. CU.................GGUGAUU.........GGGAUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .............GAACGCTGG.CGG..CGTGgataagACATGCAA.GT....C.....G AAC.....G........GG.............................AtAATCTT.... ................................GTAGCAATACcgggttgt.......... ............TC.............................................. ............................................................ ........................................................AGTG GCG.....AACGGGTGC....GTAACAC.GTG.GATtacataccgg.............. ...AA.....................AG................................ ..............................C............................G .AG.GA..ATAG.C.CCA.GGGAAACT.............T.G................. ...............GAT.......................................... ................................................TAATACCTCATG Tg.......G.................................................. ............................................................ ............................................................ .......................TCGCAAGACtaaaggCGGGGCA............... ....................................ACCTG................... ............................................................ ............................................................ ............................................................ ........................................................TCGC TT.......................................................... ............................................................ ...........Tctgatt.......................................... ............................................................ ............................................................ .GGT..........CCG.CGGC...................................... ..CT..................ATCAGC.TAGTT...GGCGG.GGTAACGGC..CCACCA AGG.CGACGAC..GGGTAGCTGGTCT.......GAG.AGG..AT..G..ACCA...GCCA CACTGGA.ACTGAGACACG.GTCC..AGAC..A.CCTACGGGtGGCAGCAGTcgagaatc attCACAAT........GGGGGCA.ACC................CT...GAT....Ggt. GCGAC.GCCGC.GT......GGAGGAT....AA...GGTCTTCGGA...........T.. ............................................................ ......................TGTAAACTCCTG................TC........ ....................Atgcg................................... ............................................................ ............................................................ ..............................AGAGCAAGAtttgagcgggtaactccgctg gatttgatagtat............................................... ............................................................ ............................................................ ............................................................ ..............................................CGC.A..AGA.... G..G...AAGAGAC..................G........................... ............GCTAACTCt..GTGCCAGCAGCCGCGGTAATACA.............G AGGtctCAAG..CGTTGTTCGGAATCAC..TGGGCGTAAAGGGT.G.C.GTAGGTGGcgt gga.............................................AAGT.CA.G... .........ATGT..........G.......AAAT.......CCG.GG.GGCTCAA.C.C TCcgaata........................................G........... ......................CATC...C..................G..AT..ACTCC CatN................C.T...AGA..GA......ACtG................. .GAGGG..GGATCTGGAATTCTCGG..........T.................GTAGCAG TG..AAATGCGTA.GATAT.CGA.G.AGGAACACtAG.TGGCGAA............GGC GAGAT..CCTGG......AC..AGtntCTGACACTGAT.GCACGAAGGtCAGGGGAGCAA ACGGGATTAGATACCCCGGTAGTCCTGa.CAGTAAACGGTGcacgtttGGTGT....... ...............................................G.GGAggatt... .................................CGA.....CC........CCT...... .......TCT.................................................. ...............GTGCCGG.......AGCT..AACGCGTT..........AAACgT. ..............GCCGCCTGGGAAGTACGGTCGCAAGATTAAAACTCAA...AGAAAT TGACGGGG.ACCC.GCACA.AG.C.GGTGGAGTATGTGGCTTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCTGG........................................... ....GCTTGACATG.............................................. ............................................................ ...CACTgtgtcgtcggt.......................................... ..............GAAAGCC...GGCtagngTAGCAATAcacgctt............. ............................................................ ............................................................ ............................................................ .......................T................................G... ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTGTGA...TTTGTT..........GC..C .Accggagcaatcc........................................GAG..C A.CTCgaaTCA............G.ACTGCCCagatcaact........G.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCAGTATGGCCCTTACGC.CCAG.GG CTGCACA.CGTACTACAAT.GCC.C.....AGCACAatgt...............G.... ....A.AC...............CG........AA........ACC.....GC.GA.G.. ......GT........GGAGGAAAt.....CCTC.....A..A.AActggg........C TC.A....GTTCAGATTGCAGGCTGCAACTCGCCTGCATGAAGTT.GGAATCGCTAGTAA TggtaCATCAG.CTAcggtacc..GT.....GAATACG.TCCCGGGTCTTGT..ACACAC CGCCCGTCACATCATGGAA......G..........................CTGGTTt. ...........C.............GCCCGAA....GTgcccgc................ ...............G.C............C.G.........A.........CCG..... ..............C.A...AG.G.................AG.....GCAaggccct.. .................................................A.......... .AGGCAAG.................ActGGTGACTGGGATGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TGCGG............................. ............................................................ ........................................................... > ..................AGAGUUUGAUUAU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CGUGGAUA....AGACAU.GCAAGUC.....G AAC.....G.......A.G...AU................U................... ..UUucgUUG.............................................UAGC. .................A......A.................UACG.AUGGAAAA..... ...............U...UU....................................... .......................................................AGU.G GCG.....AACGGGUG....CUUAACAC.GUG.GGC.AACC..................U .G.......................................................CC. ......AU....................GA......A......................G .UG.GGGGAUAGC.UCG.............C.CGAAAG.GC.Ga................ ............................................................ ............................................................ ...............................................AUUAAUACC.... ...................................GCAU...G....U............ GAUuagaGA...........GGACAUCCUUucgaaauU..........AAAGU....... ......................................CGGGGCA............... ....................................ACC..................... ...........UGACGCUU......................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...........C................................................ ............................................................ ..............................................UU.........GUG GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...AG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CUUUGAC..GGGUAGCUGG...U....CUGAG.AGG..A..CG..ACCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..A.CCUACGGGUGGCAGCAGUCGAGAAUU UU.....UG...ACAAUGGGGGAA.ACC................Cgaucuaaccac.... .......CCGC.GU......GGAGGAUG...AA...GGU.C.........UUCc.GAUUG UAAAC..........................UC.CA.........GU............. ...................................................C........ ....................A.U.....U............................... ...UG........GG..................AAcaaggugcacac............. .......................................G.........UUAACUGcgug c.............GU..................AUUGA..............UAGUA.. ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCA.GA..AGA.... G..G...AAGAGAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AGGUCUCAAG..CGUUGUUCGGAUUCAUUGGGCGU..AAAGGGU.G.C.GUAGG...... ........C.GG.............CG....CG.............GUAAG.UCG.GG.. ....................UGUG.......AAA.......UCUC.GG.AGCUUAA.C.. ..U..C....C...GA.................AAC........U...G........... ......................CAU...UC..................G..A..UACUGC CGU...............G.CU....UGA..G..G....AC.............UGG... AGAGG..AGA..CUGGAAUUUA......C.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCGUaaggaag..ACCAG.UGGCGAA............GGC GGGUCU.C.UGGA..CAGUUC..CUGACGCU....GAG.GCACGAAGGuCAGGGGAGCAA ACGGGAUUAGAUACCCCGGUAGUCCUG.ACAGUAAACGGUGC....ACGU.......... ....UUGGU........................G.......U...G.G.G..A...G... ....................GA.U.......U.CGA.....CC........CC....... ....................UU.....................C................ .U.....GC........GCCGG.......AGC..UAACGCGU..........UAAAC..G U.............GCCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGAAAU UGACGGGGG.CCC.GCACA.AG.C.G.UGGAGUAUG.UGGCUCAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....CCUUGA.....C...A.................UG..................... ...................C....A....U...C.......................... ...................UC.....UAAG.........................U.U.G ............GUGAAAGCCagcga.................................. ............................................................ ...GUCCCG..........AAggca................................... ............................AU.............................. .....................U.................................UG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGACGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUG...UgAACUG......U....UGC..C .AC.Cgagccgugagcguca............................U......GG..C A.CUCUGUUCA............G.ACUGCC.C...CGC.UU.UAACG.G.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAGUAUGGCCCUUACG.GCCUG.GG CUGCACA.CGUACUACAAU.GCC.C.....AGCACAgaac...............G.... ....A.UC...............CG........A......G..ACC.....GCUAA.G.. ......G........UGGAGGAAAU......CUC.....U..A.AAA..CU....GGG.C CC.A....GUUCAGAUUGAAGUCUGCAACUCGACUUCAUGAAG.UUGGAAUCGCUAGUAA UGGCGCAUCAG.C.UACGG.CGCCG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCAUGGGA......GU..........................C...G.. ..........................CUUGUA....G...................CCC. ....Ggaaaguucggc...........GUGCU.....A....A.........C....... ..........U.....AGCAAUAG.................AG.....GCA.......GC ....C..GCCUAC....Gcuaugag................................... .C.................GGUAACU.........GGGAUGAAGUCG.UAACAA.GcUAG CCG.U....................................................... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G UAC.....G......CA........................................... .........Gcuucccugacu.....................................C. .................UCUG..........................AG........... ..............GA...Agggaagg..CUG............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACGC.GUGA.G.UAACC..................U .G.......................................................CC. ......UU....................GA............................GG .AG.GGGGAUAA.C.CC.C...........U.CGAAAG.GG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............CCAUA.......................................... ............................................................ ............................................................ .............................................Cacuccagggccg.. ................CA.......................................... .......................GGGCUUC.............................. .............................U...............GGAGGAaagc..... .......................U.......G............................ .........................GCCUCUGccuggcau.................... ...........................GCUGG............................ ......CGCCUC................................................ ............................................................ ..............................................AA.........GAG GGG..........CUCG.CGUC...................................... ..CC..................AUCAGCU...UG.UUGGUGG.GGUAACGGC..CUACCA AGG.CGAUGAC..GGGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUC UUG.....GG...CAAUGGGCGAA.AGC................CU...GAC.C...C.A GCGAC.GCCGC.GU......GGGGGAAG...AA...GG.CC.........UUC.GGGUCG UAAACC..........................C.CU.........GUuc........... ............................................................ ...UGGG.............A......GA............................... ...AG....................................................... ............................................................ ............................................................ ............................................................ ............................................................ ..........................AAGAgggaaggggugaacagcuccuucC...... ..........................................U................. ......GU..GACGGU............................AUCCC.A.G.G..AGA .......AAGCUCC..................G........................... ............GCUAAUUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AAGGAGCGAG..CGUUGUCCGGAUUCACUGGGCGU..AAAGCG.CU.C.GUAGG...... ........C.GG.............C....UUC.............CUAAG.UCUU.... .........AC..........GUG.......AAAG.......CCC.CC.GGCUCAA.C.C ...G........G.G........G.........AGGGU...................... ......................CGUG...G..................G..A..AACUGG GGA...............G.CUC....GA..G..GG....C.............AGG... AGAGG..AGAG..UGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUAR.AU.AUCG.GG.AGGAACACCAG.UGGCGAA............GGC GGCUC.U.CUGGU..CUGUCC..CUGACGCU....GAG.GAGCGAAAGCCAGGGGAGCGA ACCGGAUUAGAUACCCGGGUAGUCCUG.GCUGUAAACGAUGGG....UAC.......... ....UAGGU........................G.......U...G.G.G..A...G... ....................G..U.......U.CGA.....CC........CC....... ....................UU.....................C................ ...C...GU........GCCGC.......AGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AGGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UU.............G....... ........................U....................G.........GUG.. ..........GUA............................................... ............................................................ .................................GGAGCCCG.AAAGGGUGA......... ..CGACCCCU.GGUUUCC.......................................... .......................AGG............................GGAGCC ....................................................AC...A.. ................A.CAGG.UGCUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUGC...CCUUAG......U....UGCU.. .AC.C.GGGGCAAC......................................CCGGG..C A.CUCUAAGG............GG.ACUGCC.G..G.CG.A.CAA..GCC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCCUCAUGGCCCUGAUGC.CCUG.GG CGACACA.CGUGCUACAAU.GGC.CG..G.UACA.GAG................GG.... ....UC..G..............CG........AA........CCC.....GC.GA.G.. ......GG........GGAGCCAAU......CCC.....AG...AAA.GC..CG.G..CC UC.A....GUUGGGAUUGCAGGCUGCAACCCGCCUGCAUGAACG.CGGAAUCGCUAGUAA UCGCGCAUCAG.CCAU.G.GCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......GU..........................C...GAC ........U.UC.............ACCUGAA....GU...................C.. ...GC.U.......GG.............GCU.....A....Acc.......CUCG..CA AG........AG.........G.G.................AG.....GCA.......GG ....C..GCCGA....GGGUG......................GGG...U.......... .U.................GAUGAUU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.GUGAACGCUGG.CGG..CGUGGAUU....AGACAU.GCAAGUC.....G UAC.....G.......A.UC........................................ ...............Ccgagaa..........AUC......................... ............G.......G....................................... .......G...........AU....................................... .......................................................AGC.G GCA.....AACGGGUGA....GUAACGC.GUGA.G.UAACC..................U ........................................A................CC. .C....................UC.....U......A......................G .A.CUGGGAUAAC..CUU.G...........UGAAA.A.CG.A................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ..................................AGAUA.AG............UC.... ......................CCgacugacCGAAGUC...................... ............................................................ ............................................................ ............................................................ ....AAUCG................................................... ..................G..........................G.............. ...............AGAAAGG.......UGG.......CUUAAUUCCggCGGUAACGuc g........................................................... ..............GA.AUGCUA..................................... ...C..CGCU.....A............................................ ..............................GA............................ ..................GG.......A.......U........................ GGG..........CUCG.CGUC...................................... ..C..................UAUCAGCU...AG.UUGGUAG.GGUAACGGC..CUACCA AGG.CGAUGAC..GGGUAGCUGG...A....CUGAG.AGG..U..CGG..CCA...GCCA CACGGGG.ACUGAGACACG.GCCCC..GAC..U.CCUACGGGAGGCAGCAGUCGAGGAUC UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GCGCGAUG...AA...GU.CC.........UUC.GGGAUG UAAAGCgcugucaguuuggaauaaaccuuaGAU.CAA.........A...AA........ ............................................................ ......................U.....A............................... ...UU....................................................... ............................................................ ............................................................ ...................................................G.....G.U C.UAAGGuc................................................... ............................................................ ............................................................ ..........GACUGU............................ACgaA..C.AGA.... G..G...AAGCCAC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGUGGCAAG..CGUUACUCGGAUUCACUGGGUGU..AAAGGGU.A..UGUAGG...... ........C.GUu.................CCG.............GUAAG.UUCU.... .........AG..........GUG.......AAA.......UCC.UUC.AGCUCAA.C.. ..UG.........AA........G.........AA......U..U...G........... ......................CCU...AG..................A..A..AACUG. CCG...............Gaauugg......GU......UCG.............GG... AGAGGG..AAG..CGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUAR.AU.AUCG.GG.AAGAACACCCG.UGGCGAA............GGC GGCU.U.CCUaGA..CCGAA..ACCGACGCU....GAAA.UACGAAAGCUAGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCGUAAACGAUGGG....UAC.......... ....UAGGUaucccu...................................GC........ ...............U.....C.........AAA........C.G............... .........................GG................................. .....G.GU........GCCG.......UAGC..UAACGCGU..........UAAG..UA CC.............CCACCUGGGGACUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCUACACG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A....................G.........G.... ........GAGUA............................................... ............................................................ .................................GGAACCCG.AAAGGGGGA......... ..CGACCCG..........UUAAGU................................... ......Cggga............A.................................... ..................CC...................................UG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCUGUGAAGUGU UGGGUUAAGUCCCA.CAACGAGCGCAACCCUUGC...CCUUAG......U....UGC..C .A..C...CAGcucuucgcaAG.A.........AG.AG......G..CU.....GAG..C A.CUCUAAGG............GG.ACUGCC.Cucuccaaga.......G.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCGUAUGGCCUgUAUGC.CCUG.GG CCACACA.CGUGCUACAAU.GGGA.G...CUACA.GCG................GG.... ....A.A.G..............CG........AA........GCC.....GC.GA.G.. ......G........CGGAGCAAAU......CCC.....UG...AAAAg...CUC...CC CC.A....GUUCAGAUUGGAGUCUGCAACUCGACUCCAUGAAG.ACGGAAUCGCUAGUAA CGGCGGAUCAG.CCAU.G.CCGCCG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACUUGA......GU..........................CA...A. ........AUGC.............ACCUGAA....GU...................C.. ...GC.U.......G.AC............C.....CA....A.........Cucugacg gcaacgUUG.................................G.....GGA.......GG GAGGC..GCCCAA....GGUGU......................G...UU.......... .UGGCAAG.................A.........GGGacu................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.GUGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G UAC.....G........GG......................................... .CUUCGG..G.............................................UAGC. .................A......A.................UAC.C.......C..... ....Gg....................AGUCAG............................ .......................................................UGU.. .CG.....AACGGGUGA....GUAACAC.GUG.GG.UAACC..................U .........................................................CC. .C.....CCCG.........................A......................G .UG.AGGGAUAAC..CU.CG............CGAAAG.CG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.UACCCcggcgcAUAAGC GUU......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ..............CGGGG......................................... ...UC............AAAGC...................................... ............................................................ ..........................CGCAAGGC.......................... .......GCU.....U............................................ ..............................GG............................ ..................GG.......A.......U........................ GGG..........CCCG.CGUC...................................... ..C..................UAUCAGCU...AG.UUGGUAG.GGUAAUGGC..CUACCA AGG.CGAUGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..UCCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GGGGGAUG...AA...GG.CC.........UUC.GGGUUG UAAACC..........................C.CU.........GU............. ...................................................C........ ....................A......GAG.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCCC................................ .................................CGCA................AGGg... ............................GU.............................. ............................................................ .......U..GACGGU............................ACCCU..C.AGA.... G..G...AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGGGCAAG..CGUUACUCGGAAUUACUGGGCGU..AAAGGGU.G..UGUAGG...... ........C.GG.............C....CGG.............GUAAG.UCGaaga. ......................UG.......AAA.......UCCC.A.UGGCUCAA.C.C .........A...UG........G.........AA......U..U...Guc......... ........................U...UC..................G..A..UACUGU CCG...............G.CU....UGA..G..GG....U.............AGUg.. .GAGG..AGAG..CGGAAUUC......CC.....................GGUGGAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AGGAACACCGG.AGGCGAA............GGC GGCUC.U.CUAU..GCUACUC..CUGACGCU....GAG.GCACGAAAGCUAGGGGAGCAA ACGGGAUUAGAUACCCCGGUAGUCCUA.GCCUUAAACGAUGGG....CAC.......... ....UAGAUA...............................UUccc.............. ............G............................................C.. .....................AGUUUUgcGGG............................ .A.....GU........GUCG.......AAGC..UAACGCGU..........UAAG..UG CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCUACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGAAC.........................UG..................... ...................C....U....................G.........GUG.. ..........GUA............................................... ............................................................ .................................GGAGCCCG.AAAGGGUGA......... ..CGACCC...............UGGUUCUCC............................ .......................AGG............................GAG... ..................CC...................................AG... .............CAG...AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...CCUUAG......U....UGC..C .AG.C.G...GGUA......................AU............G.CCGGG..C A.CUCUAAGG............GG.ACUGCCUG..GG....A.UAAC.C.AG........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AGUCAGCAUGGCCUUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGG.CG..G.UACAA.AG................GG.... ....A.U.G..............CA........AA........GCC.....GC.GA.G.. ......G........CCGAGCUAAU......CCC.......CA.AAG..C..C..GCU.C UC.A....GUUCGGAUCGCAGGCUGCAACUCGCCUGCGUGAAGG.CGGAAUCGCUAGUAA UCGCGGAUCAG.CCA.CG.CCGCGG.....UGAAUACGUUCUCGGGCCUUGU..ACACAC CGCCCGUCACAUCACGAAA......GU..........................C...GG. .......UC.G.............UACCCGAA....GU...................C.. ...GC.U.......G.A............GC.....CA....A.........CC...CGC .A........AG.........G.G.................AG.....GCA.......GG ....C..GCCGA....GGGUAU......................GG...U.......... .C.................GAUGAUU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.AUGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AGC.....GA........G.........G............................... ....CGG..G.............................................UAGC. .................A......A.................UAC.C.......C..... ........A.....GUC..............G............................ .......................................................AGC.G GCGG.....ACGGGUGA....GUAACGC.GUG.GA.UAAUC..................U ........................................A................CC. ......UU..............U......U............................GG .UG.GGGGAUAA.C.CCG.GGGAAAC.............UC.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU...G....A............ GAU......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ..............CGAAA................................G........ ..A............UGAAAGGGG......GC............................ ..............................GCAA....GUCCC................. ............................................................ ............................................................ ............CGCCG.............GAA........................... ...................G.......AG............................... GAG.....U.....CCG.CGUC...................................... ..CG..................AUUAGCU...AG.UUGGUAG.GGUAAUGGC..CUACCA AGG.CGACGA..UCGGUAGCCGGCC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCAAC.GCCGC.GU......GGAGGAUG...AA...GGU.C.........UUU.GGAUUG UAAAC..........................UC.CU.........GU............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGGCCUcg............................. ..........................................GCGAAGAGccgAGG.... ............................................................ .......................................................A...U .......U..GACGGU............................ACCU.G.C.AGA.... G..G...AAGCCCC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AGGGGGCAAG..CGUUAUUCGGAAUUAUUGGGCGU..AAAGGG.CG.C.GUAGG...... ........C.GGU.................CG.............UGCAAG.UggA.... .........AG..........GUG.......AAA.......UCCC.UC.GGCUCAA.C.C ...G.........AG........G.........AAC........U...G........... ......................CCU...U..................UC..A..AACUGC UUGA................CU....UGA..GU..C....CG.............GG... AGAGG..UGAG..UGGAAUUC......CCA.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUUG.GG.AGGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGA..CCGGA..ACUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCCGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UUGGU........................G.......UA....GC.G.....G... ....................G..U.......AUCGA.....CC........CC....... ....................UG.....................C................ .U.....GU........GCCG.......AAGC..UAACGCAU..........UAAG..UG CC.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCCGG........................................... ....GUUUGAAcuca........................AC................... ...AGGAA...............UU....A.............................. ...............................U..U....CAG............AG.AUG A......................A.UAcg............................... ............................................................ ............................................................ ......CC..................U.CUUCGGA...................GGucug ..........UUGA..............U............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCAUAG......U....UACU.. .A.AC....A..........UG.U.........A.AUG......G...U.....GAGA.. A.CUCUAUGGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCUUUAUG.UCCGG.GG CUACACA.CGUGCUACAAU.GGA.CG..G.UACAA.AGA................G.... ....UC..G..............CA........A......G..GCC.....GC.GA.G.. ......G........CAGAGCUAAU......CUC.....A..A.AAAA.C..C..GUU.C UC.A....GUUCGGAUUGCAGUCUGCAACUCGACUGCAUGAAGC.UGGAAUCGCUAGUAA UCGCGGAUCAG.C.A.CG.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCACGAAA......GU..........................C...GG. .......UU.Gc.............ACUAGAA....GU...................C.. ...GG.U.......GG.............GCU.....A....A.........CC...CGC .A........AG.........G.G.................AG.....GCA.......GC ....C..GCCUAAa....GUGU......................G...AU.......... .C.................GGUAAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CUG.UAGGAGAACC............UGUG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAG.GAUGAACGCUAG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AGC.....GA........G...AA.............................A...... .....GG..G.............................................UAGC. .................A......A.................UAC.CUG........... .............A.GU.............AAAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUG.GA.UAACC..................U .G.......................................................CC. ......UC....................GA......A......................G .UG.GGGAAUAA.C.CC.CG...........GG.AA.ACCG.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AU.UCUGAcgga..AUUUGC GGAUUUUGUC.................................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..A.........G...GAAAGG.......AGC............................ .....................AAUU................................... ............................................................ ......CGCU.....UU........................................... ...............................GA........................... ...................G.......AG............................... .....GGGU.....CUG.CGGC...................................... ..UG..................AUUAGCU...AG.UUGGUAA.GGUAAUGGCU..UACCA AGG.CCACGA..UCAGUAGCCGG...U....CUGAG.AGG..A..CGG..UCG...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UU.....UCG...CAAUGGGGGAA.ACC................CU...GAC....GA.A CCAAC.GCCGC.GU......GGGUGAUG...AA...GUA..........UUUC.GGUACG UAAAACCC............................U.........U...UCGA...... ......................................................CGGGGA CGAAA....................................................... ............................................................ ............................................................ ............................................................ ...........................C................................ .................................CGCA................AGG.... ............................................................ .......................................................U...U .......U..GACGGU............................ACCC.GU..AGAA... ...G...AAGCCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG GGGGGGCAAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGGG.CG.C.GUAGG...... ........C.GGU.................UCGc.............UAAG.UUGA.... .........A..........UGUG.......AAA.......UCUC.UG.GGCUUAA.C.C .....C.......AGAaccugcauccaAAAC..........UG.....G........... ......................C..........................G....AACUGG AGUA................CU.................................GG... AGGGG..AAAG..CGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGCU.UU.CUGGA..CAGUA..ACUGACGCU....GAG.GCGCGAAAGCUAGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCCUAAACUAUGG....AUAC.......... ....UUGGU........................G.......U...GAG.GG.....G... ....................GA.U.......UG........................... .......................................................AAUCc cuUC...GU........GCCG.......UAGC..UAACGCAA..........UAAG..UA AU.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUCGAAcgggC...U.................AGUG................... .............................A...Ccgg....................... ..........................................................AG A......................UGAA..............AGUUUCuuu.......... ............................................................ ....U.....................................C................. ..............CCGCA....AGG............................GACAcu aguc........................................................ ...............G...AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...CUUUAG......U....UGCU.. .A.AC....Acg.....................U.AUG......G...U.....GAG..C A.CUCUAGAG............GG.ACUGCC.G..G.UG.AA.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCUUUAUG.UCCAG.GG CUACACA.CGUACUACAAU.GGG.CG..GC.ACAA.UGA................G.... ....UC..G..............CA........AA........CCC.....GC.AA.G.. ......GG........GGAGCCAAU......CUC.....A..A.AAAA.C..C..GUU.C UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAGC.UGGAAUCGCUAGUAA UCGCUGAUCAG.C.AA.G.CAGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCACGAAA......G..........................CCc...G. .......UU.G.............UACUAGAA....G...................CC.. ...GG.U.......G.AaU.................CA....A.........CCG..... ..............C.A...AG.GG.................GAU.....A.......GC ....C..GUCCAA....GGU......................AUG...A........... CU.................GGUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGAGAACC............UGUG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.AUCAACGCUGG.CGG..CGUGCCUC....AGACAU.GCAAGUC.....G AAC.....G.......A.U......................................... ........UaaagCUC.......................C.................... ..CUUC......GGG.....G..........................AGUGC........ ........A.......U.............AAAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUA.GG.UAAUC................... ........................................UA................C. .C.....U..............UC.......G....A......................G .UG.GGGAAUAA.CAG.U............CGG.AA.ACG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AAC...GC............ ...........................AGC.............................. ...........................................GG............... .....................................................CA..... .............UCGCAAGA....................................... .......................UG..ACAG............................. ...........................................UUG.............. ...............UUAAAGG.......AGC............................ .....................AAU.................................... ............................................................ ...C..CGCU.....U............................................ ..............................GAA........................... ...................G.......AG............................... GAG..........CUUG.CGGC...................................... ..AG..................AUUAGCU...AG.UUGGUAA.GGUAAUGGCU..UACCA AGG.CUACGA..UCUGUAUCCGG...U....CUAAG.AGG..A..CGG..UCG...GACA CACUGAC.ACUGAaUAACG.GGUC..AGAC..U.CCUACGGGAGGCAGCAGUCGGGAAUU UUG.....GG...CAAUGGGCGAA.AGC................CU...GAC.C...C.A GCAAC.GCCGC.GU......GAAGGAUG...AA...GUA..........UUUC.GGUAUG UAAAC..........................UU.CGA.........A...AG........ ............................................................ ......................A.....A............................... ...UGGGAA................................................... ............................................................ ............................................................ ......G................AA................................... ............................................................ .............................U.............................. .......................A...............................A...A .......U..GACGGU............................ACCAU.U....UA..U .......AAGCUCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGAGCAAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGGG.CG.C.GUAGG...... ........C.GG.............CG....CG.............GUAAG.UCAC.... .........U..........UGUG.......AAA.......UCUC.UG.AGCUUAA.C.. ..U..C.......AGaaaggc....................................... ......................CAAG.....................UG..A..UACUGC AGU...............G.CU....AGA..GU..G....C.............AGA... AGGGGCAA..U..CGGAAUUCU......U.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCAA.G.AGGAACACCUG.AGGuGAA............GAC GGGU.UGC.UGG..GCUGAC..ACUGACGCU....GAG.GCGCGAAAGCCAGGGGAGCAA ACGGGAUUAGAUACCCCGGUAGUCCUG.GCCCUAAACGAUGA....AUAC.......... ....UUGGU........................G.......UCU.G.Gagu......... ............UCUAAUACu..............................CC....... ..........................G................................. .....G.GU........GCCG.......UCGC..UAACGUUU..........UUAG..UA UU.............CCGCCUGGGGAGUACGCUCGCAAGAGUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....ACUAGAA......UGUGAG...............G.............G....... ........................AAGGUCGGUUAAUGccguccuuc............. .....CG....GGA.....A..............A...CCGG............Accc.. ............................................................ ............................................................ ............................................................ ..........................................................A. ........................AAACA............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCAACAG......U....UGC..C .A.UC....A..........U..U.........U.AAG.U........U.....GGGA.. A.CUCUGUUGA............G.ACUGCC.G...UUG.AU.AAA..AC.G........ ...GAGGA.A.GGUG.GGGAUGAUGUC..A..AGUCAUCAUGGCCUUUAUG.UUCAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.Aac................G.... ....UC..G..............CA........AU........CCC.....GC.AA.G.. ......GG........GGAGCUAAU......CGC.....U..A.AAA..C..CG.G.U.C UC.A....GUUCGGAUUGAAGUCUGCAACUCGACUUCAUGAAG.UUGGAAUCGCUAGUAA UCGCAAAUCAG.C.AU.GU.UGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACAUCACGAAA......GU.............................AGG. .......UU.G.............UACUAGAA....GU...................A.. ...GG.A.......GG.............GCU.....A....A.........CUCG..CA AG........AG.........G.Ggcau...............................C .....UU.ACCAC....GGUAU......................G...AU.......... .UU.................AUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CUG.UAGGAGAACC............UGUG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.AUCAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AAC.....G......C..G...AA................AG.CC............... .CC................GCAA................GGG...............GC. .................A......A................................... .......G...........UA..........GAG....U..................... ...........................................................G GCAG.....ACGGGUGA....GUAAUAC.GUG.GG.UGACC..................U G.........................................................C. .C.....U..............UC.......G....A......................G .UG.GGGGAUAACG..U.C...........U.CGAAAG.GG.AC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU...G....Acauccugcc... ...UUUUGACaggc...........................GGAGAUCAAAGU....... ......................................CGGGGGUCGCAA.......... ..............................G.....ACC..................... ...........UGACGCUUGA....................................... .......................AG..AGgggc........................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............CCA..CGUC...................................... ..CG..................AUUAGCU...AG.UUGGUGA.GGUAACGGC..CCACCA AGG.CGACGA..UCGGUAGCCGGCC.........U.AAGAG..GGCGG..ACG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU gU.....UCG...CAAUGGGCGCA.AGC................CU...GAC....GA.C GCAAC.GCCGC.GU......GGAGGAUG...AA...GAU.C.........UUC.GGGUCG UAAAC..........................UC.CU.........GU............. ...................................................CGAGCGGGA CGAAUgauccg....................CG........................... ............................................................ ............................................................ ............................................................ .......ACCUAAUACGUcgu....................................... ............................................................ ............................................................ .......................................GGAA................. ......GU..GACGGU............................ACCGC.U..AGA.... 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AGAGGG..AUG..CGGAAUUC......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCU.GG.AGGAACACCGG.UGGCGAA............GGC GGCA.U.CCUGGA..CCGAC..ACUGACGCU....GAG.GAGCGAAAGCCAGGGGAGCAA ACGGGAUUAGAUACCCCGGUAGUCCUG.ACCCUAAACGAUGA....AUGC.......... ....UUGGU........................G.......U...G.GC.G.....G... ....................G..U.......AUCGAUCCC.................... ....................UG.....................C................ ...C...GU........GCCG.......AAGC..UAACGCAU..........UAAGC..A UU.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUCAAUUCGAC.GCAACGCG .AAGAACCUUA.CCCAG........................................... ....GCUUGAAC.........................AG..................... ...................Cg....................................... ............................................................ ......................................................AGUGAC CAcu........................................................ ......C................A.................CGAAAGUGAGCU....... .............UCCGCA....AGGACACUC............................ ................................................G..U........ ..............AG...AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUCUG......U....UGC..C .A.UC....A.....C.....G.U.........U.AUG......G...U.....GGG..C A.CUCUGAGGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGCAUGGCCUUUAUG.UCUGG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.ACC................G.... ....UC..G..............CG........AU........CCC.....GC.GA.G.. ......GG........GGAGCUAAU......CGG.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAG.UUGGAAUCGCUAGUAA UCGCGGAUCAG.C.A.CG.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCACGAAA......G..........................CC...GGC ........U.G.............UACUAGAA....GU...................CC. ....G.U.......GC.............GC.....CA....A.........CC...CGC .A........AG.........G.G.................AG.....GUGaGU...... .......GCCUAA....GGUAU......................GG...U.......... .C.................GGUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CUG.UAGGAGAACC............UGUG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..................UGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUCAAGGGu ............................................................ ..........................................................C. .................A......U.................UUCG.............. ...............................GugacACU..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUG.GA.UAAUC..................U ........................................A................CC. ......UU..............U......A......A......................G C..CUGGGACAAC.A.............GUUGG.AA.ACG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................G.C..................................... ............................................................ ............................................................ ............................................................ ............................................................ ....................................................ACUCCGGU G..................G....AAAGAUGGUUUCGcccAU.................. ............................................................ ..........U................................................. .......GCU.....UA........................................... ...............................UA........................... ...................G.......A.......U........................ 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AGGGG..AAAG..CGGAAUGU......CC.....................GGUGUAGCAG UG..AAAUGCGUA.GAG.AUCG.GA.UGGAACACCG.AAAGCGAA............GGC AGCUUU.C.UGG..GCAGUA..ACUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUGC.......... ....UAGAU........................G......UU.......GG......... ..................................C.....................GAGG UUAC.......................................C................ .UugUCAGU........GUCGG.......AGC..UAACGCAA..........UAAGC..A UC.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....UCUUGA.....C...A.................UC.C............C...... ...Uu....................................................... ...................UGCUCGGUA................................ 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CU.................GGUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ....UAC......UAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGG.....G........G.......................................... ...............CAGCga......GGC..G......G...A........AGCUUGC. .................U......U..........................CCgcuguC. ..............GGC..............G............................ .......................................................ACC.G GCGC.....ACGGGUG....CGUAACGC.GUAU.G.UAACC..................U ........................................A................CC. ......UU..............A......U......A......................C .AG.GAGGAUAA.C.CCG.G........................................ ............................................................ .AGAAAUUCGGAcuaauacuccauagguauauuuucggcAUCGGAGAUAUAU........ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ................GAAAGAU..................................... .....................UC....................AU............... ............................................................ ......CGGU.....AU........................................... ...............................AA........................... ...................G.......A.......U........................ 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UGAGG..UAGG..CGGAAcgcG......UA.....................GUGUAGCGn UG..AAAUGCAUA.GAU.AUUACG.C.AGAACUCCG.AUUGCGAA............GGC AGCUUA.Ccaaacc...GCA..ACUGACACU....GAA.GCACGAAAGCGUGGGUAUCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCAGUAAACGAUGA....UUAC.......... ....UCGGA..........................................G........ .......................U.......AUGC......................... ..........GAUAUAugguaugcuccc................................ ............................AAGGGAAAC..CGA..........UAAG..UA AU.............CCACCUGGGGAGUACGCCGGCAACGGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGAGGAACAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCCGG........................................... ....GAUUGAA......AUGUACaugacgguugggcgAGAGCC................. ........UGAC................................................ ............................................................ ............................................................ ............................................................ .......................U............................U....... .....CCCUUC..G..........GG............................G..... ...................CAUGUAUG.U............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU CGGCUUAAGUGCCA.UAACGAGCGCAACCCACA...UCGUCAG......U....UACU.. .AG.C....AGG........U..Ag..........A........G..CU.....GAGG.. A.CUCUGACGA............G.ACUGCC.G...UCG.UA.A...GgC.G........ ..CGAGGA.A.GGUGU.GGAUGACGUC..A..AAUCAGCACGGCCCUUACA.UCCGG.GG CGACACA.CGUGUUACAAU.GGUA.G..GG.ACAA.AG................GGC... ......A.G..............CU........A........CCUGGCGAC.......A. .......G........GAUGCGAAU......CUC.......C..AAAC.C..CU..AU.C UC.A....GUUCGGAUCGGAGUCUGCAACUCGACUCCGUGAAGC.UGGAUUCGCUAGUAA UCGCGCAUCAG.CCAU.G.GCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGCCAUGGAA......GU..........................C...GGG G.........G.............UACCUGAA....GU...................... ..GC..........................GUC.........A.........CCG..... ..............C.A...AG.G.................AUCgc.............. ........ACGA....GGGUAA......................Ga.............. CC.................GGUAACU.........GGGGCUAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........G.................................. ............................................................ ........................................................... > NUAUUAC......AAUGAAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CUa..CAGGCUUA....ACACAU.GCAAGUC.....G AGG.....G........G.......................................... ...............CAGC...AugguC..............UU........AGCUUGC. .................U......A.................A..GNCnA......U... ..............GGC..............G............................ .......................................................ACC.G GCGC.....ACGGGUGA....GUAACAC.GUAU.CCAA.CC..................U .G.......................................................CCg uC.....U..............A......C......U......................C .UU...GGACAGCC..UU............CU.GAAAG.G.AA................. ...............GAUUAAUAC.................................... ............................................................ .......AAGAUGGCAUCAUgaguccgcauguucacAUGAUUAAAGGUAUU...CC.... ...................................GGUAGAC.................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..GAUGGGG.....AUG.CGU....................................... .UCC..................AUUAGAU...AG.UAGGCGG.GGUAACGGC..CCACCU AGU.CUUCGA..UGGAUAGGGGU...U....CUGAG.AGG..A..AGG..UCCC...CCA CAUUGGA.ACUGAGACACG.GUCC..AAAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....G...UCAAUGGGCGAG.AGC................CN...GA.AC...C.A GCCAA.GUaGC.GU......GAAGGAUG...A...CUG.CC.........CUAUGGGUUG UAAAC..........................UU.CUU.........U...UA........ ............................................................ ......................U.....A............................... ...AA....................................................... ............................................................ ............................................................ ...................................................G.....G.A A.....U.AAAGucggguaugg...................................... ............................................................ ............AUACCCGNUUGCAU.................................. ..............GU............................ACUUU.A..UGAA..U .......AAGGAUC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGNAUCCGAG..CGUUAUCCGGAUUUAUUGGGUUU..AAAGGGA.G.C.GUAGaugga.. ...........................................UGUUUAAG.UCA.G... .........U..........UGUG.......AAAG.......UU.UGC.GGCUCAA.C.C ...G.........UAA.................AA......U..UG.............. .........................CAGU..................UG..A..UACUGG AUAU................CU....UGA..GU..G....C.............AGU... UGAGGC..AGG..CGGAAUUCG......U.....................GGUGUAGCGG UG..AAAUGCUUA.GAU.AUCAC.G.AAGAACUCCG.AUUGCGAA............GGC AGCC.UG.CUNA..GCUGCA..ACUGACAUU....GAG.GCUCGAAAGUGUGGGUAUCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CACgGUAAACGAUGA....AUAC.......... ....UCGcU..........................................G........ .......................U.......UUGC......................... ..........GAUAUACUGC...........AAgcGG....................... ..........................CCAAGCG.AAA.GCGU..........UAAG..UA UU.............CCACCUGGGGAGUACGCCGGCAACGGUGAAACUCAA...AGGAAU UGACGGGGG.CC.NGCACA.AG.C.GGAGGAACAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCCGG........................................... ....GCUUA..............................A.................... ........AUUGCA.....GAUGAA....U.............................. ...............................U..A....C...................G ............GUGAAAGCC...G................................... ............................................................ ......................UA............................AG...... ..............CCGCA....AGG..CAUC............................ ......................UG.UG.A............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU CGGCUUAAGUGCCA.UAACGAGCGCAACCCUUG...UUGUCAG......U....UACU.. .A.AC....AGG........U..U.........A.U........G..CU.....GAGG.. A.CUCUGACAA............G.ACUGCCAUCGU.....AAGA.....UGU....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAGCACNGCCCUUACG.UCCGG.GG CUACACA.CGUGUUACAAU.GGGG.G..G.UACA.GAG................GGC... ......N.G..............CU........A........CCAC.....GC.GA.GU. .......G........GAUGCCAAU......CCC.......CA.AAAC.CU.....CU.C UC.A....GUUCGGACUGGAGUCUGCAACCCGACUCCACGAAGC.UGGAUUCGCUAGUAA UCGCGCAUCAG.CCA.CG.GCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCAUGGGA......G..........................CC...GGG G.........G.............UACCUGAA....GU...................... ..GC..........................GU.....A....A.........CCG..... ..............Cgagg..........................A..GCGC........ ........CCUA....GGGUAAA.........................A........... CU.................GGUGACU.........GGGGCUAAGUCG.UAACAA.GGUAG CNG.UA.CCGG.AAG..........GA................................. A............CACCUCCUUUCU................................... ........................................................... > ..................AGAGTTTGATCCT............................. ..GGCTCAG.GATGAACGCTAGCta...CAGGCTTAACACATGCAA.GT....C.....G AGG.....G........G...............................AAACgACA... ........................................GAG.........AG.TGCTT GCACa.CTTTGGGcgt............................................ ................C..............G............................ .......................................................ACC.G GCG.....AAtGGGTGA....GTAACGC.GTAtC.C.AACCT.................. .G.......................................................CC. .CTTGac..................................................... .AG.AGGGATAG.C.CCA.Gtga...........AA.ACTGA.................. ................AT.......................................... ................................................TAATACCTCATG TcctcctccgacggCATCA......................................... .................................................GAcgaggagt. ............................................................ ............AAAGATT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TATC... ............................................................ ......................................GGT................... ..........C.....A........................................... ...............................AG........................... ..................GAT....................................... GGGgat..........G.CGTCT..................................... ...G..................ATTAGG.TAGT...AGGCGG.GGTAACGGC..CCACCt AG.CCGACGATC..AGTAGGGGtTCT.......GAG.AGG..A..AGGt..CCC...CCA CATTGGt.ACTGAGACACG.GACC..AAACT...CCTACGGGAGGCAGCAGTGAGGAATA TTGGTCAAT........GGGCGGA.AGC................CT...GA.AC...C.A GCCAA.Gtagcgt.......GCAGGACG...A...CGG.CC.........CtaTGGGT.. ............................................................ ......................TGTAAACTgCTTTTATAggggaataaagTT........ ....................ATCCACgt................................ ............................................................ ............................................................ ............................................................ .........................................GTGGATAtttgcat..... ............................................................ ............................................................ ............................................................ ......................................G....TACCCTaT...GAAT.. .......AAGGACC..................G........................... ............GCTAATTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AAGGtccggG..CGTTATCCGGATTTA..TTGGGTTTAAAGGGA.G.C.GTAGG...... ........C.GGTatattaagcgtgt.................................. ..........TGT..........G.......AAATGtaggt.........GCTCAA.Cat ct.....................G.........ACTT...........G........... ......................CAGcgcgaactggttt...................... ...A................CTT....GA..GT......ACGcacaacgt.......... ........AGG..CGGAATTCgtCG..........T.................GTAGCGG TG..AAATGCTTA.GATATG.AC.G.AAGAACtccg.ATTGCGAA............GGC AGCTTacgggagcgc..C........ACTGACGCTGAa.GCTCGAAAGTGcgggtatCGA ACAGGATTAGATACCCTGGTAGTCCgcacg.GTAAACGATGGATGCccgctctgagtcct tttggatttgg................................................. ............................................................ ...................................GG....................... ..........................CCAAGCG.AAA.GCATT..........AAGCAT. .C.............CCACCTGGGGAGTACGCCGGCAACGGTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGAGGAACATGTGGTTTAATT.CGA.TGATACGCG .AGGAACCTTA.CCCGG........................................... ....GCTTGAatt.........................G..................... ...................C....A....................G.........GAGaa cg...........A.......................TCCAG............AG.ATG GTGag....................................................... ............................................................ ......................................GCC.CTTC.............. ........................GG............................GG.... ..........................................CTcctgtga......... ...................AGGT.GCTGCATGGTTGTCGTCAGCTCGTGCCGTGAGGTGT CggCTTAAGTGcca.TAACGAGCGCAACCCCTcT...CCTTAGTT..........GC..C .AT.C....AGgtaatGC...................................TGGG..C A.CTCTGGGGac.............ACTGCCA..CCGtaaggtgt............... ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCAGCACGGCCCTTACGt.CCGG.GG CTACACA.CGTGtTACAAT.GGCGT...GT.ACA.GAGA................Gt... ....................................TGGTGACAtgcaaatgtcat.... ....................CTAAT......CCT.....A..A.AAG..CA.C..G.T.C TC.A....GTTCGGAcTGGGGTCTGCAACCCGACCCCACGAAGCT.GGAtTCGCTAGTAA TCGCGCATCAG.CCAT.G.GCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCAAGCCATGAAA......G..........................CC...GGG G.........Gtg.............CCTGAA....GTCCGTG................. ..........................................A.........CCGGA..A ggatcg.......................................GCCT........... ........AGGGC.......AAA.........................A........... CT.GG.................TA........ATTGGGGCTAAGTCGT.AACAA.GGTAG CCGT........................................................ ............................................................ ........................................................... > ............................................................ ............UGAACGUUAG.CGG..CGGGCUUA....ACACAU.GCAAGUC.....G AGG.....G........G.......................................... ...............CAacaugaggucuAUAUUUUUAGA....UUUcg............ .................................................A......U... ..............GGC..............G............................ .......................................................ACC.G GCG.....AACGGGUG....CGUAACAC.GUACGU.AACUUACCUuuugcuagaaaaUAG ...................CCUGAGGAAACUUGG.......................... ............................................................ .........AUU................................................ ............................................................ ............................................................ ............................................................ ....................................AAU.AU.U................ ......................CUAU.................................. .......................................A.................... ............................................................ ......................AC....................AUA............. .GUAUUAUUGCA...........UG................................... .............................AUAAUA.......UUAU.............. ............................................................ ..............UAAAGc.....................................AGA UAUGC..........................GGCAA...AAGAUAGGC............ ............................................................ ............................................................ ............................................................ .........G.....UG.CGUC...................................... ..UG..................AUUAGUU...AG.UUGGUAG.GGUAAAAGC..CUACAA AGA.CAAUGA..UCGGUAGGGGGCC.........UG.AGAG..GGUG..AUCCC...CCA CACUGGU.ACUGAGAUACG.GACC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....G...UCAAUGGAGG.................AAACUCU...GA.AC...C.A GCCAC.GCCGC.GU......GCAGGAAG...AA...GG.CC.........CUAUGGGUUG UAAACGgc.................................................... ............................................................ ............................................................ ............................................................ ............................................................ ...............U..................UUUGU..............AUA.... GGAAUAAAA.........A....UUC....UUACGAGAU....................A AGAAU....................................................... .........C.................................................. .........................................AU................. ......GAa....GGU............................ACUAU.A..CGAA..U .......AAGUGUC..................G........................... ............GCAAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGACACAAG..CGUUAUCCGGAUUUAUUGGGUUU..AAAGGGU.G.C.GUAGG...... ........C.GGU.................UU.............AUUAAG.UCA.G... .........U..........AGUG.......AAA.......UGU.UGC.AGCUUAA.C.. ..UG.........UUA.................AA......A..UG..G........... ......................CUA...U..................UG..A..UACUGA UAA...............G.CUggagUGA..GA......UUG.............GA... ....G..UAG..CUGGAAUGUG......U.....................GGUGUAGCGG UG..AAAUGCUUA.GAU.AUCAC.AC.AGAACACCG.AUcGCGAAA............GC AGGU.UA.CU..AAGUCUAU..ACUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....UCAC.......... ....UAGUU........................G......UU.......GG......... ......................AU.......UUU.......................... ...........UUAUUCAGC........................................ .....G.G...........CU.......AAGCG.AAA.GUGA..........UAAG..UG AU.............CCACCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.G.UGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCAAG........................................... ....GUUU.................................................... ............................................................ .........AAA.......UGU............G....CUGcgaauaaGCU........ AGAAAUAGUUUA................................................ ............................................................ ............................................................ .........................GU.CUUCGGA....................C.... .....................GG................................AGU.. ................A.CAagaUGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCCU.CAACGAGCGCAACCCUUG...UUGUUAG......U....UGC..C .AG.C.G.............AG.U.........A.AAGU..............CGGGG.. A.CUCUAACAA............G.ACUGCC.G...ACG.UA.A...GUC.GA....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCACGGCUCUUAUGC.CUUG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACAA.AG................GG.... ....UCUUG..............CU........A........CUggguaauc........ ...............AGAAGCUAAU......CUC.....U..A.AAA.GC..C..GAU.C UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCUAUGAAG.UUGGAAUCGCUAGUAA UCGCAUAUCAG.CCAU.GA.UGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CrCCCGUCAAGCCAUGGAA......GU..........................C...GGG G.........GG.............ACCUGAAA....U...................C.. ...GG.U.......G.AC.CG......................................U .A........A.....A...AG.G.................AAcu............... .......GCUUAA....GGUAAA.........................A........... ............................................................ ............................................................ ............................................................ ........................................................... > NUACG.........AUGAAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGG.....G........G...............................UAU....A... ........................................GAG.........AGCUUGC. .................U......U.................U........CUAgagacc n........................................................... ............................................................ GCGG.....AUGGGUGA....GUAACGC.GUAU.GC.AACC..................U ........................................N................CC. ......UU..............U......U......A......................C .AG.GGGAAUAG.C.CCG.G........................................ ............................................................ .AGAAAUUCGGAUU.............................................. ............................................................ ............................................................ ............................................................ .................................................Aaugc...... ............................................................ .......................................................UCCAU GGUUUAUAUGAAU...........GGCAUCg............................. ..............................UUURU.......AUAA.............. ............................................................ ..............UAAAGAUU....................UAU............... ............................................................ ......CGGU.....AA........................................... ...............................AA........................... ...................G.......A.......U........................ GGG..........CAUG.CGU....................................... .AUC..................AUUAGCU...AG.UUGGUGU.GGUAACGGCA..UACCA AGG.CUNCGA..UGAUUAGGGGUCC.........UG.AGAG..GGAG..AUCCC...CCA CACUGGU.ACUGAGACACG.GACC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....G...UCAAUGGAGGC.................AACUCU...GA.AC...C.A GCCAU.GCCGC.GU......GCAGGAUG...A...CGGUCC.........UAU.GGAUUG UAAAC..........................UG.CNU.........U...U......... ....................................................GUA..... .............................C.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAUGUAAUUACGUGUA....................A Uuau........................................................ .............................U.............................. ............................................................ .......U..GACGGU............................ACCGU.A..AGAA..U .......AAGGAUC..................G........................... ............GCUNACUCC.G.UGCCAGCAGCCGCGNNNAUAC.............GG AGNAUCCNAG..CGUUAUCCGGAAUUAUUGGGUUU..AAAGGGU.U.C.GUAGG...... ........C.GGU.................UG.............AGUAAG.UCA.G... .........UG..........GUG.......AAA.......UCU.UA.UAGCUUAA.C.. ..U......A...UAA.................AA......U..U...G........... ......................CC...GU..................UG..A..UACUGC UUGA................CU....UGAA..U......AgUAUGGAAGUAAUUAGA... AUA.................UG......UA.....................GUGUAGCGG UG..AAAUGCUUA.GAU.AUUAC.A.UGGAAUACCA.AUUGCGAA............GGC AGAU.UACU.AcGU..ACUU..AUUGACGCU....GAU.GAACGAAAGCGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUAC.......... ....UAGCU........................G......UUCGG..............U ...............U......UUCGG...........AC..UG................ .......................................................A...G ....UG.G...........CU.......NAGCG.AAA.GUGA..........UAAG..UA UC.............CCACCUGGGGAGUACGUUCGCAAGAAUGAAACUCAA...AGGAAU UGACGGGGG.CC.NGCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.GNUACGCG .AGGAACCUUA.CCAAG........................................... ....GCUNA..............................A.................... ........AUGU................................................ .........AGAUUGA......CAGGUU................................ U......................AGAGAU.........AGA................... CU.......................................................... .............................UU............................. ..........................U.CUUCGGA....................CAAU. ........................UUACA............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU CAGGUUAAGUCCUA.UAACGAGCGCAACCCCUA...UUGUUAG......U....UGC..C .AG.C.G...GGUC......................AA............G.CCGGGA.. A.CUCUAACAA............G.ACUGCC.G..G.UG...CAAA..CC.GU....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCACGGCCNNUACG.UCUUG.GG CUACACA.CGUGCUACAAU.GGC.CA..G.UACA.GAAA................GC... ......A.G..............CU........A........CCAGGCAAC.......U. .......G........GAUGCGAAU......CUC.....A..A.AAA..CU..N.G.U.C UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAGC.UGGAAUCGCUAGUAA UCGGAUAUCAG.CCAU.GA.UCCGG.....UGAAUACGUUCCCGGGCNUUGU..ACACAC CGCNCGUCAAGNCAUGGAA......G..........................CCngg... .........NG.............UACCUGAA....GU...................C.. .............................GGUcg..................CCG..... ..............C.A...AG.G.................AGCU............... .......GCCUA....GGGUAAA.........................A........... CU.................GGUAACU......A...GGGC.................... ............................................................ ............................................................ ........................................................... > NUACG.........AUGAAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AGG.....G........G...............................UAU....AUGU C..................................UU....................... .........CGG.........................................A...... ...UAUAGA......................G............................ .......................................................ACC.G GCGC.....ACGGGUG....CGUAACGC.GUAU.GC.AAUC..................U ........................................A................CC. ......UU..............U......U......A......................C .AG.GGGAAUAG.C.CCA.G........................................ ............................................................ ............................................................ .....................................AGAAAUUUGGAUUAAU....... ............................................................ ............................................................ ............................................................ ..............................................G........CCC.. .......................C....................AUA............. .GUAUUAUUAAAU...........GGCAUC.............................. .............................AUUUUA.......UAAU.............. ............................................................ ..............UAAAGUcAC....................AA............... ............................................................ ......CGGU.....AA........................................... ...............................AA........................... ...................G.......A.......U........................ GAG..........CAUG.CGUC...................................... ..CC..................AUUAGUU...AG.UUGGUAA.GGUAACGGCU..UACCA AGA.CAAUGA..UGGGNAGGGGUCC.........UG.AGAG..GGAG..AUCCC...CCA CACUGGU.ACUGAGACACG.GACC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CN...GA.UC...C.A GCCAU.GCCGC.GU......GCAGGAAG...A...CGGUCC.........UAU.GGAUUG UAAAC..........................UG.CUU.........U...UA........ ............................................................ ......................U.....AC.............................. ....A....................................................... ............................................................ ............................................................ ...................................................G.....G.A AGAAA....................................................... .........C.................................................. .........................................AcuCCGACGUGucggagCU .......U..GACGGU............................ACUGU.A.G.GAA..U .......AAGGAUC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGAUCCAAG..CGUUAUCCGGAAUCAUUGGGUUU..AAAGGGUC..C.GUAGG...... ........C.GGU.................UU.............AAUAAG.UCA.G... .........UG..........GUG.......AAA.......UCUG.Gucgc....U.C.. ..A......ACGA....................UC......A..AacgG........... ......................CCA...U..................UG..A..UACUGU UAGA................CU....UGAA..U......UAUAAGGAAGUAAcUAGA... AUA.................UG......UA.....................GUGUAGCGG UG..AAAUGCUUA.GAU.AUUAC.A.UGGAAUACCA.AUUGCGAA............GGC AGGU.UA.CU..A..CUUAUgGAUUGACGCU....GAU.GGACNAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUAC.......... ....UAGCU........................G......UU.......GG.....GA.. ....................GC...................................AA. ....................UC.........UC......................A...G ....UG.G...........CU.......AAGCG.AAA.GUGA..........UAAG..UA UC.............CCACCUGGGGAGUACGUUCGCAAGAAUGAAACUCAA...AGGAAU UGACGGNNGnCC..GCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCAAG........................................... ....GCUUA..............................A.................... ........AUGU................................................ .........AGAUUGA......CAGGAC..............................UG ..................G....A.AACAGUU............................ .U.......................................................... .............................UU............................. ..........................U.CUUCGGA....................CAAU. ........................UUACA............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU CAGGUUAAGUCCUA.UAACGAGCGCAACCCCUG...UUGUUAG......U....UGC..C .AG.C.G.............AG.UC..........AUGU..............CGGGA.. A.CUCUAACGA............G.ACUGCCAG....UG...CAAA..C.UGU....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCACGGCCCUUACGC.CUUG.GG CUACACA.CGUGCUACAAU.GGA.CG..G.UACA.GAGA................GC... ......A.G..............CC........ACugcgca................... ............AGCAGGAGCGAAU......CU.....AC....AAAA.C..C..GUU.C UC.A....GUUCGGAUCGGAGUCUGCAACUCGACUCCGUGAAGC.UGGAAUCGCUAGUAA UCGGAUAUCAG.CCAU.GA.UCCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGCCAUGGAA......G..........................C...UnGG G.........G.............UACCUGAA....GU...................C.. .............................GGUG.........A.........CCG..... ..............C.A...AG.G.................AGCU............... .......GCCUA....GGGUNNA.........................A........... CU.................GGUAACU......N...GGGCUAAGNNG.UAACAA.GGUAG CNG.UA.CCGG.AAG..........GA................................. A............CACCUCCUUUCU................................... ........................................................... > cuagc....................................................... .........................G..CAGGCCUA....ACACAU.GCAAGU.....AG AAC.....G........GU..................AACAG..............A... ........................................GAG.........AGCUUGC. .................UCUC....................................... ...UGC..U.....GAC..............G............................ .......................................................AGU.. ..UG.....ACGGGUk....CGUAACGC.GUAU.GC.AACC..................U ........................................A................CC. .C.....A..............U......A......A......................C .AG.GGGGAUAG.C.CCA............UAG.AA.AUG.................... ............................................................ ............................................................ ............................................UGGAUUAAUACC.... .............CCAUAAcauc..................................... ............................................................ ............................................................ ............................................................ ............................................................ ......AUAGAUU...........GGCAUC.............................. .............................AUG..A.......AAUGAUuaaaACUCCGGU G..................G....UUA................................. ............................................................ ............................................................ ............................................................ ...............................U............................ ..................GG.......A.......U........................ GGG..........CAUG.CGUG...................................... ..AC..................AUUAGCU...AG.UUGGUGA.GGUAACUGCU..CACCA AGG.CAACGA..UGUCUAGGGGU...U....CUGAG.AGG..A..UG..AUCCC...CCA CACUGGU.ACUGAGACACG.GACC..AGAC..U..CUACGGGAGGCAGCAGUGAGGAAUA UUG.....CG...CAAUGGAGG.................AAACUCU...GA.....GC.A GCCAU.GCCGC.GU......GCAGGAAG...A...CUG..C.........CUAUGGGUUG UAAAC..........................UG.CUU.........U...UA........ ............................................................ ......................U.....A............................... ...UA....................................................... ............................................................ ............................................................ ...................................................G.....G.A AGAAcuACAGCUACG............................................. UGUAGCU..................................................... ..................GUUUGac....GC............................. ..............GU............................ACUAU.A..CGAA..U .......AAGGACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCSGUAAUAC.............GG AGGGUccaaugcCGUUAUCCGG..UUAUUGGGUUU..AAAGGGUC..C.GUAGG...... ........C.GG.................GUU.............AUUAAG.UCA.G... .........UG..........GUG.......AAA.......UCC.UAC.AGCUCAA.C.. ..UG.........UA........G.........AAC........U...G........... ......................CCA...U..................UG..A..AACUGG UAAC................CU....UGA..GU......AU.............AAU... UGAAGUG..GG..CGGAAUGUG......UCA.....................UGUAGCGG UG..AAAUGCUUA.GAU.AUGAC.AC.AGAACACCG.AUUGCGAA............GGC AGCUC.A.CUAA..GUUAUA..ACUGACGCU....GAG.GGACGAAAGCGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGU....ACAC.......... ....UCGUU........................Gc......U.......GG......... ..................................C.....................GAU. ....................AC.........AC......................A...G ....UCAGU........GA.......CCAAGCG.NAA.GUGU..........UAAG..UG UA.............CCACCUGGGGAGUACGCUCGCAAGAGUGAAACUCAA...AGGAAU UGACGGGGG.CC..GCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCUGG........................................... ....GCUUA..............................A.................... ........AUGCAAA.ACgacag..................................... ...................AC.....UAUG.........................A.AAA UAG............................U............................ .U.......................................................... .............................UU............................. ..........................U.CUUCGGA....................C.... .....................GuuuUGCA............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UUCUUAG......U....UGC..C .AG.C.G.............AG.U.........A.AUGU..............CGGGG.. A.CUCUAAGAA.............AACUGCC.C...CGC.AAGC...G..UG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCACGGCCCUUACG.UCCAG.GG CCACACA.CGUGCUACAAU.GGUA.G..GG.ACA.GAG................GGC... ......A.G..............CC........ACcuggugacA................ .......G........GGAGCGAAU......CC.....UA....AAAC.C..CU..AU.C UC.A....GUUCGGAUCGAAGUCUGCAACUCGACUUCGUGAAGC.UGGAAUCGCUAGUAA UCGCGCAUCAG.CCAU.G.GCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGCCAUGGAA......G..........................C...UGGG ........A.G.............UGCCUGAA....GU...................C.. .............................GGU.....A....A.........CCG..... ..............C.A...AG.G.................AGCN............... .......GCCUA....GGGUAAA.........................A........... ............................................................ ............................................................ ............................................................ ........................................................... > ..NUUAC......AAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUAG.CGG..CAGGCCUA....AUACAU.GCAAGUC.....G GAC.....G........G.......................................... .....GA.U......C....CAU......C..G......G...U........AGCUUGC. .................U......A.................U........CAA...... ...UGguG............A..........GAG....U..................... ...........................................................G GCGC.....ACGGGUG....CGUAACGC.GUGA.GCAA.CC..................U .G.......................................................CC. ......UCC....................A......U......................C .AG.GGGGAUAG.C.C............................................ ............................................................ ............................................................ .....................................................UCU.... .............CG.AA.......................................... ............................................................ ............................................................ ............................................................ ............................................................ ..........................................AG.AGAGAUUAACACCGC AUAacauaauauuccggcaucgggauauuAUUAAA.......UAUU.............. ............................................................ ..............UAUAGgau...................................... ............................................................ .............G.............................................. ...............................GA........................... ...................G.......A.......U........................ GGG..........CUCG.CGUG...................................... ..AC..................AUUAGCU...AG.UUGGURG.GGUAACGGC..CYACNA AGG.CGACGA..UGUCUAGGGGC...U....CUGAG.AGG..AGAAucccn.......NN CACUGGU.ACUGAGACACG.GACC..AGNC..U.CCUACGGGAGGCAGCAGUAAGGAAUA UUG.....G...UCAAUGGGCGGA.AGC................CUN...A.AC...C.A GCCAU.GCCGC.GU......GCAGGAUG...A...CUG.CC.........CUAUGGGUUG UAAAC..........................UG.CUU.........U...U......... ....................................................GUCC.... ............................................................ ....G........GG..................AAuaaaCCUCCUUACGAG.......UA GGGAGC...................................................... ....................................UGA..............AUGUA.. ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCG.GA..AGAA..U .......AAGGAUC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGNNNAUAC.............GG AGNAUCCNAG..CGUUAUCCGGAUUUAUUGGGUUU..AAAGGGU.G.C.GUAGG...... ........C.GG.............C....CUG.............UUAAG.UCA.GG.. ..........G..........GUG.......AAA.......UACg.G.UGGCUCAA.C.C .........A...Ucgc.........................AGU...G........... ......................CCU...U..................UG..A..UACUGA CGG...............G.CU....UGAA..UC......C.............AUA... UGAAGUG..GG..CGGAAUAAG......ACA.....................AGUAGCGG UG..AAAUGCAUA.GAU.AUGUC.U.UAGAACUCCG.AUUGCGAA............GGC AGCUC.A.CUNA..GCUGGU..AUUGACGCU....GAU.GCACGAAAGCGUGGGGAUCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUgAACGAUGA....UAAC.......... ....UCGAU........................G......UU.......GG......... ..................................C.....................GAUA GACAGCcagc.................................................. .................GUCCC.......AGCG.AAA.GCGU..........UAAG..UU AU.............CCACCUGGGGAGUACGCCCGCAAGGGUGAAACUCAA...AGGAAU UGACGGNNG.CC.NGCACA.AG.CGG.AGGAGCAUG.UGGUUUAAUUCGAU.GNUACGCG .AGGAACCUUA.CCCGG........................................... ....GCUUGAA......AGU.................UA.............G....... ........................U....................G.........GAG.. ..........GAU............................................... ............................................................ .................................Gcagagacgc................. .........AUC..........NGU................................... ......CCUUC..G..........GGA.CA.............................. ......................CGAAACU............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCCN.CAACGAGCGCAACCCCUA...UgUUUAG......U....UGC..C .AG.C....A..........UG.U.........U.AUG......G...U.....GGGG.. A.CUCUAAACA............G.ACUGCCUG....UG...CAAA..C.AGU....... ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.UCCGG.GG CUACACA.CGUGCUACAAU.GGA.CN..G.UACA.GCG................GG.... ....N.A.G..............CU........A......G..CUGGCAAC.......A. .......G........CAUGCUAAU......CUC.....U..A.AAA.GC..C..GUU.C AC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UUGGAUUCGCUAGUAA UCGCGUAUCAG.CAAU.GA.CGCGG.....UGAAUACGUUCCCNGGCNUUGU..ACACAC CGCNCGUCAAGCCAUGAAA......GU.............................UGGG G.........G.............UA......................CCUAAAGCAU.. ..............................GU.....U....A.........CCG..... ..............C.A...AG.G.................AGCGUguc........... ...........A....GGGUAAA.........................A........... CC.................GAUAAUU.........GGGGc.................... ............................................................ ............................................................ ........................................................... > ............................................................ ............................CAGGCCTAATACATGCAA.GT....C.....G AGG.....G........G.......................................... ...............CAGC...A......CAGGTAGCAATACt...G............. ......................................................GG..C. ..............GGC..............G............................ .......................................................ACC.G GCA.....AACGGGTGC....GGAACAC.GTAc.GT.AACCTtcctctaaatggagcatA .G.......................................................CC. .C.........................G.AAG....Aaatt................... ........................................C.G................. ...............GAT.......................................... ................................................TAATACTCCATA agat........................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................................TGTGGAGtgGCATCACTcagcaat taaagaatttcgtttagAGAT....................................... GGG..........CgtgcgG.CT..................................... ...G..................ATTAGG.TAGTT...GGTGA.GGTAACGGCT..CACCA AG.CCGACGATC..AGTAactggc.......GT..G.AGAGC..GCG..ACCA...GTCA CACGGGC.ACTGAGACACG.GGCCC..GACT...CCTACGGGAGGCAGCAGTAAGGAATA TTGGTCAAT........GGACGCA.AGT................CT...GA.AC...C.A GCCAT.GCCGC.GT......GAAaGATG...AA...GGTcctctggatn........... ............................................................ .......................GTAAACTTCTTTTAT...................... ............................GT.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AACCActcctttctagggtG................. ............................................................ ............................................................ ............................................................ ...............................TTGACG.G....TACCAT.A.G.GAAT.. .......AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTATCCGGATTCAC..TGGGTTTAAAGGGT.G.C.GTAGG...... ........C.GG.................GTCaG......T.......AAGT.CCgt.G. ...........GT..........G.......AAAT.......Ctcca..AGCTTAA.C.. ............................................................ ........................TTG.....................G..A..AACTGC CGtggatactataAGT....CTT....GAA..T........................... .....GTT..G..TGGAggttagcggaatatgtcaT.................GTAGCGG TG..AAATGCTTA.GATATG.ACat..AGAACACCA.ATTGCGAA............GGC AGCTggct....A..CACAA..A..TATTGACGCTGAG.GCACGAAAGCGTGGGGAtCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCCTAAACGATGAttact............. ...................................................CGA...... ......................CA.TTtgcgatatacagtaa.................. ...GTGTCTG.................................................. .............................AGCG.AAA.GCATT..........AAGT..A at.............CCACCTGGGAAGTACGACCaCAAGGTTGAAACTCAA...AGGAAT TGACGGGGGt.CC.GCACA.ACG..GGTGGAGCATGTGGTTTAATT.CGA.TGATACGCG .AGGAACCTTA.CCTGG........................................... ....GCTagaat................................................ ............................................................ .......................................................G.ATG GTGgcccgatncct.............................................. ............................................................ ............................................................ ................GAAAGGGA.................................... ..................Ctttgtacgaataacaccta...................... ...................AGGT.GGTGCATGGCTGTCGTCAGCTCGTGCCGTGAGGTGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTAT...CTTTAGTT..........GC..C .A.AC....AGGTcaagc...................................TGGGA.. A.CTCTAAAGA.............AACTGCC.GTcgtaaga........C.G........ ..CGAGGA.A.GGAG.GGGATGAtGTCAA....GTCATCATGGCCTTTATGC.CCAG.GG CTACACA.CGTGCTACAAT.GGTA.G..G.AACAA.AG................GGC.T. ........G..............Ctacctggt................AAC.......A. .......G........GAtGCTAAT......CTC.....A..A.AAAt.C..CT..AT.C TC.A....GTTCGaATTGAGGGCTGCAACTCGCCCTCATGAAGCT.GGAATCGCTAGTAA TCGTAtATCAG.C.AAtgaT.ACGGT.....GAATACGTCCCCGGACCTTGT..ACACAC CGCCCGTCAAGCCATGAAA......G..........................CC...GGG G.........GG.............ACCTGAA....GTC..................... .................GG............T.....A....A.........CCG..... ..............C.A...AG.G.................AACcGCCT........... ........AGGGtaaa.................................ATC........ ...GG.................TA........ATTGGGGCTAAGTCnT.AACAA.GGTNA CCGT.AT.CGG.AAGt............................................ ............................................................ ........................................................... > nuUCAU.......UAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CGG..CAGGCUUA....AUACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................GU CCUUCGG..G.............................................A.... ......................................................C..... ....GC..U.....GAC..............GAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACGC.GUACa.CAAUC...................U .G.......................................................CC. ......UUC....................A......U......................C .AG.GGGGAAAGu..CACUG........................................ .......GA................................................... .......................................AACGGUGAAUAAUcccgcaua caacucuUAGAUGGCAUCAUcauag................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................AG.............. ...............UAAAAGC.......UC............................. ............................................................ .......................C......GG............................ ......CGGA.....U............................................ ..............................GAA........................... ...................G.......A.......U........................ GAG.....UG.....UG.CGUC...................................... ..UG..................AUUAGCU...AG.AUGGUGA.GGUAACGGCU..CACCA UGG.CAACGA..UCAGUAGGGGGC.........GUG.AGAGC..GUG..AUCCC...CCA CACGGGU.ACUGAGACACG.GACC..NGAC..U.CCUACGGGAGGCAGCAGUAAGGAAUA UUG.....GG...CAAUGGACGGA.AG................UCU...GAC.C...C.A GCCAU.GCCGU.GU......GCGGGAAG...AA...GG.CC.........CUUUGGGUUG UAAACC..........................G.CUU.........U...UA........ ............................................................ ......................U.....C............................... ...UA........GG..................AA...................G..... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................AAuggcccugauucaucagGGNA................. ......GA..GACGGU............................ACUA.GA..UGAA..U .......AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCNCGGUAAUAC.............GG AGNGUGCNAG..CGUUAUCCGGAAUCACUGGGUUU..AAAGGGU.A.C.GUAGG...... ........C.GGU.................UC.............AAUAAG.UCA.G... .........A..........UGUG.......AAA.......UGUC.GG.AGCUCAA.C.. ..U......UCGA....................AC......U..U...G........... ......................CAU...U..................UG..A..AACUGU UGAA................CU....UGAA..U......UAG.............GUGGA AGUGUG.......CGGAAUGUA......UCA.....................UGUAGCGG UG..AAAUGCAUA.GAU.AUGAU.A.UAGAACACCA.AUAGCGAA............GGC AGCAC.A.CUAcgcu..UU..GAUUGACGCU....GAG.GUACNAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGC....UAAC.......... ....UGGA...................................................U ...............A......UU.......UU..................CACGAguga gu...........................GGG............................ .A.....GU........GUCu...G....AGGGAAAC..CAU..........UAAG..UU A.............GCCACCUGGGGAGUACGUUCGCAAGAAUGAAACUCAA...AGGAAU UGACGGGNNU.C.NGCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.NNUACGCG .AGGAACCUUA.CCUGG........................................... ....NCUc.................................................... ............................................................ ...............................................GAACGCUAG.AUG A......................A.UAUU............................... ............................................................ .........GGGGAAACUuAAUAGA................................... ......CCUUC..G..........GGA.CAUCuag......................... ............................................................ ..............UG...AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCCN.CAACGAGCGCAACCCCUA...UCUUUAG......U....UGC..C .AG.C.G.............AUUCG............GU..............CGGGG.. A.CUCUAGAGA............G.ACUGCCU..CCGU...AAG...G..AGU....... ...GAGGA.A.GGAA.GGGACGACGU..NN..AGUCAUCAUGGCCUUUAUGC.CCAG.GG CUACACA.CGUGCUACAAU.GGCG...C.CUACA.GAG................GGC... ......A.G..............CG........AA........CCU.....GC.GA.G.. ......GG........UAAGCGAAU......CUC.....AG...AAA.Gggc....GU.C CC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UUGGAAUCGCUAGUAA UCGCGCAUCAG.CCAU.G.GCGCGG.....UGAAUACGUUCCCGGACCUUGU..ACACAC CGCNCGUCAAGNCAUGGGA......GU..........................CN...N. .......NN.G.............UGCCUGAA....GA...................U.. ...GG.U.......G.AC.CuuaccagGAGCU.....A....U.........C....... ..........U.....AGgguaaac................................... ............................................................ CU.................GGUGACN......A...GGNc.........NACAA.GGNAG CC.................................................G......GA AU............ACCUCCUUUA.................................... ........................................................... > accg...U.....U...UAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUAG.CGGA..AGGCCUA....AUACAU.GCAAGUC.....G AGG.....G........G...............................UAACA...... .....GG..G.............................................A.GC. .................U......U.................SUC.C.......C..... ....GC..U.....GAC..............G............................ .......................................................ACC.G GCG.....AACGGGUGA....GUAACGC.GUAC.G.UAACC..................U ........................................A................CC. ......U..................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .....................UCAAGAG................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................................................A........ ...........GG...GAUAGCCCUgggaaacuggga...UUAAUACCucauggcaucau aagaucaccUGGUCUAAUGAUU....................AAAGcugaggcgCU.UGA ANAUg........................................GGC............ ............................................................ ............................................................ ............................................................ .........G.....UG.CGU....................................... .UCU..................AUUAGAU...AG.UUGGUGA.GGUAACGGCU..CACCA AGU.CAGCGA..UaGAUAGGGGGC.........GUG.AGAGC..GUGG..UCCC...CCA CACGGGU.ACUGAGACACG.GACCC..GAC..U.CCUACGGGAGGCAGCAGUAAGGAAUA UUG.....G...ACAAUGG.CGAA.AGC................CU...GA.UC...C.A GCCAUU.CCGCcGU......GUAGGAUG...A...CGG.CC.........Uc.UGGGUUG UAAAC..........................UA.CUU.........U...UA........ ............................................................ ......................U.....U............................... ...UGGGAA.....G..................AAA........................ ............................................................ ............................................................ ..............................................CCCUGG.....G.A U.....U.UAUCCCg............................................. .......GGCUGA............................................... ............................................................ ............CGGU............................ACCAA.A..AGAA..U .......AAGCACC..................G........................... ............GCUAAUUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AAGGUGCAAG..CGUUAUCCGGAAUCACUGGGUUU..AAAGGGU.G.C.GUAGG...... ........C.GGU.................UGC.............GUAAG.UCA.G... .........A..........AGUG.......AAAG.......CUC.AC.AGCUUAA.C.. ..UG.........UG........G.........AA......U..U...G........... ......................CUU...U..................UG..A..UACUGC GCGA................CU....AGAA..U......UAG.............GU... UGAGG..UUGG..CGGAAUGUG......ACA.....................UGUAGCGG UG..AAAUGCAUA.GAU.AUGUC.A.UAGAACACCA.AUUGCGAA............GGC AGCUG.A.CUGGA..CCUAU..AUUGACGCU....GAG.GCACGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGC....UUAC.......... ....UCGAU........................G......UGU.......G........A ...............A......AU.......UUUGCG..C..A................. .....................U.....................CCAAG............ ......................................GCGU..........UAAG..UA A.............GCCACCU.GGGAGUACGUUCGCAAGAAUGAAACUCAA...AGGAAU UGACGGGGGU.C..GCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCUGG........................................... ....GCUCGAA......UG......................................... ............................................................ .........................................G............AU.UUG ..................GacaaU.UUCUGAA............................ .AGGA....................................................... .............AAUCU.......................................... .......C..................U.CUUCGGA...................GCUGA. ........................AUUCA............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UUCUUAG......U....UAC..C .AG.C....A.....C....A..U.........A.AUG......G...U.....GGGG.. A.CUCUAGGAA............G.ACUGCC.G...Ng.....UAA.GCC.G........ ..CGAGGA.A.GGUG.GGGACGACGUC..A..AAUCAUCAUGGCCUUUAUGC.CCAG.GG CUACACA.CGUGCUACAAU.GGAG.G..G.UACA.GAG................GG.... ....UC..G..............CG........AA........GCC.....GC.AA.G.. ......G........UGGAGCCAAU......CUC.....A..U.AAA.GC..CC..UU.C CC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UUGGAAUCGCcAGUAA UCGCGCAUCAG.CCAU.G.GngnGG.....UGAAUACGUUCCCGGACCUUGU..ACACAC NGnCNGUCAAGCnAUGGAA......GN.............................NGGG ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ........................................................... > ..NUUAC......AAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CGG..CAGGCCUA....AUACAU.GCAAGUC.....G AGG.....G........G...............................UAACA...... .....GG..G.............................................AAGC. .................U......U.................NNUUC.......C..... ....GC..U.....GAC..............G............................ .......................................................ACC.G GCGC.....ACGGGUG....CGUAACGC.GUAUAc.AAU.C..................U .G.......................................................CC. .C.....U..............U......A......A......................C .UG.GAGGAUAgCC..A.C...........UGG.AA.ACAG.U................. ...............GAUUAAUACuccauaacacugcacgaucgcaugagagagcaguua aAGAAUUUCGGUUA.............................................. ............................................................ ............................................................ ............................................................ .................................................A.......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................GG.......A.......U........................ GAG.....U.....AUG.CGUG...................................... ..AC..................AUUAGCU...AG.UUGGUGA.GGUAACGGCU..CACNA AGG.CAACGA..UGUCUAGGGGU...U....CUGAG.AGG..A..UG..AUCCC...CCA CACUGGU.ACUGAGACACG.GACC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUA UUG.....GG...CAAUGGAGGC.................AACUCU...GAC.C...C.A GCCAU.GCCGC.GU......GCAGGAUG...AA...GG.Cguucugc.........GUUG UAAAC..........................UG.CUU.........U...UA........ ............................................................ ......................U.....A............................... ...UGGGAA.....G..................AAA........................ ..AAGGUc.................................................... ............................................................ ..................U....UGCGA.............................G.A C.AAA....................................................... .........CUGA............................................... ............................................................ ............CGGU............................ACCAU.A..UGAA..U .......AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUNAUAC.............GG AGGGUGCAAG..CGUUAUCCGGAUUUAUUGGGUUU..AAAGGGU.G.C.GCAGG...... ........C.GG.............C....CU.............AUUAAG.UCA.G... .........UG..........GUG.......AAA.......UCU.UAC.AGCUUAA.C.. ..UG.........UG.........................AaAGU...G........... ......................CCA...U..................UG..A..UACUGG UAG...............G.CU....UGA..GU..G....CG.............GUg.. .AAGG..UAGG..CGGAAUUC......CUCA.....................UGUAGCGG UG..AAAUGCAUA.GAU.AUGA.GG.AAGAACACCG.AUAGCGAA............GGC AGCUUA.C.UGuA..CCGUU..ACUGACGCUC....AU.GCACNAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....UUAC.......... ....UCGGU..........................................G........ .......................U.......UGGCNAUA.................GAUU GUCAGCGC.................................................... ..........................CCAAGCG.AAA.GCGU..........UAAG..UA AU.............CCACCUGGGGAGUACGCCGGCAACGGUGAAACUCAA...AGGAAU UGACGGGGGU.C.NGCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCUGG........................................... ....GCUCGAA......UGUGAGcgac................................. ............................................................ ............................................................ ............................................................ .................................GGUUCCAG.AAA............... .......................UGGAACUU............................. ..........................U.CUUCGGA....................C.... .....................GCGAAACA............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUAC...UGUUAG......U....UAC..C .A.UC....AGa........U..A.........A.U........G..CU.....GGGG.. A.CUCUAACA............G.AACUGCCUACG...C..AAGU.....AGU....... ...GAGGA.A.GGCG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACGC.CCAG.GG CUACACA.CGUGCUACAAU.GGC.CA..G.UACA.GAG................GG.... ....UC..G..............CU........A........CCUGGCAAC.......A. .......G........GAUGCCAAU......CUC.....A..A.AAA.GCU..G.G.U.C UC.A....GUUCGGAUCGGAGUCUGCAACUCGACUCCGUGAAG.UUGGAAUCGCUAGUAA UCGCGCAUCAG.CAAU.G.GCGCGG.....UGAAUACGUUCCCGGACCUUGU..ACACAC CGCCCGUCAAGCCAUGGAA......GU..........................C...AnG G.........GG.............ACCUGAA....G...................CA.. ...GG.U.......G.AC.CG......................................U .A........A.....U...AG.G.................AGCU.....U.......Gu ..........UA....GGGUUAA.........................A........... CU.................GGUAACU......A...GGGC.................... ............................................................ ............................................................ ........................................................... > NAUUUAC......AC.GGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUAG.CGGU..AGGCUUA....AUACAU.GCAAGUC.....G UAC.....G........GG.............................AUUU....AAGA C..................................UU....................... .........CGG.........................................U...... ...UUUAA..U........NN..........GAG....U..................... ...........................................................G GCGC.....ACGGGUG....CGUAACAC.GUAU.G.UAACC..................U ........................................A................CC. ......UU....................GU......A......................G .AG.AGGNAUAG.C.CCG.......................................... ............................................................ ............................................................ ....................................AAGAAAUUUGGAUUAAUACC.... ..................................U......................... ...............................CGUAGUC...................... ............................................................ ............................................................ ............................................................ ....UUAUAGAAA...........GGCAUC.............................. .............................UUUUUA.......UAAG.............. ...............UAAAUGG.......AGC............................ .....................AAUU................................... ..........UGCUAC............................................ ............................................................ ...............................AA........................... ...................G.......A.......U........................ GG.....A.....CAUG.CGC....................................... .AUG..................AUUAGAU...UG.UUGGUGA.GGUAAYGGCU..CACNA AGU.CcUUGA..UCAUUAGGGGU...U....CUGAG.AGG..A..AGG..UCCC...CCA CACUGGC.ACUGAGAUACG.GGCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUA UUG.....G...ACAAUGGAGGC.................AACUCU...GA.UC...C.A GCCAUA.CCGC.GU......GAAGGAAG...A...CGGUCC.........UCU.GGAUUG UAAAC..........................UU.CUU.........U...UA........ ............................................................ ......................U.....AC.............................. ....A....................................................... ............................................................ ............................................................ ...................................................G.....G.A AGAAAUGCAGA................................................. ............................................................ ......Cuugcga.....GUUUGU...............................U...U .......U..GACGGU............................ACUGU.A..UGAA..U .......AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCNCGNNNAUAC.............GU AGGGUGCNAG..CGUUGUCCGGAAUUACUGGGUUU..AAAGGGU.A.C.GUAGG...... .........UGGgc..............................GUCUAAG.UCU.GG.. ....................AGUG.......AAAG.......UU.UG.AGGCUCAA.C.C .........UC...Ga.................AAG........U...G........... ......................CUU...UG..................G..A..UACUGG GCGU................CU....AGAA..U......UAG.............Au... AUAGG..UAG..CUGGAAUUUG......U.....................GGUGUAGCGG UG..AAAUGCAUA.GAU.ACCAc.G.ANNNACACCA.AUUGCGAA............GGC AGGC.UA.CUGG..GUCUAU..AUUGACACU....GAU.GUACGAAAGUGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CACCGUAAACGAUGA....UUAC.......... ....UCGGU..........................................Gcuuguac. ................UUACGU.A.......UG........................... .......................................................A...G ....UGCC.....U..............UAGGGAAAC..CGU..........UAAG..UA AU.............CCACCUGGGGAGUACGUUggcaacAAUGAAACUCAA...AGGAAU UGACGGGGGU.C.NGCACA.AG.CGG.UGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AGGAACCUUA.CCUGG........................................... ....GCUAGAA......UGCgcgugacg................................ ........................A....U.............................. ...............................U..U....CAG............AG.AUG A......................U.UUUUucucgcaagAGA................... CACA........................................................ ............................................................ ............................................................ ..........AAGN..............N............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCCN.CAACGAGCGCAACCCCNA...UUUGUAG......U....UAC..C .A.UC....AGG........U..U.........A.A........G..CU.....GGGN.. A.CUCUAcAAA............G.ACUGCCUACG...C..AAGU.....AGU....... ...GAGGA.A.GGUG.GGGACGACGN..NN..AGUCAUCAUGGCCCUUACG.UCCAG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACA.GCGU................Gcagu ........................A........A......G..CUAGCGAU.......A. .......G........UuaaCGAAU......CAC.G......A.AAA.GC..CG.G.U.C AC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UUGGAAUCGCUAGUAA UCGCAUAUCAG.C.AACGA.UGCGG.....UGAAUACGUUCCCGGACCUUGU..ACACAC CGCNCGUCAAGCCAUGGGA......GU.............................UGGG ........U.G.............UGCCUGAA....GGcagu.................. ...GC.UCGCAAG............................................... ..............................................AaGCU.......GC .....UU.AGGGC.......AAA.........................A........... CUA.................GCGACU.........GGGGCUNAGUNN.NNNCAA.GGUAG CCG......................................................... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUCAAGGc. ............................................................ .....................................GU....AG.........CUUCGG C.....Uacg.................................................. ....................................ACU..................... ...........................................................G GCGC.....ACGGGUGA....GUAACGC.GUA.GG.UAA.Ccuacccc...........U ........................................A................CC. .C.....C..............UG............A......................C ........AUAAC.A.C.CG...........AGAAA.U.CG.G................. ................U........................................... .............................................G.C............ .................................................UAAUAuca... ....................................GAUG.................... ....................................A....................... ...........................................GG............... AA.....................CCGAAAGG.....UUUCa................... ............................................................ .............A.......AGGGGCAACccggg......................... ............................................................ ............................................................ ............................................................ ............................................................ ...............UA........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CCUG.CGUC...................................... ..CG..................AUUAGGU...AG.UUGGUAG.GGUAAUGGC..CUACCA AG.CCGACGA..UCGGUAGCUGGCC.........UG.AGAG..GGUGG..UCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....GG...CAAUGGGCGAA.AGC................CU...GAC.C...C.A GCGAC.GCCGC.GU......GUGGGAUG...A...CGGAgcucugc..........UUCG UAAACC..........................A.CU.........GU............. ...................................................CGG...... ....................AG...................................... ....GGGAA.....G..................AAA........................ ..AGCGgggac................................................. ............................................................ ........................GCCC................................ .................................CGCUgg..................... ............................................................ ............................................................ ..........GACUGU............................ACCCU..C.AGA.... G..G...AAGGAUC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAAAC.............GU AGGAUCCGAG..CGUUGUCCGGAAUCACUGGGUGU..AAAGGGU.G.C.GUAGG...... ........C.GG.................GCU.............UgCGCG.UCAa.G.. ..........G..........GU.......UAAAG.......ACC.UC.GGCUCAA.C.C ...G.........AG........GG.........A......A..U...G........... ......................CCU...U..................UG..A..UACggc aggC................CU....UGA..GU..G....CG.............GG... AGAGG..AUGG..UGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCA.GG.AGGAACACCG.AAGGCGAA............GGC AGCC.AU.CUGGA..CCGCC..ACUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGU....ACGC.......... ....UUGG.....................................C....G........U C.........GG........................G.....A................. .....................A.....................CCUAGUucuc....... .................GGUGCCGG....AGGUAACC..CGU..........UAAGC..G UA.............CCACCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAUCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGAAC.........................UGug................... .............................................G.........GUAG. ............................................................ ............................................................ ...........................................UAGGGAGA......... ..CGAAagucg............................................AACGA A........................................................... .....................CC.................................Guaa agccgguugcccaCAG...AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UCCCUAG......U....UGC..C .A..C...CAGUUC.......................G......G..CU.....GGG..C A.CUCUAGGGA............G.ACUGCC.C..GCGC.AAGC...G...GU....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUAUG.UCCAG.GG CUACACA.CGUGAUACAAU.GGA.CG..G.UACAA.UG................GG.... .......................CG........AA........GCC.....GC.GA.G.. ......G........CGGAGGUAAU......CCC.....A..A.AAG..C..C..GU.CC UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAGG.UGGAAUCGCUAGUAA UCGCGCAUCAG.C.A.CG.GCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGCCAUGGGA......G..........................C...UGGg gg.........C.............GCCCGAA....G...................CC.. ...GC.ACGCAAG............................................... ..............................................UG............ ....C..GUCGAA....GGCGAA.........................AC.......... .CA.................GUGACU.........GGGGCU................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.AUGAACGCUGG.CGG..CGUGCUUU....ACACAU.GCAAGUC.....G AGC.....G........GAguc...............................A...... .....GU.U......C....CAA................GGG...............GC. .................A......ACCCgaggGACUGGU..................... ............................................................ ...........UC..........................................AGC.G GCA.....AACGGGUGA....GUAAUGGAc.............................. ............................................AGGUAACGUACccCC. ......AA....................GAC............................G .UG.GA..UAG..CU.C............AU.CGAAAG.A.UG................. ................A........................................... .............................................G.............. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......................A..................................... .....................UAAU....................ACG............ ........................................CG.................. ................AUAAUGUUGCagggcgauggcucugcaaagaaagCGGG...... ............CGCAAGCUCgCGCUUC...C............................ ..................GG.......A.......UC....................... .GG..........CCuguc.UC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUAGC..CUACCA AGG.CGAUGAC..GGGUAGCUGG...U....CUUAG.AGG..A..UGG..UCA...GCCA CAUUGGA.ACUGcGAUACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC AUG.....G...UCAAUGGGCGAA.AGC................CU...GA.AC...C.U GCGAC.GCCGC.GU......GAGUGAUG...AA...GGU.Cguaa..........GAUCG UAAAAC..........................U.CUU.........U...UC........ ............................................................ ......................A..................................... ....GGGAACUUAA.............................................. ............................................................ ............................................................ ............................................................ ....................AGCUCCGgUUCUAACAUAGCc................... ............................................................ ..................................................UG........ ......GA..GUCUGAcc..........................AUCCC.U.G.GAA..U .......AAGCCCCa............................................. ............GCCAACUAC.G.UGCCAGCAGCUGCGGUAAUAC.............GU AGGGGGCGAG..CGUUAUUCGGAAUUACUGGGUGU..AAAGGGU.A..UGUAGG...... ........C.GG.............C....CUcACAAGUCgcgUGUCAAAG.UC.C.... .........Ag.....................................C.GCUCAA.CGC .........U..G.G........G.........UUCGCAC.................... ..........................G..C..................G..A..UACUGU CAG...............G.CU....UGA..G..G....AC.............UGG... AGAGG..UGAG..CGGAAUUC......CC.....................GGUGUAGUGG U..AAAAUACGUA.GAU.AUCG.GG.AGGAACACCAGC.GGCGUA............GGC GGCUC.A.CUAGA..CAGUU..UCUGACGCUA....AGA.UACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGG....AUAC.......... ....UUGGU........................G.......UU....G.GG.....G... ....................G....GU........UA..............CC....... ....................UU.....................C................ .A.....GU........GCCGG.......AGC..UAACGCGU..........UAAG..UA UC.............CCACCUGGGGACUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GCGagGUAUG.UGGUUUAAUUCGAC.GCUACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....U....UG............................. ............................................................ .......................AGAA..............AGAG............... ............................................................ ......CC...............A............................Agaaacug gcuCCCCCAUG..ACCGCA....AGGUCAUggcuca........................ .......................UC................................... ...............CA.CAGG.UGCUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU AAGGUUAAGUCCUU.GAACGAGCGCAACCCCUU...UUGCUAG......U....UGCU.. .A.ACC..............AG.U.........A.AUG......G........CGc.... A.CCCUAGCGA.............UACUGCCAGCuaa......AA..G.UUG........ ...GAGGA.A.GGAG.GGGAUGACGUC..A..AAUCCUCAUGGCCUUUAUG.UCCAG.GG CUACACA.CAUGCgACAAU.GGU.CG..G.UACAA.CG................GG.... ....UC..G..............CA........A........CACC.....GC.GA.G.. ......G........UGAAGCCAAU......CUC.....U..A.AAAA.C..C..GA.CC UC.A....GUUCAGAUUGCAGGCUGCAAUUCGCCCACAUGAAG.AUGGAGUUGCUAGUAA CCGCGGGUCAG.C.UACA.CCGCGG.....UGAAUAUGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAACCACCCGA......GU..........................C...UG. ........UUGC.............ACCCGAA....GU...................U.. ...GCC........................Cguu.......................... ..........................................................GG GU.....GACGAA....GGUGU......................GG.............. CC.................GGUAAGG......A...GGGUU................... ............................................................ ............................................................ ........................................................... > UU.UUACA.....AC.GGAGAGUNUGAUCCU.GG.......................... ....CUCAG.GACNAACGCUGG.CGn..CNUGCCUA....ACACAU.GCAAGUCAAa... ........G........GA..................AAGCg.................. ...............C....CUU......C..G......GGUG................. ..CGAGUACUU................................................. .......Ggcgc................................................ ............................................................ .........AAGGGUGA....GUAAGgUA.UA.GG.UAAgu..................U .G.......................................................CC. ......UAC....................A............................GG .A.CcGGCAUAA.C.CC.CG...........AGAAA.U.CG.G................. ...............G............................................ .............................................GAC............ .................................................AAUA.CC.... ...................................GGAUG.A.U..GC............ ...........................AGC.............................. ...........................................GG............... AA.......................................................... .............................C.............................. .......CGCA.......UGGU..................UA.................. ..................................UguuguuaA.......AUCAGG..AA UG.......................................................... ............................................................ ............................................................ .......GCC.....U............................................ ..............................GUA........................... ...................G.......A.......UA....................... .AG..........CCUAUa.U....................................... .UCC..................AUCAGGU...AG.UUGGCGG.GGUAACGGC..CCACCA AG.CCUACGAC..GGAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CAUUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCAAC.GCCGC.GU......GGAUGAUG...AA...GU.CC.........UUC.GGGAUG UAAAG..........................UC.CUU.........U...UGcagagga. ............................................................ ....................................................A....... ......................................................GA.... ...AC.......................A...UGC......................... ............................................................ ................................UGG......................... U.....U.UACcg............................................... ............................G........................C...... ..........................................A................. ......GU..GACGGU............................ACUCU...GCGAA..U .......AAGCCAC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUGAUACA.............G GGGUGGCAAG..CGUUGUCCGGAUUUACUGGGUGU..AAAGGGU.G.C.GCAGG...... ........C.GGA.................AU.............AAUAAG.UCG.GG.. ..........G..........GU.......UAAA.......UCC.AUG.UGCUUAA.C.. ..A..C.......AU........G.........AC......A..U...G........... ......................CUUC...C..................G..A..UACUGU UAUU................CU....AGA..GU..G....Uc.............GA... AGAGG..AAGA..UGGAAUUU......CC.....................GGUGUAACGG UGG..AAUGUGUA.GAU.AUCG.GA.AAGAACACCAG.UGGCGAA............GGC AGUC.UU.CUGGU..CGACA..ACUGACGCUC....AG.GCACGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....AUAC.......... ....UAGAU........................G......UU.......GG......... ......................Uca.........U.................UCGU.... .....G..............AU.....................C................ .A.....GU........GUCG.......AAGC..UAACGCGU..........UAAG..UA UU.............CCACCUGGGAAGUACGCUCGCAAGAGUGAAACUCAA...AGGAAU UGACGGGGG.CCCA.CACA.AG.C.GGUGGAUCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCCGG........................................... ....GCUUGAA......AGgcuggc................................... ............................................................ .........UAA.......ACC............U...CCUG............A..... .....................................................AAGGGAG GGUU........................................................ .......C...............U............................U....... .....CG.................GG............................GAG... ..................CC...................................AGU.. ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUAC...AAUUAG......U....UGCU.. .AG.C....AGG........U..A.........A.A........G..CU.....GAGG.. A.CUCUAAUU............G.AACUGCCUACG...C..AAGU.....AGA....... ...GAGGA.A.GGAG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.UCCGG.GG CUACACA.CGUGAUACAAU.GGUA.A...CUACA.GAG................G..... ........G..............CA........AA........GCC.....GC.GA.G.. ......G........CAGAGGAAAU......CCC.....U..U.AAAAGUUaucc..... .U.A....GUCCGGAUCGGAGUCUGCAACUCGACUCCGUGAAGC.UGGAAUCGCUAGUAA UCGCAGAUCAG.C.AU.G.CUGCGG.....UGAAUGUGUUCCUGGGCCUUGU..ACACAC CGCCCGUCAAGUCAUGGAA......GU.............................UGGG ........A.G.............UACCCGAA....GA...................C.. ...GCG.U........AugCG......................................U .U........U.....A...AG.G.................UAAGa.............. ..............................................C............. .CA.................GUAACU.........GGGACUAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ............................................................ ..........GAUGAACGCUGG.CGG..CGUGCCUA....ACCCAU.GUAAGUC.....G AGC.....GAUC.............................................UU. ........................................G.UU........AGC..... ............................................................ ............................................................ ............................AAUAAUAAGAGAGC.................G GCGG.....AAGGGUGA....GUAACAC.GUA.GG.AGACC..................U ........................................A................CC. ......UCA...........................U......................C gcag.GGAACAAC.U.U.CG............CGAAAG.CG.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... .............C.AAAAGgcu.......................CGUGCCUUC..... ............................................................ ............................................................ ..........................AUUGG.....UACGAGG................. ............................................................ ............................................................ .............................A...............G.............. ...............AGUAUGC.......AAAU........................... ............................................................ ...............................G............................ ......CGug.....AU........................................... ...............................GA........................... ...................G.......AG............................... .....GGU.....CCUG.CGGC...................................... ..CC..................AUCAGCU...AG.UUGGUAG.GGUAACGGC..CUACCA AGG.CAACGAC..GGGUAGGGGG...U....CUGAG.AGG..A..CG..AUCCC...CCA CACUGGA.ACUGAAACACG.GUCC..AGACG...CCUACGGGUGGCAGCAGGGAGGAAUA UUG.....GG...CAAUGGACGAA.AG................UCU...GAC.C...C.A GCAAC.GCCGC.GU......GAAGGAUG...AA...GG.CC.........UUC.GGGUCG UAAAC..........................UU.CUU.........U...UAGggga... ..........................................................GA CGAGA....................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .......AAGGACGGU............................AUCCC..C.UGAA..U .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAAAC.............GU AGGUGGCGAG..CGUUAUCCGGAUUCAUUGGGCGU..AAAGAG.CU..UGUAGG...... .........UGGUG.................CG.............AUAAG.UUG.G... .........AC..........GUG.......AAA.......ACUC.CG.GGCUUAA.C.. ..U......U..G.Gagaggc..........CG........................... ........................U...UC..................A..A..UACUGU UGU...............G.CU....AGA..G..GG....CG.............U.C.. AGAGGG..AAG..UGGAAUUC......CU.....................GGUGUAGCAG UG..AAAUGCGUA.GAU.AUCA.GG.AGGAACACCCG.UGGCGAA............GGC GGCU.U.CCUGG..GACGUAC..CUGACACU....GAGA.AGCGAAAGCUAGGGGAGCAA ACGGGAUUAGAAACCCCGGUAGUCCUA.GCUGUAAACGAUGG....AUGC.......... ....UAGGU........................G.......U...GAGuGG........A ...............U.....C.........UAA........C........C.....Ccg c........................................................... ..UC...GU........GCCG.......AAGC..UAACGCGU..........UAAGC..A UC.............CCGCCUGGGAACUACGAGCGCAAGCUUAAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.CA.GCGGAGCGUG.UGGUUUAAUUCGAU.GCUACACG .AAGAACCUUA.CCCAG........................................... ....GUUUGA.....C...A.................UG..................... ...................C....A....................G.........GUG.. ..........GUA............................................... ............................................................ .................................Gu............GAAGCGAAAGCGG AacgA.....................................C................. ..............CCGCA....AGG............................GAG... ..................CC...................................UG... ...............CA.CAGG.UGUUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGUUUAAGUaccC.UAACGAGCGCAACCCUCG...UUGCCAG......U....UACA.. .AGUG....................................................... ...UCUGGCGA.............UACUGCC.G..G.Ccg..CAA..GCC.G........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AGUCAGCAUGGCCUUUAUA.UCUGG.GG CUACACA.CACGCUACAAU.GGAUCG...CAACAA.UG................GG.... ....U.A.G..............CC........AA........ACC.....GC.GA.G.. ......G........CGGAGCCAAU......CCC.....A..U.AAAA.Cg....GU.CC UC.A....GUUCAGAUUGCAGGCUGCAACCCGCCUGCAUGAAG.UCGGAGUUGCUAGUAA ACGCGCGUCAG.CUAU.Agugcg......UUGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACuAUGGGA......G..........................C...UGGC ........A.AC.............ACCUGAA....G...................CCAg uaGC..........................GU.....A....A.........CCG..... ..............C.A...AG.G.................AGCGc............GC .U.....GUCAAA....GGUG......................GGG.............. CU.................GGUGACU.........GGagug................... ............................................................ ............................................................ ........................................................... > gaaggg.......U...UAGAGUUUGAUCCU.GG.......................... ....CUCAGA.AUGAACGUUGG.CGG..CGUGGAUU....AGGCAU.GCAAGUC.....G AGC.....GA........G...AAg................................... ............................UUUUAAAAAGA....UG.........CUUCGG ............................................................ .......................................................UUGAU UUUUAAAAcGGAC..........................................AGC.G GCG.....AAAGGGAGA....GUAACGagua............................. ............................................................ ............................................................ ................................G.AU.ACG.UACCCAaggguucGGGAUA GCCAUGcGA................................................... .......................................AACGGUGAG............ .................................................UAAUACC.... ...................................GAAU.AA.U..G............. .....................................UC..................... .........................................................Ucc ............................................................ ............................................................ ............................................................ .................GG......................................... ...AC............AAAGAU..................................... .....................UUAU....................U.............. ............................................................ .......GCCC.....U........................................... ...............................UG........................... ..................GAG...............C....................... .GGuuugcu...........U....................................... .ACU..................AUUAGCU...UG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CUUAGA..UGCUUAGCGG.............G.UGUGA..GAG..AUgacccGUCU CACUGGG.ACUGAGACACU.GCCC..AGAC..A.CCUACGGGUGGCUGCAGUCGAGAAUC UUC.....CG...CAAUGGACGAA.AG................UCU...GACA...G.GA GCGA..GCSGC.GU......GCUGGAUG...AA...GG.CC.........CUC.GGGUUG UAAAG..........................AG.CU.........GU...NG........ ............................................................ ......................UagggGAG.............................. ....GG................................................G..... .....................................................A...... .............GGA..................AAUuucACCGAUCcUAGGAG...... ....................................................GAAGU... ............................................................ ............................................................ ............................................................ ............................................................ ..........CACA..................G........................... ............GCUAAGUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GG ACUGUGCAAA..CGUUAUUCGGAAUCACUGGGCUU..AAAGGGU.G.C.GUAGG...... ........C.GG.................GUUgg.............UAGG.UCA.G... .........A..........UGUG.......AAAG.......CCC.AC.GGCUCAA.C.C ...G.........UG........G.........AA......U..U...G........... ......................CGU...U..................UG..A..AACcAC UAGU................CU....UGG..G..GGg.................AU.C.. AGAGG..AGAG..CGGAACUGA......U.....................GGUGGAGCGG UG..AAAUGCGUU.GAU.AUUAU.C.AGGAACACCGG.UGGCGAAA............GC GGCUC.U.CUGG..GAUcCU..UCUGACGCU....GAG.GCACGAAAGCUAGGGGAGCGA ACGGGAUUAGAUACCCCGGUAGUCCUA.GCUGUAAACGAUC................... ......................UGUACUAGUccG.......U...G.G.GG........A CCcacauc.......................UU..................CUCGGAC.. ............................................................ ....................G.......UAGCG.AAA.GUGU..........UAAG..UA CAg.............CGCCUGGGANGUAUGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CUCA.CACA.AGgC.GGUGGAGGAUG.UGGCUUAAUUCGAG.GCUACNCG .AAGAACCUUA.CCUAG........................................... ....ACUUaA.....C...A.................UGU.................... ........UUGAGaau............................................ .....................C............U....CUG............UG.AAA GCA...............G....AGA....................G............. ...................................UG....................... .....CC...............UU............................U....... .....CG.................GG............................GAACuc uuac......................G.U............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU CGGGUUAAGUCCCU.UAACGAGCGAAACCCUUA...UCUUCAG......U....UGC..C .AG.C.G.............AG.U.........A.AUGU..............CGGGG.. A.CUCUGGAGA............G.ACUGCC.G..G.UG.UU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCUUUAUG.UCUAG.GG CUGCACA.CGUCCUACAAU.GCAAC...G.UACAA.AGC................GA... ........G..............CG........AA........AUC.....GC.GA.GA. ...............UCAAGCAAAC......CGCACAAAACGUU.............G.C CC.A....GUUCGGAUUGCAGGCUGAAAUUCGCCUGCAUGAAGC.CGGAAUCGCUAGUAA UCGUAGGUCAG.C.AU.A.CUACGG.....UGAAUGUGUUCCUGAGCCUUGU..ACACAC CGCCCGUCAAGCCACGAAA......GU.............................UGGG G.........GG.............GCCCGAA....GU...................C.. ...GCG.A........U............GCU.....A....A.........CCG..... ..............C.A...AG.G.................AC.....Gua........G ....C..GCCGAA....GGUcaac.........................U.......... .C.................GAUGAUU.................................. ............................................................ ............................................................ ........................................................... > ...................GAGUUUGAUCCU.GG.......................... ....CUCAGA.AUGAACGUUGG.CGG..CAUGGAUU....AGGCAU.GCAAGUC.....G AGG.....Gagaa...............................C............... .CC................GCAA................GGG...............G.. ............................................................ ...A............................C........................... .......................................................ACC.G GCG.....AACGGGg............................................. ..............................UAGG.......................... ............................................................ .........AAUA..CAU............AGG.UA.ACG.UACCCUcaggacgGGGAUA GCCAAGggaaacuuuG............................................ .............................................G.G............ .................................................UAAUACC.... .............C......................GAUG.................... ....................................U....................... ...........................................GaugucA.......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................GG.......A.......U........................ GUG.....A.....AUG.CcugccaucaaaggugagauuccaccugaggagcggcuuauG CAUC..................AUUAGCU...UG.UUGGCGG.GGUAACGGC..CCACCA AGG.CUGCGA..UGAUUAGGGG.............G.UGUGA..GAGcauggcccccac. CACUGGC.ACUGAGACACU.GGCC..AGAC..A.CCUACGGGUGGCUGCAGUCGAGAAUC UUC.....GG...CAAUGGGCGAA.AGC................CU...GAC.C....GA GCGAU.GCCGC.GU......GCGGGAUG...AA...GG.CC.........UUC.GGGUUG UAAACC..........................G.CU.........GU............. ...................................................CGG...... ....................AG...................................... ....GGGAU.....G..................AA...................GUGUAU GGGAGCA.....A..............Ucucc......................UG.... ............................................................ ..................U....AU................................... ............................................................ .............................U.............................. ............................................................ .......U..GACAGAg.............................CCU..CG.GA.... G..G...AAGCAC..................GG........................... ............GCUAAGUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA ACUGUGCAAA..CGUUAUUCGGAAUCACUGGGCUU..ACAGGGU.G.C.GUAGG...... ........C.GG.............C....AU.............UUUAAG.UCA.GG.. ....................UGUG.......AAA.......UCCC.CC.GGCUCAA.C.C ...G........G.G........G.........AAC........U...G........... ......................CGCC.................................. ......UGAGACUGGAUUG.CUC....GA..GU..G....AG.............G.C.. AGGGG..UGUA..CGGAACUU......CC.....................GGUGGAGCGG UG..AAAUGUGUA.GAU.AUCG.GA.AGGAACGCCagca.GCGAAA............GC GGUACA.C.UGG..GCCUUG..UCUGACGCU....GAG.GCACGAAAGCCAGGGUAGCGA ACGGGAUUAGAUACCCCGGUAGUCCUG.GCCGUAAACAAUGAGcacugggggagggacgg .................................G.......UCACC....G........U ...............U.....C.........UUU........C........C.....C.. ............................................................ ....................G.......UAGCG.AAA.GCGU..........UAAG..UG CU.............CCGCCUGGGGAGUAUGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CUCA.CACA.AG.C.GGUGGAGCAUG.UGGCUUAAUUCGAG.GCAACGCG .AAGAACCUUAuCCUAG........................................... ....ACUUGA.....C...A.................UG.............G....... ........................U....................G.........G.... ........GAUU.......AGU.........................UGG.......... ............................................................ .....CUGAAAGGucaaugacgccuucgggUGGA.......................... ............................................................ ............................................................ ...................ACC..........................A..U........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU CGcGUUAAGUCgCU.AAACGAGCGAAACCCCUG...UUCUUAG......U....UGC..C .A.AC....A.....C.....G.Uc..........AUG......G...U.....GGGG.. A.CUCUAAGAA............G.ACCGCC.G..G.CG.U.CAA..GCC.G........ ...GAGGA.A.GGCG.GGGAUGACGUC.....AGUCCUCAUGGCCUUUAUG.UCUAG.GG CUGCACA.CGUGCUACAAU.GGGA.U..G.UACA.GAG................GG.... ....AC..G..............CC........AA........GC.....UGCGAA.... ......G........Ccga.GCAAA......CCC.......CA.AAAAgcau....C.CC UC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAGC.CGGAAUCGCUAGUAA UCGCCGGUCAG.CAAU.A.CGGCGG.....UGAAUGUGUUCCUGAGCCUUGU..ACACAC CGCCCGUCAAGCCACGAAA......G..........................Cgggggg. ..............................................CGCCUAAAGACA.. ....C.UU.......GU.............CU.....A....A.........CCG..... ..........U.....A...AG.G.................AG.....GAC.......GG .....Uguuuag.....GGCGAA.........................ACUC........ ....................GUGAUU.........GGGACUAAGUNG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > g........................................................... ...........AUGAAUGCUGG.CGG..CGUGUCUA....AGGCAU.GCAAGUC.....G AGC.....G........GA..................AGCaacA................ .......AUG.............................................UAGC. .................A......A.................UAC.......AAGGUugu uuuAGC...................................................... ...........................................................G GCAG.....ACGGGAG....CGUAACACA.UU.GG.UAACC..................U ........................................A................CC. ......UU....................GU......Acucgc.................. ......GAAUAAC.U.A.C...........UGG.AA.ACGG.U................. ................A........................................... .............................................G.C............ .................................................UAAUACgcgau auggaugcgggggC.UUAUGCCAUUCgc................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............AUUGAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGUAC................................................ ............................................................ ..............................................AA.........GAG GGG..........CCuau.GU....................................... .UCC..................AUCAGGU...AG.UUGGCGG.GGUAACGGC..CCACCA AG.CCUUUGAC..GGAUACCaggcgc.........G.AGAGC..GUG..ACCU...GgCU CACUGGG.ACUGAGACACU.GCCC..AGAC..A.CCUACGGGUGGCUGCAGUCGAGAAUA UUC.....CG...CAAUGUACGAA.AG................UaU...GAC....G.GA GCGAC.GCCGC.GU......GUCgAAAG...AA...GG.CC.........UUC.GGGUUG UAAACG..........................A.CUU.........U...UC........ ............................................................ ......................U.....C............................... ...AG........GG..................ACGA....................... ............................................................ ............................................................ ............................................................ ...................AAC...................................... .............................A.............................. ............................................................ .......U..GACGGU............................ACCU.GA.G.GAA..U .......AAGGGgUU............................................. ............GCUAACUCU.G.UGCCAGCAGCAGCGGUAAUACA.............G AGAcCCCGAG..CAUUAUCCGGAUUUAUAGGGCGU..AAAGCGU.U.C.GUAGG...... ........C.GG.............C....UU.............UGUAAG.UCAUC... ....................UGU.......UAAA.......UCU.UC.AGGCUCAA.C.C .........U..G.GAGGCUGCGGGUGAUACUGUA......AG.....G........... ......................CUC................................... ...........................GA..GU......AUG.............GG... AGAGG..UGcauggagug..C......CC.....................GGUGUAGCGG U..AAAAUGCGUUA.AU.AUCG.GG.UAGAACACCA.AAGGCGAAA............GC AaugC.A.CUGGA..ACAUU..ACUGACGCUC....AU.GAACGAAAGCGUGGGUAGCGA AAGGGAUUAGAUACCCCUGUAGUCCA.CGCCGUAAACGAUGA....UAAC.......... ....UAGAUU...............................UU....G.GG......... ...................AGU.A.......U.CGA.....CC........CU....... .................................CC........C................ .A.....GA........GUCGuugaaCCAAGC..UAACGCGU..........UAAG..UU AU.............CCGCCUGGGAAGUACGGUCGCAAGACUAAAACUCAA...AGGAAU AGACGGGG.ACCC.GCACA.AG.C.GGUGGAUCAUGC.GGUUUAAUUCGAU.GCAACGCG .AGAAACCUCA.CCUGG........................................... ....GCUUGAA......AACuagC.................................... .........UGCUAA.UCCC....U....AG............................. ............................................................ .......................AGAU..............AGGGGC............. ............................................................ ............................................................ ..............................UCCUUCGAGGGU.................. ........GcUAGU..............U............................... ...................AGG.UGCUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU ACCCUUAAGUGGAC.UAACGAGCGCAACCCCUG...UCAUgcguuauauU....UUCG.. ............................................................ ......CAUGA............G.ACUGCuuC...CGC.AAG....G...GA....... ...GAGGA.A.GGAA.GGGAUGACGUC..A..AAUCAGCAUGGCCCUUACG.UCCAG.GG CAACAC.GCAUGAUACAAU.GGC.CG..G.UACAA.AG................GG.... ....U.U.G..............CC........AA........ACC.....GC.AA.G.. ......G........UGGAGCCAAU......CCC....AU..A.AAA..C..CG.G.U.C UC.A....GUUCGGAUCGGAGUCUGCAACUCGACUCCGUGAAGC.CGGAAUCGCUAGUAA AGGu.....AG..AU.CAU.CACGcuaccUUGAAUACGUUCUCGGGUCUUGU..ACUCAC CGCCCGUCACGUCAAGAGAA......U.............................UGG. .......UAA.C.............ACCCGAAcgucGU...................C.. ...GU.UA.......GA.............Cggcg......................... ............................................................ ..........GAA....GGUG......................GG...AU.......... .CA.................GUAAUA.........GGGACG................... ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUNNU.GC.......................... ....CUCAGA.UUGAAUGCUG.ACGG..CGUGGAUG....AGGCAU.GCAAGUC.....G AAC.....G.......A.A......................................... ........A......C........................GG...............GC. .................A......ACC................................. ...............GU.............UUAG....U..................... ...........................................................G GCGG.....AAGGGUUA....GUAAUACA.UG.GauAA.CU..................U GCCUU.....................UAACUUUGGGauaacgauUGGAAACGAUCgcuaa uaccaaAU....................GU............................GG .UG.GGGGUAAU.......................U.A.A.AU................. ................Uuacc....................................... ............................................................ ............................................................ ......................................U.UU.A................ ............................................................ ............................................................ ....................................UCAAAG.................. ...........U................................................ ............................................................ ............................................................ ......................G.......GG............................ .........................GGAUCGCAA....GACCUC................ .........G.................................................. ......CGGU.....UA........................................... ...............................AA........................... ...................G.......AGagguc.......................... ............................................................ ..............CAUGGGAUAUCAGCU...AG.UUGGUGU.GGUAAUGGCG..CACCA AGG.CUAAGAC..GUCUAGGCGG...A....UUGAG.AGA..U..UG..ACCGC...CAA CACUGGG.ACUGAGACACU.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUCGAGAAUC AU.....UCG...CAAUGGGCGAA.AGC................CU...GAC....GA.U GCGAC.GCCGU.GU......GAGCGAUG...AA...GG.CC.........UUA.GGGUCG UAAAGC..........................U.CUU.........U............. ...................................................CG....... .....................C......C............................... ...UGG................................................G..... .....................................................Ag..... ..................................CAAGAGAAGccgacua.......... ..........AUAUUCGG.......................................... .............C......................UAAU...................U UGAGA....................................................... ............................................................ ..............GU............................ACCA.G..GUAAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCUGCGGUAAUAC.............GG AGGGUGCAAG..CAUUAAUCGGAUUUAUUGGGCGU..AAAGGG.CG.C.GUAGG...... ........C.GG.................GAAC.............AUAAG.UCA.G... .........A..........UGUG.......AAA.......UCC.UGG.AGCUCAA.C.. ..U..C....C...A........G.........AAC........A...G........... ......................CAU...U..................UG..A..AACUAU AUUU................CU....UGA..G..GG....U.............AGGC.. .GGAGA..AAA..CGGAAUUC......CACA.....................UGUAGCGG UG..AAAUGCGUA.GAU.AUGU.GG.AAGAACAuCGG.UGGCGAA............GGC GGUU.UUCU.AGC..UUAUUC..CUGACGCU....GAG.GCGCGAAAGCAAGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCUU.GCCGUAAACGAUGU....AUAC.......... ....UUGGU........................G.......UAA................ ........UUGGACUC..........A........A.....CC........CC....... ....................AAU..................................... .U.....GU........GCCGG.......AGC..UAACGCGU..........UAAG..UA UA.............CCGCCUGGGGAGUACGCUCGCAAGGGUGAAACUCAA...AAGAAU UGACGGGG.ACCC.GCACA.AG.CA.GUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCCAG........................................... ....ACUUGA.....C...A.................UG..................... ...................C....A....................GAagacagcUU.... ..........................................................U. ...........AGAGAUAG....AGU....................GUU..C........ .............C................U............................. ............................................................ ..................U....AGG............................GACUu. ...................C...................................UG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCAUUAG......U....UGC..C .A.AC....A.....C.....G.U.........A.AUG......G...U.....GGGA.. A.CUCUAAUGA............G.ACUGCCUG..GG....U.UAAC.C.AG........ ...GAGGA.A.GGUGA.GGAUGACGUC..A..AGUCCGCAUGGCCCUUAUG.UCUGG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACA.GAA................GGC... ......A.G..............CG........AA........GCC.....G.UGA.G.. ......G........UGAAGCAAAU......CCC.....A..A.AAA.GC..CG..AU.C CC.A....GUUCAGAUUGUAGUCUGCAACUCGACUACAUGAAG.AUGGAAUUGCUAGUAA UGGCGAGUCAG.C.AACAU.CGCCG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACAUCAUGGGA......GU.............................UGG. .......UUU..............UACCCGAA....G...................CC.. ...GC.U.......G.ACU............U.....A....A.........CCG..... ..............C.A...AG.G.................AGAGAAG............ ....C..GUCGAA....GGUGA......................GG.............. CU.................GAUGACU.........GGGAUGAAGUCG.UAACAA.GGUAG CCC.UAU.CGG.AAG..........GUGGG.....G.............CUG......GA U............CACCUCCUUUNUg.................................. ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAAUGCUG.ACGG..CGUGGAUG....AGGCAU.GCGAGUC.....G AAC.....G.......A.A........GU...................A........... .........G.............................................UAAC. .............UUGUU......A..........................C........ ........U.......AC............UUAG....U..................... ...........................................................G GCG.....AAAGGGUUA....GUAAUACA.UGaGU.AACUUACCUc.............. ............................................................ ............................................................ .........UUAC..CUG.GGGAUAACGGUUGG.AA.ACG.ACC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GAAU..................... .......GA...........GGAgagcug............................... ............................................................ ............................................................ ............................................................ ............................................................ ..GGGUAGC.........................................C......... ..U.........G...GUUUcuucAAAGUUGG............................ .........................GGAUUCU............................ ............................................................ .......GCA.....AA........................................... ...............................GA........................... ............................................................ .AC..........CUUG.CGG....................................... .UaggagagaggcuCAUGGGAUAUCAGCU...UG.UUGGUGU.GGUAAAGGCG..CACCA AGG.CUAAGAC..GUCUAGGCGG.....G..CUGAG.AGG..U..UG..ACCGC...CAA CACUGGG.ACUGAGACACU.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUCGAGAAUC AU.....UCG...CAAUGGGCGAA.A.C................GU...GAC....GA.U GCGAC.GCCGU.GU......GAACGAUG...AA...GG.CC.........UUC.GGGUUG UAAAG..........................UU.CUU.........U............. ...................................................CG....... .....................C......U............................... ...AAG................................................G..... .....................................................AA..... ..................................CAAGA..............AAA.... GGUAAc...GA................................................A U.....A.AUUGCC......................UAAU...................U UGAG........................................................ ............................................................ .............GGU............................ACUU.G..GUAAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCUGCGGUAAUAC.............GG AGGGUGCAAG..CAUUAAUCGGAUUUACUGGGUGU..AAAGGG.CG.C.GUAGG...... ........C.GG.................GUA.............AGCAAG.UCA.G... .........A..........UGUG.......AAA.......UUCC.GG.AGCUCAA.C.. ..U..C....C...G........G.........AGC........U...G........... ......................CAU...U..................UG..A..AACUAC UUAU................CU....UGA..G..GG....Ugga.............C.. .GGAGA..AAA..CGGAAUUC......CAC.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUGUA.G.AAGAACACCGG.UGGCGAA............GGC GGUU.UUCU.AGU..UCUUUC..CUGACGCU....GAG.GCGCGAGAGCAAGGGGAGCAA ACAGGgUUAGAUACCCUGGUAGUCCUU.GCUGUAAACACUGC....AUAC.......... ....UUGGU........................G.......UA....GUC.......... ..........GGUCUC..........A........A.....CC........CC....... ......G..............A.....................C................ .U.....GU........GCCG.......UA.CG.UAACGCGU..........UAAG..UA U.............GCCACCUGGGGAGUACGCUCGCAAGGGUGAAACUCAA...AAGAAU UGACGGGGG.CCC.GCACA.AG.CA.GUGcAGCAUG.UGGUUUAAUUCGAU.GCAACACG .AAGAACCUUA.CCCAG........................................... ....GCUUGA.....C...A.................UU.........UAGAG....... ............GACC............................................ .............................GCA..U....CAG............AG.AUG A......................UG................................... ............................................................ ......................UU............................UG...... ..............CCGCA....AGG..Ccuuc........................... ................................................U..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCGCUAG......U....UAC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGG.. A.CUCUAGCGA............G.ACUGCCAUGGUUAAC.........UAG........ ...GAGGA.A.GGUGA.GGAUGACGUC..A..AGUCCGCAUGGCCUUUAUG.UCUGG.GG CUcgACA.CGUGCUACAAU.GGU.CG..G.UACA.GAA................GGC... ......A.G..............CG........AA........GCC.....G.AAA.G.. ......G........UGAAGCAAAU......CCC.....A..A.AAG..CU.C..Gau.. CC.A....GUUCGGAUUGAAGUCUGCAACUCGACUUCAUGAAG.UUGGAAUUGCUAGUAA UGaCGUGUCAG.C.AAUAA.CGuCG.....UGAAUACGUUCCCGGGCCUUGU..ACACgC CGCCCGUCACAUCAUGGAA......GU.............................UGG. .......UUU..............UACCCGAA....GU...................C.. ...GUC........G.ACU.................CA....A.........CCG..... ..............C.A...AG.G.................AGAGAga............ ....C..GCCGAA....GGU......................AGGG.............. CU.................GAUGACU.........GGGAUGAAGUCG.UAACAA.GGUAG C.G.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUA..................................... ........................................................... > ggc..........U...UAGAGUUUGAUCCU.GGU......................... .....UCAGA.UUGAAUGCUGGACGG..CGUGGAUG....AGGCAU.GCAAGUC.....G AAC.....G.......A.A........GUGUgcucuu....................... ............................................................ ....................G..........................AGUGC........ ........A.......AC............UUAG....U..................... ...........................................................G GCGG.....AAGGGUUA....GUAAUACA.UG.GG.UAAUC..................U ........................................A................CC. ............................................................ .......UUUAAC.U.CU.GGGAUAACGGUUGG.AAaACG.ACC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GgugcuagagagGAUCU....................... ........................................UUUuagcauu.......... ......................................AAAG.................. ...........U................................................ ............................................................ ............................................................ ......................G.......GG............................ .........................GGAUugggcgaccGACCUUA............... ............................................................ ......CGGU.....UA........................................... ...............................AA........................... ...................G.......A.......A........................ GGG..........CCCac.......................................... .................GGGAUAUCAGCU...AG.UUGGUGAA.GUAAAGGCU..CACCA AGG.CUAAGAC..GUCUAGGCGA.....G..UUGAG.AGA..U..UG..ACCGC...CAA CACUGGG.ACcgagacgCU.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUCaaaAAUC UU.....UCG...CAAUGGGCGAA.AGC................CU...GACA....A.A cCGAC.GCCGU.GU......GAAUGAAG...AA...GG.CC.........CUU.GGGUCG UgAAU..........................UU.CUU.........U............. ...................................................CG....... .....................C......A............................... ...UGG................................................G..... .....................................................AA..... ..................................CAAGAGAAGGAU.............. .........................................................GCU A.....A.UAUCaucu............................................ ............................................................ .....................GGAUUUGAGC............................. ..............GU............................ACCUU...GUAAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCUGCGGUAAUAC.............GG AGGGUGCGAG..CAUUAAUCGGAUUUAUUGGGCGU..AAAGGGG.G.C.GUAGG...... ........CUGGA.................AU.............AUAAU..UCA.GC.. ..........C..........GUG.......AAA.......UCCC.GG.GGCUCAA.C.C .....C....C...G........G.........AAC........U...G........... ......................CGU...U..................UG..A..AACUAU AUUU................CU....AGA..G..GC....A.............AGGC.. .GGAGA..AAA..CGGAAUUC......CCCA.....................UGUUGCcg gugAAAAUGCGUA.GAU.AUUU.GG.AAAAACACCAG.UGGCGAA............GGC GGUU.UUCU.AGC..UUUGAC..CUGACGCU....GAU.GCCCGAAAGCUAGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCGUAAACGAUGC....AUAC.......... ....UUGGU........................G.......UA....GCC.......... ..........GGACUC..........A........A.....CC........C........ ............UG.......G.....................C................ .U.....GU........GCCG.......UAGC..UAACGCGU..........UAAG..UA U.............GCCGCCUGGGGAGUACGCCCGCAAGGGUAAAACUCAA...AAGAAU UGACGGGG.ACCC.GCACA.AG.CA.GUGGgGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UA.........UA....C..... .........................A.UG.Acggc......................... ..........................UC..............................U. ...........AGAGAUAG....AGU.................................A U........................................................... ........................U................................... ......CCUUC..G..........GGA.CAUa............................ ..................................................UA.....U.. ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCGUUAG......U....UGC..C .AG.C....A..........U..U.........U.A.GgA........U.....GGGA.. A.CUCUAACGA............G.ACUGCCUG..GG....U.UAAC.C.AG........ ...GAGGA.A.GGUGA.GGAUGACGUC..A..AGUCCGCAUGGCCCUUAUG.GCCAG.GG CUACACA.CGUGCUACAAU.GGCA.G..G.UACA.GAA................GGC... ......A.G..............CG........AA........ACC.....GC.GA.G.. ......G........UCAAGCAAAU......CC.....UACGAA.............G.C CuggcccgGUUCGGAUUGGAAUCUGCAACUCGGCUCCAUGAAG.UUGGAAUUGCUAGUAA UGGCGUGUCAG.C.AAUAA.CGCCG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCUCAUCAUGGGA......GU.............................UGG. .......UUU.C.............ACCCGAA....GU...................C.. ...GC.U.......G.ACU............U.....A....A.........CCG..... ..............C.A...AG.GGA...............AGAG..........GU... .......GCCGAA....GGUGA......................GG.............. CU.................GAUGACU.........GGGAUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUUA.................................... ........................................................... > ugagaa................UUUGAUCUU.GGU......................... .....UCAGA.UUGAACGCUGG.CGG..CGUGGAUG....AGGCAU.GCAAGUC.....G AAC.....G........GA..................A...................... ............................................................ .........CGG.........................................U...... ...UUUAU..AGCU.GU.............UUAG....U..................... ...........................................................G GCGG.....AAGGGUUA....GUAAUGCA.UA.Gau........................ ............................................................ ......AA..............U......U......U......................G .U.CU...UUAAC.U.UG.GGaAUAACGGUUGG.AA.ACGG.CC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GAAU..................... .......GU...........GGcgc................................... ............................................................ ............................................................ ............................................................ .......UAUUUA...........GGCAUC.............................. .............................UAG..A.......U..G.....G........ ..U.........Gu...U......AAAGAAGG............................ .........................GGAUCUUAG....GACCUUU............... ............................................................ ......CGGU.....UA........................................... ...............................AA........................... ...................Ggg...................................... GAG.....U.....CUAUgu........................................ ...................GAUAUCAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGAUGAC..GUCUAGGCGG...A....UUGAG.AGA..U..UGg..CCGC...CAA CACUGGG.ACUGAGACACU.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUCGAGAAUC UU.....UCG...CAAUGGACGGA.AG................UCU...GAC....GA.A GCGAC.GCCGC.GU......GUGUGAUG...AA...GG.C.........UCUA.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................CG....... .....................C......C............................... ...UGG................................................G..... .....................................................AAUAAGA gaagg....................................................... ............................................................ ............................................................ ............................................................ ......CGGUUAAUACCCGUcGGAUUUGAGC............................. ..............GU............................ACUA.G..GUAAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCUGCGGUAAUAC.............GG AGGGUGCUAG..CGUUAAUCGGAUUUAUUGGGCGU..AAAGGG.CG..UGUAGG...... ........C.GGA.................AG.............AGUAAG.UUG.G... .........U..........UGUC.......AAA.......UCUC.GG.GGCUCAA.C.C .....C....C...GA.................AUCg...........G........... ......................CAUC.....................UG..A..UACUAU UUUU................CU....AGA..G..GG....U.............AGA... UGGAGA..AAA..GGGAAUUU......CAC.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUGU.GG.AAGAACACCAG.UGGCGAA............GGC GCUU.UU.CU..AAuUUAUAC..CUGACGCUA....AG.GCGCGAAAGCAAGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCUU.GCCGUAAACGAUGC....AUAC.......... ....UUGAU........................G......Ug.................. .......GAUGGUCUC..........A........A.....CC........CC....... ....................AU.....................C................ ...C...GU........GUCGG.......AGC..UAACGCGU..........UAAG..UA U.............GCCGCCUGAGGAGUAcaCUCGCAAGGGUGAAACUCAA...AAGAAU UGACGGGGG.CCC.GCACA.AG.CA.GUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGgACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UG..................... ...................C....A....Uaugaccg....................... .............C...................GG....CAG............AA.AUG UC......................G................................... ............................................................ ......................UU............................U....... .............UCCGCA....AGGACAU.............................. .....................A.................................UG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCGUUAG......U....UGC..C .AG.C....A.....C....U..U.........AG..G......G...U.....GGGA.. A.CUCUAACGA............G.ACUGCCUG..GG....U.UAAC.C.AG........ ...GAGGA.A.GGCGA.GGAUGACGUC..A..AGUCAGCAUGGCCCUUAUGC.CCAG.GG CGACACA.CGUGCUACAAU.GGC.CA..G.UACA.GAA................GG.... ....U.A.G..............CA........A......G..AUC.....Gu.GA.GA. ...............UGGAGCAAAU......CC.....UU..A.AAGCU......GG.CC CC.A....GUUCGGAUUGUAGUCUGCAACUCGACUACAUGAAG.UCGGAAUUGCUAGUAA UGGCGUGUCAG.Cc.AUAA.CGCCG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCAUGGGA......GU.............................UGG. .......UUU..............UACCUUAA....GU...................C.. ...GU.U.......G.ACU.................CA....A.........CC...CGC gagggga..................................................... GAGGC..GCCCAA....GGUGA......................GG.............. CU.................GAUGACU......A...GGAUGAAGUCG.UAACAA.GGUAG CCC.UA.CCGG.AAG..........GUGGG.....G.............CUG......GA U............CACCUCCUUUU.................................... ........................................................... > ............................................................ ..........GAUGAACGCUGG.CGGUc..UGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GG......................................... .CU...................................................CUUCGG ..........A................................................. .......G.......C....U....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACAC.GUGA.G.AAUC...................U .GG.......................................................C. ......UcccG....................G............................ ..UC.GGGACAA.CAG.A.GGGAAAC.............U.UC................. ................U........................................... .............................................G.C............ .................................................UAAUCCC.... ...................................GGAUG.................... ....................................A....................... ...........................................GCCGAA........... ............................................................ ............................................................ ............................................................ .................AG..........................G.............. ...............UAAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGC..CgG.............................................. ...............................GA........................... ...................G.......A.......U........................ GAG..........CUCG.CGUC...................................... ..UG..................AUUAGCU...AG.UUGGUGA.GGUAAAGGCU..CACCA AGG.CGACGA..UCAGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUC.....CG...CAAUGGGCGNA.AGC.................U...GAC....G.GA GCAAGA.CCGC.GU......GGGGGAGG...AA...GG.C.........UCUU.GGGUNG UAAACC..........................C.CUU.........U...UC........ ............................................................ ......................U.....C............................... ...AA........GG..................AA...................G..... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................AAcac..............................A...A .......U..GACGGU............................ACUU.GA.G.GAA..U .......AAGCCUC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGAGGCAAG..CGUUAUCCGGAAUGAUUGGGCGU..AAAGCGU...CCGUAGG...... .........UGG.............C....AGUUCAAGUCUGCUGUCAAAG.ACA.G... .........U..........AGCUCAAC................................ ............................UACUGAA......AG.....G........... ......................CA.G..UG..................G..A..AACUGA ACA...............G.CU....AGA..GU......ACG.............GU... AGGGGC..AGA..GGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AAGAACACCGG.UGGCGAAA............GC GCUC.UGC.UGG..GCCGUA..ACUGACACU....GAG.GGACGAAAGCUAGGGGAGCGA AUGGGAUUAGAUACCCCAGUAGUCCUA.GCCGUAAACGAUGG....AAAC.......... ....UAGGU........................G.......UA....GCC.......... ...................UGU.A.......U.CGA.....CC........C........ ............GG.......G.....................C................ .U.....GU........GCCG.......AAGC..UAACGCGU..........UAAG..UU UC.............CCGCCUGGGGAGUACGCACGCAAGUGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UGUC................... ...........................CGG.............................. ..........................AAUC.........................U.U.G ............GUGAAAGCCG...AG..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA...........................G..... ...................CC.........................G.G..A........ ..............ACA.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UCCUUAG......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUUUAGGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUACG.UCCUG.GG CUACACA.CGUACUACAAU.GGGG.G..GG.ACAA.AG................GG.... ....U.A.Ga..............C........AA........GAC.....GC.GA.GUc ........U........GAGCCAAU......CCC.G......U.AAA..C..Cuc.U.CC UC.A....GUUCAGAUUGCAGGCUGCAACUCGCCUGCAUGAAGG.AGGAAUCGCUAGUAA UCGCAGGUCAG.C.AU.A.CUGCGG.....UGAAUCCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGAA......GU.............................UaGC C.........AC.............GCCCGAA....GU...................C.. ...GU.UACUCUA.....................................A......CCG UUCGCG....................................GAG..........GA... .......GG................AU......GCCGAAGGCAGGG.............. CU.................GAUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGUG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ga.....A.....AC.GGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGGU..AUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GUCU....................................... ......................................................CUUCGG ..........A................................................. .......G...........AU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUGA.G.AAUC...................U ag........................................................C. ......UUC....................A............................GG .U.CGGGGACAACC..A.C...........UGG.AA.ACGG.U................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAUG.................... ....................................U....................... ...........................................GCCGAA........... ............................................................ ............................................................ ............................................................ .................AG..........................G.............. ...............UGAAAGAU..................................... .....................UUAU....................U.............. ............................................................ .......GCC.....U............................................ ..............................GAA........................... ...................G.......A.......U........................ GAG..........CUCG.CGUC...................................... ..UG..................AUUAGCU...AG.UUGGUGU.GGUAAGaGCG..CACCA AGG.CGACGA..UCAGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUC.....CG...CAAUGGGCGAA.AGC................CU...GAC....G.GA GCAAUA.CCGC.GU......GAGGGAGG...AA...GG.C.........UCUU.GGGUUG UAAACC..........................U.CUU.........U...UC........ ............................................................ ......................U.....C............................... ...AG........GG..................AAU........................ ............................................................ ............................................................ ................................A........................... ...................................AAAAA...................A UGAA........................................................ ............................................................ .............GGU............................ACCU.GA.G.GAA..U .......AAGCAUC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGAUGCAAG..CGUUAUCCGGAAUGAUUGGGCGU..AAAGCGU...CCGCAGG...... .........UGG.............C....ACUGUAAGUCUGCUGUUAAAG.AG...... ............................................C.A.AGGCUCAA.C.C .........U...UGu.................AA......AG.....G........... ......................CA.G..UG..................G..A..AACUAC AGA...............G.CU....AGA..GU......ACG.............UUC.. .GGGGC..AGA..GGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCA.GG.AAGAACACCGG.UGGCGAAA............GC GCUC.UGC.UaG..GCCGUA..ACUGACACU....GAG.GGACGAAAGCUAGGGGAGCGA AUGGGAUUAGAUACCCCAGUAGUCCUA.GCCGUAAACGAUGG....AUAC.......... ....UAGG.....................................C....G........U g...............GCUUGU.A.......U.CGA.....CC........C........ ............G.......AG.....................C................ ...C...GU........GCCGG.......AGCC..AACGCGU..........UAAG..UA UC.............CCGCCUGGGGAGUACGCACGCAAGUGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....ACUUGA.....C...A.................UGUCGcgaaucUU....C..... .........................U.UG.AAAGg......................... ............................................................ ..................G....A.AG..............AGUG............... ............................................................ ......CC...............U............................UA...... ......G.................GGAGCG.C............................ ................................................G..A........ ..............ACA.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUUUUAG......U....UGC..C .AG.C....A..........U..U.........A.A.G.U........U.....GGG..C A.CUCUAGAGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGCAUGCCCCUUACG.UCUUG.GG CUACACA.CGUACUACAAU.GCUAC...GG.ACA.GAG................GGC... ......A.G..............CA........A......G..CUAGCGAU.......A. .......G........CAAGCAAAU......CCC.G......U.AAA..C..CG..UAGC UC.A....GUUCAGAUCGCAGGCUGCAACUCGCCUGCGUGAAGG.AGGAAUCGCUAGUAA UuGCAGGUCAG.C.AU.A.CUGCAG.....UGAAUUCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGAA......G..........................C...UGGC ........A.AC.............GCCCGAA....GU...................CAU uacuccaa.............................................C.....U .U........U.....U...AG.G.................AGAG..........GA... .......GG................AU......GCCUAAGGCAGUG.............. CU.................GGUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGUG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ............................................................ ..........GAUGAACGCUGG.CGGU..AUGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.A........GUC.............................. ............................................................ ...........UUU.....................................UA....... ...............G.ACUU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUGA.G.AAUC...................U .G.......................................................CC. ......UC....................GA............................GG .AU.GGGGACAAC.A.............GUUGG.AA.ACG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... .............C.AAUAuggcg..............AG.................... ....................................A....................... ...........................................GC............... ............................................................ ..............................................U............. .GAAAUUAUUUAGccuuGAG........................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...........................AG............................... GAG..........CUCG.CGUC...................................... ..CG..................AUUAGUU...AG.UUGGUGGU.GUAAUGGA..CUACCA AGG.CAGCGA..UCGGUAGCUGG...U....CUGAG.AGG..A..UG..AgCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUC.....CG...CAAUGGGCGAA.AGC.................U...GAC....G.GA GCAAUA.CCGC.GU......GAGGGAGG...AA...GG.C.........UUUU.GGGUUG UAAACC..........................U.CUU.........U...UA........ ............................................................ ......................U.....U............................... ...AA....................................................... ............................................................ ............................................................ ...................................................G.....G.A AGAAU....................................................... .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACUUA.A..AGAA..U c.......AGCAUC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGAUGCAAG..CGUUAUCCGGAAUCAUUGGGCGU..AAAGCGU...CCGCAGG...... .........UGG.............C....UCAUCAAGUCUGCUGUUAAAG.ACA.G... .........A..........AGCUCAAC................................ ............................UUCUGAGC........A...G........... ......................CA.G..UG..................G..A..AACUGG UGA...............G.CU....AGA..GU......AUG.............GU... AGGGG..UUGA..GGGAAUUC......CCA.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUUG.GG.AAGAACACCAG.UGGCGAA............GGC GCUC.AA.CUGG..GCCAUA..ACUGACACUC....AG.GGACGAAAGCUAGGGUAGCGA AAGGGAUUAGAUACCCCUGUAGUCUUA.GCUGUAAACGAUGA....ACAC.......... ....UAGG.....................................C....G........U ...............UGCUUGU.A.......U.CGA.....CC........C........ ............G.......AG.....................C................ .A.....GU........GCCG.......UAGCC..AACGCGU..........UAAG..UG UU.............CCGCCUGGGGAGUACGCACGCAAGUGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....ACUUGA.....C...A.................UC...................U. .........................C.................................. .............................................GAGAACugaacc... ..UAAUAGUUc...............A......G........GUG............... ............................................................ ......CC...............U............................UA...... ......G.................GGA................................. .................ACUCG..........................A..A....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCUUAG......U....UGC..C .AG.C....A..........U..U.........A.A.G.U........U.....GGG..C A.CUUUAGGAA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAGCAUGCCCCUUACG.UUCUG.GG CUACACA.CGUACUACAAU.GGUU.G..GG.ACAA.AG................GGC... ......A.G..............CA........A......G..CUC.....GC.GA.GA. .......G........UAAGCGAAU......CUC.....A..UC.AAA.C..CCA.G.CC UC.A....GUUCAGAUUGCAGGCUGCAACUCGCCUGCAUGAAGG.AGGAAUCGCUAGUAA UCGCAGGUCAG.C.AU.A.CUGCGG.....UGAAUUCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGAA......GU.............................UGGC C.........AC.............GCCCGAA....GU...................C.. ...GU.UACCCUA.....................................A......CCA A.....UUUAU.....UG..AG.GG.................G.....GA.Ug....... ...................................CGAAGGCAGGG.............. CU.................GGUGACU......A...GGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGUG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ...CAA.......AAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GG......................................... .CU...................................................CUUCGG ..........A................................................. .......G.......C....U....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUGA.G.AAUC...................U .G.......................................................CC. ......UAC....................A............................GG .A.CGGGGACAAC.A.............GUUGG.AA.ACG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... .............C......................GAUG.................... ....................................U....................... ...........................................GCCGAGAGG........ ............................................................ ............................................................ ............................................................ ..............................UG..A.......AA..........CAUUUA UG.......................................................... ............................................................ ............................................................ .......GCC.....U............................................ ..............................GUA........................... ...................G.......A.......U........................ GAG..........CUCG.CGUC...................................... ..UG..................AUUAGCU...AG.UUGGUGG.GGUAAGGGC..CUACCA AGG.CGACGA..UCAGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUC.....CG...CAAUGGGCGCA.AGC.....................GAC....G.GA GCAAC.GCCGC.GU......GGGGGAGG...AA...GGU..........UUUU.GGACUG UAAACC..........................C.CUU.........U...UC........ ............................................................ ......................U.....C............................... ...AG........GG..................AA...................G..... .....................................................AAG.... ............................................................ ..................A....A.................................... ............................................................ ............................................................ ..........................................A................. ......GU..GACGGU............................ACCU.GA.G.GAA..U .......AAGCCUC..................G........................... ............GCUAAUUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG GAGAGGCAAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGCG.C..CUGCAGG...... ........C.GGU.................UA.............AUCAAG.UCU.G... .........U..........UGUC.......AAAgcg........UGG.GGCUCAA.C.C .........UC................AUAC..........AG.....G........... ......................CAA...UG..................G..A..AACUGA UUGA................CU....AGA..GU......AUG.............GU... AGGGG..UAG..CGGGAAUUC......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCU.GG.AAGAACACCAGC.GGCGAAA............GC GCGC.UA.CUGG..GCCAUA..ACUGACGCUC....AU.GGACGAAAGCUAGGGGAGCGA AAGGGAUUAGAUACCCCUGUAGUCCUA.GCCGUAAACGAUGA....ACAC.......... ....UAGGU........................G.......UU....GC.G......... ...................UGA.A.......U.CGA.....CC........C........ ............GC.......G.....................C................ .A.....GU........GCCG.......UAGCC..AACGCGU..........UAAG..UG UU.............CCGCCUGGGGAGUACGCACGCAAGUUgGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GUUUGA.....C...A.................UC.C............CCCGAAU CUCUUGGAAACga............................................... ............................................................ .....................G...AG..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA...........................G..... ...................C.GG.......................G.G..A....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCACG...UUUUUAG......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAGAGA.............AACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUGU.GGACGACGUC..A..AGUCAUCAUGCCCCUUACA.UCCUG.GG CUACACA.CGUACUACAAU.GCUcC...GG.ACA.GCGA................G.... ....AC..G..............CG........AA........GCC.....GC.GA.G.. ......G........UGAAGCAAAU......CUC.......Cc..AAA.C..C..GGGGC UC.A....GUUCAGAUUGCAGGCUGCAACUCGCCUGCAUGAAGG.CGGAAUCGCUAGUAA UCGCAGGUCAG.C.AU.A.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGAA......GU.............................UGGC C.........A.............UGCCCGAA....GU...................C.. ...GU.UACCCUA.....................................A......CCG UUCGCG....................................GAG..........GggGG ....C..GCCGAA....GGU......................AGGG.............. CU.................GAUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGUG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > .................GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.AC........................................ ...............C................UUC......................... ............G.......G....................................... .......G...........UU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUGA.G.AAUC...................U .G.......................................................CC. .C.....UC....................A............................GG .AG.GGGGAUAAC.A.............GCUGG.AA.ACGG.C................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... .............CCAUAUGCCg..................................... ............................................................ ............................................................ ......................................CGAGG................. ............................................................ ............................................................ .............................U...............G.............. ...............A.AAUG.A..................................... .....................AUUU................................... ............................................................ ......CGC..C................................................ .............................UGA............................ ..................GG.......A.......U........................ GAG..........CUCG.CGUC...................................... ..UG..................AUUAGCU...AG.UUGGUGUAGGUAAAGGCU..CACCA AGG.CAUCGA..UCAGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUC.....CG...CAAUGGGCGAA.AGC.................U...GAC....G.GA GCAAC.GCCGC.GU......GAGGGAUG...AA...GG.CC.........UCU.GGgCUG UAAACC..........................U.CUU.........U...UA........ ............................................................ ......................U.....C............................... ...AA........GG..................AA...................G..... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................AAGA...............................UC... .......U..GACGGU............................ACUU.GA..UGAA..U .......AAGCCAC..................G........................... ............GCUAAUUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG GAGUGGCAAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGCGU...CCGCAGG...... ........C.GG.............C....CCAGAAAGUCUGCUGUUAAAacg....... .............................................UGG.AGCUUAA.C.. ..U..C....C...AUc.................A......UG.....G........... ......................CA.G..UG..................G..A..AACUGU UGG...............G.CU....UGA..GU..G....UG.............GU... AGGGGC..AGA..GGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AAGAACACCAG.UGGCGAA............GGC GCUC.UG.CUGG..GCCAUU..ACUGACGCUC....AU.GGACGAAAGCCAGGGGAGCGA AAGGGAUUAGAUACCCCUGUAGUCCUG.GCCGUAAACGAUGA....ACAC.......... ....UAGGU........................G.......UC....G.GG.....G... ....................GA.A.......U.CGA.....CC........CC....... ....................UU.....................C................ ......GGU........GUCG.......UAGC..UAACGCGU..........UAAG..UG UU.............CCGCCUGGGGAGUACGCACGCAAGUGUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GUUUGA.....C...A.................UC.C................... ...UGAGAAC.......................C.......................... ...................UC.....UUAG.........................A.AAU UUG............................AgG........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................AUUC..A........................G..U....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCACG...UCUUUAG......U....UGC..C .AG.C....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCUAGAGA............G.ACCGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUGU.GGAUGACGUC..A..AGUCAUCAUGCCCCUUACA.UCCUG.GG CUACACA.CGUACUACAAU.GCUAC...GG.ACAag.G................GGC... ......A.G..............CA........A......G..UUC.....GC.GA.G.. ......G........ACAAGCAAAU......CCC.....A..U.AAA..C..CG..UGGC UC.A....GUUCAGAUCGUAGGCUGCAACUCGCCUACGUGAAGG.AGGAAUCGCUAGUAA UCaCAGGUCAG.C.AU.A.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGAA......GU.............................UGGC C.........AC.............GCCCGAA....G...................CC.. ...GU.UACUCNA.....................................A......CCC .UC........G.........G.G.................AG.....GAGgaa...... ...G.....UNNA....GGUG......................GGG.............. CU.................GAUGACU.........GGGGUNAAGUCG.UAACAA.GGUAU CCG.UA.CCGG.AAG..........GUGCG.....GU.............UG......GA U............CACCUCCUUg..................................... ........................................................... > .....UC......AAUGAAGAGUUUGAUCCU.GG.......................... ....CUCAGA.ACGAACGCUGGU.GG..CGUGUCUU....AUACAU.GCNAGUC.....G AGC.....GA........G.........G............................... ....C...................................................AGC. .................A......A.................U..GUC............ .......................................N.................... .......................................................AGC.G GCG.....AACGGGUGA....GUAACGC.GUAA.GC.AAUC..................U .G.......................................................CC. .C.....C.................................................... ............................................................ ............................................................ ............................................................ ..................................................AUAUC..... ..................................AGGAA.AU.ACCCGUGCCAACgc.GC GGUUAAUGUCcaggagagugG.C..................................... ..CC........................................................ ............................................................ .................................................UCU........ ........GCA.......UGGA...................................... .................................................GGG.......U UGACUAG..................................................... .................AGAUU....................UAU............... ............................................................ ......CGGU.....AU........................................... ...............................G............................ ..................GG.......A.......U........................ GAG..........CUUG.CGUC...................................... ..CG..................AUUAGCUAG....UUGGCGG.GGCAACGGC..CCACCA AGG.CGACGA..UCGGUAGCCGGCC.........UG.AGAG..GGUG..AUCG...GCCA CAUUGGG.ACUGAGAUACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUA UUG.....C...ACAAUGGGGGAA.ACC................CU...GA.U...GC.A GCAAC.GCCaC.GU......GUGGGAAG...AA...GCAU..........UUC.GGUGUG UAAACC..........................A.CU.........GU............. ...................................................C........ ....................A.U.....G............................... ...AGG................................................G..... .....................................................AAUAAGg cccgccuccgggcGGN..................AUUGA..............AUGUA.. ............................................................ ............................................................ ............................................................ ............................................................ .............................................CCUUG...AGA.... G..G...AAGCACC..................G........................... ............GCAAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA GGGGUGCAAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGGGA.G.C.GUAGG...... ........C.GGAGauucaa......G....CG.............GAUUG.UACA.... .........Aucccggggccca....................ACC.CC.GGCUCUgcagu ccgaaC.......UG........G.........AUC........Ucuugg.......... ............................AUA..................G....UUCAG. ..............................................G............. ...GGC..AGG..CGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGUA.GAG.AUCA.GG.AAGAACACCG.AUGGCGAA............GGC AGCC.UG.CUGG..GGacUN..AUCGACGCU....GAG.GCUCGAAAGUGcGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCg.CACCGUAAACAAUGC....AUAC.......... ....UGGgU........................G......UCC......GG.....G... ....................G....GU........U.....CC........CCcg..... ............................................................ ......GGUA........CCG.......UAGCC..AACGCGU..........UAAG..UA U.............GCCGCCUGGGGAGUACGUACGCAAGUAUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAN.NNAACGCG C.AGAACCUUA.CCAGG........................................... ....GUUUGA.....C...A.................UG.............G....... ............GA................................AC............ ....................GC.....C......G....CGGcgaGAGAUCGCNNuuUUG ....................C......................AG............... ............................................................ ......C...............AA............................UgcAACGU U........................................................... .....................CC.................................G... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCCN.CAACGAGCGCAACCCACG...UUUCCAG......U....UGC..C AN..Cccgcaagg.........................................GGGN.. N.CUCUGGAGA............G.ACUGCC.G..G..GGACAAC...CC.G........ ...GAGGA.A.GGUGU.GGAUGACGUC..A..AGUCCUCAUGGCCCUUACA.UCCUG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACAA.UG................GG.... ....UC..G..............CA........A........CGCC.....GC.GA.G.. ......G........CGGAGCCAAU......CCU.......CA.AAG..C..C..GU.CC UC.A....GUUCGGAUCGGAGUCUGCAACUCGACUCCGUGAAGC.UGGAAUCGCUAGUAA UCGUGGGUCAG.C.AC.A.CCACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGCCAUGGGA......GA.............................AGGG ........A.G.............UNCUCUAA....GUcgugcaanCGCCUAAAGCAA.. ..............................GAc........................... ............................................................ ............................................................ .CU.................UUGACU.................................. ............................................................ ............................................................ ........................................................... > ............................................................ ..........GAUGAACGUUGG.CUGU..GUGCCUA....AGgUAU.GCAAGUC.....G AAC.....G.......A.U......................................... ........U......C................UUUAUGA....AAUUUcugAAACUUCGG ..........UUGAUGAU......U.................UUucg............. .........CU.UAGA...AU....................................... .......................................................AGU.G GCA.....AACGGGUGA....GUAACAU.GUG.GA.UAAUC..................U .G.......................................................CC. ......UC..............A......A......A......................G .Ucgugaac.AGC.UCG.............C.CGAAAG.GC.G................. ...............G............................................ .............................................G.G............ .................................................UAAUACU.... .............CG.AUAGUCU..................................... ...........................................UGUUCUUUC........ ............................................................ ............................................................ ............................................................ ............................................................ ...........................................AUA.............. ............................................................ ..............AUguuugaa...............................CA.AGU AAAGCuCAGG.................................................. ......CGCU.....UU........................................... ...............................GA........................... ...................G.......A.......U........................ GAG.....U.....CCG.CaUC...................................... ..C..................UAUCAGCU...UG.UUGGUGA.GGUAAAAGCU..CACCA AGG.CUAAGAC..GGGUAGCUGGC.........GUG.AGAGC..GCGG..UCA...GCCA CcAUGGA.ACUGAGACACG.GUCC..AUAC..U.CCUACGGGAGGCAGCAAUUAGGAAUC UUG.....C...ACAAUGGGGGCA.ACC................CU...GA.U...GC.A GCGACA.CAGC.GU......GGAGGAUG...AA...GGU.C.........UUC.GGAUUG UAAAC..........................UC.CUU.........U...UA........ ............................................................ ......................U.....A............................... ...UGGGA.................................................... ......................................................CG.... ............................................................ ..................A....AUAG.........................A....... ............................................................ ..........UGA............................................... ............................................................ ............CGGU............................ACCAU.A..UGAA..U .......AAGUACCU............................................. ............GCUAACUAC.G.UGCCAGAAGCauCGGUGAUgC.............GU AGGGUACGAA..CGUUAUCCGGAUUAAUUGGGCGU..AUAGAGAaG.C.GUAGG...... ........C.GUU.................UU.............UGUUAG.UCUU.... .........U..........AGU.......UAAA.......UACC.AC.GGCCUAA.C.C ...G.........UG........GG.........A......A..A...G........... ......................CUA...U..................AG..A..UACUGC AGAAAUUGAGACAGGAAUG............G..GC........................ ........GAA..UGGAAUUC......CCA.....................GUGGAGCAG UG..AAAUGCGUU.GAU.AUUG.GG.AGGAACAUCA.UUGGCGAA............GGC GAUUC.G.CUGGU..CCUUG..UCUGACGCUA....AG.GCUCGAAAGCGUGGGUAGCAA AACGGAUUAGAUACCCGUGUAGUCCA.CGCCGUAAACAAUGG....AUGC.......... ....UAGGU........................G.......UUUGGUAcaacUAC..... .....................CUA.......AU..................CcuucGGGA UUGGAuggaaGUAUU............................................. GA.....GU........GCCGC.......AGC..UAACGCGU..........UAAGC..A UC.............CCGCCUGGGAAGUACGGCCGCAAGGCUAAAACUCAA...AUGAAU UGGCGGGG.ACCC.GCACA.AG.C.GGAGGAGCGCG.UGGUUUAAUUCGAC.GgcAAUCG .AAGAACCUUA.CCAGG........................................... ....GUUUGAA......AUGUACcug.................................. .....C.........................AUG.......................... .....................CC...............CCUAGA................ A......................A.UA......G........G................. ..........................................................GG AGGCUUU........................................CGAA......... ............................................................ .......................................GGU....GAU..A........ ...............CA.CAGG.UGCUGCAUGGCCGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GAAACGAGCGCAACCCCUA...UCCUAUG......U....UACA.. .AGUG....................................................... ...UCUUAGGA.............AACUGCCU..CG..G.UA.AAACG.G.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..UG..GUCCGCAUAGCCCUUAUG.UCCUG.GG CGACACA.CGCGCUACAAU.GGC.CG..A.UACAA.UG................GG.... ....A.A.G..............CC........AA........AUC.....GUA.A.GA. ...............UGGAGCAAAU......CC.....UA..U.AAA.G.U.CG.G.U.C UC.A....GUUCGGAUUGAGGUCUGAAACUCGACCUCAUGAAG.UUGGAUUCGCUAGUAA UCGUGGAUCAG.CCAU.G.CCACGG.....UGAAUACGUUCUCGGGUCUUGC..ACACAC CGCCCGUCAAGCCAUGGAA......GU.............................AGG. .......UGAuac............................................... ............................................................ ............................................................ ............................................................ ............................................................ CCG.AAGGUGUUCCgcuccuugugAGUGGGAUgacGA.............AG......GU AACgcuu..............................AUGACUGGgguu........... ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....AUACAU.GCAAGUCAAGGAG AAC.....G.......U.U......................................... ........U......C................UUUcgag..................... ............................................................ ............................................................ .................AAACUAUUAAAc............................U.G GCG.....AACGGGUGA....GUAACGC.GUA.GGC.AACC..................U .G.......................................................CC. .C.....U..............AG............A......................G .AU.UGGGAUAAC.A.C.C...........AGG.AA.ACCG.G................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GAAU.AA.U..GC............ ...........................AGC.............................. ...........................................GG............... AU.......................................................... .............................C.............................. .......Cu....U.......AGGGAUACAG............................. ...........................................UUG.............. ...............UUAAAGCG.......GGC........UUCGGCUCg.......... ............................................................ .................................CA......................... ............................................................ ........................CU...UUA............................ ..................GG.......A.......U........................ 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AGAGG..AAAG..UGGAAUUC......CU.....................GGUGUAGCGG UG..AcAUGCGUA.GAU.AUCA.GG.AGGAACACCA.AUGGCGAA............GGC AGCUUU.C.UGGC..CUAUU..ACUGACGCU....GAG.GGACGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UAC.......... ....UUGGU........................G.......UC....G.GG.....G... ....................GA.U.......U.CGA.....CC........CC....... ....................UU.....................C................ ......GGUA........CCG.......UAGC..UAACGCAU..........UAAG..UA CU.............CCGCCUGGGAACUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGG.ACCCC.CACA.ACG..GGggg.ACAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UA.........UU....C..... .........................A.UG.AAAG.......................... .....................C............U....CUG............UG.AAA GCA...............G....AGC.................................. ............................................................ ............................................................ ......CC..................U.CUgcGAGCUUGCUcaaaga............. .........................CAU.....................GUU.....U.. ................A.CAGG.UGAUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UCCUUAG......U....UGC..C .AG.C....A.....C....A..U.........U.AUG......G...U.....GGGG.. A.CUCUAAGGA............G.ACUGCCUAGGAUAAC.........UAG........ ...GAGGA.A.GGUG.GGGAUGAUGUC..A..AGUCAGUAUGUCCCUUAUG.UCCAG.GG CUACACA.CGUGUUACAAU.GGUU.G..G.UACAA.UG................GGC... ......U.G..............CG........AA........GCC.....GC.GA.G.. ......G........UGGAGCCAAU......CCC.......CA.AAAA.C..CA..A.CC UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAGC.AGGAAUCGCUAGUAA UCGUGGAUCAG..AA.CG.CCACGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACGCCAUGGAA......GU..........................C...AG. ........UAG.............UACCCAAAUCg.......................A. ....G.U.......GG.C............CU.....A....A.........CC.....U .U........AG.........G.G.................AG.....GGA.......GC .UcG.....UUAA....GGUAAN.........................A........... CU.................GGUAACU.........GGGGCGAAGUCG.UAACAA.GGUAG C.G.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.AUCAACGCUGG.CGG..CGUGCCUC....AGACAU.GCAAGcC.....G AAC.....G......C..G...AA................AGUCC............... .CC......................................................... ....UUCG....GGG.....GgcgA................................... .......G...........UA..........GAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUA.GG.UAAUC................... ........................................UA................C. .C.....U..............U......U............................GG aUG.GGGAAUAA.C.CA.C...........CGG.AA.ACGG.U................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.U..GC............ ...........................AGC.............................. ...........................................GG............... .....................................................CACCUAA UGG......................................................... .......................UG..ACAG............................. ...........................................UUG.............. ...............UUAAAGCG.......GG............................ .........................GGAUCGuAA....GACCUC................ .........G.................................................. ......CGuc.....U............................................ ..............................GAA........................... ...................G.......AG............................... GAG..........CCUG.CGGC...................................... ..AG..................AUUAGCU...AG.UUGGUAA.GGUAACGGCU..UACCA AGG.CGAUGA..UCUGUAGCCGGCC.........UG.AGAG..GGCGG..UCG...GCCA CACUGAC.ACUGAcAUACG.GGUC..AGAC..U.CCUACGGGAGGCAGCAGUCGGGAAUU UUG.....GG...CAAUGGGCGAA.AGC................CU...GAC.C...C.A GCAAC.GCCGC.GU......GAAGGAUG...AAa...U.CC.........UUC.GGGAUG UAAAC..........................UU.CGc.........A...A......... ....................................................GAA..... .............................C.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AUAAGUG.............................. ............................................................ ..........AGAguuaaCAUCUCUUAUGA.............................. ............................................................ .......U..GACGGU............................ACUG.......UUUGU .......AAGCUCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG GGGGAGCAAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGGG.CG.C.GUAGG...... ........C.GG.............C....ACc.............GCAAG.UCG.G... .........U..........UGUG.......AAA.......UCUC.CG.GGCUUAA.C.C .....C......GgA..................AAGGU...................... ......................CAA...UC..................G..A..UACUGC GGG...............G.CU....AGA..GU..G....C.............AGA... AGGGGCAA....CUGGAAUUCU......C.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCGA.G.AGGAACACCUGC.GGCGAA............GGC GGGU.UGC.UGG..GCUGAC..ACUGACGCU....GAA.GCGCGAAAGCUAGGGGAGCGA ACGGGAUUAGAUACCCCGGUAGUCCUA.GCCUUAAACGAUGA....AUGC.......... ....UUGGU........................G.......UCU.G.G.GG........U ...............U......UU.......AUAGU.....CC........CC....... ..........................G................................. .....G.GU........GCCG.......UCGC..UAACGCUc..........UAAGC..A UU.............CCGCCUGGGGAGUACGGUCGCAAGACUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUAGAA......UGC..................C.C................... ...UCU......GACAA.CC....U....AG............................. ............................................................ .......................AGAU..............AGGGccuu........... ............................................................ ...............................C............................ .......................UGG............................GUAAAA Ccagacagag...............UGCA............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCAAUAG......U....UGC..C .AG.C.G...GU...........UC.....G...................G.CCGGG..C A.CUCUAUUGA............G.ACUGCC.G...UUG.AC.AAA..AC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCUUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGCA.G..G.UACAA.ACC................GC... ......U.G..............CA........AA........CCagcaau......... ......GG........GGAGCCAAU......CGG.....A..A.AAA.GC..CU.G.U.C UC.A....GUUCGGAUUGGAGUCUGCgACUCGACUCCAUGAAGC.UGGAAUCGCUAGUAA UCGCAGAUCAG.C.AU.G.CUGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACAUCACGAAA......GUG.............................GG. .......UU.G.............UACUAGAA....GU...................C.. ...GUC........GC.............GC.....CA....A.........CC...CGU .A........AG.........G.G.................AG.....GCA.......GG ....C..GCCCAC....GGUAU......................G...AUC......... ..C.................AUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CUG.UAGGAGAACC............UGUG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ............................................................ .........A.AUCAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AACA............A.G...AA................AG................G. ................................G....................ACUUCGG .............................................UC.......Cuga.. ...............GUAC.............AG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUGA.C.UAACC..................U ........................................A................CC. .C....................UC.......G....A......................G 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AGAGG..UGAG..UGGAAUUU......CC.....................GGUGUAGCGG UG..AAAUNCGUA.GAU.AUCG.GA.AGGAACACCUG.UGGCGAAA............GC GGCUC.A.CUGGA..CCACA..ACUGACGCU....GAU.GCACGAAAGCUAGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCCUAAACGAUGA....UCGC.......... ....UUGGU........................G.......U...G.GC.G.....G... ....................G..U.......A..........C........CC....... ....................AAUcccg................................. ..UC...GU........GCCG.......UAGC..UAACGCGU..........UAAGC..G AU.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUNAUUCGAC.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUCGAA......AUGUAguggaccg........G.............G....... ............GU................................A............. ........GAAA.......UA.....UCccu............................. ............................................................ .....................................................U...... ........................................C.C................. ..............CCGCA....AGG............................GGCugc uau..........A..............U............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UUGCCAG......U....UGCU.. .AC.C...............A..U.........U.UAG.U........U.....GAG..C A.CUCUGGUGA............G.ACCGCCU.C.GG....A.UAACG.G.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCUUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.ACC................GC... .....C..G..............CA........AA........CCC.....GC.GA.G.. ......GG........GGAGCUAAU......CGG.....A..A.AAA.GC..CG.G..CC UC.A....GUUCGGAUUGUAGUCUGCAACUCGACUACAUGAAGCUUGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACAUCACGAAA......GUG.............................GG. .......UC.G.............UACUAGAA....G...................C... ...GGGU.......G.A............GC.....CA....A.........CCG..... ..........U.....A...AG.G.................AG.....GCA.......GC .....UU..CCAA....GGUGU......................G...AU.......... .UC.................AUGAUU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ...........AGUAUGGAGAGUUUGAUUCU.GG.......................... ....CUCAGA.GCGAACGUUGG.CGau..GCGUCUU....AAGCAU.GCAAGUC.....G AGC.....G........GGC........U...................Uau......... ........U......C........................GG...............GC. .................A......ACUGGA.............................. ..............................UAAG....UU.................... .......................................................AGC.G GCG.....AACUGGUGA....GUAACAC.GUA.GG.UAAUC................... ........................................Ug................C. .C.........................G.UAG....A......................G .UG.GGGGAUAAC..CCA............UGG.AA.A.CaU.................. ............................................................ .........G...................................GAC............ .................................................UAAUACC.... ...................................GCAU.AU.ACUCuug.......... ......................CUACA................................. ............................................................ ............................................................ ................CAAGU....................................... .......................AG..AG............................... ..........................................U.......AG........ ..A.........G...GAAAGG.......AGC............................ .....................AAU.................................... ............................................................ ...C..CGCU.....UUac......................................... ............................................................ ...................G.......A.......U........................ GAG..........CCUG.CGG....................................... .UCU..................AUUAGC...CUG.UUGGUGG.GGUAACGGC..CUACCA AAG.CUACGA..UaGGUAGCCGACC.........UG.AGAG..GGUG..ACCG...GCCA CAUUGGG.ACUGAGAUACG.GCCC..AGAC..U.CCNACGGGAGGCAGCAGCUGAGAAUC UUC.....C...ACAAUGGACGAA.AG................UCU...GA.U...G.GA GCGACA.UCGC.GU......GAGGGAUG...AA...GG.CC.........UUC.GGGUUG UAAACC..........................U.CggaaauuaucGA...AG........ ............................................................ ......................A.....A............................... ...UG.............................A...................G..... .....................................................U...... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..........GACAGU............................Ag..A.U....AAUGU .......AAGCCUC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGNNNUNAUAC.............GU AGGAGGCAAA..CGUUGCUCGGAUUUACUGGGCGU..AAAGGGU.G..AGUAGG...... ........C.GGA.................CU.............UAUAAG.UCUA.... .........AG..........GUG.......AAAG.......ACC.G.AAGCUCAA.C.. ..U......UCG...........GG.........AAC...........G........... ......................CCUC...G..................G..A..UACUGU GAGU................CU....UGGaua........U.............UGU... AGGGG..AUGA..UGGAAUUCN......C.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCGA.G.AGGAACACCU.AUAGCGAA............GGC AGUC.AU.CUGG..GCAUUU..AUCGACGCU....GAAU.CACGAAAGCUAGGGGAGCAA ACAGGCUUAGAUACCCUGGUAGUCCUA.GCCGUAAACGUUGU....ACAC.......... ....UAGGU........................G.......................... ....................................................C....... ....................UUCUAUUU.............AA..........AUA...G GA.....GU........GCCG.......UAGC..UAACGUcU..........UAAG..UG UA.............CCGCCUGAGGAGUAUGCCCGCAAGGGUGNAACUCAA...AGAAAU UGACGGGUC.CCC.GCACA.AGu..GGUGGAGCAUG.UGGUUUAAUUCGAU.NAUACGCG .AAAAACCUUA.CCUGG........................................... ....GUUga................................................... ............................................................ ..........................AUUG.........................U.AAG A......................UGAA..............UGAUUUAGAGAUAAGUc.. ............................................................ ............................................................ .........AG..ACCGCA....AGGAC..........................GUUUUA C............A..............U............................... ...................AGG.UGCUGCAUGcCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCAC...CCUUUG......U....UGCU.. .AC.C.G.............AG.U.........A.AUGU..............CGGG..C A.CUCUUAGG............GG.ACUGCCUACGU.....UCAA..G.UAG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGCA.A..G.UACAA.AGA................G.... ....A.A.G..............CG........A......G..ACC.....GC.GA.G.. ......G........UGGAGCAAAA......CUC.....A..A.AAAAGUU....G..CC UC.A....GUUCGGAUUGGAGUCUGAAACUCGACUCCAUGAAG.UUGGAAUCaCUAGUAA UCGUAGAUCAG..AA.CG.CUACGG.....UGAAUACGUUCCCGGGNAUUGU..ACACAC CGNCCGUCACGCCAUcGGA......GU.............................UNG. ........UUU.............UACCUGAA....GU...................C.. ...GU.UA.......G.C............CU.....A....A.........CCG..... ..............C.A...AG.GG.................G.....GGC.......GG ....C..GCCGAA....GGU......................NGG...A........... CU.................GAUGA.................................... ............................................................ ............................................................ ........................................................... > ..................AGAGTTTGATCCT............................. ..GGCTCAGA.ACGAACGCTGG.CGG..CGCGttttaaGCATGCAA.GT....C.....G AGG.....G........Gt......................................AA. ........................................G.AA........AGTCTTCG GActttt..................................................... .......GA......................G............................ .......................................................ACC.G GCG.....AACGGGTGA....GTAACAC.GTA.GAT.AATCT.................. .GTCTtggga.................................................. ............................................................ T.G.GGGGATAG.C.CCA.T...........GG.AA.ACAT.G................. ...............GGG.......................................... ................................................TAATACC..... ..GCATAAGctcttttacc......................................... ....................................................CATAAGGG TGA..................................TagaGG.....AAAGGC...... ...................GCTTaggcgtcgacct......................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...............................AA........................... ...................G.......AG............................... GAGT..........CTG.CGGTC..................................... ...C..................ATTAtgtTAGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CGGCGAT..GGATAGCCGGCCT.........G.AGAG..GGTG..AACG...GCCA CACTGGG.ACTGAGACACG.GGCC..AGACT...CCTACGGGAGGCAGCAGCtaaGAATC TTCCGCAAT........GGGCGAA.AGC................CT...GAC....G.GA GCGAC.GCCGC.GT......GAACGAAG...AA...GG.CCgaaa..........GGT.. ............................................................ ......................TGTAAAGTTCTTTTctt..................... ............................................................ ...................................................GGAG..... .....................................................A...... .............GGA..................AtaagcctatcaggaaatggatgggT ............................................................ ............................................................ ............................................................ ............................................................ ...........................GA...TGACGT.....TAacc.GA.G.GAA..A .......AAGCCCC..................G........................... ............GCTAATTAC..GTGCCAGCAGCCGCGGTAACAC.............GT AaGGGGCGAG..CGTTGTTCGGAATTA..TTGGGCGTAAAGGG.CG.C.GTAGG...... ........C.GG.............C....AtG.............GCAAGT.CA.GG.. ..........TGT..........G.......AAAGG.......CtccA..GCTCAA.CTg ga.....................G.........AAAC...........G........... ......................CGCTT.....................G..A..AACTGT Cgtgctggagtct........A.................................GG... AGGGG..AAG..CTGGAATTCCTAG..........T.................GTAGGGG TG..AAATCTGTA.GATATT.A.GG.AAGAACACCGG.TGGCGAA............GGC GAGCTT..CTGGCcat........AGACTGACGCTGAG.GCGCGAAAGCGTGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGTGcactgGGTGTCGGcccG TTGG........................................................ ......................................................GGTC.. .........G.................................................. ...............GTGCCG.......AAGC..AAACGCGAT..........AAGT..G CA.............CCGCCTGGGGAGTAtgcTCGCAAGGGTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGA.TGATACGCG .AGAAACCTTA.CCAGG........................................... ....GCTTGACAT.........................ATGgtggacggtgg........ ............................................................ ................TA...................GAGATAccGC............. .TT......................................................... ............................................................ .......................................CC.CTTC.............. ........................GG............................GG.... ..........................................Ccgct..A.......... .......T........A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGCTGTGAAGTGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTGctatctgttgg...............C .AT.C....ATTAAGT.....................................TGGGG.. A.CTCAgatG............G.AACTGCC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGACGACGTCAAc....TCATCAT.GCCCTTATGT.CCTG.GG CTACACA.CGTGCTACAAT.GAA.CG..GT.ACA.GAGCnc................... .....C..G..............CG........A......G..ACC.....GC.GA.G.. ......GT........CAAGCAAAT......CCC.....A..A.AAA.GC..CGT..T.C TC.A....GTaCAGATTGGAGTCTGAAACCCGACTCCATGAAGGT.GGAATCGCTAGTAA TCGCGCATCAG.C.AT.G.GCGCGGT.....GAANACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACCCGA......GTtggggg........................... ..T......................ACCCGAA....GT...................C.. ...GCTAGT.....................CT.....A....A.........CCGGT..A .AC..................G.G.................AG.....GAC.......GG T......GCCGAA....GGTATGcctagt............................... ...........................A.AGG...GGGGTGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGCGGCTGGATCACCTCCTT.............. ............................................................ ........................................................... > ucga.C...............GUUUGAUCCU.GG.......................... ....CUCAGA.ACUAACGCUGG.CGG..CGCGUCUU....AAACAU.GCAAGUCAAGc.. ............................................................ ......GGAG.............................................UAGC. .................A......A.................UAC.......U....... ............................................................ ............C..........................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UAAUC..................U ........................................U................CC. ......UCC....................G......A......................G .U.CUGGGAUAA.CU.UU............C.CGAAAG.GG.G................. ................A........................................... .............................................G.C............ .................................................UAAUAC..... ..................................UGGAUG..GUCCCGAG.......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .........AGGUCAUAUGAUU....................UUU............... ............................................................ ......CGGg.......UAAAGAUU................................... .............................UAUU........................... ..................GCUCg........GAGCU........................ GAG..........CCCG.CGCC...................................... ..CG..................AUUAGCU...AG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CGACGA..UCGGUAGCCGGCC.........UG.AGAG..GGUG..UUCG...GCCA CAAUGGA.ACUGAGACACG.GUCC..AUAC..U..CUACGGGAGGCAGCAGUUAAGAAUC UUG.....C...UCAAUGGGGGGA.ACC................CU...GA.A...GC.A GCGAC.GCCGC.GU......GAACGAUG...AA...GGU.C.........UUC.GGAUUG UAAAG..........................UU.CAA.........U...AAG....... ............................................................ ............................C............................... ...AG........GG..................AAA........................ ............................................................ ............................................................ ................................A........................... ...................................AUAAgcaGCGAUGUG.........A UGAU........................................................ ............................................................ .............GGU............................ACCU.G.Cc...U..A .......AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AUGGUGCAAG..CGUUGUUCGGAAUCAUUGGGCGU..AAAGGGU.G.C.GUAGG...... ........C.GGA.................CA.............UGUAAG.UCA.GG.. ....................UGUG.......AAA.......ACUG.CG.GGCUCAA.C.. ..U..CGc.......A........G.........CC........U...G........... ......................CAC...U..................UG..A..AACUAU gUGU................CUG....GA..GU......UUG.............GG... AGAGGC..AAG..UGGAAUUC......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCU.GG.AGGAACACCAG.UGGCGAA............GGC GACU.UGC.UGGC..CUAAA..ACUGACGCU....GAG.GCACGAAAGCGUGGGUAGuGA ACGGGAUUAGAUACCCCGGUAaUCCA.CGCCCUAAACGUUGUC....UACCAGU...... ........U........................G.......UU....G.GG.....G... ....................GU.U.......Uua.........A.......CC....... .................C...U.....................C................ .A.....GUA........ACG.......AA.CUAACGG..AU..........UAAG..UA GA.............CCGCCUGGGGACUAUGCUCGCAAGAGUGAAACUCAA...AGGAAU UGACGGGGGUnn.N.CACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GAUACGCG .AAAAACCUCA.CCUAG........................................... ....GCUUGA.....C...A.................UG.............G....... ........................A....................Guggaa......... ......................................................UU.AUG U......................AGAGAU.........AcaUGAG............... ............................................................ ......C................U............................U....... .....CG.................GGccG............................... .....................C..........................U..U........ ...............CA.CAGG.UGCUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCAC...CUUAUG......U....UGC..C .A.UC....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCgUAAG............G.AACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AAUCCUCAUGGCCUUUAUG.UCUAG.GG CAACACA.CGUGCUACAAU.GGC.CG..G.UACAA.AG................GG.... ....U.A.G..............CC........AA........CUC.....GC.GA.G.. ......GG........GGAGCUAAU......CUC.....A..A.AAA.GC..C..GGU.C CC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGACCUUGU..ACACAC CGCCCGUCACACCACCUGA......GUG.............................GGG .........AGC.............ACCCGAA....GU...................... ..GGUCUU........U............GC.....CA....A.........CCG..... ..........U.....A...AG.G.................AA.....GCA.......Ga cu......ACUAA....GGUGAA.........................ACUC........ ....................GUGAA......G...GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGC............................... ............................................................ ........................................................... > ..................AGAGTTTGATNNT............................. ..GGCTCAaA.GCGAACGCTGG.CGG..CATGCTTAACACATGCAA.GT....C.....G CA........CGaa.............................................. ...............C.......................CT................... ...TTC..GGG...GTT........................................... ............................................................ ........................................................AGTG GCGG.....ACGGGTGA....GTAACGC.GTA.GGG..ATCTat................ ..........................................................C. .C.....ACG................................................GG T.G.GGGGATAA.CTTT..G...........GG.AA.ACTGA.................. ................A........................................... .............................................G.CTAATACC..... ..GCATgacACCTGAGGGTca....................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................AAGGC.......................... .......GCA.....A............................................ ..............................GtcgccTGTGGAGga............... ............................................................ .......A.....CCTGCGTT....................................... ..CG..................ATTAGC.TAGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CGATGATC..GATAGCTGGTCT.......GAG.AGG..AT..G..ATCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGGACAAT........GGGCGCA.AGC................CT...GAT.C...C.A GCAAT.GCCGC.GT......GTGTGAAG...AA...GGTTTTCGGA...........T.. ............................................................ ......................TGTAAAGCACTT................TC........ ....................A......GCGGGGAtga....................... ............................................................ ............................................................ ...........................................................T ............................................................ ............................................................ ............................................................ ............................................................ ...........................GA...TGACG.G....TACCC.G.C.AGAA... ...G...AAGCCCC..................G........................... ............GCTAACTTC..GTGCCAGCAGCCGCGGTAATAC.............GA AGGGGGCAAG..CGTTGCTCGGAATgAC..TGGGCGTAAAGGG.CG.C.GTAGG...... ........C.GGT.................T......GACAC.......AGT.CA.G... .........ATGT..........G.......AAATt.......CC.CG.GGCTTAA.C.C T...........G.G........GGG.........CT...........G........... ......................CATTT.....................G..Atacgtggc ..GA................C.T...AGA..GT..GT....G.............AG... AGAGGGTT..G..TGGAATTCCCAG..........T.................GTAGAGG TG..AAATTCGTA.GATATT.G.GG.AAGAACACCGG.TGGCGAA............GGC GGCA.A.CCt.GG......CTCAT.GACTGACGCTGAG.GCGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCTGTAAACGATGTGtgctggaT........G TTGG........................................................ ......................................................GTgact ttgtca...................................................... ...........TTCAGTGtcgt.......AGTT..AACGCGAT..........AAGC..A CA.............CCGCCTGGGGAGTACGGCCGCAAGGTTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAA.GCAACGCG C.AGAACCTTA.CCAGG........................................... ....GCTTGACATG.............................................. ............................................................ ...CGGAGGCCGtg.......................TCCAG............AG.ATG GGcattt..................................................... ............................................................ .......................................CTCGCAAGAGAcctcc..... ............................................................ ...................................................A....G... ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGC...CTTTAGTT..........GC..C .AT.C....A.....CGTctG............GG..................TGGG..C A.CTCTAAAG............G.AACTGCC.G..GT.G.A.C.AA.GCC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCCTTATGT.CCTG.GG CTACACA.CGTGCTACAAT.GGCG.GT..G.ACAgt.G................GG.... ....A.A.G..............CC........AggTGGTGACACC.....G.AGccg.. .......................AT......CTC.....A..A.AAA.GC..C..G.T.C TC.A....GTTCGGATTGCACTCTGCAACTCGAGTGCATGAAGGT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GTT.............................GGT TTgacctt......................AA....G...................CC.. ...GGT........GAG.............CG.....A....A.........CCG..... ..............C.A...AG.G.................AC.....GCA.......GC ....C..GACCAC....GGTCGGGTCAGC............................... ...............................GACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TGCGGCTGGATCACCTCCTTT............. ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AAC.....G......CA.UC........................................ ...............C................UUC......................... ............G.......G....................................... .......G...........AU..........GAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUG.GG.AA.CG..................U ........................................A................CC. ......UUgga................................................G .UGC.GGAAUAAU..CUU............UGG.AA.ACG.A.................. ............................................................ .........G...................................GAC............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UUAGGGG...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGCUcc.....AA......................................... ............................................................ ...................G.......A.......UC....................... .GG..........CCCG.CGUC...................................... ..CG..................AUUAGCUAG....UUGGCGG.GGUAAUGGC..CCACCA AGG.CGACGA..UCGGUAGCUGG...U....CUGAG.AGG..A..UGG..CCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGGGCA.ACC................CU...GAC....GC.A GCCAU.GCCGC.GU......GAGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................CGGgu.... ......G.............U......GA............................... ...AG....................................................... ............................................................ ............................................................ ............................................................ ............................................................ ..........................AUGA.............................. ............................................................ .......U..GACGGU............................AACAC..C.AGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCAAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGAG.CG.C.GUAGG...... ........C.GGU.................CUG.............AUUAG.UCA.G... .........AG..........GUG.......AAA.......UCCC.AG.AGCUCAA.C.. ..U......U...UG........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGU UAGA................CU....AGAA..UC......CG.............UG... AGAGGG..UGG..UGGAAUUC......CCA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUUG.GG.AGGAACACCAG.UGGCGAA............GGC GGCC.A.CCUGGcgc..GGU..AUUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAGAU........................G......UC.......GG.....G... ....................GU.ACAUG.........UACc................... ............................................................ ....UCGGU........GUCGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....CCUUGA.....C...A.................UC.C............C...... ......GUGAC....................A............................ .............C.....U..............U...CCAG............AG.AUG ..................G....A.A...................GG............. ............................................................ .......................U............................U....... .....CCCUUC..G..........GG............................G..... .................ACAC.........................G.G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCA...UCUUCAG......U....UGC..C .AG.C....A..........AG.U.........A.AcG.U........U.....GGG..C A.CUCUGAAGA............G.ACUGCC.G..G.UG.A.CAA..GCC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGCUG.GG CUACACA.CGUGCUACAAU.GGCG...C.CUACAA.UG................GGC... ......A.G..............CG........A........CCUC.....GC.GA.G.. ......GG........GAAGCUAAU......CUC.......CA.AAA.G..GC..G.U.C UC.A....GUUCGGAUUGCACUCUGCAACUCGGGUGCAUGAAG.UCGGAAUCGCUAGUAA UCGUGGAUCAG.C.AU.G.CCACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UUC..............UACCCGAA....GA...................C.. ...GG.UA.......C.............GCU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GC ....C..GGCCAC....GuUA......................GGG...U.......... .CA.................GCGACU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .............GAACGCTGG.CGG..CAGGCCTAACACATGCAA.GT....C.....G AAC.....G......C.......................................T.... ................................GTAGCAATAC.................. ..................................A.................G....... ............................................................ ........................................................AGTG GCAG.....ACGGGTGA....GTAACAC.GTG.GG..AATCTtcctatcggtac...... ............................................................ ............................................................ ..G.GA..ATAG.Ct.CA.GGGAAACT.............T.G................. ...............GGG.......................................... ................................................TAATACC..... ..GCATAC.................................................... ..............................................GCCCTtCG...... ............................................................ ........GGGGAAAGATT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TATC... ............................................................ ......................................GCCG.................. ................A......................TA................... ............................................................ ..................GAT....................................... GAG..........CCCG.CGTCT..................................... ...G..................ATTAGC.TAGTT...GGTGA.GGTAATGGCT..CACCA AGG.CGACGATC..AGTAGCTGGTCT.......GAG.AGG..AT..G..ACCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGGACAAT........GGGCGCA.AGC................CT...GAT.C...C.A GCCAT.GCCGC.GT......GAGTGACG...AA...GGTCTTCGGA...........T.. ............................................................ ......................TGTAAAGCTCTT................TTGGCGGGGA CGA......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .........................TA.A...TGACG.G....TACCC.G.C.AGAAT.. .......AAGCCCC..................G........................... ............GCTAACTTC..GTGCCAGCAGCCGCGGTAATAC.............GA AGGGGGCTAG..CGTTGTTCGGAATTAC..TGGGCGTAAAGCG.CA.C.GTAGG...... ........C.GGAttgc.......................T.......AAGT.CA.GGG. ...........GT..........G.......AAAT.......CCC.GG.GGCTCAA.C.C TC............G........G.........AACT...........G........... ......................C.CTTT....................G..AT..ACTGA c............AGT....CTT....GA..GT..C....CG.............GA... AGAGGT..GAG..TGGAATTCCTAG..........T.................GTAGAGG TG..AAATTCGTA.GATATT.A.GG.AAGAACACCAG.TGGCGAA............GGC GGCTCACTGGtccgg..........TACTGACGCTGAG.GTGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACtATGGATGCTAGCCGT....... .........................................C.......GG......... ..................................CA........................ .....................AGCttgcttgtCGGT........................ .....G.G...........CGC.......AGCT..AACGCTTT..........AAGCAT. .C.............CCGCCTGGGGAGTACGGCCGCAAGGTTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCAGCT.......................................... .....CTTGACATttacggaccgt.................................... ............................................................ ....................................TTCCAG............AG.ATG Gattcatcc.......................TAGCAATAggccgtag............ ............................................................ ............................................................ ............................................................ ........................................................G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGC...CATTAGTT..........GC..C .AT.C....ATTTAGT.....................................TGGG..C A.CTCTAGTG............GG.ACTGCC.G..GT.G.AT..AA.GCC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGGCCCTTACG.GGCTG.GG CTACACA.CGTGCTACAAT.GGCG.GT..G.ACAAT.G................GGC... ......A.G..............CA........A........CAC.....AGCaat.... ......GT........GAAGCTAAT......CTC.....A..A.AAA.GC..C..G.T.C TC.A....GTTCGGATTGGGCTCTGCAACTCGAGCCCATGAAGTT.GGAATCGCTAGTAA TCGCGCATCAG.C.AT.G.GCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GTT.............................GGT TTT......................ACCCGAA....GA...................C.. ...GGTGC........G.............CT.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GC ....C..GGCCAC....GGTAaGGTCAGC............................... ...............................GACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TGCGG............................. ............................................................ ........................................................... > UG..AACU.....U...GAGAGUUUNAUCCU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GG......................................... .CG............CAGCGCAUG.................................... .................................................CGUA....... ...............G.AC.............AG....U..................... ...........................................................G GCAG.....ACGGGUGA....GUAACGC.GUG.GG.AA.CG..................U ........................................A................CUU ....UC....................................................GG .UUC.GGAAUAAC.U.CA.GGGAAAC.............U.WA................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................G.C..C.................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .....UUAAGGGG...GAAAGAU..................................... .....................UUAU....................UCG............ ........................................CG.................. ................AAA......................................... ............................................................ ...................G.......A.......UC....................... .GG..........CCCG.CGUC...................................... ..CG..................AUUAGCUAGCUG.UUGGUGA.GGUNAAGGCU..NACCA AGG.CGACGA..UCGGNAGCUNG...U....CUGAG.AGG..A..UG..AUCA...GCKA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CUAc..GGAGGCAGCAG.UGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........UUA.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................CG....... .....................C......C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCU.G..GAUAA... ...G...AA.CCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCAAG..CGUAGUUCGGAAUCgCUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GGA.................UUG.............UUCAG.UCC.GG.. ..........G..........GUG.......AAA.......U.CC.G.AGGCUCAA.C.C .........UC...G........G.........AAC........U...G........... ......................CCU...N..................NN..A..UMCUGC GUAU................CU....UGA..GU..C........................ ...GGG..AAG..AGGUAAGUAugacuCGA.....................GUGUAGAGU ..G..AAUUCGUA.GAU.AUU.CG.C.AGAACACCAG.UGGCGAA............GGC GGCU.A.C.UGGC..CCGNN..ACUGACGCU....GAG.GUGCGNAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUGC.......... ....UAGC.................................................... ......CGUUGG........................GG...................... .....................AGCUUGCUGUUC......................A...G ....UG.G...........CGC.......AG.G.UAACGCUU..........UAAGC..A UU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACcgcuaggAGUURU UG..GGGG.UCCCA.Ccgc.AG.C.GGUGGAGUNAnnUNGUUAAUNUaannc....CGCG C.AGAACCUUA.CCAGC........................................... ....UUUUGA.....C...A.................UGUC................... ...........................CGG.............................. ..........................UAUGgugGU....CAG............AG.AUG ACUuc....................................................... ............................................................ ...................................................CU....... .............UCCGCA....AGG............................GGCC.. .....................G..........................G..A.....U.. ................A.CAGG.UGCUGCAUngcuNUCGUCAGNUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCAUCagccgACUUAG......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAGGGA.............NACUGCC.G..G.UG.AU.AAU..CC.G........ .ACGAGGA.AgGUAG.GGGAUGACGUC..A..AGUCCUmau.GCGCUUACG.AGgcuvGG CUACACA.CGUGCUACAAU.GGCG.GU..G.ACAA.UG................GG.... ....A.ACgacgamgugac......................................... ......G........CCGAGCUAAU......CUC.......CA.AAA.GC..C..G.U.C UC.A....GUUCGGAUUGCACUCUGCAACUCGAGUGCAUGAAGG.UGGAAUCGCUAGUAA UCGCAGAUCAG.C.A.CG.CUGCGG.....UGAAUACGUUCCCUGGCCUUGU..ACACAC C.CNCGUCACACCAUGGGA......GU.............................NGG. .......UUU..............UGCCAGAA....GU...................A.. ...GU.UA.......G.C............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GGCN.......A .....UU.ACCAC....GGCA......................GGG...U.......... .UC.................AUGACU.........GGGGUNAAGUNN.NNACAA.GGUAG CCG.UA...................................................... ............................................................ ........................................................... > NU.UAACU.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AAC.....G......CU........................................... .........G.............................................UAGC. .................A......A.................UACG.............. ...............................G............................ .......................................................AGU.G GCN.....NACGGGUGA....GUAACAC.GUG.GG.AA.CA..................U ........................................A................CC. .C.....U..............U......U............................GG .UUC.GGAAUAAC.U.CA.GGGAAAC.............U.UG................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UACGGGG...GAAAGAU..................................... .....................UUAU....................U.............. ............................................................ .......GCCG................................................. ..............................AA............................ ..................GG.......A.......UU....................... .GG..........CCCG.CGUC...................................... ..UG..................AUUAGCU...AG.UUGGUGA.GGUAANGGCU..CACNA AGG.CGACGA..UCAGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........UUA.GGGUUG UAAAGC..........................U.CUU.........U...U......... ............................................................ ....................AC......C............................... ...UGG................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCA.G..GAGAA..U .......AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCNGCGGUNAUAC.............GA AGGGGGCUAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GGA.................UC.............UUUAAG.UNA.GG.. ..........G..........GUG.......AAA.......UCCC.A.AGGCUCAA.C.C .........U...UG........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGG GGAU................CUc....GA..GU..C....CG.............GG... AGAGG..UGAG..UGGAACUG......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CG.CAAGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGC..CCGGU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUGC.......... ....UAGC.................................................... ......CGUUAGG............................................C.. .....................AGCUUGCUG......................CUUA...G ....UG.G...........CGC.......AGU..UAACGCUU..........UAAGC..A UC.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGNCGGGGG.CC.NGCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.NNAACGCG C.AGAACCUUA.CCAAC........................................... ....CUUUGA.....C...A.................UGUC................... ...Ucguu..............................U..................... ...........GGU.....U..............A...CCAG............AG.AUG ..................G....U.UUCCU.............................. ....UCAGUUAGGC................UGGcg......................... ............................................................ ............................................................ ....................AG..........................A..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCACGC...CCUUAG......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAGGG............GG.ACUGC.NG..G.UG.AU.AA..GCC.GA....... ...GAGGA.A.GGUGU.GGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGUUG.GG CUACACA.CGUGCUACAAU.GGCG.GU..G.ACAA.UG................GG.... ....A.N.G..............CG........AA........G................ .......GGGCGNCCCucAGCAAAU......CUC.....A..A.AAA.GC..C..G.U.C UC.A....GUUCGGAUUGUACUCUGCAACUCGAGUGCAUGAAG.UUGGAAUCGCUAGUAA UCGUAGAUCAG..AA.CG.CUACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UUC..............UACCCGAA....GG...................C.. ...GU.UU........U............GCU.....A....A.........CCG..... ..............C.A...AG.GG.................G.....GCAn.......G ....C..GACCAC....GGUA......................GGG...U.......... .CA.................GCGACN......N...GGG..................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.GCGAACGCTGG.CGG..CAGGCTTAACACATGCAA.GT....C.....G AGC.....G........GGC........................................ ................................GTAGCAATACgtc............... ............................................................ ...AGC...................................................... ...........................................................G GCAG.....ACGGGTGA....GTAACGC.GTG.GG..AACGT.................. ........................................A................CCT TTTggtt..................................................... ...C.GGAACAAC.A.CA.GGGAAACT.............T.GT................ ............................................................ .............................................G.CTAATACC..... ..GGAT...................................................... ........................................AA.................. ....................G.C..................................... ..CCttacGGGGAAAGATT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TATC... ............................................................ ......................................GCCG.................. ................AAA......................................... ............................................................ ...................G.......AT.......C....................... .GG..........CCCG.CGTCT..................................... ...G..................ATTAGC.TAGTT...GGTGA.GGTAATGGCT..CACCA AGG.CGACGATC..AGTAGCTGGTCT.......GAG.AGG..AT..G..ATCA...GCCA CATTGGG.ACTGAGACACG.GCCC..AAACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGGACAAT........GGGGGCA.ACC................CT...GAT.C...C.A GCCAT.GCCGC.GT......GAGTGATG...AA...GG.CC.........CTA.GGGT.. ............................................................ ......................TGTAAAGCTCTT................TTGTgcGGGA AGA......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .........................TA.A...TGACG.G....TACCGC.A..AGAAT.. .......AAGCCCC..................G........................... ............GCTAACTTC..GTGCCAGCAGCCGCGGTAATAC.............GA AGGGGGCTAG..CGTTGCTCGGAATCAC..TGGGCGTAAAGGGT.G.C.GTAGG...... ........C.GG.................GTCTT......T.......AAGT.CA.GGG. ...........GT..........G.......AAAT.......CCtggA..GCTCAA.CT. .....C....C...A........G.........AACT...........G........... ......................C.CTTT....................G..AT..ACTGA ggA............T....CTT....GA..GTT......CG.............GG... AGAGGT..GAG..TGGAActgCGAG..........T.................GTAGAGG TG..AAATTCGTA.GATATT..CG.CAAGAACACCAG.TGGCGAA............GGC GGCTCACTGGc........CCGA..TACTGACGCTGAG.GCACGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGAATGCcAGCCGTTagt... ...G........................................................ ......................................................GGTTTA ctcacTA...........................GT........................ .....G.G...........CGC.......AGCT..AACGCTTT..........AAGCAT. .T.............CCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAA...AGGAAT TGACGGGGG.CC..GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAC.GCAACGCG C.AGAACCTTA.CCAGC........................................... ....CCTTGACATGT............................................. ...................C.....CAGGA...C.......................... ...........CGGT............C......G....CAG............AG.ATG TGAccttCTCTT................................................ ............................................................ ............................................................ .......C.................................................... .......................................GGAGCCTG.G..A....G... ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCCGT...CCTTAGTT..........GCT.. .AC.C....ATTTAGT.....................................TGAG..C A.CTCTAAGGA............G.ACTGCC.G..GT.G.AT..AA.GCC.G........ ..CGAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCCTTACG.GGCTG.GG CTACACA.CGTGCTACAAT.GGCG.GT..G.ACAAT.G................GG.... ....ATgct........................AA........G................ .......GGGCGACCCttcGCAAAT......CTC.....A..A.AAA.GC..C..G.T.C TC.A....GTTCGGATTGGGCTCTGCAACTCGAGCCCATGAAGTT.GGAATCGCTAGTAA TCGTGGATCAG.C.A.CG.CCACGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GTT.............................GGT TTT......................ACCTGAA....GA...................C.. ...GGTGC........G.............CT.....A....A.........CC...CGC .A........AG.........G.G.................AG.....GCA.......GC ....C..GGCCAC....GGTAGGGTCAGC............................... ...............................GACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC.............................................. ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AAC.....G......CA..C........................................ ...............C................UUC......................... ............G.......G....................................... .......G............U..........GAG....U..................... ...........................................................G GCAG.....ACGGGUGA....GUAACGC.GUG.GG.AAUC...................U ........................................A................CC. .C.....A..............U......U............................GG .UGC.GGAAUAAC.U.CG.GGGAAAC.............UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.................. ....................G.C..................................... ..CC........................................................ ............................................................ .................................................UC......... ............................................................ ............................................................ ........CGGGG...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGC..C................................................ .............................AAU............................ ..................GG.......A.......U........................ GAG..........CCCG.CGU....................................... .UGG..................AUUAGCU...AG.UUGGUGG.GGUAAUGGC..CCACCA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................C........ ....................A......GU............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCUA..C.AGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCUAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GGA.................UUG.............UUAAG.UCA.GG.. ..........G..........GUG.......AAA.......UCCC.G.AGGCUCAA.C.C .........UC...G........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGG CAAU................CU....AGA..GU..C....CG.............GA... AGAGG..UGAG..UGGAAUUC......CUA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUUA.GG.AAGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGU..CCGGA..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUGC.......... ....UAGC.................................................... ......CGUCGGc............................................C.. .....................AGCUUGCUGgUCG.........................G ....UG.G...........CGC.......AGC..UAACGCAU..........UAAGC..A UC.............CCGCCUGGGGAGUACGAUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAAC........................................... ....CCUUGA.....C...A.................UC.C............C...... ......GAUC..G............................................... ..........CGGU.....U..............A...CCGG............AG.ACG ..................G....U.UUCCU.............................. ....UCAGUUCGGC................UGGA.......................... ............................................................ ............................................................ ...................UC.........................G.G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CCUUAG......U....UGC..C .AG.C....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCUAAGG............GG.ACUGCC.G..G.UG.AU.AA..GCC.G........ ...GAGGA.A.GGUG.GGGAUGcAGUC..A..AGUCCUCAUGGCCCUUACG.GGUUG.GG CUACACA.CGUGCUACAAU.GGCG.GU..G.ACA.GUG................GGC... ......A.G..............CG........A........CUucu.....C.GA.G.. ......G........AGGAGCUAAU......CCC.......CA.AAA.GC..C..G.U.C UC.A....GUUCGGAUUGUUCUCUGCAACUCGAGAGCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGAUCAG.C.UU.G.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGGC ........UU..............UACCCGAA....GG...................C.. ...GC.U.......GC.............GCU.....A....A.........CC...CGC .A........AG.........G.G.................AG.....GCA.......GG ....C..GACCAC....GGUA......................GGG...U.......... .CA.................GCGACU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ............................................................ ........GA.ACGAACGCUGG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AGC.....G..................................CC............... .CC................GCAA................GGG...............G.. ............................................................ ...AGC...................................................... ...........................................................G GCAG.....ACGGGUGA....GUAACGC.GUG.GG.AAUC...................U ........................................A................CC. .C.....A..............U......C......U......................C .UAC.GGAAUAACG..CA............UGG.AA.ACG.UG................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GUAU.AC.................. ....................GUC..................................... ............................................................ ...................................C........................ ............................................................ .....UUCG................................................... ..................G..........................G.............. ...............AGAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGAG................................................. ..............................AU............................ ..................GG.......A.......U........................ GAG..........CCCG.CGU....................................... .UGG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................C........ ....................AC......CG.............................. ....G.............................U...................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................AACC.G..GAGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCUAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GGA.................CU.............AUUAAG.UCA.GG.. ..........G..........GUG.......AAA.......UCCC.GG.GGCUCAA.C.C .....C....C...G........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGG UAGU................CU....UGA..GU......UCG.............AG... AGAGG..UGAG..UGGAAUUC......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AGGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGC..UCGAU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACUAUGAG....AGC.......... ....UAGC.................................................... ......CGUCGGG............................................C.. .....................AGUAUACUGUUCG.........................G ....UG.G...........CGC.......AGC..AAACGCAU..........UAAGC..U CU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....CCUUGA.....C...A.................UC.C............C...... ......GAUC..G............................................... ..........CGGU.....U..............A...CCAG............AG.AUG ..................G....U.UUCCU.............................. ....UCAGUUAGGC................UGGA.......................... ............................................................ ............................................................ ...................UC.........................G.G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CCUUAG......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAGG............GG.ACUGCC.G..G.UG.AU.AA..GCC.GA....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGCUG.GG CUACACA.CGUGCUACAAU.GGUG.GU..G.ACA.GUG................GGC... ......A.G..............CG........N......G..ACC.....GC.GA.G.. ......G........NNGAnNUAAU......CUC.......CA.AAA.GC..C...AU.C UC.A....GUUCGGAUUGCACUCUGCAACUCGAGUNCAUGAAG.UUGGAAUCGCUAGUAA UCGUGGAUCAG..AAU.G.CCACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UUU..............UACCCGAA....GGU..................... ...GC.U.......G.U............GCU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GG ....C.A.ACCAC....GGUA......................GGG...U.......... .CA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC.............................................. ............................................................ ........................................................... > ............................................................ ....CUCAGA.ACGAACGCUGG.CGG..CAGGCUUA....ACACAU.GGAAGUC.....G AGC.....G..................................CC............... .CC................GCAA................GGG...............G.. ............................................................ ...AGC...................................................... ...........................................................G GaAG.....ACGGGUGA....GUAACGC.GUG.GG.AA.CG..................U ........................................A................CC. ......AU..............U......U............................GC .UAC.GGAAUAAC.U.CA.GGGAAAC.............U.UG................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GUAU..................... .......GU...........G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UUCGGGG...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGC.....AAAU......................................... ............................................................ ...................G.......A.......UC....................... .GG..........CCCG.CGU....................................... .UGG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGCU..CACCA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................C........ ....................AC......CG.............................. ....G.............................U...................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................AACC.G..GAGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCUAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GGA.................CU.............UUUAAG.UUA.GG.. ..........G..........GUG.......AAA.......UCCC.GG.GGCUCAA.C.C .....C....C...G........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGG AAGU................CU....UGA..GU......AUG.............GU... AGAGG..UGAG..UGGAAUUC......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AGGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGA..CCAUU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAN ACAGGAUUAGAUACCCUGGUAGNCCA.CNCCGUAAACGAUGA....AUGU.......... ....UAGC.................................................... ......CGUCGGGg.............................................. .....................UGUUUACAcUUCG.........................G ....UG.G...........CGC.......AGC..UAACGCAU..........UAAAC..A UU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....CCUUGA.....C...A.................UC.C............C...... ......GGU................................................... ...........................C......G....CGG.................. ....UUAGUGGAGAC..A..C..U.AUCCU.............................. ....UCAGUUAGGC................UGGA.......................... ............................................................ ............................................................ ...................CC.........................G.G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CCUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAGG............GG.ACUGCC.G..G.UG.AU.AA..GCC.GA....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGCUG.GG CUACACA.CGUGCUACAAU.GGUG.GU..G.ACA.GUG................GGC... ......A.G..............CG........A......G..CAC.....GC.GA.GU. .......G........UGAGCUAAU......CUC.......CA.AAA.GC..C...AU.C UC.A....GUUCGGAUUGCACUCUGCAACUCGAGUGCAUGAAG.UUGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UUU..............UACCCGAA....GG...................C.. ...GC.U.......G.U............GCU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GG ....C..GACCAC....GGUA......................GGG...U.......... .CA.................GCGACU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > .....................GUUUGAUCCU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AGC.....G..................................CC............... .CC................GCAA..................G...............G.. ............................................................ ...AGC...................................................... ...........................................................G GCAG.....ACGGGUGA....GUAACGC.GUG.GG.AAUC...................U ........................................A................CC. ......UU..............U......U............................GC .UAC.GGAAUAACG..CA.GGGAAAC.............U.UA................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GUAU..................... .......GU...........GUC..................................... ............................................................ ...................................C........................ ............................................................ .....UUCG................................................... ..................G..........................G.............. ...............AGAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGC.....AA........................................... ...............................GA........................... ...................G.......A.......U........................ GAG..........CCCG.CGU....................................... .UGG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................C........ ....................AC......CG.............................. ....G.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................AUCC.G..GAGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCUAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........Ccgauc..................G.............AUCAG.UCA.GG.. ..........G..........GUG.......AAA.......UCCC.AG.GGCUCAA.C.C .....C.......UG........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGU CGAU................CUG....GA..GU......AUG.............GA... AGAGG..UGAG..UGGAAUUC......CGA.....................GUuUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AGGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGU..CCAUU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....AUGU.......... ....UAGC.................................................... ......CGUCGGG............................................C.. .....................AGUAUACUGUUCG.........................G ....UG.G...........CGC.......A.CG.UAACGCAU..........UAAAC..A UU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....CCUUGA.....C...A.................UC.C................... ...UGUGUUAC......CUC....U....AG............................. ............................................................ .......................AGAU..............AGGGG.............. ............................................................ .......................GU................................... ......CC..................A.CUUCGGU...................GGCG.. ....................C..A........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CCUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAGG............GG.ACUGCC.G..G.UG.AU.AA..GCC.GA....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGCUG.GG CUACACA.CGUGCUACAAU.GGUG.GU..G.ACA.GUG................GGC... ......A.G..............CG........A......G..CAC.....GC.GA.GU. .......G........UGAGCUAAU......CUC.......CA.AAA.GC..C...AU.C UC.A....GUUCGGAUUGCACUCUGCAACUCGAGUGCAUGAAG.UUGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UUU..............UACCCGAA....GGUA.................... ....G.U.......GC.............GCU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GC .....UA.ACCAC....GGUA......................GGG...U.......... .CA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCU.......................................... ........................................................... > ...........................UCCU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AGC.....G..................................CACUcUUUU....A... ........................................GAG.........UG...... ............................................................ ............................................................ .......................................................AGC.G GCA.....AACGGGUGA....GUAACGC.GUG.GG.AAUC...................U ........................................A................CC. .C.....A..............U......C......U......................C .UAC.GGAAUAAC.A.CA.G...........AGAAA.U.U.UG................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GUAU.AC.................. ....................GUC..................................... ............................................................ ...................................C........................ ............................................................ .....UUAG................................................... ..................G..........................G.............. ...............AGAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGAG................................................. ..............................AU............................ ..................GG.......A.......U........................ GAG..........CCCG.CGU....................................... .UGG..................AUUAGCU...AG.UUGGUGA.GGUAACGGCU..CACCA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGGGCA.ACC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................C........ ....................AC......CG.............................. ....G.............................U...................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................AACC.G..GAGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCUAG..CGUUGUUCGGAUUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GGA.................UA.............UUUAAG.UCA.G... .........AG..........GUG.......AAA.......UCCC.AG.GGCUCAA.C.C .....C.......UG........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGG GUAU................CU....UGA..GU......AUG.............GA... AGAGG..UGAG..UGGAAUUC......CGA.....................GUGUAGAGG U..AAAAUUCGUA.GAU.AUU.CGG.AGGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGU..CCAUU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....AUGU.......... ....UAGC.................................................... ......CGUCGGG............................................Cgg ............UUUACUGC...........UCG.........................G ....UG.G...........CGC.......A.CG.UAACGCAU..........UAAAC..A UU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....CCUUGA.....C...A.................UC.C............C...... ......GAUC..G............................................... ..........CGGA.....AG....................................... .......GUGGAGAC..A..Ccc...UCCU.............................. ....UCAGUUAGGC................UGGA.......................... ............................................................ ............................................................ ...................UC.........................G.G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CCUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAGG............GG.ACUGCC.G..G.UG.AU.AA..GCC.GA....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGCUG.GG CUACACA.CGUGCUACAAU.GGUG.GU..G.ACA.GUG................GGC... ......A.G..............CG........A......G..ACC.....GC.GA.G.. ......G........UCGAGCUAAU......CUC.......CA.AAA.GC..C...AU.C UC.A....GUUCGGAUUGCACUCUGCAACUCGAGUGCAUGAAG.UUGGAAUCGCUAGUAA UCGUGGAUCAG.C.AU.G.CCACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UUU..............UACCCGAA....GGU..................... ...GC.U.......G.U............GCU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GG ....C.A.ACCAC....GGUA......................GGG...U.......... .CA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGG.AACC............UGUG.....G.............CUG......GA U............CACCU.......................................... ........................................................... > ............................................................ .........A.GCGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AAC.....G........GAC........................................ .CC......................................................... ....UUCG....G.......G....................................... .......G...........UU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACAC.GUG.GG.AA.CG..................U .G.......................................................CC. ......UU..............U......U............................GG .UUC.GGAACAAC.U.CA.GGGAAAC.............U.UG................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GAAU..................... .......GU...........G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UUCGGGG...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGC..C................................................ .............................AUUA........................... ..................GAG...............C....................... .GG..........CCCG.CGUC...................................... ..UG..................AUUAGCU...UG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CUACGA..UCAGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCCAU.GCCGC.GU......GAAUGAUG...AA...GGU.C.........UUA.GGAUUG UAAAA..........................UU.CUU.........U............. ...................................................C........ ....................AC......CG.............................. ....GG................................................G..... .....................................................ACG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCC.G..GAGAA... ...G...AAGCCCC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGGGCUAG..CGUUGCUCGGAAUUACUGGGCGU..AAAGGGA.G.C.GUAGG...... ........C.GGA.................UAG.............UUCAG.UCA.G... .........AG..........GUG.......AAAG.......CCC.AG.GGCUCAA.C.C .........U...UG........G.........AAC........U...G........... ......................CCU...U..................UG..A..UACUGG CUAU................CU....UGA..GU......UUG.............GG... AGAGG..UAUG..UGGAACUC......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AAGAACACCAG.UGGCGAA............GGC GACA.UA.CUGGC..CCAAU..ACUGACGCU....GAG.GCUCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGAG....UGC.......... ....UAGUU........................G......UC.......GG......... ..................................CA........................ .....................UGCAUGCA..........................U...G ....UCGGU........GACGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAcC........................................... ....UUUUGA.....C...A.................UG..................... ...................C.....CUGGA...C.......................... ...........CGC.......U............G....CAG............AG.AUG ....................C......................AG............... ............................................................ ......C...............UU............................U....... .....CCCUUC..G..........GG............................G..... .................ACU..AG........................G..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...UGUUAG......U....UGC..C .AC.C....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCUAACA............GG.ACUGCC.G..G.AG.UU.AAU..CC.G........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUACA.AggUG.GG CUACACA.CGUGCUACAAU.GGCG.A...CUACA.GAG................GGC... ......U.G..............CA........A......G..CC.....AGCGAU.... ......GgU........GAGCCAAU......CCC.....A..A.AAA.G.U.C..G.U.C UC.A....GUUCGGAUUGUUCUCUGCAACUCGAGAGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGGC ........UU..............UACCCGAA....GG...................C.. ...GG.U.......GC.............GCU.....A....A.........CC.....A GC........A.....A...UG.G.................AG.....GCA.......GC ....C..GACCAC....GGUA......................GGG...U.......... .CA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGC............................... ............................................................ ........................................................... > c...AACU.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAGA.AUGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGC.....GAAGU............................................... ......................................................CUUCGG ..........A................................................. ...................C..................UU.................... .......................................................AGC.G GCGG.....ACGGGUGA....GUAACGC.GUG.GG.AA.CG..................U .G.......................................................CC. .C.....U..............U......U............................GC .UUC.GGAAUAG.C.CC.CG...........GG.AA.ACU..G................. ...............G............................................ .............................................GAG............ .................................................UAAUACC.... ...................................GAAU..................... .......GU...........G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UUUGGGG...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGC.....AAA.......................................... ............................................................ ..................GG.......A.......UC....................... .GG..........CCCG.CGU....................................... .UGG..................AUUAGGU...AG.UUGGUGG.GGUAAUGGC..CUACCA AG.CCGACGA..UCCAUAGCUGG...U....UUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UU.....AG...ACAAUGGGCGCA.AGC................CU...GA.UCU....A GCCAU.GCCGC.GU......GAUCGAUG...AA...GG.CC.........UUA.GGGUUG UAAAG..........................AU.CUU.........U............. ...................................................C........ ....................A......GG............................... ...UGG................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCAC..C.AGAA... ...G...AAGCCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGGGCUAG..CGUUAUUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GGA.................UCG.............GAAAG.UCA.G... .........AG..........GUG.......AAA.......UCCC.AG.GGCUCAA.C.C .....C.......UG........G.........AAC........U...G........... ......................CCU...U..................UG..A..AACUCC cGAU................CU....UGA..G..G....UCG.............AG... AGAGG..UGAG..UGGAAUUC......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AGGAACACCAG.UGGCGAA............GGC GGCUC.A.CUGGC..UCGAU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....AUGC.......... .......CA........................G.......................... .....UCGUCGGG............................................C.. .....................AGCAUGCUGUUCG.........................G ....UGaca............C.......ACCUAACGG..AU..........UAAGC..A UU.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAAC........................................... ....CCUUGA.....C...A.................UG.............GC...... ......GAUC..G............................................... ..........CGG......U..............U...CCAG............AG.AUG ..................G......UUCCU.............................. ....UCAGUUCGGC................UGGA.......................... ............................................................ ............................................................ ...................UC.........................GC...A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UCGGUUAAGUCCG.GCAACGAGCGCAACCCACG...UCCUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAGGGA.............AACUGCC.G..G.UG.AU.AA..GCC.G........ ...GAGGA.A.GGUGU.GGAUGACGUC..A..AGUCCUCAUGGCCCUUACG.GGUUG.GG CUACACA.CGUGCUACAAU.GGCA.GU..G.ACAA.UG................GG.... ....U.U..................................................... ......................AAU......CCC.....A..A.AAA.G...CU.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGUAACAG.C.AU.GA.CGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGAA......U.............................UGG. .......UUC..............UACCCGAA....GG...................C.. ...GG.U.......GC.............GC.....CA....A.........CCUcgC.. ..........A.....AG..AG.G.................AG.....GCA.......GC ....C..GACCAC....GGUA......................GG...AU.......... .CA.................GUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CACGCCUA....ACACAU.GCAAGUC.....G AAC.....G.......A.Gg........................................ .........................................................GC. .................A......U.................U........CUU...... ...UcggggauguuCC....U....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUG.GG.AAUC...................U .G.......................................................CC. ......U..............GA......U......A......................G .UG.GGGGAUAAC.U.............GUUGG.AA.ACG.AC................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.CUg................................GAG AGCC........................................................ ............................................................ .................................................UCU........ ............................................................ ........C.........................................C......... ..A.........G...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGCU.....AU........................................... ...............................CA........................... ...................G.......A.......U........................ GAG..........CCCG.CGUC...................................... ..AG..................AUUAGGU...AG.UUGGUGA.GGUAAAGGCU..CACCA AG.CCAAUGA..UCUGUAGCUGG...U....CUGAG.AGG..A..UG..ACCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGGGCA.ACC................CU...GA.UC...C.A GCGAU.GCCGC.GU......GAAUGAAG...AA...GG.CC.........UUA.GGGUUG UAAAG..........................UU.CUU.........U............. ...................................................C........ ....................AC......Cc.............................. ....GU................................................G..... .....................................................ACG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................AGCG.G..GAGAA... ...G...AAGCCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAGAC.............GG AGGGGGCUAG..CGUUGUUCGGAAUGACUGGGCGU..AAAGGG.CG..UGUAGG...... ........CUGuug...............................AUCAAG.UCAA.G.. ..........C..........GUG.......AAAG.......CC.UCG.GGCUUAA.C.C .....C......G.A........G.........AAC........U...G........... ......................CGU...U..................UG..A..UACUGG UUGA................CU....UGA..G..G....ACG.............AG... AGAGG..AAAG..UGGAAUUC......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AGGAACAUCAG.AGGCGAA............GGC GGCU.UU.CUGGC..UCGUA..UCUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGAG....UGC.......... ....UAGAC........................G.......UU....G.GG.....G... ....................G....GU........U.....CC........CC....... ....................UU.....................C................ .A.....GU........GUCGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....UCUUGA.....C...A.................UG.............G....... ............G..................GAUUAUGg..................... ............................................................ ......AGAGGAGAGAUU..C..U.UUCCU.............................. ....UCAGUUCGGC................UGGA.......................... ............................................................ ............................................................ ...................UCCC.................................G... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCA...UUUUUAG......U....UGC..C .A.UC....AGG........U..U.........U...G......G..CU.....GGGU.. A.CUCUAAAGA.............AACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.GGCUG.GG CUACACA.CGUGCUACAAU.GGCG.GU..G.ACA.GAGA................GG... ......A.G..............CA........AA........G................ .......GGGCGACCUGGAGCGAAU......CU.....UU..A.AAA.GC..C..G.U.C UC.A....GUUCGGAUUGCACUCUGCAACUCGAGUGCAUGAAG.UUGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCACGGGCCUUGU..ACACAC CGCCCGUCAUACCAUGGGA......GU.............................UGA. ........UUc.............AACCUUAA....GG...................C.. ...GG.U.......G.A............GCU.....A....A.........CCG..... ..........A.....A...AG.GG....................A..GCA.......GC ....C..GACCAC....GGUG......................GGG...U.......... .CA.................AUGACU.........GGGGUAAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUUUNN................................... ........................................................... > NN.AAACU.....U...GAGAGUUUNANCCU.GG.......................... ....CUCAGA.ACGAACGCUAU.CGGU..AUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GACUAAU................UG................G. ................................G......GCUUGCuc...........C. .................A......A.................UUA.............G. ..............................UUAG....U..................... ...........................................................G GCAG.....ACGGGUGA....GUAACAC.GUG.GG.AAUC...................U ........................................A................CC. .C.....A..............U......C......A......................G .UAC.GGAAUAAC.U.UU............UAGAAA.U.A.AA................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GUAU.AU.U................ ......................CNC................................... ............................................................ ............................................................ ............................................................ .........................................UG................. .................C...........................G.....G........ ..A.........G...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGCUG................................................. ..............................AU............................ ..................GG.......A.......U........................ GA.....N.....CCCG.CGUC...................................... ..AG..................AUUAGGU...AG.UUGGUGA.GGUAAUGGCU..CACCA AG.CCGACGA..UCUGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CNNACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCAAUA.CCGA.GU......GAGUGAUG...AA...GG.CC.........UUA.GGGUUG UAAAGC..........................U.CUU.........U...U......... ............................................................ ....................A......Gcaa............................. .....G................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGUU............................ACUU.G.C.AGAA..A .......AAGCCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAGAC.............GG AGGGGGCNAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGAGU.G.C.GUAGG...... ........C.GGU.................UU.............AGUAAG.UUG.G... .........A..........AGUG.......AAAG.......CCC.GG.GGCUUAA.C.C .........UC...GN.................AA......U..U...G........... ......................CUU...UC..................A..A..AACUAC UAAUn................U....AGA..GU..G....U.............AGU... AGGGG..AUGA..UGGAAUUC......CUA.....................GUGUAGAGG UG..AAAUUCUUA.GAU.AUUA.GG.AGGAACACCGG.UGGCGAA............GGC GGUC.AU.CUGG..GCUACC..ACUGACGCU....GAU.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAGAUA...............................UcggaagauuC........ ...............U.....C.........UUU........C.G............... .........................GU..............U.................. ..................UCGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CUC.GCNCA.AG.C.GGUGGAGCAUGC.GGUUUAAUUCGAU.GUUACGCG .AAAAACCUUA.CCAAC........................................... ....CCUUGA.....C...A.................UG.............G....... ........................U....................G.........GUUGc gga.......................UC......G....CAG............AG.AUG ....................C..U.UUUC............................... ..UUcagc.UCGGC................UGGA.......................... ............................................................ ............................................................ ...................CCA.........................C...A........ ...............CA.CAGG.UGUUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCA...UUCUUAU......U....UGC..C .AG.C.G...GGUA......................AU............G.CCGGGA.. A.CUAUAAGAA.............AACUGCC.G..G.UG.AU.AA..GCC.G........ ...GAGGA.A.GGUN.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.GGUUG.GG CUACAC.GCGUGCUACAAU.GGUG.U..U.UACA.GAG................GG.... ....A.A.G..............CA........A......G..ACggc............ ...GACG........UGGAGCAAAU......CCC.....U..A.AAA.G.A.C...AU.C UC.A....GUUCGGAUUGUUCUCUGCAACUCGAGAGCAUGAAG.UUGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCUCGGGCCUUGU..ACACAC UGCCCGUCACGCCAUGGGA......GU.............................UAG. ........UUU.............UACCUGAA....GG...................U.. ...GG.U.......G.A............GCU.....A....A.........CGC..... .....................AAG.................AG.....GCA.......GC ....C.A.ACCAC....GGUAAa.........................AU.......... .UA.................GCGAC................................... ............................................................ ............................................................ ........................................................... > cug..AUU.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAGA.ACGAACGCUAG.CGGU..AGGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GA..................AUCAG................G. ................................G........................... ..CUGCUUGC.A.G.....................................CCUUGG... ...........Uccc..................G....U..................... ...........................................................G GCAG.....ACGGGUG....CGUAACGC.GUG.GG.AA.CU..................U GCCUgguaguagggaauaaCCAGUGGAAACAUUGGGcaacA................CC. .C.....U..............A......UacgccCU......................G .AG.GGGGAAAA.......................U.U.U.AU................. ................U........................................... .............................................G.C............ .................................................UAU........ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..............CA............................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................G.......A.......UA....................... .GG..........CCCG.CGU....................................... .UAG..................AUUAGCU...AG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGA..UCUAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCCAUA.CCGCa.U......GAGUGAUG...AA...GG.CC.........CUU.GGGUUG UAAAGC..........................U.CUU.........U...U......... ............................................................ ....................A......GUG.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCCA..C.AGAA... ...G...AAGUCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGGGCUAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGGGU.G.C.GUAGG...... ........C.GGU.................CCC.............GUAAG.UUA.GG.. ....................UGUG.......AAA.......UCC.UUG.GGCUUAA.C.C .....C.......AA........G.........AAC........U...G........... ......................CAU...U..................UA..A..AACUGU GGgacucgaacg..............UGA..GA..G....AG.............GGc.. .........AA..UGGAAUUUU......U.....................GGUGUAGGGG UG..AAAUCCGUA.GAU.AUCAA.G.AGGAACGucag.GGGCGAAA............GC GAUug..CCUGGA..UCACAg..UUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGAG....UGuuaa....... .........................................AA....GU.G.....G... ....................G..U.......UAU.......................... ...........UUUAUCUGC...........UU........................... ...................UG.......UAGC..UAACGCGU..........UAAAC..A CU.............CCGCCUGGGGACUACGGUCGCAAGACUAAAACUCAA...AGGAAU UGACGGGG.ACUC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCAU............................................ ...ACCUUGA.....C...A.................UGUG................... ............................................................ ............................................................ ........................GAU..............UGUAUCCCUCUgAAGGGAG GGAGUCAGUUCGGC................UGGA.......................... ............................................................ ............................................................ ...................UCC..........................A..A........ ...............CA.CAGG.UGUUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCA...UCCUUAG......U....UGC..C .AG.C.G...GU...........UC.....G...................G.CCGGGA.. A.CUUUAAGGA.............AACUGCCAG....UG..ACAA..GC.UG........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUAUG.GUAUG.GG CUACACA.CGUACUACAAU.GGCA.A...CUACAA.UGA................GC... ......UAG..............CU........A........CACC.....G.UAA.G.. ......G........UGAcGCCAAU......CUC.....U..U.AAAgG.U..U.G.U.C UC.A....GUACGGAUUGCcUUCUGCAACUCGAaGGCAUGAAG.UUGGAAUCGCUAGUAA UCGCAGAUCAG.C.AU.G.CUGCGG.....UGAAUACGUUCUCGGGUCUUGU..ACACAC UGCCCGUCAGGCCAUGGGA......GU.............................Ucau cuu.........ACU.............CGAA....G...................CUA. ....G.U.......G.A............GCUG.........A.........CCG..... ..............C.A...AG.G.................AG.....GCA.......GC .....UA.UCUAC....GGUG......................GGG...Ug......... ...................GGUGACU.........GGGGUUAAGUCG.UAACAA.GGUAG CCG.UAGGUGAACC............UGCG.....G.............CUG......GA UU............ACCUCCUUU..................................... ........................................................... > ............................................................ ........GA.ACGAACGCUGG.CGG..CAUGCCUA....ACACAU.GCAAGUC.....G AAC.....G.......A.A........G................................ ............................................G.........CUUCGG C........................................................... .................C............UUAG....U..................... ...........................................................G GCGC.....ACGGGUG....CGUAACGC.GUG.GG.AAUC...................U .G.......................................................CC. .C.....U..............U......A............................GG .UUC.GGAAUAAC.A.............GCUGG.AA.ACGG.C................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAUG.................... ....................................A....................... ........................................UAUCG............... ............................................................ ............................................................ .............................C.............................. .................................................GAG........ ..AUC............AAAGAU..................................... .....................UUAU................................... ............................................................ ......CGC..C................................................ .............................UGA............................ ..................GG.......A.......U........................ GAG..........CCCG.CGU....................................... .UGG..................AUUAGGU...AG.UUGGUGG.GGUAAAGGC..CUACCA AG.CCGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................U.CUU.........U...U......... ............................................................ ....................AC......CC.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACUGU............................ACCG.G..GAGAA..U .......AAGCCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGGGCUAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GG.............C....UU.............UGUAAG.UCA.G... .........AG..........GUG.......AAAG.......CC.UGG.AGCUCAA.C.. ..U..C....C...A........G.........AAC........U...G........... ......................CCU...U..................UG..AG..ACUGC AUC...............G.CU....UGAA..UC......C.............AGG... AGAGG..UCAG..UGGAAUUC......CGA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUU.CGG.AAGAACACCAG.UGGCGAA............GGC GGCUG.A.CUGGA..CUGGU..AUUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....UAAC.......... ....UAGCU........................G......UCC......GG.....GCAC U..................................UGG...................... .....................UGCUUG......G.........................G ....UG.G...........CGC.......A.CG.UAACGCAU..........UAAG..UU AU.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGGG.CC.UGCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG C.AGAACCUUA.CCAGC........................................... ....GUUUGA.....C...A.................UG.............G....... ........................UAGGACGA............................ .............C.....U..............U...CCAG............AG.AUG ..................G....A.UUUC............................... ..UU........................................................ .......C...............U............................U....... .....CG.................GG............................GAccu. .....................A.........................C...A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CUUUAG......U....UAC..C .A.UC....A..........U..U.........UG..G.U........U.....GGGU.. A.CUCUAAAG............GaNACCGCC.G..G.UG.AU.AA..GCC.G........ ...GAGGA.A.GGUG.GGGAUGACGcC..A..AGUCCUCAUGGCCCUUACGC.GCUG.GG CUACACA.CGUGCUACAAU.GGCA.A...CUACA.GUG................GGC... ......A.G..............CG........A........CCCU.....GC.GA.G.. ......GG........CGAGCUAAU......CCC.......CA.AAA.G.U..U.G.U.C UC.A....GUUCGGAUUGUUCUCUGCAACUCGAGAGCAUGAAGG.CGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCAGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......AUU.C.............ACCCGAA....GG...................C.. ...GU.U.......GC.............GC.....CA....A.........CCUAGC.. .A........A.....U...AG.G.................AA.....GCA.......GG ....C..GACCAC....GGUG......................GG...UU.......... .CA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G........................ ............................................................ ........................................................... > UG..AACA.....U...AAGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAUGCUUU....ACACAU.GCAAGUC.....G GAC.....G........G.......................................... ...............CAGC...A......CAGG......G...A........AGCUUGC. .................U......U..........................C........ ........UCGGGUGGC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAUA.UC.GG.AA.CG..................U ........................................A................CCG ...........................GGU......A......................G C.G.GGGGAUAAC.U.............GAU.CGAAAG.A.UC................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................GUCUUGAG................................ ............................................................ ............................................................ ............................................................ ............................................................ ...................................................A........ ...........GG...GAAAGC.......AGG............................ .........................GGACCUUCGGG....CCUU................ .........G.................................................. ......CGCU.....AU........................................... ...............................CC........................... ..................GAG...............C....................... .GG..........CCGAUa.UC...................................... ..UG..................AUUAGCUGG....UUGGCGG.GGUAAAGGC..CCACCA AGG.CGACGA..UCAGUAGCGGG...U....CUGAG.AGG..A..UG..AUCC...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GUCUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGG..........................A.CUU.........U...UG........ ............................................................ ......................U.....C............................... ...AG........GG..................AA...................GA.... ...AAA.............GGCUgu................................... ..........................................UG................ ........CCAAUAUCGG.......................................... .............Cgg............................................ ............................................................ .......CCG.................................................. .......AU.GACGGU............................ACCU.GA..AGAA..U .......AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCGg.G.C.GCAGA...... ........C.GGU.................UAC.............UUAAGc.AG.G... .........A..........UGUG.......AAA.......UCCC.CG.GGCUCAA.C.C .....C......G.G........G.........AAC........U...G........... ......................CGU...UCU..................G....AACUGG GUGA................CUC....GA..GU..G....UG.............U.C.. AGAGGG..AGG..UGGAAUUC......CAC.....................GUGUAGCAG UG..AAAUGCGUA.GAG.AUGU.GG.AGGAAUACCG.AUGGCGAA............GGC AGCC.U.CCUGG..GAUAAC..ACUGACGUUC....Au.GUCCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGUC....AAu.......... ....UAGCU........................G......UU.......GG.....Gc.. .....................A.ACUUG.........AUUGCUU................ ............G.............GU..........A..................... ..................GCG.......UAGC..UAACGCGUG..........AAa..UU GA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAUGAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....UUUUGA.....C...A.................UGUGC.................. ....GGAA...............U.........C.......................... .....................C............U...CCGG............AG.ACG ..................G....AG.G..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA...........................G..... ...................CC.........................GUA..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCAUUAG......U....UGC..C .A.UC....A..........U..UC.........G..G.U........U.....GGG..C A.CUCUAAUGA............G.ACUGCC.G..G.UG.A.CAA..GCC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.ACCAG.GG CUUCACA.CGUCAUACAAU.GGU.CG..G.UACA.GAG................GG.... ....U.A.G..............CC........AA........GCC.....GC.GA.G.. ......G........CGGAGCCAAU......CUC.....AC.A.AAA..C..CG..AU.C GU.A....GUCCGGAUUGCACUCUGCAACUCGAGUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGGUCAG.C.AU.A.CUGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GGG g........A..............UACCAGAA....GU...................A.. ...GG.UA.......G.............GGU.....A....A.........CCG..... ..............C.A...AG.G.................AGUC.....C.......GC .....UU.ACCAC....GGUAU......................Gc...U.......... .UC.................AUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > UG..AACU.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGGA..AUGCUUA....ACACAU.GCUAGUC.....G AAC.....G.......A.UCaac..................................... ...........................C..............UU........AGCUUGC. .................U......A.................A..G.............. ...............................G............................ .......................................................AGU.G GCGG.....ACGGGcgaguaCUAAUCUC.Gg......A.CG..................U .G.......................................................CC. ......UU....................GUC............................G .UG.GGGGACAAC.U.AG............U.CGAAAG.A.UC................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.C..C.................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .....UgA.GGGG...GAAAGCG.......GG............................ .........................GGAUCUUCG....GACCAA...C............ ............................................................ .....................GUUA................................... .............................AUAA........................... ..................GAG...............C....................... .GG..........CCGAU.GUC...................................... ..UG..................AUNAGCU...AG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGA..UCAGUAGCURG...U....CUGAG.AGG..A..CG..ACCA...GCCA CACUGGA.ACUrAGACACG.GUCC..AGAC..U..CURCGGGAGGCAGCAGUGGGGAAUU UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCVUU.CCGC.GU......GAGUGAAG...AA...GG.C..........UUC.GGGUUG UAAAGC..........................Uv.UU.........U............. ...................................................CG....... .....................C......R............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAAcu................................ ............................UACAUUCUAAUA...................A AGUGUgaGGCUGA............................................... ............................................................ ............CGGU............................ACCUA...GAUAA... ...G...AAGCACC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCAAUAAUAC.............GA AGGGUGCAAG..CGUAAAUCGGAAUUACUGGGCGU..AAAGCGU...C.GCAGG...... ........C.GGU.................UU.............AGUAAG.UCA.G... .........A..........UGUG.......AAA.......UCCC.CG.AGCUCAA.C.. ..U......H..G.G........G.........UAC........U...G........... ......................CGU...U..................UG..A..AACUAC AAA...............G.CU....UGAA..U......AUG.............U.C.. AGAGGG..GGG..UcGAAUUC......CAC.....................GUGUAGAGU ..G..AAAUgcgugGAG.AUGU.GG.AGGAAUACCAG.UGGCGAA............GGC GGCCC..C.UGG..GAUAAU..AUUGACGCU....GAG.GUGCGNAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUNGUAGUCCA.CGCCCUNAACGAUGUC....UAC.......... ....UAGUU........................G......UU.......GG......... ......................UG........Gaguaaa...A................. .....................U.....................CCAUGAGUAacgc.... ............................AS.S..UAACGCGUG..........AAG..UA GA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CUC.GCACAgAG.C.GGUGGAUUAguggugauugAUUCGAU.GCAACGCG .AAAAACCUUA.CCUGG........................................... ....CCUUGA.....C...A.................UG..................... ...................C.....CACuaacg........................... ...............A.....A............G....CAG............AG.AUG ....................C..A.UUAggug............................ ......................................CCG.UAAGGGAAAG........ ............................................................ ............................................................ ......................UG........................G..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAG.CCA.GCAACGAGCGCAACCAAagccau.AAAUA......U....AGC..C .A.UC....A..........U..U...........A.G.U........A.....GGG..C A.CUAUUAAU............GG.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUAAGGGAUGACGUCgUA..AGUCCUCAUGCCCUAAUggaGGCAG.GG CUUCACA.CGUAAUACAAU.GGU.CG..G.UACA.GAGA................G.... ....U.U.G..............CC........AA........CCgccgag......G.. ......GG........GAAGCUAAU......CUC.....AG...AAA.GC..CN..AU.C GU.A....GUCCGGAUUGUACUCUGCAACUCGAGAGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCCCGGGCCUAGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................VGG. .......UAU..............UACCAGAA....GU...................A.. ...GU.UA.......GU.............CU.....A....A.........CCG..... ..........U.....A...AG.GG.................G.....GA.V.......A .....UU.ACCAC....GGUA......................Gu...AU.......... .UC.................AUGACU.........GGGGUNAAGURA.NNACAA.GGUAG CCG.U....................................................... ............................................................ ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAUGCUUU....ACACAU.GCAAGUC.....G AAC.....G........G.......................................... ...............CAGC...A......C..G......GGG...............GC. .................A......ACCCu............................... ...........GGUGGC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAAUACA.UC.GG.AA.CG..................U ........................................AU................C. .C.....U..............U......A......A......................G .UG.GGGGAUAACG..CA............C.CGAAAG.G.UG................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.UCUC............. ............................................................ ............................................................ ......................................CGAGG................. ............................................................ ............................................................ .............................A...............G.............. ...............A.AAAGC.......AGG............................ .........................GGAUCGCAA....GACCUU................ .........G.................................................. ......CGCU.....UU........................................... ...............................UG........................... ..................GAG...............C....................... .GG..........CCGAU.GUC...................................... ..UG..................AUUAGCU...AG.UUGGUGA.GGUAAAGGCU..UACCA AGG.CGUCGA..UCAGUAGCUGG...U....CUGAG.AGG..A..CG..ACCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....G...ACAAUGGGGGAA.ACC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................C........ ....................A......GCC.............................. ....GGA..................................................... .....................................................ACG.... ............................................................ ..................A....AAcgguc.............................. ..........A................................................. ............................................................ ......CGGUUAAUACCCGUgacU...............................AC... .......U..GACGGU............................ACCG.GA..AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCGU.G.C.GCAGG...... ........C.GGU.................UU.............UGUAAG.UCA.G... .........A..........UGUG.......AAA.......UCCC.CG.GGCUUAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CGU...U..................UG..A..AACUAC AAG...............G.CU....AGA..GU..G....UG.............G.C.. AGAGGG..GGG..UGGAAUUC......CAC.....................GUGUAGCAG UG..AAAUGCGUA.GAG.AUGU.GG.AGGANCACCG.AUGGCGAA............GGC AGCCC..CCUGG..GUUAAC..ACUGACGCUC....AG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGUC....AAC.......... ....UAGUU........................G......UC.......GG.....GUCU ...............U......AACGG...........AC..UuG............... .........................GU..............A.................. ..................ACGC.......AGC..UAACGCGUG..........AAG..UU GA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAUUAUG.UGGAUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCUAC........................................... ....CCUUGA.....C...A.................UGUGCC.........G....... ............GAgcccgccg...................................... ........................................AG............AG...G UGGN........................................U............... ..................................GUGCCCG.AAAGGGAACG........ ............................................................ ............................G............................... .....................C..........................A..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCAUUAA......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUUUAAUGA.............AACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.GGUAG.GG CUUCACA.CGUAAUACAAU.GGCG...CG.UACA.GAG................GG.... ....U.U.G..............CC........AA........CCC.....GC.GA.G.. ......GG........GGAGCUAAU......CUC.....AG...AAA.GC.GC..G.U.C GU.A....GUCCGGAUCGGAGUCUGCAACUCGACUCCGUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUcC.............ACCAGAA....G...................CA.. ...GG.UA.......GU.............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GGC.......GC cug......CNAC....GGUGA......................G...AU.......... .UC.................AUGACU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.UUGAACGCUGG.CGG..CAUGCUU.....ACACAU.GCAAGUC.....G AAC.....G........G.......................................... ...............CAUCG.........C..G......GG.AA........AGCUUGC. .................U......U.................U........CCUGG..C. ..............GGC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACACA.UC.GG.AA.CG..................U ........................................A................CCG ...........................GcU......A......................G .UG.GGGGAUAAC..CCG............U.CGAAAG.A.C.................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.CUC................................... ............................................................ ............................................................ ............................................................ .........................................U.................. ..................................U.......A..G.....G........ ..A.........G...GAAAGC.......AGG............................ .........................GGACCUUUGGG....CCUU................ .........G.................................................. ......CGCU.....AN........................................... ...............................C............................ ..................GAG...............C....................... .GG..........CCGAU.GUC...................................... ..CG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCAGUAGCGGG...U....CUGAG.AGG..A..CG..AUCC...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UUG.....G...ACAAUGGGGGCA.ACC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GGGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGCCC............................U.........U...UCG....... ............................................................ ...........................GC............................... ...AG........GG..................AA...................GA.... ...AAUc..................................................... ............................................................ ..GGCGGGGcg................................................. ............................................................ ............................................................ ..........AAUAACCCUgcugG...................................A .......U..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUAAUCGGAUUUACUGGGCGU..AAAGCGU.G.C.GCAGG...... ........C.GG.............C....CCG.............UUAAG.ACA.GG.. ....................UGUG.......AAA.......UCCC.UG.GGCUCAA.C.C .........U...AG........G.........AA......U..U...G........... ......................CGC...U..................UG..UG..ACUGG CgG...............G.CUC....GA..GU......ACG.............GU... AGAGGG..GGG..UGGAAUUC......CU.....................GGUGUAGCAG UG..AAAUGCGUA.GAG.AUCA.GG.AGGAACACCG.AUGGCGAA............GGC AGCCC..CCUGG..GCCUGU..ACUGACGCUC....AU.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGGG....UAC.......... ....UAGC.................................................... ......CGUUUGGugcgcg............AUAGCG..C..UG................ .......................................................A...G ....UG.G...........CG.......AA.N..UAACGCGUG..........AAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGG.A.CC.GCACA.AG.C.GGUGGAUGAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....CCUUGA.....C...A.................UG..................... ...................C.....C.CC............................... ..........................................GAACCUGG.......... ..................G....AGA....................GAU..C........ .............C................UGGGGUGCCCG.AAAGGGAACG........ ............................................................ ............................G............................... .......................G........................G..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...CAUUAG......U....UGC..C .AG.C.G...Gcuu................G...................G.CCGGG..C A.CUCUAAUG............GG.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUAUG.GGUAG.GG CUUCACA.CGUCAUACAAU.GGCG...CG.UACA.GAG................GG.... ....U.U.G..............CG........AA........GC......GC.GA.G.. ......G........CGGAGCCAAU......CCC.....AG...AAA.GC.GC..G.U.C GU.A....GUCCGGAUUGCAGUCUGCAACUCGACUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GGG .........UGC.............ACCAGAA....GU...................C.. ...GG.UA.......G.C............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GC........GC ....C..GCCCAC....GGUGU......................GC...UC......... ..C.................AUGACU.........GGGGUGA.................. ............................................................ ............................................................ ........................................................... > ............................................................ .........A.UUGAACGCUGG.CGG..CAUGCCUU....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACGcg......N........G. ................................G......G...A................ .................A......ACcn.........................UGG..C. ..............GAC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAAUGCA.UC.GG.AA.CG..................U .G.......................................................CC. .C.....U....................GA......A......................G .UG.GGGGAUAACG..UA.G............CGAAAG.U.UAC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AU.UCUGUgag......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................................................C......... ..A.........G...GAAAGC.......AGG............................ .........................GGAUCUUAG....GACCUU................ .........G.................................................. ......CGCU.....UU........................................... ...............................GG........................... ..................GAG...............C....................... .GG..........CCGAU.GUC...................................... ..GG..................AUUAGCU...AG.UUGGUGA.GGUAAAAGCU..CACCA AGG.CGACGA..UCCGUAGCGGG...U....CUGAG.AGG..A..UG..AUCC...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....G...ACAAUGGGGGAA.ACC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GAGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................U.CUU.........U............. ...................................................CGGCG.... ............................................................ ....G........GG..................AA...................GA.... ...AAU.............GGCAcu................................... ....................................GGC..................... ...UAAUACCUGgug............................................. ............................................................ ..................................UC........................ .......................G...................................A .......U..GACGGU............................ACCC.GA..AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCGU.G.C.GCAGG...... ........C.GGU.................UG.............UGUAAG.ACA.G... .........AC..........GUG.......AAA.......UCCC.CG.GGCUCAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CGU...U..................UG..UG..ACUGC ACA...............G.CU....AGA..GU......UUG.............G.C.. AGAGGG..GGG..UGGAAUUC......CAC.....................GUGUAGCAG UG..AAAUGCGUA.GAG.AUGU.GG.AGGAACACCG.AUGGCGAA............GGC AGCCC..CCUGG..GCCAAU..ACUGACGCUC....AU.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGUC....AAC.......... ....UAGGU........................G.......UU....G.G..U...G... ....................G....GGUUAAA..........C........CC....... ....................AUU..................................... .A.....GU........GCCG.......UAGC..UAACGCGUG..........AAG..UU GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAUGAUG.UGGAUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCUAC........................................... ....CCUUGA.....C...A.................UGUC................... ...AGGAA...............U.........C.......................... .....................C............Uugag.AG............AU.UAG ..................G........................GA............... ..................................GUGCCCG.AAAGGGAAC......... ............................................................ ............................................................ ...................CUG..........................A..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUG...UCAUUAA......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAUGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.GGUAG.GG CUUCACA.CGUCAUACAAU.GGU.CG..G.UcCA.GAG................GG.... ....U.U.G..............CC........AA........CCC.....GC.GA.G.. ......GG........GGAGCCAAU......CCC.G.......CAAA.GC..CG..AU.C GU.A....GUCCGGAUUGCAGUCUGCAACUCGACUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......G..........................CG...GG. .....................UUCUGCCAGAA....GU...................A.. ...GU.UA.......G.C............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GGC.......GA .....UU.ACCAC....GGCA......................GGG...U.......... .UC.................GUGACU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ucA..........AAUGAAGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGNCN.G..CAUGCCUU....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................G. ................................G....................ACUUCGG .............................................UC.......C..... ....GC..U.....GAC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAAAGCA.UA.GG.AAUAC................... ........................................AU................C. .C.....A..............U......U......A......................G .UG.GGGGAUAACG..CA............U.CGAAAG.G.UG................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.CUC................................... ............................................................ ............................................................ ............................................................ .........................................U.................. ..................................A.......A..G.....G........ ..A.........G...GAAAGC.......ANgggauc....................... ...............................CNA....GACCUU................ .........G.................................................. ......CGCU.....AA........................................... ...............................UG........................... ..................Ggc...............U....................... .AG..........CCUAU.GUC...................................... ..CG..................AUUAGCU...AG.UUGGUAGa.GUAAAAGC..CUACCA AGG.CGACGA..UCGGUAACUGG...U....CUGAG.AGG..A..UG..AUCA...GUCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....G...ACAAUGGGGGAA.ACC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GGGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGCCC............................U.........U...UCG....... ............................................................ ...........................GGA.............................. .....G................................................G..... .....................................................A...... ............................................................ ...........................................................A AGAAAAGCAUUGC................UCUAACAUAGCaaug................ ...........................UGA.............................. ............................................................ .......U..GACGGU............................ACCUC..C.AUAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCNGCCGCGGUAAUAC.............GU AGGGUGCNAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCGU.G.C.GCAGG...... ........C.GG.............C....UAG.............AUAAGC.CA.G... .........A..........UGUG.......AAA.......UCCC.CG.AGCUCAA.C.. ..U......U..G.G........G.........UAUC...........G........... ......................CGC...U..................UGG....AACUGU CUA...............G.CN....AGA..GU......UUG.............G.C.. NGAGGG..GGG..UAGAAUUC......CAC.....................GUGUAGCAG UG..AAAUGCGUA.GAG.AUGU.GG.AGGAAUACCG.AUGGCGAA............GGn NGCCC..CCUGG..GCUAAA..ACUGACGCUC....AU.GCNCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGUC....AAC.......... ....UGGUU........................G......UU.......GG.....GA.. ....................G....GGUAAAcc..U.....CUU................ ............................................................ .A.....GUA........ACG.......AAGC..UAACGCGAG..........AAG..UU GA.............CUGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGG.ANCC.GCACA.AG.C.GGUGGAUUAUG.UGGAUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCUAC........................................... ....CUUUGA.....C...A.................UGUCGa................. ............................................................ ........GAAUCC.......U............G....CAG............AG.AUG ....................CG..G.G..............NGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACUCG..........................A..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCAUUAG......U....NGCU.. .ACgc..................................A........A.....GGG..C A.CUCUAAUGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.GGUAG.GG CUUCACA.CGUAAUACAAU.GGU.CG..G.UACA.GAG................GG.... ....U.U.G..............CC........AA........CCC.....G.UGA.G.. ......GG........GGAGCUAAU......CUC.....AG...AAA.GC..CG..AU.C GU.A....GUCCGGAUUGCAGUCUGCAACUCGACUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CNGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUUC.............ACCAGAA....GU...................A.. ...GU.UA.......G.C............CU.....A....A.........CCG..... ..............C.N...AG.G.................AG.....GGC.......GA .....UU.ACCAC....GGUGN......................G...AU.......... .UC.................AUG.......................G.UAACAA.GGAAG ............................................................ ............................................................ ........................................................... > ............................................................ ..............AACGCTAGCggg...ATGCTTTACACATGCAA.GT....C.....G AAC.....G........G.......................................... ...............CAGC...A......C..GA.......AG.........AGCTTG.. ...CTCTt....................TGGTGG.................CG....... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAATGTATC..GG..AACGT.................. .G.......................................................CC. .CAGT...............................A......................G C.G.GGGGATAA.CT.A.CG............CGAAAG.CG.T................. ...............G............................................ .............................................G.CTAATACC..... ..GCATAC.................................................... ..............................................GCCCTACG...... ............................................................ ........GGGGAAAGGGGGGgaTCGCAAGAC............................ .....................................Ctctcactat............. ............................................................ ............................................................ ............................................................ ............................................................ ...............................................T............ ............................................................ ............................................................ ................................G........................... ..................GAG...............C....................... .GG..........CCGATAtc.G..................................... ...G..................ATTAGC.TGGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CGACGATCC..GTAGCTGGTTT.......GAG.AGG..A..CG..ACCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATT TTGGACAAT........GGGGGCA.ACC................CT...GAT.C...C.A GCCATc.CCGC.GT......GTGCGATG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAAGCACTT................TTG....... ...........................GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AACggcgc............................. ...........G.G.............................................. ............................................................ ............................................................ ..........GCTAATAACCtgtgcTA.A...TGACG.G....TACCT.G.C.AGAAT.. .......AAGCACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCAAG..CGTTAATCGGAATTAC..TGGGCGTAAAGCGT.G.C.GCAGG...... ........C.GGT.................TCG.............GAAAG.AAA.GG.. ..........TGT..........G.......AAAT.......CCC.AG.GGCTTAA.C.C T.....T.......G........G.........AACT...........G........... ......................CActtttaact.........................AC CGG...............G.C.T...AGA..GTAc......GT..............C.. AGAGGG..GGG..TAGAATTCCACG..........T.................GTAGCAG TG..AAATGCGTA.GAGATG.T.GG.AGGAATACCG.ATGGCGAA............GGC AGCCC..CCTGGGAT......GA..TACTGACGCTCAT.GCACGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCCTAAACGATGTCAACTAGCT........G TTGG........................................................ ......................................................GGTTTA ttaaCCTTAGT..............................A.................. .......G...........CGC.......AGCC..AACGCGTG..........AAGTT.. GA.............CCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAA...AGGAAT TGACGGGG.ACCC.GCACA.AG.C.GGTGGATGATGTGGATTAATT.CGA.TGCAACGCG .AAAAACCTTA.CCTAC........................................... ....CCTTGACATGT............................................. ...................CTGGAATC................................. .....................C.....C......G.......................A. ...........AGAGATTT......................................... ............................................................ ..................GGG..............AGTGCTCGCAAGAGAACC....... ............................................................ ........G............G..........................A..A........ ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGC...CATTAGTT..........GCT.. .ACattca..........................G..................TGGG..C A.CTCTAATG............GG.ACTGCC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCCTTATG.GGTAG.GG CTTCACA.CGTCATACAAT.GGT.CG..GG.ACA.GAG................GGT.T. ........G..............CC........AA........GCC.....GC.GA.G.. ......G........CGGAGCCAAT......CTC.....AG...AAAC.C..CG..ATCG .T.A....GTCCGGATCGCAGTCTGCAACTCGACTGCGTGAAGT.CGGAATCGCTAGTAA TCGCGGATCAG.C.AT.GT.CGCGGT.....GAATACGTTCCCGGGTCTTGT..ACACAC CGCCCGTCACACCATGGGA......GT..........................G...GGT TT.........C.............ACCAGAA....GTAGGTA................. ...............G.C............CT.....A....A.........CCG..... ..............C.A...AG.GG.................G.....GGC.......GC TT......ACCAC....GGTGaGA..........................TTCA...... ..............................TGACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AT.CGGAA............................................... ............................................................ ........................................................... > cG..AACU.....A...UAGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAUGCUUU....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................GU C..................................UU....................... .........CGG.........................................A...... ...UGC..U.....GAC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAAUACA.UC.GG.AA.CG..................U .G.......................................................CC. ......UA....................GU......A......................G .UG.GGGGAUAAC.U.A.C...........U.CGAAAG.AG.U................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU...G....A............ GAU......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ..............CUAC...........................G.....G........ ..A............UGAAAGC.......AGG............................ .........................GGACCUUCGGG....CCUU................ .........GUGCUAC............................................ ............................................................ ...............................UA........................... ...................G.......A................................ .....GCGG.....CUGauGGC...................................... ..AG..................AUUAGGU...AG.UUGGUGG.GGUAAAGGCU..UACCA AG.CCUGCGA..UCUGUAGCUGG...U....CUGAG.AGG..A..CG..ACCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GCAGGAUG...AA...GG.CC.........CUC.GGGUUG UAAAC..........................UG.CUU.........U...U......... ....................................................GUA..... .............................C.............................. ....GGA..................................................... .....................................................ACG.... ............................................................ ..................A....AAAGccuG...................GG.....GCU A.....A.UAUCCCCg.GG.UC...................................... .............................A.............................. ............................................................ .......U..GACGGU............................ACCGU.A..AGAA..U .......AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCGU.G.C.GCAGG...... ........C.GGU.................UU.............UGUAAG.ACA.G... .........UG..........GUG.......AAA.......UCCC.CG.GGCUCAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CCA...U..................UG..UG..ACUGC AAG...............G.CU....AGA..GU..G....CG.............G.C.. AGAGGG..GGA..UGGAAUUC......CGC.....................GUGUAGCAG UG..AAAUGCGUA.GAU.AUG.CGG.AGGAACACCG.AUGGCGAA............GGC AAuCC..CCUGG..GCCUGC..ACUGACGCUC....AU.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGUC....AAC.......... ....UGGUU........................G......UU.......GG.....GUCU ...............U......AACuga................................ .................C...U.....................C................ .A.....GUA........ACG.......AAGC..UAACGCGUG..........AAG..UU GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAUGAUG.UGGUUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCCAC........................................... ....CUUUGA.....C...A.................UG.............GC...... ....AGGAAC.................................................. .............U.....U..............A...CCAG............AG.AUG ..................G....U.UU......G........GUG............... ............................................................ ......C................U.................CGAAAGAGAACCu...... ............................................................ ..............................................GC...A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUGC...CAUUAG......U....UGCU.. .ACAuuc.............................AG.U........U.....GAG..C A.CUCUAAUG............GG.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUAG.GUGG.GG CUACACA.CGUCAUACAAU.GGCU.G..G.UACAA.AG................GG.... ....U.U.G..............CC........AA........CCC.....GC.GA.G.. ......GG........GGAGCUAAU......CCC.....A..U.AAA.GC..CA.G.U.C GU.A....GUCCGGAUCGCAGUCUGCAACUCGACUGCGUGAAG.UCGGAAUCGCUAGUAA UCGUGGAUCAG..AAU.GU.CACGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......G..........................CG...GG. .....................UcucGCCAGAA....GU...................A.. ...GG.UA.......G.C............CU.....A....A.........CCG..... ..........U.....A...AG.G.................AG.....GGC.......GC .....UU.ACCAC....GGCg......................GGG...U.......... .UC.................GUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > ............................................................ ............................................AA.GT....C.....G AAC.....G........G.......................................... ...............CAGC...A......C..G......GGG...............GC. .................A......ACCCTGGTGG.................CG....... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAATAcATC..GG..AACGT.................. .Gtcctg..................................................... ..T.................................A......................G T.G.GGGGATAG.C.CCG.G............CGAAAG.CC.G................. ...............GAT.......................................... ................................................TAATACC..... ..GCATAC.................................................... ..............................................GATCT......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ................AC...........................G.....G........ ..A............AGAAAGCG.......GG............................ .........................GGAtcttcggacctcgcgctataggg......... ............................................................ ............................................................ ............................................................ ....................G...............C....................... .GG..........CCGATggca...................................... ...G..................ATTAGC.TAGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CGACGATCt..GTAGCTGGTCT.......GAG.AGG..A..CG..ACCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATT TTGGACAAT........GGGGGAA.ACC................CT...GAT.C...C.A GCAAT.GCCGC.GT......GTGTGAAG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAAGCACTT................TTGT...... ............................Cc.............................. .....G................................................G..... .....................................................A...... ............................................................ ...........................................................A AGAAAActtCGG.G.............................................. ............................................................ ............................................................ ..........GCTAATA.CCTCtggagGA...TGACG.G....TACCG.GA..AGAAT.. .......AAGCACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCGAG..CGTTAATCGGAATTAC..TGGGCGTAAAGCGT.G.C.GCAGG...... ........C.GGTC.................T......GTT.......AAG.ACA.G... .........ATGT..........G.......AAAT.......CCC.CG.GGCTTAA.C.C T...........G.G........G.........AACT...........G........... ......................CATTT.....................GTG....ACTGG CAG...............G.C.T...AGA..GTAT......G.............G.C.. AGAGGG..GGG..TAGAATTCCACG..........T.................GTAGCAG TG..AAATGCGTA.GAGATG.T.GG.AGGAATACCG.ATGGCGAA............GGC AGCCC..CCTGGG......CCAA..TACTGACGCTCAT.GCACGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCCTAAACGATGTCAACTAGTT........G TTGG........................................................ ......................................................GGattc atttCCTTAGT..............................A.................. ..................ACGT.......AGCT..AACGCGTG..........AAGTT.. GA.............CCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAA...AGGAAT TGACGGGG.ACCC.GCACA.AG.C.GGTGGATGATGTGGATTAATT.CGA.TGCAACGCG .AAAAACCTTA.CCTAC........................................... ....CCTTGACATGgtcggaaccctggtgagagctgggg..................... ............................................................ ............................................................ ............................................................ ............................................................ ....................................GTGCTCGAAAGAGAACC....... ............................................................ ........G............A.........................C...A........ ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGT...CCTTAGTT..........GCT.. .ACGc..................................A........A.....GAG..C A.CTCTAAGGA............G.ACTGCC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCCTTATG.GGTAG.GG CTTCACA.CGTCATACAAT.GGT.CG..G.AACA.GAG................GGTCGC t................................AA........GCC.....GC.GA.G.. ......GT........GGAGCCAAT......CCC.....AG...AAAA.C..CG..ATCG .T.A....GTCCGGATCGtAGTCTGCAACTCGACTaCGTGAAGCT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGTCTTGT..ACACAC CGCCCGTCACACCATGGGA......GT..........................G...GGT TTT......................ACCAGAA....GTg..................... ...GCTAGT.....................CT.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GAC.......GG T.....C.ACCAC....GGTAGGA..........................TTCA...... ..............................TGACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AT.CGGAAAG..........GTGCGGCTGGATCACCTCCTTTCTcgagcttaacg tgtcagaagttgagcgctcacgcttatcggctgtaagAAGACAGGctaagggtctgtagc tcagtcggttagagcaccgtcttgataaggcgggggtcgttggttcgaatccaaccaga > gtttgak.....................CCT............................. ..GGCTCAGAT.TGAACGCTGG.CGG..CATGCTTTACACATGCAA.GT....C.....G AAC.....G........G.......................................... ...............CAGC...At........G......GGG...............GC. .................A......ACCTga.TGG.................CG....... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAATATATC..GG..AACGT.................. ........................................A................CC. .C.....C..............AG............A......................G T.G.GGGGACAACC..AG.T............CGAAAG.At.T................. ...............G............................................ .............................................G.CTAATACC..... ..GCATAC.................................................... ..............................................GATCT......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ................Atggatgaaagt................................ ......................G.......GG............................ .........................GGACCTTCGGGCCTcacgctccT............ ............................................................ ............................................................ ................................G........................... ..................GAG...............C....................... .GG..........CCGATAG.CT..................................... ...G..................ATTAGC.TAGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CGATGATC..AGTAGCTGGTCT.......GAG.AGG..A..CG..ATCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATT TTGGACAAT........GGGGGAA.ACC................CT...GAT.C...C.A GCAAT.GCCGC.GT......GAGTGAAG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAAGCTCTT................TTGT...... ............................C............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAttgatt............................. ...........G.G.............................................. ............................................................ ............................................................ ..........GCTAATATCCcgatta.GA...TGACG.G....TACCT.GA..AGAAT.. .......AAGCACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCGAG..CGTTAATCGGAATTAC..TGGGCGTAAAGCGT.G.C.GCAGG...... ........C.GGT.................T......GtgT.......AAG.ACA.G... .........ATGT..........G.......AAATG.......CC.CG.GGCTCAA.C.C T...........G.G........G.........AATT...........G........... ......................CATTT.....................GTG....ACTGc aCG...............G.C.T...AGA..GT..GT....GT..............C.. AGAGGG..GGG..TAGAATTCCACG..........T.................GTAGCAG TG..AAATGCGTA.GATATG.T.GG.AGGAATACCG.ATGGCGAA............GGC AGCCC..CCTGGGATAAC........ACTGACGCTCAT.GCACGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCACTAAACGATGTCGACTAGTT........G TTGG........................................................ ......................................................GTctta atagaCTTAGT..............................A.................. ..................ACGC.......AGCT..AACGCGTG..........AAGT..C GA.............CCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAA...AGGAAT TGACGGGG.AA..AGCACA.AG.C.GGTGGATGATGTGGATTAATT.CGA.TGCAACGCG .AAAAACCTTA.CCTAC........................................... ....CCTTTACATGT............................................. ...................CagaAATC................................. .....................C.....C......G.......................A. ...........AGAGATTT......................................... ............................................................ ..................GGG..............AGTGCTCGAAAGAGAGCct...... ............................................................ .....................G..........................A..A........ ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TCGGTTAAGTCCC.GCAACGAGCGCAACCCTTGT...CATTAGTT..........GCT.. .ACGa..................................A........A.....GGG..C A.CTCTAATGA.............AACTGCC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCCTTATG.GGTAG.GG CTTCACA.CGTCATACAAT.GGTGc.A..T.ACA.GAG................GGT.T. ........G..............CC........AA........CCC.....G.AGA.G.. ......GG........GGAGCTAAT......CTC.....AG...AAAgtgc.....ATCG .T.A....GTCCGGATTGAAGTCTGCAACTCGACTTCATGAAGTT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.GT.CGCGGT.....GAATACGTTCCCGGGTCTTGT..ACACAC CGCCCGTCACACCATGGGA......G..........................CG...GGT TTT......................ACCAGAA....GTAGGTA................. ...............G.CTTAA...................................CCG TA........AG.........G...................AG.....GGC.......GC TT......ACCAC....GGTAGGA..........................TTC....... .............................GTGACTGGGGTGAAGTCGT.AACAA.GGTAA agcgcgaattnccagcacactg.....GCG.....G.............CCGtt...... ............................................................ ........................................................... > ................GAAGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUNAACGCUGG.CGG..CAUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................G. .CC......................................................... ....UUCG....G.......G.................................C..... ....GC..U.....GAC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUA.GG.AAU.C..................U .G.......................................................CC. ......U....................GGU......A......................G .UG.GGGGACAACC.CCG.GGGAAAC.............UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......AA.GGGG...GAAAGCG.......GG............................ .........................GGcUCUUCG....GACCUC................ .........G.................................................. ......CGCU.....AU........................................... ...............................CA........................... ...................G.......A.......U........................ GAG..........CCUG.CGU....................................... .UGG..................AUUAGCU...UG.UUGGUGG.GGUAAUGGC..CUACBA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGNacuN..CUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.ACC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UGC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GUG.............................. ....GG................................................G..... .....................................................A...... .............GGA..................AAAGCgggUG................ ........CCUAAUACGUgc........................................ .............CU...G.AC...................................... .............................U.............................. ............................................................ .......U..GACGUU............................ACCCA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GN NNnnaaggcgcgg..UAUUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... .........UGGU.................UA.............UGUAAG.UCG.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUCAA.C.C .........U..G.GA..................A......U..U...G........... ......................CAUC...C..................G..A..UACUGC AUG...............G.CU....AGA..GU......UUG.............GU... AGAGG..AGAG..UGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AGGAACACCAG.UG.CGAA............GGC GGCUC.UB.BGGA..CCAAA..ACUGACGCU....GAG.GUGnNNAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGuUGUAAACGCUGAggccUAGC.......... .......CU........................G......UUCGG..............U ...............Ucgc....ACUAG.........AAC..UG................ .......................................................A...G ....UG.G...........CGC.......AGU..AAACGCAU..........UAAG..UC CU.............CCG.CUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGC........................................... ....CCUUGA.....C...A.................UC.C................... ...UGGAA...............U.........C.......................... .....................C............B....CAG............AG.AUG ....................CG..G.G..............AGUG............... ............................................................ ......C................U............................U....... .....CG.................GGA................................. .................ACCC..A........................G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCCcGCAACGAGCGCAACCCUUG...UCCCUAG......U....UGC..C .A.AC....A.....C....U..U.........UG..G......G...U.....GGGA.. A.CUCUAGGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGgcaag..AGUCAUCAUGGCCCUUAUG.GGCAG.GG CUACAsaGCGKGCUACAAU.GGC.CG..G.UACAA.UG................GG.... ....U.U.G..............CC........AA........GCC.....GC.GA.G.. ......G........UGGAGCCAAU......CCC.....A..A.AAR.GC..CG.G.U.C GU.A....GUCCGaAUUGGAGUCUGCAACUCGACUCCAUGARG.UCGGAAUCGyUAGWAA UCGSGGHUCAG.C.AU.UCCCGCGG.....UGAAUACGUUCCCGGGGCcuugugACACAC CGCCCGUCACACCAUGGGA......GU.............................UGGC ........UUGC.............ACCAGAA....GU...................... ..GGA.UA.......GUCU............U.....A....A.........CC.....U .UC........G.........G.G.................AG.....GAC.......GU .....UC.ACCAC....GGUGU......................GG...U.......... .CA.................AUGACU.........GGGGUGAAGUCG.UAACAA.GG... ............................................................ ............................................................ ........................................................... > .......................TTGATCCT............................. ..GGCTC.GWT.TGAACsCTGG.CGG..CATkCCTAACMCATGCMAaGT....C.....G AACscgaaa.................................................G. ................................G......GCTTCGG.............. .....CCT......................GAGTA......................... ............................................................ .......................................................RAGTG GCGG.....ACGGGTGA....GTAACGCa.TG.GG..AATCTK................. .........................................................CCt gg.................................CA......................G .AG.GGGGATAA.C.CCG.GGGAAACTc..............G................. ...............G............................................ .............................................G.CTAATACC..... ..GCATAC.................................................... ..............................................GCCCTACG...... ............................................................ ........GGGGAAAGGGGGGC...................................... ............................................................ ............................................................ ............................................................ ............................................................ ......................................................TTC... ............................................................ ......................................GGCTctcgttgCC......... ........................................A................... ............................................................ ..................GAT....................................... GAG..........CCCAt.GTC...................................... ..CG..................ATTAGC.TAGTT...GGCGG.GGTAAAGGC..CCACCA AGG.CGACGATC..GGTAGCTGGTCT.......GAG.AGG..AT..G..ACCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGGACAAT........GGGGGAAccctg....................GAT.C...C.A GCAAT.GCCGC.GT......GGGTGAAG...A...CGG.CCTg.........C.GGGT.. ............................................................ ......................TGTAAAGCCCTT................TC........ ...........................GGT.............................. ....GG................................................G..... .....................................................A...... ............................................................ ...........................................................A AGAAAAGCACGG.G.............................................. ............................................................ ............................................................ ..........GCTAATA.CCTCcgtgT...ATTGACGT.....TACCCA..C.AGAA... ...G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTAATCGGAATTcacTTGGGCGTAAAGCG.CA.C.GTAGG...... ........C.GG.............C....AC......GGTCA.......GT.CT.GC.. ..........TGT..........G.......AAAG.......CCC.CG.GGCTCAA.C.C T...........G.G........G.........AACT...........G........... ......................CAGTG.....................G..AT..ACTCC CgC...............G.C.T...AGA..GT..GT....G.............AA... AGAGGG..GGG..TGGAATTCCAGG..........T.................GTAGCGG TG..AAATGCGTA.GAGAT.CT.GG.AGGAACACCAG.TGGCGAA............GGC GGCCC..CCTGGttcAAC........ACTGACGCTGAG.GTGCGAAACGtgggggtSCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCTGTAAACGcTGTCGACTAGCCGTTtggtcc atttaagggctg................................................ ............................................................ ......A...........................GT........................ .....G.G...........CGC.......At...AAACGCGCT..........AAGT..C GA.............CCGCCTGGGGAGTACGGCCGCAAG.TTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.G.TGGAGCATGTGGTTTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCAGC........................................... ....CCTTGACATC........................C..Tcggaact........... ............................................................ ......................T...........G....CAG............AG.ATG Ccattggtgctc................................................ ............................................................ ...........................................C................ ........................GG............................GAG... ..................CCG..A........................G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GTAACGAGCGCAACCCTTGT...CCCTAGTT..........GC..C .AG.C....A.....CTTC.G............GG..................TGGGA.. A.CTCTAGGGA............G.ACTGCC.G..GT.G.AT.AAA.GCC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGGCCCTTATG.GGCTG.GG CTACACA.CGTGCTACAAT.GGT.CG..GT.ACA.GAGCgt................... .......C...............CG........AA........GCC.....GC.GAtG.. ......GT........GGAGCCAAT......CGCACAAAAt........C..CG..ATCG .T.A....GTCCGGATCGCAGTCTGCAACTCGACTGCGTGAAGT.CGGAATCGCTAGTAA TCGCGGATCAG.C.AT.GT.CGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GTT.............................GGT T.........GC.............ACCAGAA....GTAGATA................. ...............G.CTTAA...................................CCT TC........GG.........G...................AG.....GGC.......GT TT......ACCAC....GGTGTGA..........................TcaA...... ..............................TGACTGGGGTGAAGTCGT.AACAA.G.... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.UUGAACGCUGG.CNnN..NUGCUUA....ANACAU.GCAAGUC.....G GAC.....G........G.......................................... .....Ggg............................................UACUUCGG ..........UAc............................................... ...................U........................................ ......................................................CAGU.G GCGG.....ACGGGUGA....GUAACAC.GUG.GG.AAUC...................U .G.......................................................CC. ......U..............GU......U......A......................G .UG.GGGGACAGCC..CA.G............CGAAAG.C.................... ............................................................ ............................................................ ............................................UGGAUUAAUACC.... ...................................GCAU.AC.................. ....................G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UACGGGG...GAAAGC.......AGCA........................... ..........................................AU................ .........G.................................................. ......CGCU.....AA........................................... ...............................CA........................... ...................G.......A.......U........................ GAG..........CCCG.CGU....................................... .UAG..................AUUAGCUG...G.UUGGUGG.GGUAAAGGC..CCACCA AGG.CGACGA..UCUAUAGCUGG...U....CUGAG.AGG..A..UGG..CCA...GCCA CAUUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUCGGGAAUA UUG.....G...ACAAUGGGCGCA.AGCN................U...GA.UC...C.A GCAAUA.CCGC.GU......GUGUGAAG...AA...GG.CC.........UGC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GUG.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGUU............................ACCCA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GG.............C....CC.............UUUAAG.UCA.G... .........A..........UGUG.......AAA.......UCCC.CG.GGCUCAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CACC.....................UG..A..UACUGG GGG...............G.CU....AGAA..U..G....UG.............GG... AGAGG..AGAG..UAGAAUUU......CC.....................GGUGUAGCGG UG..AAAUGCAUA.GAG.AUCG.GA.AGGAAUACCAG.UGGCGAA............GGC GGCUC.U.CUGGA..CCAAC..AUUGACGCU....GAG.GUGCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....AAC.......... ....UAGC.................................................... ......CGUCaggccc.................GCUUUA.................GGGU UUGGUgg..................................................... ...................UGC.......AGC..UAACGUAU..........UAAG..UU GA.............CCGCCUGGGGAGUACGCUCGCAAGAGUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....UCUUGA.....C...A.................UG..................... ...................C....A....................GU............. ........GAACU..U.....U............G....CAG............AA.AUG U......................A.UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACAC..U........................G..A........ ...............CA.CAGG.UGCUGCACGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUG...UCCCUAG......U....UGC..C .AG.C....A.....C....A..U.........U.AUG......G...U.....GGGA.. A.CUCUAGGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUAUG.ACCAG.GG CUACACA.CGUGCUACAAU.GGG.CA..G.UACA.GAG................GG.... ....A.A.G..............CG........AA........GC.....UG.UGA.G.. ......G........UGGAGCAAAU......CCC.....AG...AAA.GCu..G..UU.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGAAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UUG. ........UUGC.............ACCAGAA....G...................CA.. ...GG.UA.......GU.............CU.....A....A.........CC.....U .UC........G.........G.G.................AG.....GGC.......GC .....UU.GCCAC....GGUGU......................GG.............. CC.................GAUGACU.........GGGGUGAAGUCG.UAACAA.G.... ............................................................ ............................................................ ........................................................... > ..................AGAGTTTGATCCT............................. ..GGCTCAGAT.TGAACGCTGGt.GG..CATGCTTAACACATGCAA.GT....C.....G AAC.....G........GT..................AGC..............Agatc. ........................................T...........AGCTTG.. ...CTAGAtgctga.....................................CG....... ............................................................ ........................................................AGTG GCGG.....ACGGGTGA....GTAACGC.GTG.GG..AATtT.................. ........................................A................CCT TTT.................................A......................G T.G.GGGGATAA.CTTT.............AGG.AA.ACTGA.................. ................A........................................... .............................................G.CTAATACC..... ..GCATAAGACCTGAGGGTt........................................ ............................................................ ............................................................ ............................................................ ......................................AAAG.................. ...........A................................................ ............................................................ ............................................................ ......................G.......GGCCTCTatttataagctcttgctagg... ............................................................ ............................................................ ........................................A................... ............................................................ ..................GAT....................................... GAG..........CCCG.CGTtG..................................... ...G..................ATTAGC.TAGTT...GGTAG.GGTAAAGGCt..TACCA AGG.CGACGATCC..ATAGCTGGTTT.......GAG.AGA..AT..GG..CCA...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGGACAAT........GGGGGGA.ACC................CT...GAT.C...C.A GCAAT.GCCaC.GT......GTGTGAAG...AA...GG.CCT.........TA.GGGT.. ............................................................ ......................TGTAAAGCACTT................TC........ ....................A......GCGGGGAGGA....................... ..........................................................AG Gt.......................................................... ............................................................ ............................................................ ............................................................ .............................A.............................. ............................................................ .......A..GCTAATtaatacttggcttaATTGACGT.....TACCT.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCGAG..CGTTAATCGGAATTAC..TGGGCGTAAAGGG.CG.C.GTAGG...... ........C.GGA.................AG.............Attaagtt.G.G... .........ATGT..........G.......AAAT.......CCC.AG.GGCTCAA.C.C T.....T.......G........G.........AACT...........G........... ......................CATC...C..................G..A..AACTGG tatt................C.T...AGA..GTAT......G.............GT... AGAGG..AAAG..TGGAATTTCAGG..........T.................GTAGCGG TG..AAATGCGTA.GATAT.Ct.GA.AGGAACACCGG.TGGCGAA............GGC GACTTT..CTGG......AtCAA..TACTGACGCTGAG.GCGCGAAAGCATGGGTAGCGA ACAGGATTAGATACCCTGGTAGTCCAT.GCTGTAAACGATGTCAACTAGCCGTTgga... ............................................................ ........................TT................C........CCTTGAGGA GTt..TA...........................GT........................ .....G.G...........CGT.......AGCT..AACGCGAT..........AAGTT.. GA.............CCGCCTGGGGAGTACGGCCGCAAGGTTAAAACTCAA...AGGAAT TGtCGGGGG.CCC..CACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGA.T.CAACGCG .AAGAACCTTA.CCTGGT.......................................... .....CTTGACATC........................C..Taagaattct......... ............................................................ .......................................CAG............AG.ATG C........................................................... ............................................................ ..................GGa..............AGTGCCTTC................ ........................GG............................GAG... ..................Ctt..A........................G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTAT...CCTTAGTT..........GC..C .AG.C....A.....C.....GTGA.......TGG..................TGGGA.. A.CTCTAGGGA............G.ACTGCC.G..GT.G.AT.AAA..CC.G........ ...GAGGA.A.GGTG.GGGACGACGTCAA....GTCATCATGGCCCTTACG.ACCAG.GG CTACACA.CGTGCTACAAT.GGGGC...GT.ACA.GAC................GG.... ....Ag..G..............CG........AA........GC.....AGCGAt.... ......GT........GGAGCGAACCt......G.....AG...AAA.GC.GCc...TCG .T.A....GTCCGGATTGGAGTCTGCAACTCGACTCCATGAAGT.CGGAATCGCTAGTAA TCGCGAATCAG.C.AT.GT.CGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GT..........................Gaa...T T.........GC.............ACCAGAA....GGggc................... .....TAG........G.............CT.....A....A.........CTTT.... ..........AG.........G.G.................AG.....GCC.......GG T.....C.ACCAC....GGTGTGG..........................TTCA...... ..............................TGACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TGCGGCTGGATCACCTCCTT.............. ............................................................ ........................................................... > ..............UUGAAGAGUUUGAUCAU.GG.......................... ....CUCAGA.UUGAACGCUGGU.GG..CAUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................GU C..................................UUa...................... ..........GG.........................................A...... ...UGC..U.....GAC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUA.GG.AAU.C..................U .G.......................................................CC. .C.....A..............U......U......U......................G .AG.GGGGAUACC.A.............GUUGG.AA.ACG.AC................. ................U........................................... .............................................G.............. ................................................UUAAUACC.... ...................................GCAU.AA.UA............... .....................................UC..................... .........................................................UGU GG....................................A..................... ............................................................ ............................................................ ............................................................ ...............UUAAAGG.......UGG.......CUUUCGGCGUg.......... ........................U................................... ............................................................ ......CGCAG................................................. ..............................AU............................ ..................GG.......A.......U........................ GAG..........CCUG.CGU....................................... .UGG..................AUUAGCU...AG.UUGGUGG.GGUAAGGGC..CCACCA AGG.CUACGA..UCCAUAGCUGA...U....UUGAG.AGG..A..UG..AUCA...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGGGCA.ACC................CU...GA.UC...C.A GCAAU.GCCaU.GU......GUGUGAAG...AA...GG.CC.........CUA.GGGUUG UAAAGC..........................A.CUU.........U...AG........ ............................................................ ......................U.....UG.............................. ....GG................................................G..... .....................................................A...... .............GGA..................AAGCCUCAAGguuaauagccuugggg GAG......................................................... ............................................................ ............................................................ ............................................................ ..........GACGUU............................ACCCA.A..AGAA..U .......AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG GGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGGGUC...UGUAGG...... .........UGGU.................UUG.............UUAAG.UCA.G... .........A..........UGUG.......AAAG.......CCC.AG.GGCUCAA.C.C .........U...UG........G.........AAC........U...G........... ......................CAU...U..................UG..A..UACUGG CAAA................CU....AGA..GU......ACG.............GU... AGAGG..AAUG..GGGAAUUU......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCA.GA.AGGAACACCA.AUGGCGAA............GGC AACA.UU.CUGGA..CCGAU..ACUGACACU....GAG.GGACGAAAGCGUGGGGAUCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGAG....UAC.......... ....UAGCU........................G......UU.......GG......... ......................AGucggug............................U. ....................AAAGGCUC..........................UA...G ....UG.G...........CGC.......A.CG.UAACGCGA..........UAAG..UA CU.............CCGCCUGGGGACUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UG....C..GA................AC............................ ...................UU.....UC..............................U. ...........AGAGAUAG....A.UU......G........GUG............... ............................................................ ......C................U............................U....... .....CG.................Gaa.............................CG.. ....................C..A........................G..U....G... ................A.CA.G.UGCUGCACGGCUGUCGUCAGCUCGUGUUGUGAAAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UUGAUAG......U....UAC..C .A.UC....A..........U..U.........A.A.G.U........U.....GGGU.. A.CUCUAUUAA............G.ACUGCC.GCUGa.....CAAG.G.C.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.ACCAG.GG CUACACA.CGUGCUACAAU.GGGU.A..U.UACA.GAG................GGC... ......U.G..............CG........AA........G................ .......GUGCGAGCUGGAGCGAAA......CUC.....A..A.AAA.Gguac....U.C UU.A....GUCCGGAUUGCAGUCUGCAACUCGACUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGGUCAG..AAU.A.CUGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUGC.............UCCAGAA....GU...................A.. ...GA.UA.......G.CU............U.....A....A.........CG...... .......................................AAUG.....GGC.......GU .....UU.ACCAC....GGAGU......................G...AU.......... .UC.................AUGACU.........GGGGUGAAGUCG.UAACAAuGGUAG CCG.UA.GGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ..A..C.........UGAAGAGUUUGAUUCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GA..................AACG.......AU.......... ................................G......G...AG.........CUUGC. ........................U..........................CCAGG..C. ..............GUC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACGCA.UG.GG.AAUC...................U .G.......................................................CC. ......UU..............U......U............................GC .UG.GGGGAUAACG..UA.GGGAAAC.............U.UAC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AAC................. .....................AC..................................... ............................................................ ...................................C........................ ............................................................ .....UAAG................................................... ..................G..........................G.............. ...............UGAAAGCG.......GG............................ .........................GGACCGAAA.G....CCUC................ .........G.................................................. ......CGGC.....AA........................................... ...............................GA........................... ...................G.......A.......U........................ GAG..........CCCAU.GU....................................... .UGG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCCAUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCNACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACNAUGGGGGGA.ACC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GU............................... ...AGG................................................G..... .....................................................A...... .............GGA..................AAGgUGC..............GUA.. .GUUAAUACCUGCGC........AA................................... ............................................................ .............................U.............................. ............................................................ .......U..GACGUU............................ACCUA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAG..CGUUAUUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GCAGG...... ........C.GGU.................UGCC.............CAAG.UCA.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUUAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CAU...U..................UG..A..AACUGG GCGA................CU....AGA..GU......AUG.............AA... AGAGG..AAAG..CGGAAUUU......CCA.....................GUGUAGCAG UG..AAAUGCGUA.GAU.AUUG.GA.AGGAACACCG.AUGGCGAA............GGC AGCUUU.C.UGG..GUCGAU..ACUGACGCUC....AU.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGUC....AAC.......... ....UAGG.....................................C....G........U C.........GG........................G.....U................. .....................UguUA.......AAGACUCG................... .......GU........GCNGG.......AGC..UAACGCAU..........UAAG..UU GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGAAAU UGACGGGG.ACCC.GCNCA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....CCUUGA.....C...A.................UC.C................... ...UAGGAAC.................................................. .............U.....U.............GG....CAG............AG.AUG ....................CC...UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACC..UA........................G..A....G... ................A.CAGG.UGUUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCCUUAc......U....UGC..C .AG.C....A.....C....U..U.........UG..G......G...U.....GGGA.. A.CUgUAAGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUACG.GCCUG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACA.GAC................GG.... ....U.A.G..............CG........AA........GCC.....GC.GA.G.. ......G........UGGAGCCAAU......CUG.....AG...AAA.GC..CG..AU.C GU.A....GUCCGGAUUGCAGUCUGCAACUCGACUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGAAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC UGCCCGUCACACCAUGGGA......GU.............................UUG. ........UUGC.............ACCAGAA....G...................CA.. ...GG.UA.......G.CU............U.....A....A.........C....... ..........U.....U...AG.G.................AG.....GGC.......GC .....UU.GCCAC....GGUGU......................GG.............. CC.................GAU...................................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.GUGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AAC.....G........G.......................................... ...............CAGC...A......CAGUA.......AG.........AGCUUGC. .................UCUU.........................A........U.... ..........GGGUGGC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GGAAUACA.UC.GG.AAU.C..................U ........................................A................Cuc uu...........................UC............................G .UG.GGGGAUAACG..UA.GGGAAAC.............U.UAC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................GAC..................................... ............................................................ ...................................C........................ ............................................................ .....UACG................................................... ..................G..........................G.............. ...............UGAAAGCG.......Ga............................ .........................GGACCUUCGGG....Cuucgcgc............ .........................................GAUUGAAUGA......... ............................................................ ............................................................ ............................................................ ..G..........CCGAU.GUC...................................... ..GG..................AUUAGCUAG....UUGGCGG.GGUAAAGGC..CCACCA AGG.CGACGA..UCCGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GGGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGCCC............................U.........U...U......... ............................................................ ....................U......GU............................... ...UGG................................................G..... .....................................................A...... ............................................................ ...........................................................A AGAAAAGCAGU................................................. ............................................................ ......CGGUUAAUACCCGAUUGU...............................UC... .......U..GACGGU............................ACCCA.A..AGAA..U .......AAGCACC..................G........................... ............GCUAACUUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA AGGGUGCAAG..CGUUACUCGGAAUUACUGGGCGU..AAAGCGU.G.C.GUAGG...... .........UGGUG..............................GUUUAAG.UCU.G... .........U..........UGUG.......AAAG.......CCC.UG.GGCUCAA.C.C .........U..G.G........G.........AA......U..U...G........... ......................CA.G..UG..................G..A..UACUGG GUcA................CU....AGA..GU..G....UG.............GU... AGAGGG..UAG..CGGAAUUC......CC.....................GGUGUAGCAG UG..AAAUGCGUA.GAG.AUCG.GG.AGGAACAUCCG.UGGCGAA............GGC GGCU.A.CCUGGA..CCAAC..ACUGACACU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGCG....AAC.......... ....UGGAU........................G......UU.......GG.....GU.. ....................GC...................................AA. ....................UUUGGCACg..............C................ .A.....GUA........UCG.......AAGC..UAACGCGU..........UAAG..UU C.............GCCGCCUGGGGAGUACGGUCGCAAGACUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....UCUUGA.....C...A.................UC.C................... ...ACGGAAC.................................................. .............U.....U..............U...CCAG............AG.AUG ..................G....A.UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACCG..U........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUUAG......U....UGC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGA.. A.CUCUAAGGA............G.ACCGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUACG.ACCAG.GG CUACACA.CGUACUACAAU.GGUA.G..GG.ACA.GAG................GGC... ......U.G..............CA........AA........CCC.....GC.GA.G.. ......GG........UAAGCCAAU......CCC.....AG...AAAC.C..CU..AU.C UC.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGAUCAG.CAUU.G.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UUG. ........UUGC.............ACCAGAA....G...................CA.. ...GG.UA.......G.CU............U.....A....A.........CC.....U .UC........G.........G.G.................AG.....GGC.......GC .....UU.GCCAC....GGUGU......................GG.............. CC.................GAUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGC............................... ............................................................ ........................................................... > ..................AGAGUUUGAUUCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........G.......................................... ...............CAGC...A......CAGUC.........U........AGCUUGC. .................U......A................................... .......GACGGGUGGC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACGC.GUA.GG.AAUA...................U ........................................A................CC. ......UU....................GA......A......................G .AG.GGGGACAAC.U.UG.GGGAAAC.............UC.A................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.U..G............. .....................................UC..................... .........................................................UGA GG....................................ACGAAAG............... ............................................................ ............................................................ ....................................................Cc...... ..............................GG............................ .........................GGACCGUAA.GGC...................... ......CUGG.................................................. ......CGCU.....UU........................................... ...............................AA........................... ...................G.......A.......UU....................... .AG..........CCUG.CGUC...................................... ..CG..................AUUAGCU...AG.UUGGUAG.GGUAAAGGC..CUACCA AGG.CGACGA..UCGGUAGCUGG...U....CUGAG.AGG..A..UG..ACCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGGGCA.ACC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UGA.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GUG.............................. ....GG................................................G..... .....................................................A...... .............GGAggcuuguuagguuaAGAGCUAGA..............UAA.... GUG......................................................... ............................................................ ............................................................ ............................................................ ..........GACGUU............................ACCCA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGAGU.G.C.GUAGG...... .........UGGU.................UUG.............GUAAG.UUAU.C.. ....................UGUG.......AAA.......UCCC.UG.GGCUCAA.C.C .........U..G.G........G...........C........A...GGuCAGA..... .........UAAUACUGCUGAACUC................................... ...........................GA..GU......AUG.............GG... AcAGGG..UAG..UGGAAUUU......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCG.GA.AGGAACACCAG.UGGCGAA............GGC GGCU.A.CCUGGC..CUAAU..ACUGACACU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....AAC.......... ....UAGCU........................G......UU.......GG......... ......................UU.......AUA.......................... ...........Ug..........AAUAU.............AA..........UUA...G ....UG.G...........CGC.......AGC..AAACGCGA..........UAAG..UU GA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....CCUUGA.....C...A.................UA..................... ...................C....A....................GU............. ........GAACU..U.....U............G....CAG............AG.AUG ....................C..A.UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACAC..U........................G..A.....U.. ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCUUA...UUGUUAG......U....UGC..C .AG.C.G........C.....G.U.........A.AUG......G........CGGGA.. A.CUCUAAUGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGCG.GGGACGACGUC..A..AGUCAUCAUGGCC.UUACG.GGUAG.GG CUACACA.CGUGCUACAAU.GGUU.G..A.UACA.GAG................GG.... ....A.A.G..............CG........AA........G................ .......GAGCGAuCUGGAGCCAAU......CU.....Uacaaagu......CA..AU.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGAAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GGC .........UGC.............ACCAGAA....GU...................A.. ...GA.UA.......GU.............CU.....A....A.........CCG..... ..............C.A...AG.GG.................G.....GAC.......GU .....UU.ACCAC....GGUGU......................GG...U.......... .UC.................AUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUN...................................... ........................................................... > N.N..........AUUGAAGAGUUUGAUUCU.GG.......................... ....CUCAGA.UUGAACGCUAG.CGG..CAUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........G.......................................... ...............CAGCGCAgggagncuunc........................... ..........................................U........CCUGG..C. ..............GGCG............AG............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAAUGC.GUA.GG.AAU.C..................U ........................................A................CC. ......UU....................GU......A......................G .UG.GGGGAUAAC..CUG.GGGAAAC.............UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GUAU.AA.U................ ......................CUC................................... ............................................................ ............................................................ ............................................................ .........................................U.................. ..................................U.......U..G.....G........ ..A.........Gc...AAAGCG.......GG............................ .........................GGAUCUUCG....GACCUC................ .........GU................................................. .......GCU.....AU........................................... ...............................AA........................... ...................G.......A.......U........................ GAG..........CCUAC.GUC...................................... ..GG..................AUUAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGA..UCCGUAGCUGG...U....CUGAG.AGG..A..CG..AUCA...GCCA CACUGGG.ACUGAGACNCG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGGGAA.ACC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................CGG...... ....................UG...................................... ....GGGAA.....G..................AAA........................ ..UUC.......................UC.............................. ............................................................ ..........................A......................AGG.....G.U A.....A.UAUCCUNGGGCG........................................ .............................U.............................. ............................................................ .......U..GACGUU............................ACCCA..C.AGAA... ...G...AAGCACU..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AGAGUGCAAG..CGUUAAUCGGAAUCACUGGGCGU..AAAGCG.CG.C.GUAGG...... .........UGGA.................UA.............UUUAAG.UCG.G... .........A..........UGUG.......AAAG.......CCC.UG.GGCUNNN.C.C .........U..G.G........G.........AA......U..U...G........... ......................CACC...C..................G..A..UACUGG GUAU................CU....UGA..GU......AUG.............GU... AGAGGG..AAN..UGGAAUUU......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GA.AAGAACACCAG.UGGCGAA............GGC GACU.U.CCUGGA..CCAAU..ACUGACACU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAGACCCUGGUAGUCCA.CGCNGUcAACGAUGAG....AAC.......... ....UAGCU........................G......UU.......GG.....GAa. ....................G..U.......U..........C........CC....... ....................UUCUUAGU..........A..................... ..................GCG.......AAGC..UAACGCGU..........UAAG..UU CU.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AGAAAU UGACGGGGG.CNC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCUAC........................................... ....CCUUGA.....C...A.................UC.C................... ...UCGGAAC.................................................. .............U.....U.............GU....CAG............AG.AUG A......................U.UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACCG..A........................G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCUCG...UCCUUAG......U....UGC..C .AG.C.G.............AG.UC..........AAGU..............CGGGA.. A.CUCUAAGGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGAUGUC..A..AGUCAUCAUGGCCCUUACG.GGUAG.GG CUACACA.CGUGCUACAAU.GGG.CA..G.UACAA.AG................GG.... ....U.U.G..............CC........AA........GCC.....GC.GA.G.. ......G........UGGAGCUAAU......CCC.....AG...AAAA.CUgc....U.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UUGGAAUCGCUAGUAA UCGCGAAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCUCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUGa.............................A. ........UUG.............UACCAGAA....G...................C... ...GGGUA.......G.............GCU.....A....A.........CC.....U .UC........G.........G.G.................AG.....GCC.......GC .....UC.ACCAC....GGUAU......................G...AUC......... ..C.................ANGAC................................... ............................................................ ............................................................ ........................................................... > ...................GAGUUUGAUCAU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................G. .CC......................................................... ....UUCG....G.......G.................................C..... ....GC..U.....GAC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAAUGC.GUA.GG.AAU.C..................U .G.......................................................CC. ......UU....................GU......U......................G .UG.GGGGAUAAC.U.CU.GGGAAACC.............C.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.CUC................................... ............................................................ ............................................................ ............................................................ .........................................AG................. .................C...........................G.....G........ ..A............UGAAAGCG.......GG............................ .........................GGAUCUUCG....GACCUC................ .........G.................................................. ......CGCU.....AU........................................... ...............................AA........................... ...................G.......A.......U........................ GAG..........CCUAC.GUC...................................... ..GG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCCGUAGCUGG...U....CUGAG.AGG..A..CG..AUCA...GCCA CACUGGG.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UGA.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG...................................................... ............................................................ ......................................A..............AAGAA.. .GGGCGGGGGU................................................U U.....A.AUACCAUGccc.AC...................................... .............................U.............................. ............................................................ .......U..GACGUU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GGU.................UUG.............AUAAG.UCA.G... .........A..........UGUG.......AAAG.......CCC.UG.GGCUUAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CAU...UG..................G..A..UACUGU CAG...............G.CUC....GA..GU..G....UG.............GU... AGAGGG..UAG..UGGAAUUU......CC.....................GGUGUAGCNG UG..AAAUGCGUA.GAG.AUCU.GA.AGGAACACCAG.UGGCGAA............GGC GGCUC..CCUGGA..CCAAC..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....AAC.......... ....UAGC.................................................... ......CGUUGGc.......G....GGUUUAA..........C........C........ .........................................UU..........UUA...G ....UG.G...........CGC.......A.C..UAACGCGA..........UAAG..UU GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....CCUUGA.....C...A.................UG..................... ...................C....A....................G.........G.... ........GAAUCC.......U............G....CAG............AG.AUG ....................CG..G.G..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA...........................G..... ...................CCa.A........................G..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCUUG...UCCUUAG......U....UGC..C .AG.C.G...GU...........UC.....G...................GgCCGGGA.. A.CUCUAAGGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUAUG.GGUAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACA.GAG................GG.... ....U.A.G..............CG........AA........GCC.....GC.GA.G.. ......G........UGGAGCAAgU......CCC.....AG...AAA.GC..CG.G.U.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUGC.............ACCAGAA....GU...................A.. ...GG.UA.......GU.............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GGC.......GC .....UU.ACCAC....GGUGU...................................... ............................................................ ............................................................ ............................................................ ........................................................... > ...................GAGUUUGAUCAU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGGU..AUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................G. .CC......................................................... ....UUCG....G.......G.................................C..... ....GC..U.....GAC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAAUGC.GUA.GG.AAU.C..................U .G.......................................................CC. ......UA....................GU......A......................G .UG.GGGGAUAAC.U.UG.GGGAAAC.............UC.A................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UACGGGG...GAAAGCG.......GG............................ .........................GGACCUUCGGG....CCUC................ .........G.................................................. ......CGCU.....AU........................................... ...............................GA........................... ...................G.......A.......U........................ GAG..........CCUG.CGU....................................... .UAG..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCUAUAGCUGG...U....CUGAG.AGG..A..CG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGCA.AGC................CU...GA.UC...C.A GCAAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UGA.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................Aa...................................... ............................................................ ......U..................................................... ............................................................ ............................................................ ............................................................ ..................................................AGGGAGGAAA ACcugcCGGUUAAUACCCGgcagA..................................CU .......U..GACaUU............................ACCUA.U..AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCGU.G.C.GUAGG...... ........C.GGU.................UAG.............GUAAG.UCA.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUUAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CAU...U..................UG..A..UACUGG GUAA................CU....AGA..GU......UU.............AAU... AGAGG..AGAG..UGGAAUUU......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCU.GA.AGGAACACCAG.UGGCGAA............GGC GCCUC.U.CUGGA..CACAA..ACUGACGCU....GAG.GUACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....AAC.......... ....UAGC.................................................... ......CGUUGGUCUUAUUCGU.A.......AG........................... .......................................................AUUCG ....UG.G...........CGC.......A.C..UAACGCGA..........UAAG..UU GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....CCUUGA.....C...A.................UC.C................... ...AUGGAAUC................................................. ....................UGU..................................... ..........GAGAGAUAG....U.AG..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACUC..U........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCUUA...UCCUUAG......U....UGC..C .AG.C....A.....C.....G.U.......G...AUG......G...U.....GGGA.. A.CUCUAGGGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUAUG.GGUAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACA.GAG................GGC... ......A.G..............CG........AA........CUUGCGAA.......A. .......G........UcAGCCAAU......CCC.....A..A.AAA.GC..CG.G.U.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGAAUCAG..AAU.GU.CGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUGC.............AAAAGAA....GU...................... ..GGG.UA.......GU.............CU.....A....A.........CC.....U .UC........G.........G.G.................AG.....GGC.......GC .....UC.ACCACUU....UGU......................Gau............. ............................................................ ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAGNcUUNAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGC.....G........GA..................AACG.......AU.......... ................................G......G...A........AGCUUGC. .................U......U..........................CCAGG..C. ..............GUC..............G............................ .......................................................AGC.G GCGG.....ACGGGUGA....GUAAUGCA.UA.GG.AAU.C..................U ........................................A................CC. .C.........................GGU......A......................G .UG.GGGGAUAAC..CUG.GGGAAAC.............UC.A................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................GUC..................................... ............................................................ ...................................C........................ ............................................................ .....UACG................................................... ..................G..........................G.............. ...............AGAAAGC.......AGG............................ .........................GGAUCUUCG....GACCUU................ .........G.................................................. ......CGCU.....AU........................................... ...............................C............................ ..................GG.......A.......U........................ GAG..........CCUAU.GcC...................................... ..GG..................AUUAGUU...AG.UUGGUGA.GGUAACGGCU..CACCA AGA.CCGCGA..UCCGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACCGGG.ACUGAGACACG.GCCCG..GAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GUGUGAAG...AA...GG.C.........UUUC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GUG.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AA................................... ............................................................ .............................UccucgGGGCCAAUAccuccgAGGGAGGANA UC.......................................................... ............................................ACCCA..C.AGAA... ...G...AAGCACN..................G........................... ............GCUAACUCN.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GG.............CG....UG.............AUCAGC.CA.G... .........U..........UGUG.......AAAG.......CCC.CG.GGCUCAA.C.C .........U..G.G........G.........AAC........A...G........... ......................CAUC...C..................GG....AACUGU CAC...............G.CU....AGA..GU..G....C.............AGG... AGAGG..AAGG..UAGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUAG.GA.AGGAAUACCAG.UGGCGAA............GGC GGCC.UU.CUGGA..CUGAC..ACUGACGCU....GAG.GUGCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUCg....AC.......... ....UAGC.................................................... ......CGUUGG........................GG...................... .....................U.....................CCUUGUGAcCUUU...G ....UG.G...........CG.......AAGU..UAACGCGA..........UAAG..UC GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....UCUUGA.....C...A.................UCG.................... ...UG....C..GA................AC............................ ...................UUGU..................................... ..........GAGAGAUca..C...UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACgcac............................A....G... ................A.CAGG.UGCUGCAUGGCCGUCGUCAGCUCGUGUUGUGAAAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCCUA...UCCCUAU......U....UGC..C .AG.C.G.............AUUCG............GU..............CGGGA.. A.CUCUAGGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..AG..GUCAUCAUGGCCCAUACG.AGUAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.AG................GG.... ....U.U.G..............CA........AU........AUC.....GC.GA.GA. ...............UGUAGCUAAU......CCC.G......A.AAA.GC..CG.G.U.C UC.A....GUCCGGAUCGGAGUCUGCAACUCGACUCCGUGAAG.UCGGAAUCGCUAGUAA UCGUAGAUCAG..AAU.G.CUACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GAC .........UGC.............ACCAGAA....GU...................... ..GGU.UA.......G.C............CU.....A....A.........C......U .UC..................G.G.................AG.....GGC.......GA .....UC.ACCAC....GGUGU......................GG...U.......... .UC.................AUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > aaA..C.........UGAAGAGUUUGAUCAU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGC.....G........GU..................AACAG..............A... ........................................GAAU........AGCUUGC. .................U......A.................UUC.......UgC..... ........U.....GAC..............G............................ .......................................................AGC.G GCGG.....ACGGGUGA....GUAACGC.GUA.GG.AAU.C..................U .G.......................................................CC. .C.........................GGU......A......................G C.G.GGGGAUAG.C.CCA.G........................................ ............................................................ ............................................................ .....................................AGAAAUUUGGAUUAAUACC.... ...................................GCAU.AC.................. ....................G.C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UACGGGG...GAAAGC.......AGG............................ .........................GGAUCUUCG....GACCUU................ .........G.................................................. ......CACU.....AU........................................... ...............................C............................ ..................GG.......A.......U........................ GAG..........CCUG.CGUG...................................... ..AG..................AUUAGCU...NG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCUCUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACCGGA.ACUGAGACACG.GUCCG..GAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CUN...A.U...GC.A GCCAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UUA.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GCGAGGAGGA....................... ..........................................................AA GGUUAUUGAUUAA............................................... ............................................................ ............................................................ ............................................................ ...................UACUCAAUAG........................C...... ..........................................U................. ......GU..GACGUU............................ACUC.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GG.............C....UUG.............UUAAGC.CA.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUUAA.C.C .........U..G.G........G.........NAC........U...G........... ......................CAU...U..................UGG....AACUGG CAG...............G.CU....AGA..GU......AC.............AGA... AGAGGG..UGG..UAGAAUUU......CCU.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUAG.GA.AGGAAUACCAG.UGGCGAA............GGC GGCC.A.CCUGGU..CUGAU..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....UAC.......... ....UAGC.................................................... ......CGUUGG........................G.....A................. .....................A.....................CCUUGAGUUCUUA...G ....UG.G...........CGC.......AGC..UAACGCGA..........UAAG..UA GA.............CNGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGNGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....UCUUGA.....C...A.................UC.C................... ...AGAGAAC.................................................. .............U.....U.............GG.......................U. ...........AGAGAUA..CC...UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACUC..U........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUUGUGAAAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCCUA...UCCCUAU......U....UGCU.. .AG.C....AGUUC.......................G......G..CU.....GAGA.. A.CUCUAGGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.AGUAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACA.GAG................GGC... ......U.G..............CA........AU........AUC.....GC.GA.GA. ...............UGGAGCUAAU......CCC.....AC.A.AAA..C..CG.G.N.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGUGAAUCAG..AAU.GU.CACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUGC.............UCCAGAA....GU...................... ..GGC.UA.......GU.............CU.....A....A.........CC.....U .UC........G.........G.G.................AG.....GAC.......GG .....UC.ACCAC....GGAGU......................G...AU.......... .UC.................AUGACU.........GGGG.......G.UAACAA.GGAA. ..............................C..................CUG......GA U............CACCUCCUUA..................................... ........................................................... > ..AAAAAA.....U...G.........UCAU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.A........GU...................UA.......... ................................G......G...A........AGCUUGC. .................U......U..........................C........ ........UgAU.....ACUU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAAUGCU.UA.GG.AAU.C..................U .G.......................................................CC. ......UA....................GU......A......................G .UG.GGGGAUAAC.U.UG.GGGAAACC.............C.A................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................GAC..................................... ............................................................ ...................................C........................ ............................................................ .....UACG................................................... ..................G..........................G.............. ...............UGAAAGGGG......GC............................ .....................UUUU................................... ..........AGCUcu............................................ ......CGCU.....AU........................................... ...............................UA........................... ...................G.......A.......U........................ GAG..........CCUAA.GUC...................................... ..GG..................AUUAGCUG...G.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGACGA..UCUGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGG.AAUA UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UUUu.GGUUG UAAAGC..........................A.CUU.........U...A......... ............................................................ ....................A......GUG.............................. ....GG................................................G..... .....................................................A...... .............GGA..................AAAGCUuau................. ............................................................ ............................................................ ............................................................ .......GGUUAAUACCCAuaagCC...............................C... .......U..GACGUU............................ACCCA..C.AGAA..U .......AAGCACC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... .........UGGU.................UA.............UUUAAG.UCA.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUUAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CAUC.....................UG..A..UACUGG AUAA................CU....AGA..GU......AGG.............UG... AGAGGG..GAG..UAGAAUUC......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCU.GG.AGGAAUACCG.AUGGCGAA............GGC AGCUC..CCUGGCA..UCAU..ACUGACACU....GAG.GUGCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....UACCAGUc..... .................................G......UU.......GG.....GUCU ...............U......UU.......AAAGA.....CUU................ ............................................................ .A.....GU........GACGC.......AGU..UAACGCAA..........UAAG..UA GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....UCUUGA.....C...A.................UA.............G....... ........................U....................G.............. .........AGAAUCU.....U............G....CAG............AG.AUG ....................CG...AG..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................AUUC..Ac..........................A.....U.. ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUU...UCCUUAG......U....UAC..C .AG.C.Gac.............UCG............GU..............CGGGA.. A.CUCUAAGGA.............UACUGCCAG....UG..ACAAA..C.UG........ ...GAGGA.A.GGCG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.ACCAG.GG CUACACA.CGUGCUACAAU.GGUU.G..G.UACAA.AG................GG.... ....U.U.G..............CU........A........CAC.....AGCGAU.... ......G........UGAUGCUAAU......CUC.....A..A.AAA.GC..CA..AU.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGAUCAG..AAU.G.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGA. ........UcUC.............ACCAGAA....GU...................... ..GGU.UA.......G.C............CU.....A....A.........CGC..... .....................AAG.................AG.....GGC.......GA .....UC.ACCAC....GGUG......................GGG...U.......... .C.................GAUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....GU.............UG......GA U........................................................... ........................................................... > ....................AGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGC.....G........GU..................AG..................... ....................................AGAG...A........AGCUUGC. .................U......U..........................C........ ........UCU.U....G............AG............................ .......................................................AGA.G GCGG.....ACGGGUGA....GUAAAGCC.UA.GG.AAU.C..................U .G.......................................................CC. ......U....................GGU......A......................G .UG.GGGGAUAACG..UU............CGG.AA.ACGG.AC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AC.................. ....................GUC..................................... ............................................................ ...................................C........................ ............................................................ .....UACG................................................... ..................G..........................G.............. ...............AGAAAGC.......AGG............................ .........................GGACCUUCGGG....CCUU................ .........G.................................................. ......CGCU.....AU........................................... ...............................CA........................... ...................G.......A.......U........................ GAG..........CCUAg.GUC...................................... ..GG..................AUUAGCU...AG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CGACGA..UCCGUAACUGG...U....CUGAG.AGG..A..UG..AUCA...GUCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGAA.AGC................CU...GA.UC...C.A GCCAU.GCCGC.GU......GUGUUAAG...AA...GGU.C.........UUC.GGGUUG UAAAGC..........................A.CUU.........U...A......... ............................................................ ....................A......GU............................... ...UGG................................................G..... .....................................................A...... .............GGA..................AgGGC..................... ...AUUAACCUAAUACGUuagugUU................................... ............................................................ .............................U.............................. ............................................................ .......U..GACGUU............................ACCGA..C.AGAA..U .......AAGCACC..................G........................... ............GCUAACUCU.G.UGCCAGCAGCCGCGGUAAUACA.............G AGGGUGCAAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GUAGG...... .........UGGU.................UUG.............UUAAG.UUG.G... .........A..........UGUG.......AAA.......UCCC.CG.GGCUCAA.C.C .........U..G.G........G.........AAC........U...G........... ......................CAU...UC..................A..A..AACUGA CUGA................CU....AGA..GU......AUG.............GU... AGAGGG..UGG..UGGAAUUU......CCU.....................GUGUAGCGG UG..AAAUGCGCA.GAU.AUAG.GA.AGGAACACCAG.UGGCGAA............GGC GACC.A.CCUGGA..CUAAU..ACUGACACU....GAG.GUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGUC....AAC.......... ....UAGC.................................................... ......CGUUGG........................G.....AGCCUUGAGC........ ...................................................UCUUA...G ....UG.G...........CGC.......AGC..UAACGCAU..........UAAG..UU GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAgCCUUA.CCAGG........................................... ....CCUUGA.....C...A.................UC.C................... ...AAU......GA................AC............................ ...................UU.....UC..............................U. ...........AGAGAUAG....A.UU......G........GUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACA..UU........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCUUG...UCCUUAG......U....UAC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGG..C A.CUCUAAGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUACG.GCCUG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACA.GAG................GG.... ....U.U.G..............CC........AA........GCC.....GC.GA.G.. ......G........UGGAGCUAAU......CCC.....UC.A.AAA..C..CG..AU.C GU.A....GUCCGGAUCGUAGUCUGCAACUCGACUGCGUGAAG.UCGGAAUCGCUAGUAA UCGCGAAUCAG..AAU.GU.CGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUGC.............ACCAGAA....GU...................A.. ...GC.UA.......GU.............CU.....A....A.........CC.....U .UC........G.........G.G.................AG.....GGC.......Gg .....UU.ACCAC....GGUGU......................G...AU.......... .UC.................AUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ............................................................ ...........UUGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAu.................. ................U...............UC.........U........AGCUUGC. .................U......A.................NNNNNN............ ........U.....GAC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAAUGCU.UG.GG.AA.CU..................U GCCUU.....................UG................................ ..............................C............................G .AG.GGGGAUAAC.A.............GUUGG.AA.ACG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.U..G............. .....................................UC..................... .........................................................UUC GGACCAaacg.................................................. ............................................................ ............................................................ ............................................................ ......................G.......GGC........UUCGGCUCc.......... ............................................................ ........GG.................................................. ......CGCA.....AA........................................... ...............................GA........................... ...................G.......AG............................... .....G.......CCCAA.GUG...................................... ..AG..................AUUAGCU...AG.UUGGUAA.GGUAACGGCU..UACCA AGG.CGACGA..UCUCUAGCUGU...U....CUGAG.AGG..A..AG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGGGAA.ACC................CU...GA.U...GC.A GCCAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GU............................... ...UG................................................UG..... .....................................................A...... .............GGA..................AAAGU..............UAGUA.. .GUUAAUACCUGCuagcc.............GU....GACGUUAA............... ............................................................ ............................................................ ............................................................ ..............................................CAA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CA.C.GCAGG...... ........C.GGU.................UUG.............UUAAGC.UA.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUCAA.C.C .........U..G.G........G.........AUGGU...................... ......................CAU...UUA..................G....AACUGG CAGA................CU....AGA..GU..C....U.............UGG... AGAGGG..GAG..UGGAAUUC......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCU.GG.AGGAACAUCAG.UGGCGAA............GGC GACUC..CCUGGC..CAAAG..ACUGACGCUC....AU.GUGCGAAAGUGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CACCGUAAACGCUGUC....UAC.......... ....UAGCU........................G......UGUguu..........GNCU ...............U......UA.......ANN........C.Gugc............ ..........................GU..........A..................... ..................GCG.......AAGC..UAACGCGC..........UAAG..UA GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGACGGGGG..CC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....ACUUGA.....C...A.................UG..................... ...................C....U....................GA............. ........GAAN.......UU.....AC..............................U. ...........AGAGAUAG....N.UU..............NGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACUC..A........................G..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUUAG......U....UGC..C .AG.Cc..............U..U.........A.A.G.U........U.....GGG..C A.CUCUAAGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.UGUAG.GG CUACACA.CGUGCUACAAU.GGCA.U..U.UACA.GAG................GG.... ....A.A.G..............CG........A......G..AC.....AG.UGAU... ......G........UGGAGCGGAC......CCC.....U..U.AAA.G.AA.U.G.U.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGGUCAG..AAU.A.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........AUGC.............AAAAGAA....GU...................A.. ...GU.UA.......GU.............CU.....A....A.........C......U .UC........G.........G.G.................AG.....GAC.......GA .....UU.ACCAC............................................... ............................................................ ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAGGCCUA....ACACAU.GCAAGUC.....G AGC.....G........GCAGCacag......................A........... .........G.............................................AAAC. .............UUGUU......U..........................C........ ........UCGGGUGGC..............G............................ .......................................................AGC.G GCGG.....ACGGGUGA....GUAAUGCC.UG.GG.AAAU...................U .G.......................................................CC. .C.....U....................GA......U......................G .UG.GGGGAUAAC..CAU............UGG.AA.ACG.AU................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GCAU...G....Au........... ............................................................ ............................................................ ...AGCUUCG........................GCUCAAAG.................. ...........A................................................ ............................................................ ............................................................ ......................G.......GG............................ .........................GGACCUUCGGG....CCUCucgcg........... ............................................................ ...............UC........................................... ...............................A............................ ..................GG.......A.......UA....................... .UG..........CCcag.GUG...................................... ..GG..................AUUAGCU...AG.UUGGUGA.GGUAAGGGCU..CACCA AGG.CGACGA..UCCCUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCCAU.GCCGC.GU......GUGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................A.CUU.........U............. ...................................................C........ ....................A......GUcg............................. ...UG.............................A...................GG.... ............................................................ ................................................AAGGUG...... ....................................................GUAGUG.U U.....A.AUAGC................ACUAUCAUUU..................... ............................................................ ............................................................ ..........GACGUU............................AgCGA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAG..CGUUAAUCGGAAUUACUGGGCGU..AAAGCG.CAu..GCAGG...... .........UGGU.................UUG.............UUAAG.UCA.G... .........A..........UGUG.......AAAG.......CCC.GG.GGCUCAA.C.C .........UC...G........G.........AAC........U...G........... ......................CAU...U..................UG..A..AACUGG CAGA................CU....AGA..GU......AC.............UGU... AGAGGG..GGG..UAGAAUUU......CA.....................GGUGUAGCGG UG..AAAUGCGUA.GAG.AUCU.GA.AGGAAUACCGG.UGGCGAA............GGC GGCCC..CCUGGA..CAGAU..ACUGACACUC....AGA.UGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGUC....UAC.......... ....UUGGA........................Gguugug.................... ...........................................GCCUUGAGCcguggcuu ............................................................ ..................UCGG.......AGC..UAACGCGU..........UAAG..UA GA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AUGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....UCUUGA.....C...A.................UC.C................... ...AGAGAAUC................................................. .........UAG...........................CGG............AG.ACG c......................UG.G..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACUC..U........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUUGUGAAAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCCUUgU......U....UGC..C .AG.C.G.............AG.U.........A.AUGU..............CGGGA.. A.CUCcAGGGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACG.AGUAG.GG CUACACA.CGUGCUACAAU.GGCG...CA.UACA.GAG................GGCg.. ........G..............CC........AA........CUUGCGAA.......A. .......G........UGAGCGAAU......CCC.....A..A.AAA.G.UGC..G.U.C GU.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGUGGAUCAG..AAU.G.CCACGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GGC .........UGC.............AAAAGAA....GU...................... ..GGG.UA.......GU.U............U.....A....A.........CC.....U .UC........G.........G.G.................AG.....GAC.......GC .....UC.ACCACUU....UGU......................GG...U.......... .UC.................AUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG C.GcUAGGGGAACC............UGgc.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ...................GAGTTTGATCCT............................. ..GGCTCAGAT.TGAACGCTGG.CGG..CAGGCCTAACACAGGCAA.GT....C.....G AGC.....G........GCAGCgggaaag............................... ........................................T...........AGCTTG.. ...CTActtttgc.............................................C. ..............GGC..............G............................ .......................................................AGC.G GCGG.....ACGGGTGA....GTAATGcctg..GGG..ATCT.................. .G.......................................................CC. .CAGT.........................C............................G .AG.GGGGATAA.CAG.T.T...........GG.AA.ACG.ACT................ ............................................................ .............................................G.CTAATACC..... ..GCATAC.................................................... ..............................................GCCCTACG...... ............................................................ ........GGGGAAAGG........................................... ............................................................ ............................................................ ............................................................ ............................................................ .............................AGG............................ .........................GGACCTTCGGGCCTtttgcgattggatgaacccag g........................................................... ............................................................ ............................................................ ....................T....................................... G.....................G..................................... ...G..................ATTAGC.TAGTT...GGTGG.GGTAATaGCT..CACCA AAG.CGACGATCCC..TAGCTGGTCT.......GAG.AGG..AT..G..ATCA...GCCA CACTGGA.ACTGAGACACG.GTCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGGGGAA.ACC................CT...GAT....GC.A GCCAT.GCCGC.GT......GTGTGAAG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAAGCACTT................TC........ ....................A......GCGAGGAGGA....................... ..........................................................AA GGttggcgc................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...........CTAATA.CgtgtcaactG...TGACGT.....TACTC.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTAATCGGAATTAC..TGGGCGTAAAGCG.CA.C.GCAGG...... ........C.GGT.................T......GGAT.......AAGTt.A.G... .........ATGT..........G.......AAAG.......CCC.CG.GGCTCAA.C.C T...........G.G........G.........AATT...........G........... ......................CATTTa.......................A..AACTGT Cca...............G.C.T...AGA..GTCTT...................GT... AGAGGG..GGG..TAGAATTCCAGG..........T.................GTAGCGG TG..AAATGCGTA.GAGAT.CT.GG.AGGAATACCGG.TGGCGAA............GGC GGCTC..CCTGG......AC..AAAGACTGACGCTCAG.GTGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGTCGAtTTGGAGGctgtgt. ............................................................ ...................................................CCTTGAGac GTGGCTT..................................................... ..................CCGG.......AGCT..AACGCGTT..........AAAT..C GA.............CCGCCTGGGGAGTACGGCCGCAAGGTTAAAACTCAA...ATGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATg.CGA.TGCAACGCG .AAGAACCTTA.CCTGG........................................... ....CCTTGACATGT............................................. ...................CTGGAATC................................. .....................CT...........G....CAG............AG.ATG C........................................................... ............................................................ ..................GGG..............AGTGCCTTC................ ........................GG............................GA.... .................AtCAG..........................A..A........ ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTGT...CCTTTGTT..........GC..C .AG.C....A.....C.....GTAA.......TGG..................TGGGA.. A.CTCAAGGGA............G.ACTGCC.G..GT.G.AT.AAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGGCCCTTACG.GCCAG.GG CTACACA.CGTGCTACAAT.GGCGC...GT.ACA.GAG................GGC.T. ........G..............CA........AgctagcG..ATAGT............ .................GAGCGAAT......CCC.....A..A.AAA.GC.GC..G.TCG .T.A....GTCCGGATCGGAGTCTGCAACTCGACTCCGTGAAGT.CGGAATCGCTAGTAA TCGCGAATCAGA..AT.GT.CGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GT..........................G...GGT T.........GC.............ACCAGAA....GTAGATA................. ...............G.CTTAA...................................CCT TC........GG.........G...................AG.....GGC.......GT TT......ACCAC....GGTGTGA..........................TTCA...... ..............................TGACTGGGGTGAAGTCGT.AACAA.GGTAc cc.......................................................... ............................................................ ........................................................... > N.A..........AUUGAAGAGUUUGAUCAU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CAGGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AGCagg..............AA. ........................................G.AA........AGCUUGC. .................U......U.................U........CUU...... ...UGC..U.....GAC..............G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAAUGCU.UG.GG.AAUC...................U .GG.......................................................C. ......UU..............A......U............................GG .AG.GGGGAUAA.CUG.U.GGGAAAC.............UG.C................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCguauu.................. ............................................................ ............................................................ .....CUC.................................................... ............................................................ ...........................UG............................... ..........................................A..G.....G........ ..A.........G...GAAAGGGU.......G............................ .........................GGACCUUAGGG....CCAccU.............. ............................................................ .......GCC.....AU........................................... ...............................AA........................... ...................G.......A.......U........................ GAG..........CCCAA.GUG...................................... ..GG..................AUUAGGU...AG.UUGGUGG.GGUAAAGGC..CUACCA AG.CCUNCGA..UCUCUAGCUGG...U....CUGAG.AGG..A..UG..ACCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGGGGA.ACC................CU...GAC....GC.A GCCAU.GCCGC.GU......GAAUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAG..........................UU.CUU.........U............. ...................................................CGG...... ....................U.A.....A............................... ...UG.............................A...................GG.... ............................................................ ................................................AAGGgAUGUU.. .GUUAAAUAGAUAGCAUCA....UU............GACGUUAAu.............. ............................................................ ............................................................ ............................................................ ...............................................UA..C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAG..CGUUAAUCGGAAUAACUGGGCGU..AAAGGG.CA.C.GCAGG...... ........C.GGA.................CU.............UUUAAG.UGA.G... .........A..........UGUG.......AAA.......UCCC.CG.AGCUUAA.C.. ..U......U..G.G........G.........AAC........U...G........... ......................CAU...U..................UC..Ag..ACUGG GAGU................CU....AGA..GU......AC.............U.U... UAGGGA..GGGN.UAGAAUUC......CAC.....................GUGUAGCGG UG..AAAUGCGUA.GAG.AUGU.GN.AGGAAUACCG.AAGGCGAA............GGC AGCCC..CuUGG..GAAUGU..ACUGACGCUC....AU.GUGCNAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGCUGUCgauu............. .........................................U...G.G.GG........A ...............U......UG........GGCUAUAUGCUU................ ............G.............GUGC.............................. ..................CCG.......AAGC..UAACGUG............AUAaaUC GA.............CCGCCUGGGGAGUACGGCCGCAAGGUUAAAACUCAA...AUGAAU UGNCGGGGG..CCNGCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAC........................................... ....UCUUGA.....C...A.................UC.C................... ...UAA......GA................AGAG.......................... .....................C............U....CAG............AG.AUG AGc.......................U..............UGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA................................. .................ACU..UA........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUUGUGAAAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCCUUUG......U....UGC..C .AG.C.G.............AUUCG............GU..............CGGGA.. A.CUCAAAGGA............G.ACUGCCAG....UG..ACAAA..C.UG........ ...GAGGA.A.GGNG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUACG.AGUAG.GG CUACACA.CGUGCUACAAU.GGUG...CA.UACA.GAG................GGC... ......A.G..............CG........A......G..A................ .......GUGCGAGCUUGAGCGAAU......CUC.....AG...AAA.GUgc....AU.C UA.A....GUCCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCAAAUCAG..AAU.GU.UGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GUG.............................GG. ........UUG.............UACCAGAA....GU...................A.. ...GA.UA.......G.CU............U.....A....A.........CC.....U .UC........G.........G.GG.................G.....GGC.......GU .....UU.ACCAC....GGUAU......................G...AU.......... .UC.................AUGACN......N...GGG.......G.UAAC........ ....................................A.............AG......GA U............CACCUCCUUA..................................... ........................................................... > ............................................................ .........AT.TGAACGCTGG.CGG..CAGGCCTAACACATGCAA.GT....C.....G AGC.....G........GT..................AGC..............ACA... ........................................GAG.........AGCTTG.. ...CTTcttcagggt............................................. ..............GAC..............G............................ .......................................................AGC.G GCGG.....ACGGGTGA....GTAATGT................................ ............................................................ .........................................CTGGGAAACTGcctgatGG .AG.GGGGATAA.CT.A.CT...........GG.AA.ACGG.T................. ................A........................................... .............................................G.CTAATACC..... ..GCATAAcG.................................................. ............................................................ ............................................................ .......................TCGCAAGAC............................ .....................................CAAAG.................. ...........A................................................ ............................................................ ............................................................ ......................G.......GG............................ .........................GGACCTTg........................... ..........................CGGCCTCTtgccatcagatGTGCCC......... ........................................A................... ............................................................ ..................GAT....................................... G.....................G..................................... ...G..................ATTAGC.TAGTA...GGTGG.GGTAACGGCT..CACCT AGG.CGACGATCCC..TAGCTGGTCT.......GAG.AGG..AT..G..ACCA...GCCA CACTGGA.ACTGAGACACG.GTCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGGCGCA.AGC................CT...GAT....GC.A GCCAT.GCCGC.GT......GTaTGAAG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAAGTACTT................TC........ ....................A......GCGAGGAGGA....................... ..........................................................AG Gca......................................................... ...................................................TTGT..... ............................................................ .............GGT............................................ ............................................................ ............................................................ ............TAATAACCacagtg....ATTGACGT.....TACTC.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTAATCGGAATTAC..TGGGCGTAAAGCG.CA.C.GCAGG...... ........C.GGTC.................T......GT.......CAAGT.CG.G... .........ATGT..........G.......AAAT.......CCC.CG.GGCTCAA.C.C T...........G.G........G.........AACT...........G........... ......................CATT...C..................G..A..AACTGG CAG...............G.C.T...AGA..GTCTT...................GT... AGAGGG..GGG..TAGAATTCCAGG..........T.................GTAGCGG TG..AAATGCGTAr.AGAT.CT.GG.AGGAATACCGG.TGGCGAA............GGC GGCCC..CCTGG......AC..AAAGACTGACGCTCAG.GTGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGTCGACTTGGAGG....... ..........................................................TT G.......................TT................C........CCTTGAGGA GTGGCTT..................................................... ..................CCGG.......AGCT..AACGCGTT..........AAGT..C GA.............CCGCCTGGGGAGTACGGCCGCAAGGTTAAAACTCAA...ATGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCTACT.......................................... .....CTTGACATC........................Cacagaattt............ ............................................................ .....................A............G....CAG............AG.ATG Ctt......................................................... ............................................................ ..................................TAGTGCCTTC................ ........................GG............................GA.... .................ACYGt..........................G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTtgtgaaATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTAT...CCTTTGTT..........GC..C .AG.C.G...Gtc...........C.....G...................G.CCGGGA.. A.CTCAAAGGA............G.ACTGCCA...GT.G.AT.AAA..Ct.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGGCCCTTACG.AGTAG.GG CTACACA.CGTGCTACAAT.GGCGT.A..T.ACAA.AGA................G.... ....A.A.G..............CG........A........CCtC.....GC.GA.GA. .......Gc........AAGCGGAC......CtcaTAAAGTA..........C..G.TCG .T.A....GTCCGGATTGGAGTCTGCAACTCGACTCCATGAAGT.CGGAATCGCTAGTAA TCGTARATCAGA..AT.GcT.ACGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GT..........................G...GGT T.........GC.............AAAAGAA....GTAGGTA................. ...............G.CTTAA...................................CCT TC........GG.........G...................AG.....GGC.......GC TT......ACCACtt....TGTGA..........................TTCA...... ..............................TGACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TGC............................... ............................................................ ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGANCGCUGG.CGG..CGUcCCUA....ACACAU.GCAAGUC.....G AGC.....GAA...........AA................AGUU...............U CCUCCGGGAG.............................................AcGA. .....................................GU..................... ............................................................ ...........AC..........................................AGC.G GCGC.....ACGGGUGA....GUAACGC.GUG.GA.UAAUC..................U ........................................A................CC. ......UC....................GA............................GG .UA.UGGGAUAAC.U.CU.G............CGAAAG.CG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GUAU.AG............UCugca c.................................ACA....................... ........................................UAUCG............... ............................................................ ............................................................ .............................C.............................. .................................................GUG........ ..U.........G...GU......AAAGAUGG.......CCU.................. ............................CUGAUA.......................... ...............U.AAGCUAU.........C.......................... .......GCC.....UU........................................... ...............................G............................ ..................GG.......A.......U........................ GAG.....U.....CCG.CGUC...................................... ..UC..................AUUAGCU...UG.UUGGUGG.GGUAAAAGCU..UACCA AGG.CAACGA..UGGGUAGCUGG...U....CUGAG.AGG..A..UG..AUCAu...CCA CNCUGGG.ACUGAAACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...NCAAUGGGCGCA.AGC................CU...GAC.C...C.A GCNAC.GCCGC.GU......GUGGGAUG...AA...GG.CC.........UUC.GGGUCG UAAACC..........................A.CU.........GU............. ...................................................C........ ....................U......GG............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAUGggugauucccaauacgggucucc.......... .....................C...................................... .............................U.............................. ............................................................ .......U..GACGGU............................ACCUC..C.AGA.... G..G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUCACUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GG.............C....AGGC.............CAAG.UCA.GG.. ....................UGUG.......AAAGG.......CCcacgg..UCAA.C.C ...G.........UG........G.........AAC........U...G........... ......................CAC...U..................UG..A..AACUGU CUU...............G.CU....AGA..GU......AUG.............GG... AGAGGG..UGG..CAGAAUUC......CC.....................GGUGUAGGAG UG..AAAUCCGUA.GAU.AUCG.GG.AGGAAUACCAG.UGGCGAA............GGC GNCC.A.CCUGGA..CCAUA..ACUGACGCU....GAG.GUGCGAAAGCGUGGGGAcCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUcC.......... ....UAGGU........................G.......UU....G.GG.....Gu.. ......CGUAGGACUUca.......................................... ............................................................ .......GUA........CCG.......UAGU..UAACGCGU..........UAAGC..A UC.............CCGCCUGGGGAGUACGGUCcCAAGGCUGAAACUCAA...AGAAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCCAG........................................... ....GCUUGA.....C...A.................UC.C............C...... ......GG......................GAG........................... ....................CC............U...CCAUGA................ A......................A.UU......G........GAGGG............. ...................................UG....................... .....CCC...............U............................U....... .....CG.................GG............................GA.... .................ACCC.........................G.G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UCCUUAG......U....UGGCAG CA.......A.......GU............G.A.U.G.U........U.....GGG..C A.CUCUUAGGA............G.A.................UU..GCC.GAggugaac uUCGAGGA.A.GGUG.GGGACGACGU..AA..AGUCAUCAUGGCCCUUACGC.CUGG.GG uUACACA.CGUACUACAAU.GGUG.G..Gc.ACA.GAG................GG.... ....U.A.G..............CA........A........CAucc.....C.GA.G.. ......G........UAGAGCUAAU......CUC.....A..A.AAA.GC..CC..AU.C UC.A....GUUCGGAUCaCAGUCUGCAACUCGACUGCGUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......G..........................C...UGGC ........UC..............UACCCGAA....GU...................CA. ....G.U.......G.A............GCU.....A....A.........CC...CGU .A........UG.........G.G.................AAGCA..GCU.......GC ....C..GAC.......GGU......................AGGG.............. CU.................GGUAAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUUA..................................... ........................................................... > act.............GGAGAGTTTGATCCT............................. ..GGCTCAGA.ATGAACGCTGG.CGG..CGTGCCTAACACATGCAA.GT....C.....G TAC.....G.......A.G...AA................AG................G. ................................G......GCTTCGGC............. .....CCT......................GAGTA.................G....... ............................................................ ........................................................AGTG GCGC.....ACGGGTGA....GTAACGC.GTG.GGT.AATCTA................. .........................................................CC. .CTTGGATTT.................................................. .....GGGATAA.CT.CT.G............CGAAAGT.G.G................. ................A........................................... .............................................G.CTAATACC..... ..GGAT...................................................... ........................................Agtctggctttaattaagaa gTCGGT...................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..A............Aaggat..........G.......CCTCTGCATATGC........ ................ATTCGT...................................... ............................................................ .....CCG.................................................... ...............................AG........................... ..................GAT....................................... GAG..........CCCG.CGTCT..................................... ...C..................ATTAGC.TAGTT...GGTAG.GGTAATGGC..CTACgA AG.CCAACGAT..GAGTAGCTGGTCT.......GAG.AGG..AT..G..ATCA...GCCA CACTGGA.ACTGAAACACG.GYCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCGCAAT........GGGCGAA.AGC................CT...GAC....GC.A GCAAC.GCCGt.GT......GAGGGATG...AA...GG.CTT.........TC.GGGTC. ............................................................ .......................GTAAACCTCTG................TCgg...... ............................A............................... ...AG........GG..................AA...................GA.... ...ACGggtattGGTCT.................................AAtaggcctt tgttt....................................................... ............................................................ ............................................................ ............................................................ ............................................................ ....................................G.GACGGTACCTtt...AGA.... G..G...AAGCACC..................G........................... ............GtTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTATTCGGAATTAC..TGGGCGTAAAGCG.CA.C.GTAGG...... ........C.GG.............C....CTTG......T.......AAGT.CA.GGG. ...........GT..........G.......AAAT.......CCC.AC.GGCTCAA.C.C ...G..T.......G........G.........AACT...........G........... ......................C.CTT.....................G..A..AACTGC Aggg................CTT....GAA..Tc......CT.............GG... AGAGGGT..GG..CGGAATTCCTGG..........T.................GTAGGAG TG..AAtTCCGTA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGCC.A.CCTGG......AC..AGgTATTGACGCTGAG.GTGCGAAAGTGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CACCGTAAACGATGGATACTAGGTGTCGGggac ttgatcT..................................................... ........................................................TC.. .........G.................................................. ...............GTGCCGT.......AGCT..AACGCGTT..........AAGTAT. .C.............CCGCCTGGGGAGTACGGTCnCAAGGCTGANACTCNM...AGAAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGTATGTGGTTTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCTAG........................................... ....Gcttacctaggcttgac....................................... ........................ATC................................. .....................CT...........G....CAG............AG.ATG C........................................................... ............................................................ ..................GGG..............AGTGCC.CTTC.............. ........................GG............................GGAat. ...................CC..A........................G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGCCGTGAGGTGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTATTc...TCAGTT..........GC..C .AT.C....A.....CGT......AA......TGG..................TGGG..C A.CTCTGTGGA............G.ACTGCCC...GGGTT....AAC.CG.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGGCCCTTACGC.CTAG.GG CTACACA.CGTACTACAAT.GGTG.G..GT.ACAA.AG................GGC... ......A.G..............CG........AA........ACC.....GC.GA.G.. ......GT........CGAGCGAAT......CTC.....A..A.AAAA.C..CCAT...C aT.A....GTCCGGATTGCAGTCTGCAACTCGACTGCATGAAGTT.GGAATCGCTAGTAA TCcCGGATCAG.C.AT.G.CCGgGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGAAA......G..........................CTGGTTc. ..T......................ACCCGAA....G...................C... ...GG.A.......................CT.....A....A.........CC...CTT Gggaggt...........................................A.......GG ....C..GCCTAC....GGTAGGG.................................... CT.GG.................TA........ATTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGGGAACC............TGCGGCTGGATCACCTt................. ............................................................ ........................................................... > ...................GAGUUUGAUCCU.GG.......................... ....CUCAGA.UUGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G UGC.....GA........G...AA.............................A...... .....GUCU......C....CUU......C..G......GGAGa................ ...............................................UG........... .............A.GU.............AG............................ .......................................................AGC.G GCGC.....ACGGGUGA....GUAACGC.GUG.GG.UAAUC..................U ........................................A................CC. .Cg...................A......C......A......................G .AUC.GGGAUAAC.A.............GAUGG.AA.ACG.UC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................G.C..................................... ............................................................ ............................................................ ............................................................ ............................................................ ....................................................UuCAUAUU UGACUUUAUGGGG...GAAAGG.......UGG.......CCU.................. ............................CUAC............................ ...A.........UGU.AAGCUA..................................... ...C..CGCUG................................................. ..............................UC............................ ..................GG.......A.......U........................ GGG..........CCCG.CGUC...................................... ..UC..................AUUAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AG.CCAACGA..UGAGUAGCUGG...U....UUGAG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAAACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGGGAA.ACC................CU...GAC....GC.A GCGAC.GCCGU.GU......GCGGGAAG...AA...GG.CC.........UUC.GGGUCG UAAACC..........................G.CU.........GU............. ...................................................C........ ....................A......GG............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AACCAuuaGA....GUCGAAUAGG............. ............................................................ .....................CUCUUUUGU.............................. ............................................................ .......U..GACGGU............................ACCUC..C.AGA.... G..G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUAAUCGGAAUCACUGGGCGU..AAAGCGU.G.C.GUAGG...... ........C.GG.............CG....C.............AGUAAG.UCA.GG.. ..........G..........GUG.......AAAG.......CCC.UC.GGCUCAA.C.C ...G.........AG........G.........AA......U..U...G........... ......................CCUC.....................UG..A..UACUGC UGU...............G.CU....UGA..G..GC....U.............UGG... AGAGGC..AGG..CGGAAUUC......CA.....................GGUGUAGGAG UG..AAAUCCGUA.GAU.AUCU.GG.AGGAACACCGG.UGGCGAA............GGC GGCC.UG.CUGGA..CAAGU..UCUGACGCU....GAc.GUACGAAAGCGUGGGUANCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUGC.......... ....UAGGU........................G.......UC....G.GGc........ ......CGUUGG........................G.....U................. .....................U.....................C................ .....G.GU........GCCG.......AAGU..UAACGCGA..........UAAGC..A UC.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....ACUUGA.....C...A.................UC.C............C...... ...UG....................................................... ............................................................ ..........................................GAAUCCCUCUuaaacGAG GGAGUg...................................................... ............................................................ .......C..................U.CUUCGGA...................G..... .................Aauc..A......................G.G..U....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UUGNUAG......U....UGGCAG CA.......A.....C....A..U.........A.AUG......G...U.....GGG..C A.CUCUAAUGA.............AgCUGCC.G..G..G.UU.UAA..CC.G........ ...GgaaggA.GGUG.GGGACGACGUC..A..AGUCAUCAUGNCCCUUACG.UCCAG.GG CNACACA.CGUACNACAAU.GGCG...CA.AACAA.AG................GG.... ....U.A.G..............CU........AA........CCC.....G.UGA.G.. ......G........UCAAGCCAAU......CCC.......CA.AAA.G.UGC..G.U.C CC.A....GUCCGGAUUGCAGUCUGCAACUCGACUGCAUGAAG.UUGGAAUCGCUAGUAA UCCCGGAUCAG.C.AU.G.CCGGGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......G..........................C...UGG. ..UC.....U..............UACCCGACGucggc...................... .......A.......G.............GCU.....A....A.........CC.....U .U........U.....U...AG.G.................AG.....GCA.......Gu ....C..GCCUAC....GGU......................AAGG.............. CU.................GGUAAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....GN.............UG......GA U............CACCUCCUUA..................................... ........................................................... > ............................................................ ........GA.AUAAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AGC.....GA........G...AA.............................A...... .....GU.U......C....CUU......C..G......GGAAU.............GA. .....................................GU..................... ............................................................ ...........AC..........................................AGC.G GCGG.....ACGGGUGA....GcAACGC.GUGA.G.AAUC...................U .G.......................................................CC. .C.....U..............U......C......A......................G .Uga..AGAAUA.C.CGuCG...........AGAAA.U.CG.Ac................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................G.............. ...............UUAAUGC.......UGCA........................... ..........................................UAcgucccuucggggAGA AAAGuggccUC....U.UUGCUA..................................... ...CU..GCUG................................................. ..............................AA............................ ..................GG.......A.......U........................ GAG..........CUUG.CGU....................................... .ACU..................AUUAGCU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGG.CGAUGA..UGGUUAACCGGCC.........UG.AGAG..GGUG..UUCG...GUCA CACUGGA.ACUGAGAUACG.GUCC..UGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GGAGGAUG...AA...GGU.C.........UUC.GGAUUG UAAAC..........................UU.CU.........GU...U......... ............................................................ ....................A.A.....G............................... ...UGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAGGgcugcU........................... ...................................UUUAA...................U AGAAGCAg.....................U.............................. .......................U...............................A...A .......U..GACGGU............................ACCAU.U....AAAGA .......AAGCACC..................G........................... ............GCUAAACUC.G.UGCCAGCAGCCGCGGUAAUAC.............GA GUGGUGCAAG..CGUUAUUCGGAAUAAUUGGGCGU..ACAGGGU.G..UGUAGG...... ........C.GGU.................AUG.............UUAAG.UCU.G... .........U..........UGU.......UAAAG.......ACuc.C.GGCCUAA.C.C ...Ggagac......AGGCAGCGG...AAAC..........UG.....G........... ......................C..........................G....UACUag ag.......................................G.............GUGGA AGAGAG..AAG..UGGAAUUCU......C.....................GGUGUAGCGG U..AAAAUGCGUA.GAU.AUCGA.G.AGGAACACCG.AUGGCGAA............GGC AGCUUc.U.UGGU..CCAUAC..CUGACGCU....GAAA.CACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGA....UCAC.......... ....UAGAC........................G.......UU....G.Gu........U CU.......................................................... ..........GUUUUACAGAAU.....................C................ .A.....GU........GUCGC.......AGC..UAACGCGU..........UAAG..UG AU.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGGU.CC.GCACA.AG.C.GGUGGAACAUG.UGGUUUAAUUCGAC.ACUACGCG .AGGAACCUUA.CCUAG........................................... ....GUUUGA.....C...A.................UGUGCC................. ........UGACCG..U.CGUAGAA....A.............................. ...............................U..A....C...................G A......................U.UUUU............................... ............................................................ ............................................................ ..................U....AGG..CUUCGGU....................CUAga ca......G............G..........................U..A........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UUGGUUAAGUCCUC.UAACGAGCGCAACucuuac...UGUCAG......U....UGCU.. .ACUGCGC.........................A.A........G..CA.....GGG..C A.CUCUGAUG............G.AACUGCCUG..GG......AAAC.C.AG........ ...GAGGA.A.GGUG.GGaAUGACGUC..A..AGUCAGCAUGGUCCUUAUGC.CUAG.GG CUACACA.CGUGUUACAAU.GGC.CA..G.UACAA.AG................GGC... ......U.G..............CG........AA........CCC.....GC.AA.G.. ......GG........GGAGCUAAU......CUC.....A..U.AAAA.CU..G.G.U.C UA.A....GUUCAGAUUGCGGUCUGCAACUCGACCGCAUGAAG.UUGaAAUCGCUAGUAA UCGCGUAUCAG.C.AACGA.CGCGG.....UGAAUACGUUCUCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......G..........................C...UGuc .........UG.............UACCCAAAACc......................... ...GUCUU........A............GCU.....A....A.........CC.....U GU........A.....A...AG.G.................AG.....GC........Gg a...C..GUCUAA....GGUAU......................GGgga........... ....................GUGAUU.........GGGGUGA.................. ............................................................ ............................................................ ........................................................... > ............................................................ ..........GAUUAACGCUGG.CGG..CAUGCCUA....AUGCAU.GCAAGU.....AG AAC.....G.......A.G...Ucucgcaag..........................AGA C..................................UAGU..................... .............................................U.............. ............................................................ ............................................................ GCG.....AACGGCUGA....GUAAUGGAuAG.GA.AUUUC................... .........................................................CC. .C.....A..............A......U............................GG .UG.UGGAAUAC.CU.C............AU.CGAAAG.A.UG................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AAC................. .....................AUC.................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ................GAAAGAU..................................... .....................AAAAGCGCUUA............................ .........AC....Ugcgc........................................ .......GCCG................................................. ..............................AU............................ ..................GG.......A.......U........................ GAG..........CCUAUc.UC...................................... ..CC..................AUCAGCU...UG.UUGGUAG.GGUAAAAGC..CUACCA AGG.CUAUGAC..GGGUAGGGGGC.........GUG.AGAGC..GCG..UUCCC...CCA GAAUGGG.ACUGAGACACG.GCCC..AUAC..A.CCUACGGGUGGCAGCAACAGGGAAUC GU.....AC...ACAAUGGACGAA.AG................UCU...GA.U...Guc. GCAAU.GCCGC.GU......GGAGGAUG...AA...GG.CC.........UUC.GGGUCG UAAAC..........................UC.CUU.........U...UAcagu.... ............................................................ ....................A.A.....U............................... ...AG.............................A...................G..... .....................................................AUG.... ............................................................ ..................U....UA................................... ............................................................ .............................U.............................. ............................................................ .......U..GA..........................................GAA..U .......AAGCACCU............................................. ............GCUAACUCU.G.UGCCAGCAGCAGCGGUAAUACA.............G AGGGUGCAAG..CGUUAUCCGGAUUUAUUGGGCGU..AAAGCGU.UuC.GUAGG...... .........UUUU.................UAG.............AUAAG.UUAU.GUU UC.............................AAAG.......ACC.GC.GGCUCAA.C.C ...GCgggaA..G.G........G.........AUG........U............... .......................AA...U..................AC..U..AUCUG. ...AA.........................................UUGAAAUAUGG... UGGGG..UUU..CCGGAACUGA......U.....................GGUGUAGUAG UG..AAAUACGUU.GAU.AUCAU.C.AGGAACUCCG.AGGGCGAA............GGC AGGA.Agcuaa.C..CAUUU..UUUGACACU....GAG.GAACGAcAGCUAGGGGAGCGA AAGGGAUUAGAGACCCCUGUAGUCCUA.GCCGUAAACUAUGC....UCGC.......... ....UAGGGguucguuucgcUAAGAACAUGAguuuuuacuUGU.......G........U ...............U......UU.......UUGC......................... ..........GAAAU............................................. GA.....GccccGU..............AAGC..UAACGCGU..........UAAGC..G A.............GCCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGG.ACCCA.CACA.AC.CA.GUGGAGCAUG.UGGUUUAAUUCGAGACG.AAACG .AAagACCUCA.CCcaG........................................... ....CCUUGA.....C...A.................UA.........AUac........ .........CG................UUUUAAG.......................... .....................C............A...CCUAGA................ A......................A.UA......G........GAG............... ............................................................ ......CC...............U............................AUCUUUAG A.................................A......................... ....................Au.AUUG.AU...................GguAC...U.. ................A.CAGG.UGUUGCAUGGCCGUCGUCAGCUCGUGCCGUAGGGUGU UCCCUUcaguggG.GUAACGAGCGCAACCCUUGC...CCUGAG......U....UGa... .....AUAUUCU...................................CA.....GGGG.. A.CUCUUUGAAcuug............................UUU..C.AGA....... ...Gggaa....GUGA.GGACGACGUC..AG..GUCAGCAUGGCCCUUAUAG.CUGG.GG CAACACA.CAUACUACAAU.GGAG...CcG.ACA.GAG................GG.... ....U.U.G..............CC........AA........GUC.....GCaaga... ...............CGGAGCUAAU......CCC.....A..UCAAAcgg..C...UU.C UC.A....GUGGGGAUUGGGGGCUGCAACUCGCCCCCAUGAAC.UUGGAAUUGGUAGUAA UCGCGAAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCUCGGGUCUUGU..ACACAC CGCCCGUCAAGUgaguAAA......GU.............................UGUA UAUACCUUAA..............AUCCCGUU....GU...................Acg gg.......................................................... ............................................................ ............................................................ .................................................AUCAA.GGUAG agacagcgauaagcacu........................................... ............................................................ ........................................................... > ............................................................ ..........GGUGAACGCUGG.CGGU..GUGCCUA....AGACAU.GCAAGUC.....G AAC.....G........GG.............................AUUUGUgcguag cacauagaac....................UUAAUUUGA....AAUUUuuaauuuuu... .................A......A.................UUUUUA............ ........A.......UC............AAUuuuuaaauuuaaacauuuaauuUUGAA UAAAAAUUuuaaauuuuAAACUAAAAAUUAUUUUUUGUGUGCuaugcgcuaguuCAGU.G GCA.....AACGGGUGA....GUAUAAAA.UA.GG.AA.CG..................U ........................................A................CUU cgaagcgggacauagccccucGA......A......A......................G .AG.GGGGUAAU.......................U.Ucc.................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .....................................CAUAUGUCCG........CCAAU UGGcggaugAAAGACGCAAGUCAC....................UAcga........... ............................................................ ............................................................ ................................AAACGGCCUAUUUACuac.......... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ........................CAGCU...AG.UUGGUGA.GGUAAUGGCU..UACCA AGG.CAAUGAC..GGUUACCggcucuuaGCG..GAG.AGUCC....Gg..........CA CAAUGGG.ACUGAGACACG.GCCC..AUAC..A.CCUACGGGUGGCAGCAGUUAGGAAUU UUG.....CG...CAAUGGACGAA.AG................UCU...GAC....GC.A GCGACA.CCGC.GU......GGAGGAUG...AA...GA.CC.........CUA.GGGUUG UAAAC..........................UC.CUU.........U...UU........ ............................................................ ......................Agcggccaugaaggccac.................... .......UA.....G..................AAU........................ ..AAGU...................................................... ......................................AGCua................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............CUAACUAC.G.UGCCAGCAGuCGCGGUAAUAC.............GU AGGcuACAAG..CGUUACUCGGAUUUAUUGGGCGU..AAAGGGUC...UGUAGA...... ........C.GGU.................UU.............UUUAAG.UCUU.GUU UC.............................AAAG.......ACC.UC.Gacuuaaucga ggA......A...AG........GG.........GC........A............... ...............................................AG..A..UACUAG AAGA................CU....AGA..GU..Ggu.................AUC.. .GGGG..UUA..CUGGAAUUUU......UA.....................GUGUAGGGG U..UAAAUCCGUggauacu..AA.A.AAGAACACCA.AgcGCGAA............GGC GGGU.Aacuag.GU..ACAU..ACUGACGUUC....AGA.GACGAAAGCUAGGGUAGCAA AUCAGAUUAGAGACCUGAGUAGUCCUA.GCCGUAAACAUUGUccg............... ....................UUAGUUCUUccc............................ ..............GA......UU.......UAU........C.G............... .........................GG................................. .....G.GggauGU..............UAGC..AAACGCGU..........UAAAC..G gau.............CGCCUGGGGAGUAUaGCCGCAAGGCcGAAACUCAA...AcGAAU UGGCGGGGAGG.C.GCACA.AC.CA.GUGGAGCAUG.UGGUUCAAUUCGAU.ACAAAGCG .AUGAACCUUA.CCUGG........................................... ....GUUUGAA......AUGcacC.................................... .........UGCAAA.UCCCgagaa................................... ............................................................ ............................................................ ............................................................ ............................................................ ........AUC..G..........GGA.CAUCCUUCGAGGGU.................. ........G.............................................GUG... ...............CA.CAGC.UGUUGCAUGGCUGUCGUCAGCUCGUGACGUGAGUUGU UCUCUUAAGUGAG.GUAACGAGCGCAACCCCCG...UUCUGUG......U....UA.U.. .UGUG....................................................... ...UCACAGAA............G.ACUGCCUAGCAUUAUUU.U...GUUAG........ ...GAGGA.A.GGAG.GGGACGACGUC..A..AGUCAUCAUGAugCUUAUA.UCCAG.GG CUACACA.CAUCCUACAAUgGGCU.A..U.AACA.GAG................GG.... ....U.U.G..............CA........A......G..ACC.....G.UAA.G.. ......G........UGGAGCUAAU......CCC.....U..A.AACua......GC.CC UC.A....GUUGGGAcUGCAGGCUGAAACUCGCCUGCAcgaacC.CGGAAUUGGUAGUAA UCGCACAUCAG.C.AG..CGUGCGG.....UGAAUACGUUCUCGCCUCUUGC..ACACAC UGCCCGUCAAAUCAgcAAA......GU.............................UGGG G.........G.............UA......................CC.......... ............................................................ ....CAAAAUCucg............................GCU.....U.......GC ....CggGACUAA....GGUAAA.........................U........... CCagcga..................................................... ........................UGAGGGUU............................ ............................................................ ........................................................... > ............................................................ ..............AACGCTGG.CGG..CGTGCCTAACACATGCAA.GT....C.....G TAC.....G......C..G...AA................AGAA................ ........................................GG...............GC. .................A......ACCTtCGAGTA......................... ............................................................ .......................................................AAGTG GCGC.....ACGGGTGA....GTAACAC.GTG.GAT.AACCT.................. .G.......................................................CC. .CCA..AA....................GTCTGGGATAACgt.................. ................G.............C.CGAAAG.Gtg.C................ ............................................................ .............................................G.CTAATACC..... ..GGAT...................................................... ........................................ACctttgtgcct........ ............................................................ ............................................................ ...................................CACAA.................... ............................................................ ............................................................ ....................................................GAG..... .........GtatAAAGAAAGG.......AGG.......CCTCTGCttgcaagcttTCGC TT.......................................................... ............................................................ ...........T.......................G........................ ................................G........................... ..................GAT....................................... GGGT..........CCG.CGGC...................................... ..CT..................ATCAGG.TAGTT...GGTAG.GGTAACGGC..CTACCA AG.CCTACGAC..GGGTAGCTGGTCT.......GAG.AGG..A..CG..ATCA...GCCA CATTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGGgaaatgggagaaat.........C................CT...GAC.C...C.A GCAAC.GCCGC.GT......GGAGGATG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACTCCTG................TC........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAAAAGA tt.......................................................... .............GC........AA................................... ............................................................ .............................A.............................. ............................................................ .......A..GCTAATA.CCTTTTGcagtttgat..G.G....TACCT.G.Ct.AA.... G..G...AAGCACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCAAG..CGTTATTCGGAATCAC..TGGGCGTAAAGGG.CG.C.GCAcG...... ........C.GGT.................TTTG......T.......AAGT.Ctaaa.. ...........GT..........G.......AAAT.......CCtT.G.GGCTTAA.C.C .....C.......AG........GGG.........CT...........G........... ......................Cttta.....................G..AT..ACTGC aaaactc....................GA..GTT......CG.............Ggaaa a...GC..AAG..CGGAATTCCTGG..........T.................GAAGGGG TG..AAATCCGTAnatat..CAC.G.AAGAACACCAG.TGGCGAAA............GC GGCTtgctagaa........CGCA..ACTGACGCTtAG.GCGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCCTAAACGATGGATGttaggcgttgggaag tacacttcc................................................... .......................................................CA... ............................................................ ...............GTGCCGt......AAGCT..AACGCGTT..........AAACAT. .C.............CCGCCTGGGGAGTACGGCCGCAAGGTTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAA.GgtACACG .AAGAACCTTA.CCTGG........................................... ....GCTTGACATG.............................................. ............................................................ ...Ctagtagt.A............................................... ............................................................ .................................GGAGCCCG.AAAGGGtaacgattct.. .....................................TGCCTTC................ ........................GG............................G..... ...................CAAGAAAGct......................A....G... ...............CA.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTcTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGg...CATTAGTT..........GCT.. .A.AC....AGGTTAT..................................G.CTGAG..C A.CTCTAATGc............G.ACCGCC.G..G..GGAtAAC...CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGGCCCTTATGT.CCAG.GG CTACACA.CGTGCTACAAT.GGGAt...GT.ACAAT.G................GGT.T. ........G..............CA........AT........ACC.....GC.GA.G.. ......GT........GGAGCTAAT......CCCT.......A.AAgcat......C.CC AC.A....GTTCGGATTGCACTCTGCAACTCGAGTGCATGAAGCT.GGAATCGCTAGTAA TCaCCGGTCAG.CTAtacggt..GGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGGA......GTT.............................GAT Tctactgt......................AA....GA...................C.. ...GGTAG........G.............CT.....A....A.........CC...CGt tA........AG.........G.G.................AG.....GCA.......GC ....C..Gttcat....GGTAGGGTCAGC............................... ...............................GACcGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AGGAGAACC............TGCGGCTGG......................... ............................................................ ........................................................... > ....NA.......AUUGGAGAGUUUGAUCCU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AGC.....G..................................CGA..AU.......... ................................G......G...AG.........CAAUCC u........................................................... .............A.GU.............AG............................ .......................................................AGC.G GCGC.....ACGGGUG....CGUAACAC.GUG.GA.UAAUC..................U .G.......................................................CC. ......U....................GGG......U......................G .U.CUGGGAUAAC..CAG............U.CGAAAG.A.UU................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AA.................. ....................G.C..................................... ..CCc......................................................C GGGAGCUUCG........................GCUCUU.................... ............................................................ ............................................................ ....................................................GAG..... .........GG.....AAAAGG.......UGG.......CCU.................. ............................CUGUAU.......................... ...............ACAAGCUAU.........CA......................... ............................................................ ........................CA...UcCA........................... ...................G.......A.......U........................ GAG.....U.....CCG.CGGC...................................... ..CC..................AUCAGCUAG....UUGGCGG.GGUAAUGGC..CCACCA AGG.CAACGAC..GGGUAGCUGG...U....CUGAG.AGG..A..CG..AUCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCAAC.GCCGC.GU......GUGUGAUG...AA...GGU.C.........UUU.GGAUUG UAAAGC..........................A.CUU.........U............. ...................................................CG....... ......................A.....CCG............................. ............................................................ ............................................................ ............................................................ ....................................GGACGAAAAcCCCUGG.....GCU A.....A.UAcuccag......................................GG.... ............................................................ .......................................................N...U .......U..GACGGU............................ACCG.G..GAGAA... ...G...AAGCACC..................G........................... ............GCUAACUCUn..UGCCAGCAGCCGCGGUAAUACA.............G AGGGUGCAAG..CGUUGUUCGGAAUUAUUGGGCGU..AAAGCG.CG..UGUAGG...... ........C.GG.............C....UU.............UGCAAG.UCG.G... .........A..........UGUG.......AAAG.......CCC.UC.GGCUCAA.C.C ...G.........AG........G.........AAG........U...G........... ......................CGU...UC..................G..A..AACUGC AGA...............G.CU....UGA..GU......ACc.............GG... AGAGGG..UGG..CGGAAUUC......CCCA.....................AGUAGAGG UG..AAAUUCGUA.GAU.AUGG.GG.AGGAACACCGGC.GGCGAA............GGC GGCC.A.CCUGGA..CGGNC..ACUGACGCU....GAGA.CGCNNAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....AAC.......... ....UAGGU........................G.......UC....Gug......G... ....................G..UG.......UUGA.....CC........CNC...... .....................G.....................C................ .....G.GU........GCCG.......UAGC..UAACGCAU..........UAAG..UU CU.............CCGCCUGGGAAGUACGGUCGCAAGACUAAAACUCAA...AGGAAU UGACGGGGG.CC.NGCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGNN.NNAACGCG C.AGAACCUUA.CCUGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UCGGAAugycu.....C....A....................GA............. ........GAUR.......RN.....N................................. ...N........................................N............... ..................................GUGCCCGc.................. ....................................................AA...... ......G.................GGA................................. .................ACCG..A........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GNAACGAGCGCAACCCUCGC...CUUUAG......U....UGC..C ....GCGC.........................A.A........G..C..GN.....N.. U.CUCUAGAG............GG.ACUGCC.G..G.UG.UU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGU..NA..AGUCCUCAUGGCCUUUAUG.ACCAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.AGC................GUUGC NAACU.N.G..............CG........A......G..A................ .......G........GGAGCUAAU......CGC....AU..A.AAA..C..CG.G.N.C UC.A....GNUCAGAUUGGAGUCUGCAACUCGACUCCAUGAAGG.CGGAAUCGCUAGUAA UCGCAGAUCAG.C.A.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACNCAC CGCCCGUCACACCAUGGGA......GU..........................C...GA. ........UUGC.............UCCAGAA....GU...................CAU CUcacc...................................................... .........................A...............AGAG..........GU... .......GCCCAA....GGAGU......................GG...U.......... .C.................GGUAACU.........GGGG..................... ............................................................ ............................................................ ........................................................... > nnaac..........UGGAGAGUUUGAUCCU.GG.......................... ....CUCAGA.GCGAACGUUUG.CGG..CGGGCCUA....ACACAU.GCAAGUC.....G AAC.....G........GG......................................... .CUAgc...................................................... ............AA.....................................UA....... ...............G.UC.............AG....U..................... ...........................................................G GCGC.....ACGGGUG....CGUAACAC.GUA.GG.UAAUC................... ........................................AA................C. .CCcUC....................................................GG .UUC.GGGAUAACG..UU............CU.GAAAG.G.AGC................ ............................................................ .............................................G.C............ .................................................UAAUACC.... ...................................GNAcg...U..G............. .....................................UC..................... .........................................................UUC GGGAGCUUCG........................GCUCC..................... ...........UGUC............................................. ..............................................GAGAAAGAC.CCGC AAGGGUUGC.........................................CG........ ..A.........G...GNNc........................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ GAG..........CNUG.CGGC...................................... ..CC..................AUCAGCUAG....UUGGCGA.GGUAAUAGCU..CACCA AGG.CGAAGAC..GGGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GUCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCCAC.GCCGC.GU......GAGCGAUG...AA...GG.CC.........UUC.GGGUCG UAAAGC..........................U.CU.........GUgggg......... ............................................................ ............................................................ ...AGA................................................G..... .....................................................ACG.... ............................................................ ..................A....AGAAagccug..................UGAAGAGca g.................GNNC...................................... .............................U.............................. ............................................................ .......U..GACGGU............................AUCUC..C.UUAGC.. .......AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCGAA..CGUUGCUCGGAAUCAUUGGGCGU..AAAGCG.CA.C.GUAGG...... ........C.GG.............CGgcGUA.............AGCG.....G.G... .........A..........UGUG.......AAAG.......CCC.AG.GGCUCAA.C.C .....C.......UG........G.........AAG........U...G........... ......................CAUCCC.........................GAACUGC GUC...............G.CU....UGAA..UCuc......G................. .GAGGG..GGAcagAGAAUUC......CC.....................GGUGUAGAGG UG..AAAUUCGUA.GAU.AUCG.GG.AGGAAUACCAG.UGGCGAA............GGC GCUg.U.CCUGGA..CGAA..GAUUGACGCU....GAG.GUGCNNAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGAUGAG....UGC.......... ....UGGAcggu...................................G.G..A...G... ....................G..A.......UUUGA.....CC........CC....... ....................UU.....................C................ ......GcU........GUCG.......AAGC..UAACGCGU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGUCGCAAGACUAAAACUCAA...AGGAAU UGACGGGGG.CC.NGCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGNN.NNAACGCG C.AGAACCUUA.CCUGG........................................... ....GUUA.................................................... ......AA...............U.........C.......................... .....................C............A....CUGGAACCUGG.......... ............................................................ .....CUGAAAGGC................UGGGnUG....................... .....CCC...............U............................U....... .....CG.................GG............................GAG... ..................CCGgUG.AG.A............................... ...................AGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCCN.CAACGAGCGCAACCCCUA...UCGCCAG......U....UGC..C .AC.C....A..........U..Ug...........AG.U........U.....GGGA.. A.CUCUGGCGA............G.ACUGCC.G..G.Uc..U.AAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCCUCAUGGCCCUUAUGC.CCAG.GG CUACACA.CGUGCUACAAU.GGCU.G..G.UACAA.AGA................GCC.. ........G..............CA........A......G..CCC.....GC.GA.G.. ......GG........UGAGCAAAU......CUC.....A..A.AAAA.C..CA.G.U.C UC.A....GUUCGGAUUGCAGUCUGCAACUCGACUGCAUGAAGC.UGGAAUCGCUAGUAA UCGGAGAUCAG.C.A.CG.CUCCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU..........................C...GGC .........UGC.............UCCAGAA....GU...................A.. ...GG.AAc........CU.................CA....A.........CCG..... ..............C.A...AG.G.................AAAGgcc...........C .....UA..CCAA....GGAGcn......................G...U.......... .C.................GGUGACU......U....GG.......G.UAAC........ ....................................A.............AG......GA U............CACCUCCUUUCU................................... ........................................................... > ca.......................................................... ..................AUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G......C..G...AA................AGUU...............U CCUUCGG..G.............................................AAGC. .................N......A................................... .......G...........UA..........GAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACAC.GUG.GA.UAAUC..................U .G.......................................................CC. .C.........................G.AUG....A....................... C..CUGGGAUAA.CA.C............UU.CGAAAG.AG.G................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AA.................. ....................G.C..................................... ..CC........................................................ ............................................................ .................................................ACA........ ........Ggcu................................................ ..............CUUC...........................G.....G........ ..AgcaugcGG.....AAAAGG.......UGG............................ .........................GGACCUUCGGG....CCUAccguc........... ..................................AUCGGAUGAgu............... ............................................................ ............................................................ ............................................................ .AG.....U.....CCG.CGGC...................................... ..CC..................AUUAGCU...AG.UUGGUGG.GGUAACGGC..CCACCA AGG.CGACGA..UGGGUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGUGGCAGCAGUGGGGAAUU UUG.....CG...CAAUGGGGGAA.ACC................CU...GAC....GC.A GCAAC.GCCGC.GU......GAGUGAUG...AA...GG.C.........UUUC.GGGUCG UAAAGC..........................U.CU.........GU............. ...................................................C........ ....................A......GAG.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAC....UAUCGUGGUCGAAUAGG............. ............................................................ .....................Ccccg.................................. ......................GU...............................AC... .......U..GACGGU............................ACCCU..C.AAA.... G..G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUGUUCGGAAUUAUUGGGCGU..AAAGCG.CG..UGUAGG...... ........C.GGU.................CUG.............UUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUCAA.C.C .....C......G.G........G.........AAG........U...G........... ......................CAU...UG..................G..A..UACUGG CAGA................CU....UGA..GU......ACG.............GG... AGAGG..AAAG..UGGAAUUC......CGA.....................GUGUAGGGG UG..AAAUCCGUA.GAU.AUU.CGG.AGGAACACCGG.UGGCGAA............GGC GGCU.UU.CUGGA..CCGAU..ACUGACGCU....GAGA.CGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGGG....UAC.......... ....UAGGU........................G.......UC....GC.G.....G... ....................G..U.......AUUGA.....CC........CC....... ....................UG.....................C................ .....G.GU........GCCG.......AAGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAC.GCAACGCG C.AGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UC.C............C...... ......GAUC..GU................AC............................ ...................UU.....UC..............................UG ..................G....A.AACAGUU............................ .AGGUCAGUUCGGC................UGGA.......................... ............................................................ ............................................................ ...................UC.........................G.G..U....G... ................A.CAGG.UGCUGCAUGGUUGUCGNCAGCUCGUGUCGUGAGAUGU CGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAGGA............G.ACUGCC.G..G.UG.UU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.AG................GGC... ......A.G..............CG........AA........ACC.....GC.AA.G.. ......G........UUUAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UUGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGGGA......GU.............................UGA. ........UUG.............UACCUGAAA....U...................C.. ...GG.U.......GG.............GCU.....A....A.........CC.....U .UC........G.........G.G.................AG.....GCA.......GC ....C..GCUUAU....GGUAU......................GG...U.......... .C.................GGUAACU.........GGGGUG................... ............................................................ ............................................................ ........................................................... > ............................................................ .........A.ACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G......C..G...AA................AG................G. ................................G......GCTTCGGC............. .....CCT......................GAGTA......................... ............................................................ .......................................................AAGTG GCGC.....ACGGGTGA....GTAACAC.GTG.GAT.AATCT.................. .G.......................................................CCt gatga........................TCTGGGATAACat.................. .................T.T............CGAAAG.G.AGT................ ............................................................ .............................................G.CTAATACC..... ..GGAT...................................................... ........................................AA.................. ....................G.C..................................... ..CC........................................................ ............................................................ .................................................ACA........ ........GCA.......AcctcggttgCAGC............................ ......................................................G..... .........GG.....AAAAGGG.......GGCCTCTTCcT................... ............................................................ ..............GA.AAGCtT.................CT.................. ..................................GTCAtTA................... ............................................................ ..................GAT....................................... GAGT..........CCG.CGGTC..................................... ...C..................ATTAGC.TAGTT...GGTAG.GGTAACGGC..CTACCA AGG.CGACGAT..GGATAGCTGGTTT.......GAG.AGA..AT..G..ATCA...GCCA CACTGGA.ACTGAGACACG.GTCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATT TTGCGCAAT........GGGCGAA.AGC................CT...GAC....GC.A GCAAC.GCCGC.GT......GAGTGATG...AA...GGTTTTCGGA...........TC. ............................................................ .......................GTAAAGCTCTG................TC........ ....................A......GGA.............................. .....G................................................G..... .....................................................A...... ............................................................ ...........................................................A AGAAActccagaaG.............................................. ............................................................ ............................................................ ..........GCTAATATCCTTTTGgac....TGACG.G....TACCTC..C.AAA.... G..G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTGTTCGGAATTA..TTGGGCGTAAAGCG.CGT..GCAGG...... ........C.GGT.................TTTT......T.......AAGT.CT.G... .........ATGT..........G.......AAAG.......CCC.CG.GGCTTAA.C.C T...........G.G........G.........AAGT...........G........... ......................CATTG.....................G..A..AACTGG GAAA................CTT....GA..GT......ACG.............GG... AGAGGG..AAG..TGGAATTTCGAG..........T.................GTAGGGG TG..AAATCCGTA.GATATT..CGA.AGGAACACCGG.TGGCGAA............GGC GGCTT..CCTGG......ACCGA..TACTGACGCTGAGA.CGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGGgTACTAGGTGTTGCGGGT Att......................................................... ..................................GA.....CC........CCTgCA... ............................................................ ...............GTGCCG.......AAGCT..AACGCATT..........AAGT..A CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCTGG........................................... ....GCTTGACATC........................C.CGATcgtacgata....... ............................................................ .......................................T.................... ............................................................ ............................................................ ...........GGAAACATATTGGtcagttcggctgg....................... ............................................................ ............................................ATC.GGT.....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGT...CCTTAGTT..........GC..C .AT.C....ATTAAGT.....................................TGGG..C A.CTCTAAGGA............G.ACTGCC.G..GT.GT.T.AAA..CC.G........ ...GAGGA.A.GGTG.GGGACGACGTCAA....GTCATCATGGCCCTTATGT.CCAG.GG CTACACA.CGTGCTACAAT.GGC.CG..GT.ACAA.AG................GGC... ......A.G..............CG........AT........ACC.....GC.AA.G.. ......GT........GGAGCAAAT......CCC.....A..A.AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGAGTCTGCAACTCGACTCCATGAAGTT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGGGA......GTT.............................GAT TGT......................ACCTGAAa....T...................C.. ...GGT........GAG.............CT.....A....A.........CCTTTc.. ....................AG.G.................AG.....GCA.......GC ....C..GCttat....GGTATGG..........................TC........ ...GG.................TA........ACTGGGGTG................... ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGGA..GUGCCUA....ACACAU.GCAAGUC.....G AAC.....G.......U.G...AAgGGG................................ ............................................G.........CUUCGG .............................................UC.......CccgG. ..............................AAAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACGC.GUG.GA.UAAUC..................U .G.......................................................CC. .C.....A....................GUGa............................ .U.CUGGGAUAAC.A.U.C...........U.CGAAAG.GG.G................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AA.................. ....................G.C..................................... ..CC........................................................ ............................................................ .................................................ACggagUCCUU GGAUU.......................CUGC............................ ......................................................G..... .........GG.....AAAAGGG.......GG............................ .........................GGACCUUCGGG....CCUUuuguc........... ............................................................ ...............AC........................................... ...............................U............................ ..................GG.......A.......U........................ GAG.....U.....CCG.CGU....................................... .ACC..................AUUAGCU...AG.UUGGUGG.GGUAAUGGC..CCACCA AGG.CUACGA..UGGUUAGCUGG...U....CUGAG.AGG..A..UG..AUCU...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....CG...CMAUGGGCGAA.AGC................Cgnas.........GA GCMAC.GCCGC.GU......GAGUGAUG...AA...GG.CC.........CUC.GGGUCG UAAAGC..........................U.CU.........GU............. ...................................................CG....... ...........................GG............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGugauug..................AGG.....G.U U.....A.AUACCCCuuGG.UC...................................... .............................U.............................. ............................................................ .......U..GACGGU............................ACCUC..C..GAA... ...G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUGUUCGGAAUUAUUGGGAGU..AAAGCG.CG..UGUAGG...... ........C.GGU.................UUC.............UUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.CG.GGCUCAA.C.C .........U..G.G........G.........AAG........U...G........... ......................CAU...UG..................G..A..AACUGG GAGA................CU....UGA..GU......ACG.............GG... AGAGGG..UAG..UGGAAUUC......CUA.....................GUGUAGGAG UG..AAAUCCGUA.GAU.AUUA.GG.AGGAACACCGG.UGGCGAA............GGC GGCU.A.CCUGGA..CCGAU..ACUGACGCU....GAGA.CGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UAC.......... ....UAGGU........................G.......UU....GC.G.....G... ....................G..U.......AUUGA.....CC........CC....... ....................UG.....................C................ .A.....GU........GCCGC.......AGC..UAACGCAU..........UAAG..UA CU.............CCGCCUGGGAAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.G.UGGAGCAUG.UGGUUUAAUUCGAC.GCAACGCC .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UC.Cgcg................ ......GAAC.......................C.......................... ...................UC.....UAUG.........................A.AAG U......................AG...................GGG............. ...................................UG....................... .....CCC...............U............................U....... .....CG.................GGA...........................G..... ...................CC.........................GcG..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCUUCAG......U....UGC..C .A.UC....A..........U..U.........A.A.G.U........U.....GGG..C A.CUCUGAAGA.............AACUGCC.G..G.UG.U.CAAA..CC.G........ ...GAGGA.A.GGUN.GGGAUGACGUC..A..AGUCCUCAUGGCCCUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGC.CG..G.UACAA.AGA................G.... ....U.U.G..............CG........AU........GCC.....GC.GA.G.. ......G........UGGAGCCAAU......CUC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGGGA......GU..........................C...GAC .........UGg.............UCCCGAA....GU...................... ..Gc.GU.......G.A............GC.....CA....A.........CC...CGC .A........AG.........G.G.................AAGCA..GCGC........ ........CCUAA....GGAAU......................GG...U.......... .C.................GGUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAAC.............UGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ............................................................ .........A.ATGAACGCTGG.CGG..CGTGCCTAACACATGCAA.GT....C.....G AAC.....G.......A.G...AA................AG.CCttaa........... ......................................................TCTTCG GAtggg.......................CGAGTA......................... ............................................................ .......................................................AAGTG nCGC.....ACGGGTGA....GTAACGC.GTA.GGT.AACCTA................. .........................................................CC. .CCtgtATTT.................................................. .....GGGATNA.CAG.T.G............CGAAAGT.G.CT................ ............................................................ .............................................G.CTAATACC..... ..GGAT...................................................... ........................................ACGACCtcagag........ ............................................................ ...........................................................C GGGAGCAC.................................................... ............................................................ ...........................AG............................... ..........................................A..G.....Gtn...... .................AAAGT...................................... ............................................................ ..........................CGGCCTCTcg........................ ...................AAGAAGCtgatgtacGG........................ ................................G........................... ..................GAT....................................... GGG..........CCTG.CGTC...................................... ..CT..................ATCAGC.TGGTT...GGTAG.GGTAACGGC..CTACCA AGG.CGACGAC..GGGTAGCTGGTCT.......GAG.AGG..AT..G..ATCA...GCCA CACTGGC.ACTGGAACACG.GGCC..AGACT...CCTACGGGAGGCAGCAGTGAGGAATT TTGCGCAAT........GGccgca.........ANG........CT...GAC....GC.A GCAAC.GCCGC.GT......GGGTGAAG...AA...GG.CCT.........TC.GGGTC. ............................................................ .......................GTAAAGCCCTG................TC........ ....................A......GGT.............................. ....GG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAGGctttaggt......................... ...........................................CGAAGAG.........A ctgggga..................................................... ............................................................ .....C.........................TTGACG.G....TACCAC..C.AGA.... G..G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCGAG..CnTTATTCGGAATTAC..TGGGCGTAAAGCG.CGT..GCAGG...... ........C.GGT.................TT......GAc.......AAGT.CT.G... .........ATGT..........G.......AAAG.......CCC.CG.GGCTTAA.C.C T...........G.G........G.........AAG........A...G........... ......................CATTG.....................G..A..AACTGT TGGA................CTT....GA..GT......ACT.............GG... AGAGG..AAGG..GGGAATTCCCGG..........T.................GTAGAGG TG..AAATTCGTA.GAGAT.CG.GG.AGGAATACCAG.TGGCGAA............GGC GCCCTT..CTGG......ACggC..TACTGACGCTGAGA.CGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCTGTAAACGATGAGCACTAGGTGTaGCGGGT A........................................................CT. ......................CA.TT...............C........CTG...... ........CT.................................................. ...............GTGCCGT.......AGCT..AACGCGTT..........AAGT..G CT.............CCGCCTGGGGAtTACGGTCGCAAGACTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGTATGTGGTTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCTGG........................................... ....GCTTGACATC........................C.C............C...... ......GGA................................................... ...........................C......GgtccT.................... ............................................................ ............................................................ ...........GGAAACAGGG..............AGTtnnnCTTC.............. ........................GG............................GGGacc ......................G.......................G.G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGC...CTTTAGTT..........GC..C .AT.C....A.....CTTC.G............GG..................TGGG..C A.CTCTAGAG............GG.ACTGCC.G..GT.GT.T.AAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCTTTATGC.CCAG.GG CTACACA.CGTACTACAAT.GGG.CG..GT.ACA.GAG................GG.... ....A.A.G..............CG........Atc........CC.....GT.GA.G.. ......GG........GGAGCCAAT......CCC.....A..A.AAA.GC..CGT..T.C AC.A....GTTCGGATCGGAGTCTGCAACTCGACTCCGTGAAGTT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGAGA......GTTggc............................. T.........GC.............ACCAGAA....GTNCGTG................. .......G........G.............CT.....A....A.........Cnnttcg. .................G.........GGG............G.....GCA.......GC gt......ACCAA....GGTGTGG..........................TC........ ...GG.................TG........ATTGGGGTGA.................. ............................................................ ............................................................ ........................................................... > ............................................................ .........A.ACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G......C..G...AAcggg.............A.................. ............................................................ ..CTTC..GGtccca................AGTA.................G....... ............................................................ ........................................................AGTG GCGC.....ACGGGTGA....GTAACGC.GTA.GAT.AACCT.................. .Gtcttcatgtctggaataat....................................... ............................................................ ..............ACG.............C.CGAAAG.GG.Gta............... ............................................................ ...............................................CTAATACC..... ..GGAT...................................................... ........................................ATTCttgtttttCATAAGGt tg.......................................................... ............................................................ ............................................................ ............................................................ ............................AC.............................. .............................AAG..A.......AAAGgt............ ..............................GG.......CCTCTGCATATGCTactgcat g........................................................... ............................................................ ............................................................ ............................................................ ..............................................AA.........GAG GGGT..........CTG.CGTAC..................................... ...C..................ATTAGC.TAGTA...GGTGG.GGTAAGGGC..CTACCT AGG.CAACGAT..GGTTAGCgGGTCT.......GAG.AGG..AT..G..ATCC...GCCA CACTGGC.ACTGGAACACG.GGCC..AGACT...CCTACGGGAGGCAGCAGTGAGGAATA TTGCGCAAT........GGGGGCA.ACC................CT...GAC....GC.A GCGAC.GCCGC.GT......GAGTGAGG...AA...GG.CCT.........TC.GGGTC. ............................................................ .......................GTAAAGCTCTG................TC........ ....................A.A.....GA.............................. .....G................................................G..... .....................................................A...... ............................................................ ...........................................................A AGAAgtgcatagcGGT............................................ ............................................................ ............................................................ ............TAATAcccgttgtgt....TTGACG.G....TACCTCt...AAA.... G..G...AAGCACC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAATAC.............GG AGGGTGCAAG..CGTTGTTCGGAATCAC..TGGGCGTAAAGGG.CG.C.GTAGG...... ........C.GGT.................TT......GAT.......AAGT.CA.G... .........ATGT..........G.......AAAG.......CCC.AT.GGCTTAA.CTG T.............G........G.........AAGT...........G........... ......................CATTT.....................G..A..AACTGT CAGA................CTT....GA..GT......ACc.............AG... AGGGG..AAAG..TGGAATTCCCGG..........T.................GTAGAGG TG..AAATTCGTA.GATAT.CG.GG.AGGAATACCGG.TGGCGAA............GGC GACTTT..CTGGCtg......GA..TACTGACGCTGAG.GCGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGTCAACTAGatg.TAG.... ..GG........................................................ ......................................................GGTgtt gatcccCTCT.................................................. ...............GTGtCGC.......AGCT..AACGCATT..........AAGTT.. GA.............CCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGTATGTGGTTTAATT.CGA.TNCAACGCG .AAGAACCTTA.CCTGGT.......................................... .....CTTGACATC........................C.CG.................. .....................GGAATC................................. .....................CTt.................................... ............................................................ ............................................AGG.......AAA... ......Ct.........AGGG..............AGTGCCTTCattCGAA......... ............................................................ .......................................GGAGCCTG.G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGC...CTTTAGTT..........GC..C .AT.C....AGttcg.GC...................................TGGG..C A.CTCTAAAG............GG.ACTGCC.G..GT.GT..CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCTTTATG.ACCAG.GG CTACACA.CGTACTACAAT.GGC.CGA..T.ACAA.AG................GGC... ......A.G..............CG........A........CACTGCG......AA... ......GT........GGAGCCAAT......CCC.....ATAAAtt......CG.G.T.C TC.A....GTCCGGATTGGAGTCTGCAACTCGACTCCATGAAGTT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGGGA......GTcgg.............................T TGT......................ACCAGAA....G...................CA.. ...GtT........GAG.............CT.....A....A.........CCG..... ..............C.A...AG.GG.................G.....GCAgtcta.... ............................................................ ............................................................ ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.ACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G UAC.....G.......A.G...AA................A................... ..AUcc......................................G.........CUUCGG C............GG.....G..........................UG........... .............A.GU.............AAAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACGC.GUG.GA.UAAUC..................U .G.......................................................CC. ......UU..............U......A......A......................G C.G.GGGAAUAA.CU.UA............C.CGAAAG.G.UG................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............CCAUAAAGC...............UA.UGG....A............ GCUCCgg.....................U................UUCAUAGccaaaGAG AGCC........................................................ ............................................................ .................................................UCU........ ........GCA.......UGc....................................... ............................................................ ..................AAGCCCUca................................. ............................................................ ............................................................ ........CU.....UA........................................... ...............................GA........................... ...................G.......A.......U........................ GAG.....U.....CCG.CGU....................................... .ACC..................AUUAGCU...AG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGA..UGGUUAGCUGG...U....CUGAG.AGG..A..UG..AUCA...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGAGGAAUA UUG.....CG...CAAUGGGGGCA.ACC................CU...GAC....GC.A GCAAC.GCCGC.GU......GAGUGAGG...AA...GGU..........UUUC.GGAUCG UAAAGC..........................U.CU.........GU............. ...................................................CG....... ...........................GG............................... ...UGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AAUGUAUUgAGG......................... U.....U.AACAGCcuuuGUAC...................................... .............................U.............................. ............................................................ .......U..GACGGU............................ACCGC..C.AAA.... G..G...AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG GGGGUGCUAG..CGUUGUUCGGAAUCAUUGGGCGU..AAAGAG.CG..UGUAGG...... ........C.GG.............C....UAG.............GCAAG.UCA.G... .........A..........UGUG.......AAA.......UCCC.UG.GGCUUAA.C.C .....C.......AG........G.........ACG........U...G........... ......................CAU...U..................UG..A..AACUGC UUG...............G.CU....UGA..GU......AGG.............GA... AGAGGG..AAG..UGGAAUUC......CU.....................GGUGUAGAGG UG..AAAUUCGUA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GACU.U.CCUGGU..CCUAU..ACUGACGCU....GAGA.CGCGAGAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCAACGCCGUAAACGAUGU....UCAC.......... ....UAGGU........................G.......UU....GA.G.....G... ....................G..U.......AUUGA.....CC........CC....... ....................UU.....................C................ .A.....GU........GCCG.......AAGC..UAACGCAU..........UAAG..UG AA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....ACUUGA.....C...A.................UC.C............C...... ......GG......................GAaucuccU..................... ...........GGA.....A..............A...C.........GG.......... ..................G....AGA....................G............. ...................................UG....................... .....CC...............UU............................U....... .....CG.................GG............................GAG... ..................CCC.........................G.G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU CGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCUUUAA......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUUUAAAGA............G.ACUGCC.G..G.CG.UU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGGCCUUUAUG.UCCAG.GG CUACACA.CGUGCUACAAU.GGGU.G..G.UACAA.AGA................GC... ......A.G..............CC........AA........CUC.....GC.GA.GA. .......G........UGAGCAAAU......CUC.....A..A.AAA.GC..CA..U.CC UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCcggaaaa......U.............................UGA. ........UUGC.............ACCAGAA....GU...................C.. ...GU.U.......G.A............GCU.....A....A.........CC...CCU A.....UUUAU.....AG..AG.G.................AG.....GCA.......GG ....C..GCCUAC....GGUGU......................GG...U.......... .Ugguaauc..........................GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGUG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > ..............................T............................. ..GGCTCAGA.ATGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G.......A.G...AA................AG................G. ................................G....................AtTGCTT GCAatCCT......................GAGTA.................G....... ............................................................ ........................................................AGTG GCGC.....ACGGGTGA....GTAACAC.GTA.GAT.AATCT.................. .GTCTccaagc................................................. ........CT.................................................. .....GGGATAA.CT.AT.T............CGAAAG.GG.T................. ................A........................................... .............................................G.CTAATACC..... ..GGAT...................................................... ........................................AAagttGATTCACataagtg gattAAT..................................................... ...........GAAAGATT......................................... ............................................................ ............................................................ ............................................................ ............................................................ ...............................GCCTCTTCnT................... ............................................................ ..............GA.AAGCAAttgTTTGGGGGTgagtt.................... ............................................................ ............................................................ ............................................................ ...............TG.CGTAC..................................... ...C..................ATTAGC.TTGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CAACGAT..GGTTAGCTGGTCT.......GAG.AGG..AT..G..ATCA...GTCA CACTGGA.ACTGGAACACG.GTCC..AGACT...CCTACGGGAGGCAGCAGTGAGGAATT TTGCGCAAT........GGGGGCA.ACC................CT...GAC....GC.A GCAAC.GCCGC.GT......GAGTGAAG...AA...GG.CCT.........Tt.GGGTC. ............................................................ .......................GTAAAGCTCTG................TC........ ....................A.A.....C............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGttattatctattaataGTGGATAc........... ............................................................ ............................................................ ............................................................ ..........................T...ATTGACG.G....TACCT.GT.G.GA.... G..G...AAGCGCC..................G........................... ............GCTAACTCC..GTGCCAGCAGCCGCGGTAACAC.............GG GGGGCGCAAG..CGTTATTCGGAATTA..TTGGGCGTAAAGGG.CG.C.GTAGG...... ........C.GGTC.................Ttgtcc.............GT.CA.GG.. ..........TGT..........G.......AAAG.......CCC.GG.GGCTCAA.C.C .....C....C...G........G.........AAGT...........G........... ......................CACTT.....................G..A..AACAGC AAGA................CTT....GAA..T......ACG.............GG... AGAGG..AAAG..CGGAATTCCTGG..........T.................GTAGAGG TG..AAATTCGTA.GATAT.CA.GG.AGGAACACCG.ATGGCGAA............GGC AGCTTT..CTGG......ACCGA..TATTGACGCTGAG.GCGCGAAGGCGTGGGTAGCGA ACGGGATTAGATACCCCGGTAGTCCA.CGCAGTAAACGTTGtacactcGGTGT....... ...............................................G.Gcggatattaa aat................................................CTG...... ........CT.................................................. ...............GTGCCc.......AAGCT..AACGCATT..........AAGT..G tA.............CCGCCTGGGAAGTACGGTCGCAAGACTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCTGG........................................... ....GTTTGACATC........................C..Tgtga.............. ............................................................ ............................................................ ............................................................ ............................................................ .................ATATTGGgtaattgccaTAGTGCCTTC................ ........................GG............................GAG... ..................CAC..A........................G..A....G... ................A.CAGGT.GCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TtGGTTAAGTCCA.GCAACGAGCGCAACCCTTAT...CgTCAGTT..........GC..C .AG.C....A.....C....A.TAA.......TGG..................TGGGA.. A.CTCTGGCGA............G.ACTGCCCc...GGTC....AACG.G.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCCTCATGGCCCTTATaT.CCAG.GG CTACACA.CGTGCTACAAT.GGTA.G..GT.ACAA.AG................GGC... ......A.G..............CG........A........Ctctgcaaaa........ ...............AGAAGCGAAT......CCC.....A..A.AAG..C..CT..AT.C TC.A....GTCCGGATTGGGGTCTGCAACTCGACCCCATGAAGTT.GGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATAtGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCATGGAA......GTT.............................GAT TAT......................ACCCGACGtcgc....TG................. .......G........G.............CT.....A....A.........CTatttat a...........................GG............G.....GCA.......GG ....C..GCCTAA....GGTATGG..........................TC........ ...Ga.................TA........ACTGGGGTGAAGTCGT.AACAA.GGTAG CCGTtggag................................................... ............................................................ ........................................................... > ....UU.......UAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAGA.GUGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAC.....G.......A.U........GA...................A........... .........G.....CU...............UC.........U........AGCUUGC. .................U......A................................... .......GAgUGCU.GA.............UUAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAACGCA.Uaggucaug....................U .G.......................................................CC. ......UC..............U......U......A......................G .UU.UGGGAUAGC..CAU............UGG.AA.ACG.AU................. ...............G............................................ ............................................................ ...............................................AUUAAUACC.... ..................................AGAUAcu................... ......................C..CC................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......UACGGGG...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGCU.....AA........................................... ...............................GA........................... ...................G.......A.......Uc....................... .AG..........CCUAU.GUC...................................... ..C..................UAUCAGCU...UG.UUGGUAA.GGUAAUGGCU..UACCA AGG.CUAUGAC..GGGUAUCCGGCC.........UG.AGAG..GGUG..AACG...GACA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUA UUG.....C...UCAAUGGGGGAA.ACC................CU...GA.A...GC.A GCAAC.GCCGC.GU......GGAGGAUG...AA...GGU..........UUUA.GGAUUG UAAAC..........................UC.CUU.........U...UG........ ............................................................ ......................U.....U............................... ...AG.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................AUCUA.A..CGAA..U .......AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCAAG..CGUUACUCGGAAUCACUGGGCGU..AAAGAG.CG.C.GUAGG...... ........C.GG.................GAU.............AGUCAG.UCA.GG.. ....................UGUG.......AAA.......UCC.UA.UGGCUUAA.C.C .........A...UA........G.........AAC........U...G........... ......................CAU...U..................UG..A..AACUAC UAUU................CU....AGA..GU..G....UG.............GG... AGAGG..UAGG..UGGAAUUCU......U.....................GGUGUAGGGG U..AAAAUCCGUA.GAG.AUCAA.G.AGGAAUACuC.AUUGCGAA............GGC GACC.UG.CUGGA..ACAUU..ACUGACGCU....GAUUGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGAUGG....AUGC.......... ....UAGUU........................G......UU.......GG......... ......................AG........GGCUUAGUc................... .....................U.....................C................ .UC.....CAGUAA.....UGC.......AGC..UAACGCAU..........UAAGC..A UC.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU AGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GAUACACG .AAGAACCUUA.CCUAG........................................... ....GCUUGA.....C...A.................UU.............G....... ........................A....................G.............. .........AGAAUCc.................................GCU........ AGAAAUAGUGGAGUGU............................................ ............................................................ ............................................................ ...................................CUAGCUU............G..... ...................CUAGAcCUU.....................GAA.....A.. ................A.CAGG.UGCUGCACGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCCU...UUCUUAG......U....UGCU.. .A.AC....AGG........U..U.........A.U........G..CU.....GAGA.. A.CUCUAAGGA.............UACUGCCU..CCGU...AAG...G..AG........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUACGC.CUAG.GG CUACACA.CGUGCUACAAU.GGGGu...GC.ACAA.AGA................G.... ....A.A.G..............CA........AU........AC.....UG.UGAA... ......G........UGGAGCCAAU......CU.....UC....AAAA.Cac....CU.C UC.A....GUUCGGAUUGUAGGCUGCAACUCGCCUGCAUGAAGC.UGGAAUCGCUAGUAA UCGCAAAUCAG.CCAU.GU.UGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACUCAC CGCCCGUCACACCAUGGGA......GU.............................UGUg uuu............................................GCCUUAAGUCA.. ...GG.AU.......G.CU............A.....A....A................. UUGGCUAcu................................................... .......GCCCAC....GGCAcac.........................A.......... .CA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAA CCG.UAGGUGAACC............UGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > .....U.......UAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAGA.GUGAACGCNGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAC.....G........GA........GU...................AUUA....A... ........................................GAG.........AGCUUGC. .................U......N.................UNUUAA............ ........U.......AC............NUAG....U..................... ...........................................................G GCGC.....ACGGGUGA....GUAAUGua.UA.GU.UAAUC..................U .G.......................................................CC. .C.....U..............A......C......A......................C .UG.GAGGACAAC.A.............GUUAG.AA.AUG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACU.... .............CCAUAcuccuUCUUAAC........A.UA.A..G............. .....................................U..........UAAGU....... ......................................CGGG.................. ............................................................ ............................................................ ............................................................ ............................................................ .................AAAG.U..................................... .....................NUUU................................... ............................................................ ......CGGUG................................................. ..............................UA............................ ..................GG.......A.......U........................ GAG.....A.....CUAUauug...................................... .....................UAUCAGCU...AG.UUGGUAA.GGUAAUGGCU..UACCA AGG.CUNUGAC..GcaUAACUGG...U....CUGAG.AGG..A..UG..AUCA...GUCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUA UUG.....C...UCAAUGGGGGAA.ACC................CU...GA.A...GC.A GCAAC.GCCGC.GU......GGAGGAUG...A...CACUU..........UUC.GGAGCG UAAAC..........................UC.CNU.........U...UG........ ............................................................ ......................U.....U............................... ...AGGGAA................................................... ............................................................ ............................................................ ......G................AAC.................................. ............................................................ ............................................................ ..........................................................CA .......U..GACGGU............................ACCUA.A..CGAA..U .......AAGCACC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGUGCNAG..CGUUACUCGGAAUCACUGGGCGU..AAAGGa.CG.C.GUAGG...... ........C.GGA.................UU.............AUCAAG.UCUU.... .........U..........UGUG.......AAA.......UCU.AAC.AGCUAAA.C.. ..UG.........UUA.................AAC........U...G........... ......................CUUG.....................AG..A..AACUGA UAAU................CU....AGA..GU..G....AG.............GG... AGAGGC..AGA..UGGAAUUgG......U.....................GGUGUAGGGG U..AAAAUCCGUA.GAG.AUCAcc..AGGAAUACCC.AUUGCGAA............GGC GAUC.UG.CUGGA..ACUCA..ACUGACGCUA....Augcg.UGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUCUAAACGAUGU....AUAC.......... ....UAGUU........................G......UU.......G.......... ............................................................ ...........................CUGUGCUAGUCACG................... .......GCAGUAA.....UGC.......ACCUAACGG..AU..........UAAG..UA UA.............CCGCCUGGGGAGUACGGUCGCAAGAUUAAAACUCAA...AGGAAU AGACGGGG.ACCC.GCACA.AG.C.GGUGGAGNNNG.UGGUUUAAUUCGAN.NNUACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGAU......AUCCA...................................... ...ACUaaucu................................................. ......................C..................................... .............................................UUAGAGAUAAGAGA. ............................................................ ............................................................ ................................GUGCUAGCUU............G..... ...................CUAGAAAG.UU...................G.A....G... ................A.CAGG.UGCUGCACGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCACG...UAUUUAG......U....UGCU.. .A.AC....AGUUC.......................G......G..CU.....GAG..C A.CUCUAAAUA............G.ACUGCCUUCG...C..AAG...G..AG........ ...GAGGA.A.GGUGU.GGACGACGUC..A..AGUCAUCAUGGCCCUUAUGC.CCAG.GG CGACACA.CGUGCUACAAU.GGCA.U..A.UACAA.UGA................G.... ....A.U.G..............CA........AU........AUC.....GC.GA.GA. ...............UGGAGCAAAU......CU.....AU..A.AAAUau......GU.C CC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAGC.CGGAAUCGCUAGUAA UCGUAGAUCAG.CCAU.G.CUACGG.....UGAAUACGUUCCCGGGUCUUGU..ACUCAC CGCCCGUCACACCAUGGGA......GU.............................UGA. ........UUucACU.............CGAA....GU...................C.. ...GG.AAU......G.CU............A.....A....A.........C....... ..........U.....AGCUA......................................C ....C..GCCCAC.............................AGUGGAAU.......... .CA.................GCGACU.........GGGG..................... ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAGA.ACAAACGCUGG.CGG..CAUGCCUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AACAG................G. .CC................GCAA..................G...............G.. ............................................................ ...UGC..U.....GAC..............G............................ .......................................................AGU.G GCA.....AACGGGUGA....GUAACGC.GUG.GA.UGACC..................U ........................................Auccc............... ............................GU............................GG .UG.GGGGACAAC.A.............GUUAG.AA.AUG.AC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.UA.................. ....................G.CUC................................... ............................................................ ............................................................ ............................................................ .........................................U.................. ..................................A.......U..G.....G........ ..A.........G...GAAAGC...................................... ............................................................ ..........................CGCAAGGC.......................... .......GCC.....AU........................................... ...............................G............................ ..................GG.......Aggg............................. ..G.....U.....CCG.CGU....................................... .AAG..................AUUAGCU...UG.UUGGUGG.GGUAACGGC..CUACCA AGG.CGAUGA..UCUUUAGCUGG...U....CUGgG.AGG..A..UG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGGGAA.ACC................CU...GAC....GC.A GCAAU.GCCGC.GU......GGGUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGCCC............................U.........U...U......... ............................................................ ....................U.A.....G............................... ...UGG................................................G..... .....................................................AA..... ............................................................ .........................CGA................................ ............................................................ ............................................................ .........................................UU................. ......GU..GACGGU............................ACCCA..C.AGAA..A .......AAGCCCC..................G........................... ............GCUAACUCC.G.UGCCAGCAGCCGCGGUAAUAC.............GG AGGGGGCGAG..CGUUGUUCGGAAUUACUGGGCGU..AAAGCG.CG.C.GCAGG...... ........C.GGU.................UA.............AGUAAG.UCA.GG.. ....................AGUG.......AAAGG.......CC.AG.GGCUCAA.C.C .....C.......UG........GG.........AC........U...G........... ......................CUC...U..................UG..A..AACUAC UUGA................CUG....GA..GU......UAG.............GU... AGAGGG..UGG..CGGAACUC......CCC.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUGG.GG.AGGAACACCGG.AGGCGAA............GGC GGCC.A.CCUGG..GCCUUU..ACUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACUAUGAG....UGC.......... ....UGGUU........................G.......UC....GC.G.....G... ....................G..U.......AUUGA.....CC........CC....... ....................UG.....................C................ .....G.GUA........ACG.......AAGC..UAACGCGU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAU.GCAACGCG .AAAAACCUUA.CCUGC........................................... ....GUUUGA.....C...A.................UC.C................... ...UGAGAAC.......................C.......................... ...................U.............GU....CAG............AG.AUG A......................UG...................GGG............. ...................................UG....................... .....CC...............UU............................U....... .....CG.................GG............................GAG... ..................CUC..A........................G..A....G... ................A.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UCUUCAG......U....UGC..C .A.UC....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCUGGAGA.............UACUGCC.G..G.UG.U.CAA..GCC.G........ ...GAGGA.A.GGCG.GGGACGACGUC..A..AGUCAUCAUGGCCCUUAUA.UGCAG.GG CUACACA.CGUGCUACAAU.GGCG.A..G.UACA.GAGA................GGgug .............................................C.....G.AGA.G.. ......GGu..GACCUGGAGCGAAU......CUC.....A..A.AAA.GCU.C..G.U.C UC.A....GUUCAGAUUGAAGUCUGCAACUCGACUUCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGGC ........UUG..............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC.....U GA........A.....A...AG.G.................AA.....GGA.......GC .U.....GUCUAcggucgag.............................U.......... .UA.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGGGAACC............UGCG.....G.............CUG......GA U............CACCUCCUUUNN................................... ........................................................... > auugaac.........GAAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGACA.GA..AUGCUUA....ACACAU.GCAAGUCUA.... ............................................................ C..................................UUGA....AUUUggg.......... ..........................................UUUUUU............ ........A.......AC............UUcgauUUGG.................... ........................................................GU.G GCGG.....ACGGGUGA....GUAACGC.GUAAAG.AA.CU..................U GCCUcacagcu................................................. ............................................................ ....AGGGACAAC.A.UU............UGG.AA.ACG.AA................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................................U.......AAUA.............. ............................................................ ..............UUAUGAUU....................AUAGggcauc..CU.AGA AUUA.........UGA.AAGCUAUaugcgcuGUG.......................... ................A........................................... ...............................GA........................... ...................G.......Agc.............................. ........U.....UUG.CGUC...................................... ..CC..................AUUAGCU...AG.UUGGAGA.GGUAACGGCU..CACCA AGG.CAA..UGAUGGGNAGCCGGCC.........UG.AGAG..GGUG..AACG...GCCA CAAGGGG.ACUGAGACACG.GCCC..UUAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGACcgagAG................UCU...GA.UC...C.A GCAAUU.CU....GUGUGC...ACGAUG...A...CGUU..........UUUC.GGAAUG UAAAG..........................UG.CUU.........U............. ...................................................C........ ....................A......GU............................... ...UGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AA................................... ............................................................ .............................A.............................. .......................A...............................A...A .......U..GACGGU............................ACCAA..C.AGAA... ...G...AAGUGAC..................G........................... ............GCUAAAUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AUGUCACGAG..CGUUAUCCGGAUUUAUUGGGCGU..AAAGCG.CG..UcUAGG...... .........UGGU.................UA.............UGUAAG.UCU.G... .........A..........UGUG.......AAA.......AUGC.AG.GGCUCAA.C.. ..U..C........U........G.........UA......U..U...G........... ......................CGU...UG..................G..A..AACUGU GUAA................CU....AGA..GU......NC.............UGG... AAAGG..UAAG..CGGAACUa......CAA.....................GUGUAGAGG UG..AAAUUCGUA.GAU.AUUU.GU.AGGAAUGCCG.AUGGGGAAGC............C AGCU.UA.CUGGA..CAGAU..ACUGACGCU....GAA.GCGCNNNAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....UUAC.......... ....UAGGU........................G.......UU....G.GG.....G... ....................GU...........CGAACC..................... .UCAGCGC.................................................... ..........................CCAAGC..AAACGCGA..........UAAG..UA AU.............CCGCCUGGGGAGUACGUACGCAAGUAUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAN.GCAACGCG .AGGAACCUUA.CCAGC........................................... ....GUUUGA.....C...A.................UC...................UU ...........AGGAAU........................................... ..................GA.............GA....CAG............AG.AUG U......................U.UcagUG............................. ............................................................ ....................................................U....... .....CCCUUC..G..........GG............................G..... .................AaaccuA........................A..A....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUU...UCGUAUG......U....UAC..C .A.UC....A..........U..U.........A.A.G.U........U.....GGGG.. A.CUCAUGCGA.............UACUGCCUACGA.....Ug.A..G.UAG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUAC.GCUG.GG CUACACA.CGUGCUACAAU.GGGU.A..G.AACA.GAGA................G.... ....U.U.G..............CA........AA........GCC.....G.UGA.G.. ......G........UGGAGCUAAU......CUC.....AG...AAAA.CU..A..UU.C UU.A....GUUCGGAUUGUACUCUGCAACUCGAGUACAUGAAG.UUGGAAUCGCUAGUAA UCGCGAAUCAG.CAAU.GU.CGCGG.....UGAAUACGUUCUCGGGUCUUGU..ACACAC CGCCCGUCACACCACGAGA......GU.............................UGG. ........UUGC.............ACCUGAA....GU...................A.. ...GC.A.......GG.C............CU.....A....A.........CCG..... ..........U.....A...AG.G.................AG.....GGAuguu..... ........CCGA....GGGUGU......................G...AU.......... .UA.................GCGANN.........GGGG.......G.UAAC........ ....................................A.............AG......GU AUCCGGAACGGAUCACCUCCUUUN.................................... ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCUUU....AGGCAU.GCAAGUC.....G AAC.....G......C..G...AA................AG.CC............... .CC......................................................... ....UUCG....GGG.....G..........................UG........... .............A.GU.............AG............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UAACC..................U .G.......................................................CC. .C.....C..............U......C......R......................C .AG.GGGGAUAA.C.CGG.GGGAAACC.............CC.................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... .............CC............................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..........................GUACGCUU....Gccg.................. ............................................................ ...................................................GGG...... ............CGCAUGCUCcggCAAGGAAA............................ ..................GG.......U.......Agcuucggccauccggcga.GGGAG GGG..........CCCG.CGGC...................................... ..CC..................AUUAGCU...AG.UUGGUGG.GGUAACGGC..CCACCA AGG.CGACGA..UGGGUAGCUGGCC.........UG.AGAG..GGUGG..UCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGcCAGCAGCCAGGAAUC UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCAAC.GCCGC.GU......GGGCGAUG...AA...GG.CC.........UUC.GGGUCG UAAAGCCC............................Uguu............GU...... ......................................................CGGGGA CGAAGGG.............U......GA............................... ...AGG................................................G..... .....................................................UUA.... ...............A..................UAGCCCC................... .........................UAG................................ ............................................................ ............................................................ ........................C...............................C... .......U..GACGGU............................ACCC.GA..CGA.... G..G...AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGGGCGAG..CGUUGUCCGGAAUCAUUGGGCGU..AAAGAG.CG..UGUAGG...... ........C.GG.............C....CCG.............GUAAG.UCU.GC.. ....................UGUG.......AAA.......ACCC.GG.GGCUCAA.C.C .....C....C...G........GG.........CG........U...G........... ......................CA.G..UG..................G..A..AACUGC CGG...............G.CU....AGA..G..GG....CG.............G.C.. AGAGGc..GAG..UGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCG.GG.AGGAACACCAG.UAGCGAA............GGC GGCUC.G.CUGG..GCCGUUC..CUGACGCU....GAGA.CGCGAAAGCUAGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCGUAAACGAUGGG....CAC.......... ....UAGGU........................G.......U...G.G.GG.....G... ....................GAgucg.........AAUC.................CC.. .....................U.....................C................ ...C...GU........GCCGC.......AGCC..AACGCGA..........UAAG..UG CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AAGAAU UGACGGGGG.CCC.GCACA.AG.CA.GCGGAGCAUG.UUcUUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....U....................G.........GUG.. ..........GUA............................................... ............................................................ .................................GGcgcc.......GGAAACGgu....G UCCGACCC...............U............................U....... .....CG.................GG............................GAG... ..................CC...................................AG... ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCCA.CAACGAGCGCAACCCCCGC...CCUGUG......U....UGC..C .AG.C....A..........U..U.........A.A.G.U........U.....GGGG.. A.CUCACAGG............GG.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUAUGC.CCAG.GG CUAgAAA.CGUGCUACAAU.GGC.CG..G.UACAA.UG................GGC... ......U.G..............CG........AU........GCC.....GC.GA.G.. ......G........CGGAGCGAAU......CCC.....A..UCAAA.GC..CG.G.U.C UA.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAGG.CGGAGUUGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGGGA......GU..........................C...GGC ........AA..............UACCCGAA....G...................CA.. ...GGcgc.......G.............GC.....CA....A.........CC...CCU U.....UUG.................................G.....GGA.......GG cggcuUG..CGAA....GGU......................AGGG.............. CCG.................GCGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCUG.AAG..........GUGC............................... ............................................................ ........................................................... > ............................................................ .......AG.GAUGAACGCUGG.CGG..CGCGCCUA....ACACAU.GCAAGUC.....G ANC.....G........G.......................................... ...............CAcccgcccucgGGC..G......G...A........AGCg.... ............................................................ ..............................AG............................ .......................................................UGU.. .CG.....AACGGCUGA....GUAACAC.GUGA.CCAA.CC..................U .G.......................................................CC. .C.....U....................GCGC............................ .UCC.GGAAUAGCcg...CG...........GG.AA.ACCGc.................. ...............G............................................ .............................................G.G............ .................................................UAAUACC.... ...................................GGAUGCgccggacc........... ............................................................ ............................................................ ...........................................GCCGCAUGG........ ............................................................ ......................CGGCCcggc............................. ............................................................ ................GAAAGC.......UC............................. ............................................................ .......................C......GG............................ ......CGGcgc................................................ ............................................................ ............................................................ GGGAUGGGG.....UCG.CGGC...................................... ..CC..................AUCAGGU...AG.ACGGCGG.GGCgAGGGC..CCACCG UG.CCGACGAC..GGGUAGCCGG.....G..UUGAG.AGACC....G..AACG...GCCA GAUUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UUG.....CG...CAAUGGGGGGA.ACC................CU...GAC....GC.A GCGAC.GCCGC.GU......GCGGGAGG...AA...GG.CC.........UUC.GGGUCG cagACC..........................G.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................Ag...A.................................... ............................................................ ............................................................ .......................................................UC... .......A..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGGGCAAG..CGUUAUCCGGAUUCAUUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GG.............C....CAG.............Gcaggccgggc... .....................GUC.......AAA.......UCCG.GG.GGCUCAA.C.C .....C....C........................CGCUC.................... ..........................G..C..................GCCCGGAACcgc ccggcuc....................GG..GU..C....CG.............GU... AUGGGA..GGG..UGGAAUUC......CC.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCG.GG.AGGAACACCGG.UGGCGAA............GGC GGCCC.U.CUGGU..CCGGU..ACCGACGCU....GAG.GCGCGAAAGCUGGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCUA.GCCGUAAACGAUGG....ACGC.......... ....UAGGU........................G.......U...G.G.GG.....G... ....................GA...........CGAUCCC.................... ..........................................CC................ ...C...GU........GCCGC.......AGCC..AACGCAU..........UAAGC..G UC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GCGGAGCAUG.UGGCUUAAUUCGAA.GCgACGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A....................GcugaagccgGGGAG ACcCGGUGGCCGGA.....AG....................................... .......GAGGcugc............................................. ............................................................ ............................................................ ............................................................ ............................................................ .................GCAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCCGC...CGCAUG......U....UGC..C .A.UC....AGG........U..A.........A.U........G..CU.....GGGA.. A.CCCAUGCG............GG.ACCGCC.G..G.CG.U.CAA..GCC.G........ ...GAGGA.A.GGCG.GGGACGACGUC..A..AGUCAUCAUGCCCCUUAUGC.CCUG.GG CUGCACA.CGUGCUACAAU.GGC.CG..G.UACA.GCG................GG.... ....A.U.G..............CG........AU........G................ .......GcgcgagCCGGAGCGGAU......CCC.....U..A.AAG..C..C..GG.CC CC.A....GUUCGGAUCGGGGNCUGCAACCCGCCCCCGUGAAG.UCGGAGUUGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUGCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACCCGA......GU..........................C...GUC .........UGC.............ACCCGAA....G...................CC.. ...GCggg......................................CCCGA......CC. ............................................................ .....AG..CGAU....GGNG......................GG...A........... CgcgucgaaggucuugagGGC.......GAGG...GGGGUGAAGUC.............. ............................................................ ............................................................ ........................................................... > ..................AGAGUUUGAUCAU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G UAC.....G......C..Ggu....................................... ................................G......GCUUGCcac............ ............................................................ ................C..............G............................ .......................................................AGU.G GCG.....AACGGGUG....CGUAACAC.GUGA.GG.......................A ........................................A................CC. .C....................ACCCc.GAC............................G .UG.GGGGAUAAC.A.C.CG...........GG.AA.ACCG.G................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU...G....U............ GCUCCccug................................................... ............................................................ .A.......................................................... .............................C.............................. .......CGCA.......UGGUCgaggga............................... ............................................................ ............................................................ ...................................G....C................... ..........................................AAAGCCUU.......... ..................................................CGGG...... ............CGCgacgggacggc.................................. ............................................................ .............CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAACGGC..CCACCA AGG.CGAC.AC..GGGUAGCUGG...U....CUGAG.AGG..A..CG..AUCA...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GgAAC.GCCGC.GU......GGAGGACG...AA...GG.CC.........UUC.GGGUUG UAAAC..........................UC.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....A.................................... ............................................................ ............................................................ .......................................................AC... .......U..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAaCCGCGGUAAGAC.............GU AGGGGGCGAG..CGUUGUCCGGAUUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GG.............C....UUG.............GCAAG.UCG.G... .........A..........UGUG.......AAA.......UCAC.C.AGGCUCAA.C.C .........U..G.GUGUCGc....................................... ......................CAUC...C..................G..A..UACUCC AUG...............G.CU....UGA..GU..C....CG.............GU... AGAGG..AUCG..UGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCA.AUGUCGAA............GGC AGCgAU.C.UGG..GCCGGU..ACUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCCUAAACGUUGGG....CAC.......... ....UAGGU........................G.......U...G.G.GGC........ CUcauUCGACGGG............................................C.. .....................U.....................C................ ...C...GU........GCCG.......ACGC..UAACGCAU..........UAAG...U CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.Aa.C.GGCGGAGCAU.C.GGCUUAAUUCGAU.GCAACGCG .AAGAACCUCA.CCUGG........................................... ....GCUUGA.....C...A.................UG.............G....... ........................A....................G.........G.... ........GAAA.......AGC.....C......G....CAG............AG.AUG ....................CG..G................................... ............................................................ ......................UGU................................... ......CCUUC..G..........GGU.CCC............................. .....................U.................................UG... ...............CA.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGAGUCGUGAGAUGU UGGGUAA.GUCCC.GCAACGAGCGCAACCCUUGC...CCUAUG......U....UGC..C .A..C.G...GGUC......................AU............G.CCGGGG.. A.CUCGUAGG............GG.ACUGCC.G..G.AG.UU.AAU..UC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGCCCCUUACG.UCCAG.GG CUGCAC.GCAUGCUACAAU.GGC.CG..G.UACAA.AG................GG.... ....UC..G..............CC........AA........CCC.....GC.GA.G.. ......GG........GGAGCCAAU......CCC.....A..A.AAA..C..CG.G.U.C UC.A....GUUCGGAUCGCAGUCUGCAACUCGACUGCGUGAAG.UCGGAGUCGCUAGUAA UCCCGGAUCAG.C.A.CG.CCGGGG.....UGAAUACGUUCCCGGG.CUAGU..ACACAC CGCCCGUCACACCACGAAA......GU..........................C...GGC ........AA.C.............ACCCGAA....G...................C... ...GG.U.......GG.C............C.....CA....A.........CC...CGC .A........AG.........G.G.................AG.....GGA.......GC ....C..GUCGAA....GGUG......................GGG...U.......... .C.................GGCGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.U....................................................... ............................................................ ........................................................... > ........................UGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G GAC.....G........GU........GA...................AC.......... .......CUg..........CUU......C..G......GGUGG................ ................................................G........... ..............GGAUC.............AG....U..................... ...........................................................G cCG.....AACGGGUGA....GUAACAC.GUG.GCC.AACC..................U .G.......................................................CC. .C.....CCg....................G............................C .U.CUGGGAUAAC.U.C.C...........AAGAAA.U.UG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAUG.................... ....................................U....................... ...........................................Gaccgcu.......... ............................................................ ........................GC...C.............................. .......CGCA.......UGGUCUG...G............................... ..........................................U..G.....G........ ..U.........G...GAAAGGGUuuccgg.............................. ............................................................ ............................................................ ..............CU............................................ ..............................GG............................ ..................GG.......A.......U........................ GG.....A.....CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAGUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..ACCG...GCCA GACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGGA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GGGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCc................................. ............................................................ ............................................................ ...............................................GUGAG........ ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................UGG.............UCGCG.UCG.GC.. ....................UGUG.......AAA.......ACCC.GG.AGaUCAA.C.. ..U..C....C...G........GG.........CC........U...G........... ......................CA.G..UC..................G..A..UACGGG CCGA................CU....UGA..GU..G....U.............UGU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCAACA..ACUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGcAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG.....GC.. .....................C.........AUU........C........CACGGUC.. .....................U.....................C................ ...C...GU........GCCGC.......AGA..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UUGCUUAcUUCGAU.GCAACGCG .AAGAACCUUA.CCUAG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A.C............................G.... ........GAAA.......UC.....UC......G....CAG............AG.AUG ....................CG..G.G................................. ............................................................ ............................................................ ..........G..UCCGCA....AGG............................GC..C. ......................................................GUG... ...............CA.CAGG.UGGUGCAUaGUUGUCGCCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCCAUG......U....UGC..C .AG.C....A.....C.....G.U.......G...AUG......G...U.....GGGG.. A.CUCAUGGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUAG.GG CUGCAAA.CAUGCUACAAU.GGC.CG..G.AACAA.AG................GGC... ......U.G..............CG........AU........ACC.....GC.AA.G.. ......G........UGGAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UUGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGGCUUGU..ACACAC CGCCCGUCACGUCACGAAggucguu................................... ........A.AC.............GCCCGAA....G...................CC.. ...GG.U.......GG.C............C.....CA....A.........CC...CCU UG........UG.........G.G.................AG.....GGA.......GC ....C..GUCGA....GGcgG......................GG...AU.......... .C.................GGUGAUU.........GGGACGAAGUCG.UAACAA.GGUUG CCG.UA...................................................... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CTTC..GGG...GT................................ACTCG....... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTG.GGT.AACCT.................. .G.......................................................CC. .CTCAGC......................TTC............................ .....GGGATAA.CT.C.CG...........GG.AA.ACCG.G................. ...............G............................................ .............................................G.CTAATACC..... ..GGAT...................................................... ........................................ATTCattgtctG.....CCG ...........................CATGGTG.GGTGGTGG.....AAAG.T...... .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTC... ............................................................ ......................................GGCT.................. ..................................GG........................ ................................G........................... ..................GAT....................................... GGG..........CCCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTGATGGC..CTACCA AGG.CGTCGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCGCAAT........GGGCGGA.AGC................CT...GAC....GC.A GCGAC.GCCGC.GT......GAGGGATG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TC........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....Atgta................................ ............................................................ ............................................................ ............................................................ .................................GACG.G....TACCT.GT..AGAA... ...G...AAGCACC..................G........................... ............GCCAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GGTC.................T......GT.......CGCGT.CGa.... .........ATGT..........G.......AAA.......ACCC.GG.GGCTCAA.CT. .....C....C...G........GGC.........TT...........G........... ......................CATT...C..................G..AT..ACGGG CAG...............G.C.T...AGA..GTT......CG.............GT... AGGGG..AG..TCTGGAATTCCTGG..........T.................GTAGCGG TG..AAATGCGCA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGGACT..CTGGG......CCGA..TACTGACGCTGAG.GAGCGAAAGCGTGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGTTGGGCGCTAGGTGT....... ...............................................G.GG.....G... ....................GTCCTT................C........CACGATc.. .......TCC.................................................. ...............GTGCCGC.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGCGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCAAG........................................... ....GCTTGACATG.............................................. ............................................................ ...CACG....GGA.....A..............AgTTCCAG............AG.ATG GTT......................................................... ............................................................ .......................................CC.C................. ..............CCGCA....AGGT................................. ....................CcgT................................G... ...............CA.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGT...CTTATGTT..........GC..C .AG.C....A.....C.....GTGA.......TGG..................TGGGG.. A.CTCATAAGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATGT.CTTG.GG CTTCACG.CATGCTACAAT.GGC.CG..GT.ACAA.AG................GGC.T. ........G..............CG........AA........ACC.....GT.GA.G.. ......GT........GGAGCGAAT......CCC.....A..A.AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCACGAAA......GT..........................C...GGT ........AA.C.............ACCCGAA....G...................CCA. ....Gtggct..........................CA....A.........CC...CCT T.......GTGG.........G.G.................AG.....GGA.......GC T......GTCGAA....GGT.......................GGG...ATC........ ...GGC.................G........ATTGGGACGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........G.................................. ............................................................ ........................................................... > ........................UGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G ANC.....G........GU........GA...................AC.......... .......CA......C....CUU......C..G......GGUGG................ ................................................G........... ..............GA...U........................................ ......................................................CAGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GGC.AACC..................U .G.......................................................CC. .C.....C..............U......AG............................C .U.CUGGGAUAAC.U.C.CG...........GG.AA.ACCG.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GACACcgAGC.............................. ...........................................GG............... .....................................................CA..... .............UCGCUc......................................... ............................................................ ................................................GGUG........ ..U.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGC.....UA........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAACGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GAGGGACG...AA...GG.CC.........UUC.GGGUCG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GG.............C....UUG.............UCACG.UCU.GC.. ....................UGUG.......AAA.......ACUC.GG.GGCUCAA.C.C .....C....C...GA........G.........CC........U...G........... ......................CA.G..UG..................G..A..UACGGG CUA...............G.CU....AGA..GU..G....CG.............GU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCCGAU..ACUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG........A ...............U.....C.........UUU........C........CACGAUC.. .....................U.....................C................ ...C...GU........GCCGC.......AGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CC..GCACA.AG.C.GGCGGAGCAUG.UGGCUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UA.........UA....CCGAAA C........................................................... ...................U.............GG....CAG............AG.AUG UCA..........................................G.............. ............................................................ .......................GU................................... ......CC..................N.CAAgggcg........................ .................................................GUA.....U.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCUAUG......U....UGC..C .AG.C.G........C.....G.U.........A.AUG......G........CGGGG.. A.CUCAUAGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUGCACA.CAUGCUACAAU.GGC.CG..G.UACAA.AG................GGC... ......U.G..............CG........AU........ACC.....GC.AA.G.. ......G........UGGAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCACGAAA......GU..........................C...GG. .......UUA.C.............ACCCGAAA.......................CC.. ...GG.U.......GG.C............C.....CN....A.........CC...CUU .U........UG.........G...................AG.....GGAa.......C ....C..GUCGAA....GGUG......................GG...A........... CU.................GGCGAUU.................................. ............................................................ ............................................................ ........................................................... > c......................UUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AGC.....G........GGG........................................ ...........................................AG.........CUUCGG C.....U..............C.........................C............ .......................................U.................... .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUG.GGC.AACC..................U .G.......................................................CC. .C.....C...................G.AG............................C .U.CUGGAAUAAC..CU.CG...........GG.AA.ACCG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUGCC.... ...................................GGAU.AU.................. ....................GACAUCA................................. ............................................................ ............................................................ ................CU.......................................... .......................GGGCAUC.............................. .............................U...............GGUGGUG........ ..U.........G...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGC.....Uc........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUGAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGCGGA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GG.............C....UUG.............UCACG.UCG.GC.. ....................UGUG.......AAA.......ACCC.GG.GGCUCAA.C.C .....C....C...G........GG.........CC........U...G........... ......................CA.G..UC..................G..A..UACGGG CAG...............G.CU....AGA..GU..C....CG.............G.C.. AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCCGGA..ACUGACGCUA....AG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG.....G... ...............A.....CC..........UU.......C........CACGGCC.. .....................U.....................C................ ...C...GU........GCCGC.......AGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGCUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A....................G.........G.... ........GAAA.......UC.....UC......G.......................U. ...........AGAGAUA..CG..G.G................................. ............................................................ ............................................................ ..........G..UCCGUAAGGGU.................................... ..................CC...................................UG... ...............CA.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UCCUAUG......U....UGC..C .AG.C.G.............AG.U.........A.AUGU..............CGGGG.. A.CUCAUAGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUACG.UCCUG.GG CUGCACA.CAUGCUACAAU.GGC.CG..G.UACAA.AG................GGC... ......U.G..............CG........AU........ACC.....GC.GA.G.. ......G........UGGAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAAU.G.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCACGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...C.. ..........U.....UG..UG.GG.................G.....GGA.......GC ....C..GUCGAA....GGUG......................GG...A........... CC.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUA. ............................................................ ............................................................ ........................................................... > t.....C......AC.GGAGAGTTTGATCCT............................. ..GGCTCAG.GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G.......ATGAagcc.................................... .......................................GCTTCGGtgg........... ..........TGGA.TT........................................... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTG.GGC.AATCT.................. .G.......................................................CC. .CTGCAC......................TCTGGGAcAAGCCCTGGAAACGGG....... ............................................................ ...............GT........................................... ...............................................CTAATACC..... ..GGAT...................................................... ........................................ATGACtgccg.G.....CCG ...........................CATGGcctGGTGGTGG.....AAAGcgttagtg g........................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .......................................TGC.................. ...............................AG........................... ..................GAT....................................... GAG..........CCCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTGATGGC..CTACCA AGG.CGACGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGGCGGA.AGC................CT...GAT....GC.A GCGAC.GCCGC.GT......GAGGGATG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TC........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCttttatc........................... ............................................................ ............................................................ ............................................................ .....GG.........................TGACG.G....TACCT.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GG.............CG....T......GT.......CacGT.CG.G... .........ATGT..........G.......AAAG.......CCC.GG.GGCTTAA.C.C .....C....C...G........GGt.........CT...........G........... ......................CATT...C..................G..AT..ACGGG CtC...............G.C.T...AGA..GTT......CG.............GT... AGGGG..AGAT..CGGAATTCCTGG..........T.................GTAGCGG TG..AAATGCGCA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGATCT..CTGGG......CCGA..TACTGACGCTGAG.GAGCGAAAGCGTGGGGAGCGA gCAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGTTGGGAACTAGGTGT....... ...............................................G.GGCGA...... ......................CA.TT...............C........CACGtcg.. .......TCC.................................................. ...............GTGCCGC.......AGCT..AACGCATT..........AAGTT.. CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGTGGCTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCAAG........................................... ....GCTTGACAT.........................ATG................... .........................CC............................G.... ........GACACtcCTGGA.............GA....CAGgggctcccttt....... ............................................................ ............................................................ ............................................................ ........................GG............................G..... ...................CC.........................G.GTG......... .......T........A.CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTAT...CCTGTGTT..........GC..C .AG.C....A.....C.....GCCCttcgGGGTGG..................TGGGG.. A.CTCACGGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGACGACGTCAA....GTCATCATGCCCCTTATGT.CTTG.GG CTGCACA.CGTGCTACAAT.GGC.CG..GT.ACAAT.Ga................GC.T. ........G..............CG........A......Ggccgt........AA.... ......G........CGGAGCGAAT......CTC.....A..A.AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.ATtG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCACGAAA......GT..........................C...GGT ........AA.C.............ACCCGAA....G...................CC.. ...GGT........GG.C............C.....CA....A.........CC...CCT T.......G.................................G.....GGA.......GG GAatC..GTCGAA....GGT.......................GGG...A.......... .CTGGC.................G........ATTGGGACGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGCGGCTGGATCACCTCCTTTCT........... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AGC.....G........GT..................AAanA.................. ............................................................ ..CTTC..GGG...GT................................AC.......... ...............AC..............G............................ .......................................................AGC.G GCG.....AACGGGTGA....GTAACAC.GTGA.GC.AACaT.................. .G.......................................................CC. .CCTGAC......................TCTGGGATAAGCCCTGGAAACGcC....... ............................................................ ...............GT........................................... ...............................................CTAATACC..... ..GGAT...................................................... ........................................ACGACCCGC........... ......................CacctCATGGTG.GaGGGTGG.....AAAG........ .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTC... ............................................................ ......................................GGT................... ..........Ca.......................G........................ ................................G........................... ..................GAT....................................... GGG..........CTCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTAACGGC..CTACCA AGG.CGATtAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTgCGGGAGGCAGCAGTGGGGAATA TTGCGCAAT........GGGCGAA.AGC................CT...GAC....GC.A GCGAC.GCCGC.GT......GGGGGATG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TT........ ....................A....................................... .......................................CCACCAAcgcaggcttccagt tctctggaa................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..................................ACG.G....TAGgtgG..G.GAAT.. .......AAGGACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTCCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GG.............CG....T......GT.......CGCGT.CT.GC.. ..........TGT..........G.......AAAG.......ACC.GG.GGCTTAA.CT. .....C....C...G........Gtt.........CT...........G........... ......................CAGTG.....................G..AT..ACGGG CAT...............G.C.T...AGA..GGTA......G.............GT... AGGGG..AGA..CTGGAATTCCTGG..........T.................GTAGCGG TG..AAATGCGCA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGGTCT..CTGGG......CCTtaC..CTGACGCTGAG.GAGCGAAAGCATGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCAT.GCCGTAAACGTTGGGCGCTAGGTGT....... ...............................................G.GGNa....... .......................CTTT...............C........CACGGTTT. ...........................................C................ ...C...GC........GCCGT.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGTTGCTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCAAG........................................... ....GTTTGACATCAC............................................ .........................CC............................Gtgga c.............T............C......G....CAG............AG.ATG TGAggtcatttagttggc.......................................... ............................................................ ............................................................ ............................................................ ..............................................G.GGT.....G... ................A.CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGTTCC...ATGTT..........GC..C .AG.C....A.....C.....GTAA.......TGG..................TGGGG.. A.CTCATGGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGCCCCTTATGT.CTTG.GG CTGCAAA.CATGCTACAAT.GGC.CG..GT.ACAAT.G................GGCgT. ........G..............CG........AT........ACC.....GT.AAA... ......GT........GGAGCGAAT......CCCT.......A.AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGGT.GGAGTCGCTAGTAA TCGCGGATCAG.C.AACG.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCATGAAA......GT..........................C...GGC ........AA.C.............ACCCGAAA.......................CtT. ....GC........GG.C............CT.....A....A.........CC...CCT T.......GTGG.........G...................AG.....GGAGTagta... ..........GAA....GGT.......................GGGG............. .CTGGC.................G........ATTGGGACGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGC............................... ............................................................ ........................................................... > ............................................................ ................CGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AGC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CUUC......GGG.....G..........................UAC.......... ...............UC..............G............................ .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAACC..................U .G.......................................................CC. .C.....C..............UG............A......................C .U.CUGGGAUAAG..CC.CG...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GACACauguC.............................. ...........................................GG............... .....................................................CA..... .............UCG............................................ ..........A.......UGGU...................................... .................................................GUG........ ..U.........G...GAAAGUU..................................... .....................UUUU................................... ............................................................ ......CGGU.....U............................................ ..............................GG............................ ..................GG.......A.......U........................ GG.....A.....CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GGGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGUUgac.............................. ............................................................ ...GU....................................................... ............................................................ ..............GU............................ACCU.G.C.AGAA... ...G...AAGCGCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGCGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... .........UGG.............C....UUG.............UCACG.UCG.GG.. ....................UGUG.......AAAG.......CU.UGG.GGCUUAA.C.. ..U..C....C...A........GG.........UC........U...G........... ......................CAU...UC..................G..A..UACGGG CUG...............G.CU....AGA..G..G....UAG.............GU... AGGGG..AGAA..CGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGUUCU.C.UGG..GCCUUAC..CUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG........A CC..............................UU........C........CACGGU... ....................UU.....................C................ ...C...GC........GCCG.......UAGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UUGCUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UCG.................... .........................CCCGG.............................. ..........................AAAGCU..U....CAG............AG.AUG ..................G....AGC.................................. ............................................................ ............................................................ ......CC..................U.CUUCGGA....................CU... ......................G.......................G.G..U....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UUCAAUG......U....UGC..C .AG.C....A..........ACAUCCUUCGGGG.G.UG......G...U.....GGGG.. A.CUCAUUGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCUUG.GG CUGCAAA.CAUGCUACAAU.GGC.CG..G.UACA.GAG................GG.... ....U.U.G..............CG........AU........ACC.....GC.AA.G.. ......G........UGGAGCGAAU......CCC.....U..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCACGAAA......GU..........................C...GGC ........AA.C.............ACCCGAA....G...................CCC. ....G.U.......GG.C............C.....CA....A.........CC.....A GC........U.....UGucUG.GG.................G.....GGA.......GC G......GUCGAA....GGUG......................GGG.............. CU.................GGCGAUU.........GGGACGAAGUCG.UAA......... ............................................................ ............................................................ ........................................................... > ............................................................ .....TCAG.GACGAA.GCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AGC.....GA........G.........Gacc............................ ............................................................ GCACTCCTTTGGGgtgtggagC.........................C............ .......................................A.................... .......................................................AGC.G GCG.....AACGGGTGA....GTAACACt.TGA.GT.AACCT.................. .G.......................................................CC. .CCTGGC......................TTC............................ .....GGGATAG.C.CC.CG...........GG.AA.ACCG.G................. ...............GAT.......................................... ................................................TAATACC..... ..GGAT...................................................... ........................................ATGACCgggaagggcatcct tacc.................................TGGTGG.....AAAGGT...... .................Tccctc..................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ..........................TTTGGGGGTtctGGCT.................. ..................................GG........................ ................................G........................... ..................GAT....................................... GGG..........CTCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTGATGGC..CTACCA AGG.CGACGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATC TTGCGCAAT........GGGCGGA.AGC................CT...GAC....GC.A GCGAC.GCCGC.GT......GGGGGATG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TC........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AG................................... ............................................................ ............................................................ ............................................................ ............................G...TGACGTG....TACCT.G.C.AGAA... ...G...AAGCGCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGCGCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GG.............Ctg..........GT.......CGCGT.CT.GCC. ...........GT..........G.......AAAGtgcc......T.G.GGCTTAA.CT. .....C......G.G........GTT.........TT...........G........... ......................CGGTG.....................G..AT..ACGGG CCG...............G.C.T...AGA..GGTA......G.............GT... AGGGG..AGAA..CGGAATTCCTGG..........T.................GTAGCGG TG..AAATGCGCA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGtTCT..CTGGG......CCTatC..CTGACGCTGAG.GAGCGAAAGCGTGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCA.CGCTGTAAACGTTGGGCGCTAGGTGT....... ...............................................G.GG.....GTt. .......................CTT................C........CACGGGtc. ........CC.................................................. ...............GTGCCGT.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGTTGCTTAATT.CGAC.GCAACGCG .AAGAACCTTA.CCAAG........................................... ....GTTTGACATCAC............................................ .........................CC............................G.... ........GATCGC.......................TCCAG............AG.ATG GGTTT....................................................... ............................................................ ........................................C.CTTC.............. ........................GG............................GG.... ..........................................CT..G.GGT.....G... ................A.CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGTTCC...ATGTT..........GC..C .AG.C....A.....C.....GCCCgtttGGGTGG..................TGGGG.. A.CTCATGGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGCCCCTTATGc.CTTG.GG CTGCAAA.CATGCTACAAT.GGT.CG..GT.ACA.GAG................GGTg.. ........G..............CG........AT........ACC.....GT.AA.G.. ......GT........GGAGCGAAT......CCC.GT.......AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCACGAAA......GT..........................C...GGC ........AA.C.............ACCCGAA....G...................CCC. ....GT........GG.C............CT.....A....A.........CCGGTTgt cc...................G.GG.................G.....GGA.......GC G......GTCGAA....GGT.......................GGGG............. .CTGGC.................G........ATTGGGACGAAGTCGT.AACAA.GGTAG Cagtaccgcag................................................. ............................................................ ........................................................... > .......................TTGATCCT............................. ..GGCTCAG.GATGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G........GT........GA...................A........... .........G.....C.........................AG.........AGCTTG.. ...CTCTGTGGATC.............................................. ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTGA.GC.AACCT.................. .G.......................................................CC. .CCgGAC......................TCTGGGATAAGCgCTGGAAACGGC....... ............................................................ ...............GT........................................... ...............................................CTAATACT..... ..GGAT...................................................... ........................................ACGAGAcgtGAT......CG ...........................CATGGTcaacgttT................... ..........GGAAAGATT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTC... ............................................................ ......................................GGT................... ..........CT.......................G........................ ................................G........................... ..................GAT....................................... GGG..........CTCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGA.GGTAATGGCT..CACCA AGG.CGTCGAC..GGGTAGCCGGCCT.........G.AGAG..GGTG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTSGGGAATA TTGCACAAT........GGGCGGA.AGC................CT...GAT....GC.A GCAAC.GCCGC.GT......GAGGGACG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TT........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......G.........................TGACG.GACGGTACCT.G.C.AGAA..A .......AAGCGCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGCGCAAG..CGTTATCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GGTC.................T......GT.......CGCGT.CT.GC.. ..........TGT..........G.......AAAc.......CCC.G.AGGCTCAA.C.C TC............G........Ggc.........CT...........G........... ......................CAGTG.....................GG..T..ACGGG CAGA................C.T...AGA..GT..G....CG.............GT... AGGGG..AGAT..TGGAATTCCTGG..........T.................GTAGCGG TGG..AATGCGCA.GATAT.CA.GG.AGGAACACCG.ATGGCGAA............GGC AGATCT..CTGGG......CCGTA..ACTGACGCTGAG.GAGCGAAAGgGTGGGGAGCAA ACAGGCTTAGATACCCTGGTAGTCCA.CcCCGTAAACGTTGGGAACTAGTT........G T................................................GG.....G... ....................GTCCTTT...............C........CACGGA... ......TTCC.................................................. ...............GTGACGC.......AGCT..AACGCATT..........AAGTT.. CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGG.ACCC.GCACA.AG.C.GGCGGAGCATGCGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCAAG........................................... ....GCTTGACAT.........................A..................... ...................C....AC.................................. .............................................GAGAACGCt...... ............................................................ ............................................................ ............................................................ ......................................................GCAGA. ........................AAtgtagaactCTTTGGACactcgt.......GA.. ................A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGTTC...TATGTT..........GC..C .AG.C....A.....C.....GTAA.......TGG..................TGGGA.. A.CTCATGGGAt.............ACTGCC.G..GGGTg....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATGT.CTTG.GG CTTCACG.CATGCTACAAT.GGC.CG..GT.ACAA.AG................GGC.T. ........G..............CA........AT........ACC.....GT.GA.G.. ......GT........GGAGCGAAT......CCC.....A..A.AAA.GC..CG.G.T.C CC.A....GTTCGGATTGAGGTCTGCAACTCGACCTCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGTCTTGT..ACACAC CGCCCGTCAAGTCATGAAA......GT..........................C...GGT ........AA.C.............ACCTGAA....G...................CC.. ...GGT........GG.C............CT.....A....A.........CC...CTT GT...................G.G.................AG.....GGA.......GC T......GTCGAA....GGT.......................GGG...ATC........ ...GG.................TA........ATTAGGACTAAGTCGT.AACAA.GGTAG Cgtacc....GNAAG..........GTGCGGCTGnATCACCTCCTTgactctagaagatc cccggt...................................................... ........................................................... > ............................................................ ........................GG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU........GA...................A........... .........G.....C.......................C.................... ..CAGCUUGC.U.GG.....G..........................UG........... ..............GA...U........................................ ......................................................CAGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.GCAA.CC..................U .G.......................................................CC. .C.....U..............U......C......A......................C .UUC.GGGAUAAG..CCU............UGG.AA.A.CG.G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AGG....A............ GCACC....................................................... ......................................................U..... .......................G.................................... ..................................................CU........ ........GCA.......UGGU...................................... .................................................GGG.......U GUU.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGUG.....A........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAACGGC..CUACCA AGG.CGUCGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGAA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCGCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGCGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................CUG.............UCGCG.UCU.GG.. ....................UGUG.......AAA.......UCCC.A.UGGCUCAA.C.. ..U......A...UG........GG.........C......U..U...G........... ......................CAUC...G..................GG....UACGGG CAGA................CU....AGA..GU..G....C.............UGU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCG.AUGGCGAA............GGC AGGUCU.C.UGG..GCAGUC..ACUGACGCU....GAG.GAGCGAAAGCAUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGUUGGG....CAC.......... ....UAGGU........................G.......U...G.G.GGC........ CA................................GUUCC..................... .ACUGG..............UU.....................C................ .U.....GU........GCCG.......UAGC..UAACGCAU..........UAAG..UG CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UGU.................... ........ACG................AG.AAAG.......................... .....................CC...............CCAG............AG.AUG ..................G........................GGUUCUCU......... ............................................................ ............................................................ ..................U....UGGACACUC............................ ................................................G..U........ ..............ACA.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCCAUG......U....UGC..C .AG.C.G...GGUU......................AU............G.CCGGGG.. A.CUCAUGGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUUCAC.GCAUGCUACAAU.GGC.CG..G.UACA.GAG................GGC... ......U.G..............CG........AU........ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CUC. ....Acgg.........N............C.....CA....A.........CC...CCU UG........UG.........G.G.................AG.....GGA.......GU G......GUCGAA....GGUG......................GG...A........... CU.................GGCGAUU.........GGGACUAAGUCG.UAACAA.GGUAG CCG.U....................................................... ............................................................ ........................................................... > ...................GAGTTTGATCCT............................. ..GGCTCAG.GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G........GT........GATGccc.......................... ....................................................AGCTTG.. ...CTggGTGGATC.............................................. ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTGA.GT.AACCT.................. .G.......................................................CC. .CCAGAC......................TCcGGGATAAGCCTTGGAAACGaG....... ............................................................ ...............GT........................................... ...............................................CTAATACT..... ..GGAT...................................................... ........................................ACGAGAtgccCCTGCATGGG gagtgtc.................................T................... ..........GGAAAGATT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TATC... ............................................................ ......................................GGT................... ..........CT.......................G........................ ................................G........................... ..................GAT....................................... GG.....A.....CTCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTAATGGC..CTACCA AGG.CGACGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGGCGAA.AGC................CT...GAT....GC.A GCGAC.GCCGC.GT......GAGGGATG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TC........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......G.........................TGACG.G....TACCT.G.C.AGAA... ...G...AAGCGCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGCGCAAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GGT.................TT......GT.......CGCGT.CT.GG.. ..........TGT..........G.......AAA.......ACTca..AGGCTCAA.C.C T.....T.......GA........GC.........TT...........G........... ......................CATcG.....................GG..T..ACGGG CAGA................C.T...AGA..GT..G....CG.............GT... AGGGGT..GA..CTGGAATTCCTGG..........T.................GTAGCGG TGG..AATGCGCA.GATAT.CA.GG.AGGAACACCG.ATGGCGAA............GGC AGGTCA..CTGGG......CCGCA..ACTGACGCTGAG.GAGCGAAAGCATGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCAT.GCCGTAAACGTTGGGCACTAGGTGT....... ...............................................G.GG.....GCT. ......................CA.TT...............C........CACGA.... .....GTTCC.................................................. ...............GTGCCGC.......AGC..AAACGCATT..........AAGT..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGCGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCAAG........................................... ....GCTTGACAT.........................A..................... ...................C....ACC............................G.... ........GAAAC.......................TTCCAG............AG.ATG GTTg........................................................ ............................................................ ........................................C.C................. ..............CCGCA....AGGT................................. ....................C.........................G.GTG......... .......T........A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGT...CTTATGTT..........GC..C .AG.C....A.....C.....GTcA.......TGG..................TGGGG.. A.CTCATAAGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATGT.CTTG.GG CTTCACG.CATGCTACAAT.GGC.CG..GT.ACAA.AG................GGC.T. ........G..............CG........AT........ACC.....GC.GA.G.. ......GT........GGAGCGAAT......CCC.....A..A.AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCAAGTCACGAAA......GT..........................C...GGT ........AA.C.............ACCCGAA....G...................CC.. ...GGT........GG.C............C.....CA....A.........CC...CTT GT...................G.G.................AG.....GGA.......GC T......GTCGAA....GGT.......................GGG...A.......... .CTGGC.................G........ATTGGGACTAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGCGGCTGGATCACCTCC................ ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G........GT........GATGAT........................... .......................................GGG...............GCt tgcctgtctgan.C.............................................. ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTGA.GC.AACCT.................. .G.......................................................CC. .CCAGAC......................TCTGGGATANntccng............... ................................GAAA.N.CG.G................. ................A........................................... .............................................G.CTAATACC..... ..GGAT...................................................... ........................................ATGACCctcgtacgcatgtg ct.................................GGGGGTGG.....AAAG........ .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................Tnnn... ............................................................ ......................................GGT................... ..........CT.......................G........................ ................................G........................... ..................GATnnn.................................... ..............TCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGA.GGTAgTGGCT..CACCA AGG.CGACGAC..GGGTAGCCGGCCT.........G.AGAGnA..CG..ACCG...GCCA CACTGGG.ACTGAGACACN.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGGCGGA.AGCN................T...GAT....GC.A GCGAC.GCCGC.GT......GAGGGATG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TC........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......G.........................TGACG.G....TACCT.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CTt..GTAGG...... ........C.GGT.................TT......GT.......CGCGT.CT.GC.. ..........TGT..........G.......AAA.......AtCC.GG.GGCTCAA.C.C .....C....C...G........G.........ACTT...........G........... ......................CAGTG.....................GG..T..ACGGG CAGA................C.T...AGA..GT..GT....G.............GT... AGGGG..AGA..CTGGAATTCCTGG..........T.................GTAGCGG TGG..AATGCGCA.GATAT.CA.GG.AGGAACACCG.ATGGCGAA............GGC AGGTCT..CTGGG......CCAC..TACTGACGCTGAGA.AGCGAAAGCATGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCAT.GCCGTAAACGTTGGGCGCTAGGTGT....... ...............................................G.GG.....GCT. ......................CA.TT...............C........CACGA.... .....GTTCC.................................................. ...............GTGCCGC.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGCGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCAAG........................................... ....GCTTGACAT.........................A..................... ...................C....ACC............................G.... ........GACACA.......................TCCAG............AG.ATG GGTgCT..TCTT................................................ ............................................................ ............................................................ .......C.................................................... .......................................GGACT..G.GTG......... .......T........A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGTTC...TATGTT..........GC..C .AG.C....A.....C.....GTGA.......TGG..................TGGGG.. A.CTCATAGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATGT.CTTG.GG CTTCACG.CATGCTACAAT.GGC.CG..GT.ACAA.AG................GGT.T. ........G..............CG........AA........NNC.....GT.GA.G.. ......GT........GGAGCGAAT......CCC.....A..A.AAAA.C..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCAAGTCACGAAA......GT..........................C...GGT ........AA.C.............ACCCGAA....G...................CC.. ...GGT........GG.C............C.....CA....A.........CC...CTT GT...................G.GG.................G.....GGA.......GC ....C..GTCGAA....GGT.......................GGG...A.......... .CTGGC.................G........ATTGGGACTAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGC............................... ............................................................ ........................................................... > .........................GAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.U........GA...................A........... .........G.....CU......................C.................... ..CAGCUUGC.UGGG.....G..........................UG........... ..............GA...UU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAACC..................U .G.......................................................CC. .C.....U..............UG............A......................C .U.CUGGGAUAAG..CCU............UGG.AA.A.CG.G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AGG....A............ GCAuuC...................................................... ............................................................ .A.......................................................... .............................C.............................. .......CGCA.......UGGU...................................... .................................................GGG.......U GUU.........G...GAAAGAA..................................... .....................UUU.................................... ............................................................ ......CGGUC.....U........................................... ...............................U............................ ..................GG.......A.......U........................ GG.....A.....CUCG.CGGC...................................... ..CC..................AUCAGCU...UG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GU............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................UUG.............UCGCG.UCU.GC.. ..........C..........GUG.......AAAG.......UCC.GG.GGCUUAA.C.. ..U..C....C...G........G.........AUC........U...G........... ......................CG.G..UG..................GG....UACGGG CAGA................CU....AGA..GU..G....C.............AGU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCG.AUGGCGAA............GGC AGGUCU.C.UGG..GCUGUA..ACUGACGCU....GAG.GAGCGAAAGCAUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGUUUGG....CAC.......... ....UAGGU........................G.......U...G.G.GG.....GC.. .....................C.........AUU........C........CACGGU... ....................UU.....................C................ ...C...GC........GCCGC.......AGC..UAACGCAU..........UAAG..UG CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UGU.................... ........UCucGU................................UC............ ....................GC.....C......G.......................U. ...........AGAGAUA..CG..G................................... ............................................................ ......................UU............................U....... .....CCCCUUUggggcg.......................................... ..............................................G.G..U........ ..............UCA.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUG...UUCUAUG......U....UGC..C .AG.C....A.....C.....G.U.......G...AUG......G...U.....GGGG.. A.CUCAUGGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUUCAC.GCAUGCUACAAU.GGC.CG..G.UACAA.UG................GG.... ....U.U.G..............CG........AU........AC.....UG.UGA.G.. ......G........UGGAGCUAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UUGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...C.. ..........U.....UG..UG.G.................AA.....GGA.......GC ....C..GUCGAA....GGUG......................GG...A........... CU.................GGCGAUU.........GGGACUAAGUCG.UAACAA.G.... ............................................................ ............................................................ ........................................................... > ............................................................ .......................CUG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G......CU........................................... .........G.............................................AAGCc gaCAGCUUGC.U.G......................................UUGGU... ..............GGA.............UG............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAACC..................U .G.......................................................CC. .C.....C..............UG............Au...................... .UUC.GGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................GAC..................................... ............................................................ ...................................CACC..................... ...........UGACGCAUGU....................................... .......................UG..NG............................... ..........................................U..G.....G........ ..U.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGauC................................................. ..............................GG............................ ..................GG.......A.......U........................ GGG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGGGAA.ACC................CU...GA.U...GC.A GCGAC.GCAGC.GU......GCGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................G.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGUACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUACGAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... .........UGGU.................UGG.............UCACG.UCU.GC.. ....................UGUGgaaacgcaac................GCUUAA.CG. .........U...UGc........G.........CG........U...G........... ......................CA.G..UG..................GG....UACGGG CUGA................CU....AGA..GU..G....C.............AGU... AGGGG..AGU..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGACU.C.UGG..GCUGUA..ACUGACACU....GAG.GAGCGAAAGCAUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGUUGGG....CAC.......... ....UAGGU........................G.......U...G.G.GG.....G... ...............A.....C.........AUU........C........CACGUUC.. .....................U.....................C................ ...C...GC........GCCG.......UA.CG.UAACGCAU..........UAAG..UG CC.............CCGCCUGGGGAGUACGGUCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CC..GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UA..................... ...................C....ACUGGA...C.......................... ...........CG.......U.....UC..............................UG ..................G....A.AACAGUUc............UUCUCU......... ............................................................ ............................................................ ..................U....UGGA...........................G..... ...................CUGG................................UGU.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCUAUG......U....UGC..C .AG.C....A.....C.....G.U.......G...AUG......G...U.....GGGA.. A.CUCAUAGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCUUUAUG.UCUUG.GG CUUCAC.GCAUGCUACAAU.GGCU.G..G.UACA.GAGA................G.... ....AG..G..............CG........AA........CCC.....G.UGA.G.. ......GG........UAAGCGAAU......CCC.....U..U.AAA.GC..CA.G.U.C UC.A....GUUCGGAUCGUAGUCUGCAAUUCGACUACGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......G.UC............C.....CA....A.........CC...CUU .U........UG.........G.G.................AG.....GGG.......GC ....C..GUCUAA....GGUG......................GG...A........... CU.................GGUGAUU.........GGGACUAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG...................CUG......GA U............CACCU.......................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAGC............A.U........GA...................A........... .........G.....C.........................UG.........UGCUUGC. .................ACAG..........................UG........... ..............GA...UU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAACC..................U .G.......................................................CC. .C.....UC....................C......A......................C .UU.UGGGAUAAC.U.C.CG...........AGAAA.U.CG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUAC..... ..................................UGGAU.AU.................. ....................GACC.................................... .......................................U.................... ............................................................ ......................UgGC...C.............................. .......CGCA.......UGGU..................UU.................. ..................................U.......U..G.....G........ ..U.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGUG................................................. ..............................GG............................ ..................GG.......A.......U........................ GGG..........CUCG.CGGC...................................... ..C..................UAUCAGUU...UG.UUGGUGA.GGUAGUGGCU..CACCA AGG.CGAUGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGcCACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACccUGGGCGAA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GGGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......GU..GACGGU............................ACUU.G.C.AGAA... ...G...AAGCGCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGCGCAAG..CGUUGUCCGGAAUUAUUGGGAGU..AAAGGG.CU..UGUAGG...... .........UGG.............C....UUG.............UCGCG.UCU.GC.. ..........C..........GUG.......AAA.......ACUC.G.AGGCUUAA.C.C .........U...UG........GG.........CG........U...G........... ......................CG.G..UG..................GG....UACGGG CAG...............G.CU....AGA..GU..G....CG.............GU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCG.AUGGCGAA............GGC AGGUCU.C.UGG..GCCGUU..ACUGACACU....GAGA.AGCGAAAGCAUGGGGAGCGA ACAGGAUUAGAUgCCCUGGUAGUCCAU.GCCGUAAACGUUGGG....CAC.......... ....UAGGU........................G.......U...G.G.GG.....G... ...............A.....C.........AUU........C........CACGUU... ....................UU.....................C................ ...C...GC........GCCG.......UAGC..UAACGCAU..........UAAG..UG CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A.CU...........................G.... ........GAUCGC.......U............G....CAG............AG.AUG UGGU........................................U............... ............................................................ ............................................................ ..........................U................................. .................UCU..UU........................GgacugGUG... ...............CA.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCCAUG......U....UGC..C .AG.C....A.....C....U..Uc.........G..G......G...U.....GGGG.. A.CUCAUGGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUUCAC.GCGUGCUACAAU.GGU.CG..G.UACAA.UG................GG.... ....U.U.G..............CG........AU........AC.....UG.UGA.G.. ......G........UGGAGCUAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCUAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAAU.G.CUGCGG.....UGgAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GA.U.......GG.C............C......................CAAGC.. .U........U.....U...Augcg.................G.....GGA.......GU ....C..GUCGAA....GGUG......................GG...AU.......... .C.................GGUGAUU.........GGGACUAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUU..................................... ........................................................... > ..NCUU.......UUUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.U........GA...................A........... .........G.....C.......................C.................... ..CAGCUUGC.U.GG.....G..........................UG........... ..............GA...UU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAAUC..................U ........................................A................CC. .C.....C..............U......C......A......................C .UU.UGGGAUAAG..CC.C...........CGG.AA.A.CG.G................. ...............G............................................ .............................................GUC............ .................................................UAAUAC..... ..................................UGAAU.AU.................. ....................GACC.................................... .......................................U.................... ............................................................ ......................UUCCUCGCAUGAGg........................ .........................................U.................. ..................................U.......U..G.....G........ ..U.........G...GAAAGUU..................................... .....................UUUU................................... ............................................................ ......CGGUG................................................. ..............................GG............................ ..................GG.......A.......U........................ GUG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGA.GGUAACGGCU..CACNA AGG.CGAC..GAUGGGUAGCCGGCC.........UG.AGAG..GGUG..AACG...GCCA CACUGGG.ACUGAGACACG.GCCN..AGAC..Un.NUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGAA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...AA...GG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................Gg.... ......................................................AG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU..UGUAGG...... ........C.GGU.................UUG.............UCGCG.UCU.GC.. ....................UGUG.......AAA.......AUCC.AG.GGCUUAA.C.C .....C.......UG........G.........ACG........U...G........... ......................CA.G..UG..................GG....UACGGG CAG...............G.CU....AGA..GU..G....UG.............GU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCG.AUGGCGAA............GGC AGGUCU.C.UGG..GCCAUU..ACUGACGCU....GAGA.AGCGAAAGCAUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGUUGGG....CGC.......... ....UgGGU........................G.......U...G.G.GG........U CC..............................AUU.......C........CACGGA... ....................UU.....................C................ .U.....GC........GCCG.......UAGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CC.NGCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UA..................... ...................C....ACC............................G.... ........GAAA.......AGU............G....CAG............AG.AUG U......................Ac................................... ............................................................ ....................................................U....... .....CCCCUUUuU..................GGU....................C.... .....................GG................................UGU.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UCGCAUG......U....UGC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGG.. A.CUCAUGUGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUUCAC.GCAUGCUACAAU.GGC.CG..G.UACA.GAGU................GC... ......U.G..............CG........AU........ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CAC.....U..U.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCACGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...C.. ..........U.....UG..UG.GG.................G.....GGA.......GC ....C..GUCGAA....GGUG......................GG...A........... CU.................GGCGAUU.........GGGG..................... ............................................................ ............................................................ ........................................................... > ............................................................ ............CGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G......CA..CggccuuGG..............................GG UU....U.U......C....CUU................GGG...............G.. ............................................................ ...Uug...........G............UG............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAACC..................U ........................................N................CC. .C....................UC.....U......U......................C .UU.UGGGAUAACG.G.U............CGG.AA.ACGG.N................. ................U........................................... .............................................G.C............ .................................................UAAUAC..... ..................................UGGAU.AU.UCACac........... ............................................................ ............................................................ ............................................................ .........AUUGUCGCAUG........................................ .................GUGGU...................................... .................................................GUG........ ..U.........G...GAAAGG.......U..UUUUUCU..................... ............................................................ ............................................................ .......GGUG................................................. ..............................GG............................ ..................GG.......A.......U........................ GGG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUGAUGGCU..UACCA AGG.CUUUGAC..GGGUAACCGGCC.........UG.AGAG..GGUG..ACCG...GUCA CAUUGGG.ACUGAGAUACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUU UUG.....C...ACAAUGGACGGA.AG................UCU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUGG...A...GG.CC.........UUC.GGGUUG UgAACC..........................U.CUU.........U............. ...................................................CG....... .....................C......UcauggucaagccgcagCUUUGGGUUGUG... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......GU..GAGGGU............................AgUG.G..GUAAA... ...G...AAGCGCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGCGCGAN..CGUUGUCCGGAAUUAUUGGGCGU..AAAGGG.CU..UGUAGG...... ........C.GGU.................UGG.............UUGCG.UCU.GC.. ..........C..........GUG.......AAA.......AUCC.UCUGGCUUAA.C.. ..UG........G.G........GG.........CG........U...G........... ......................CG.G..UG..................GG....UACGGC CUG...............G.CU....UGA..GU..G....CG.............GU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGGC..CCGUU..ACUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.NCUGUAAACGUUGGG....CAC.......... ....UAGGU........................G.......U...G.G.GG.....GC.. .....................C.........AccC.....................GUGG UUUC.......................................C................ .U.....GC........GCCG.......UAGC..UAACGCUU..........UAAG..UN CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UG..................... ...................C....A.CccaGAG........................... ....................CC............U...CCAG............AG.AUG ..................G........................GGGugC........... ..........................................AUU............... .......................UGGUUg............................... ............................................................ .....................GG.......................G.G..U....G... ................UGCAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUAA.GUCCC.GCAACGAGCGCAACCCUUGC...CCUAUG......U....UGC..C .AG.C....A.....C.....G.U.........UG.UG......G...U.....GGGG.. A.CUCGUGGG............GG.ACUGCC.G..G..GGUUAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUAG.GG CUUCAC.GCAUGCUACAAU.GGCU.G..G.UACA.GAG................GG.... ....U.U.G..............CG........AU........GC.....UG.UGA.G.. ......G........CGGAGCGAAU......CCC.....U..U.AAA.GCU..G.G.U.C UC.A....GUUCGGAUCGAAGUCUGCAACUCGACUUCGUGAAGG.UGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCUCGGGCCUUGU..ACACAC CGCCCGUCACGUCACGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CNC. ....A.U.......GG.C............CU.....A....A.........CCGGU..U .Uuccggggn.......................................GA.......GU G......GUCGAA....GGUG......................GG...AU.......... .U.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........G.................................. ............................................................ ........................................................... > ...................GAGTTTGATCCT............................. ..GGCTCAG.GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AAC.....G.......ATGAtg...................................... .....ACCG.................................G.........AGCTTG.. ...CTTtggtTGGA.TT........................................... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTGA.GT.AACCT.................. .G.......................................................CC. .CCCttC......................TTC............................ .....GGGATAA.C.CAT.T...........GG.AA.ACGG.T................. ...............G............................................ .............................................G.CTAATACC..... ..GGgtatga....CATCA......................................... .................................................GAT......CG ...........................CATGGTTTggt.GTGG.....AAAGGT...... .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTCtgg tg.......................................................... ............................................................ ..................................GG........................ ................................G........................... ..................GAT....................................... GGG..........CTCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTGATGGC..CTACCA AGG.CtTTGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGGGGAA.ACC................CT...GAT....GC.A GCGAC.GCCGC.GT......GGGGGATG...AA...GG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCCCTT................TC........ ....................A......Gt............................... ...AAG................................................G..... .....................................................AA..... ..................................CAAGgccatgattgttgTTGT..... ............................................................ .............GGTgagggtact................................... ............................................................ ............................................................ ...............................................T.G.C.AGAA... ...G...AAcgGCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGCGCAAcg..GTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GGT.................TT......GT.......CGCGT.CT.GTC. ...........GT..........G.......AAAT.......CCC.Gat.GCTTAA.Cgt ..........C...G........GGC.........TT...........G........... ......................CGGTG.....................GG..T..ACGGG CAG...............G.C.TG...GA..GT..G....CG.............GT... AGGGGT..GA..CTGGAATTCCTGG..........T.................GTAGCGG TGG..AATGCGCA.GATAT.CA.GG.AGGAACACCG.ATGGCGAA............GGC AGGTCA..CTGGG......CCGT..TACTGACGCTGAG.GAGCGAAAGCATGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCAT.GCCGTAAACGTTGGGCACTAGGTGT....... ...............................................G.GG.....GaTT G.......................TT................C........CACGATtcc tgtaccgtacg................................................. ................................T..AACGCATT..........AAGT..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGCGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCAAG........................................... ....GCTTGACAT.........................A..................... ...................Cgcta.................................... ........GATCGC.......................TCCAG............AG.ATG GGgttttc.................................................... ............................................................ ............................................................ ............................................................ ...................................CTTTGGACT..G.GTG......... .......T........A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGTTC...TATGTT..........GC..C .AG.C....A.....C.....GTAA.......TGG..................TGGGG.. A.CTCATGGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGACGACGTCAAA....TCATCATGCCCCTTATGT.CTTG.GG CTTCACG.CATGCTACAAT.GGC.CG..GT.ACAAT.G................GGT.T. ........G..............CG........AT........ACt.....GT.GA.G.. ......GT........GGAGCGAAT......CCCT.......A.AAA.GC..CG.G.T.C TC.A....GTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGT.CGGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCAAGTCACGAAA......GTT.............................GGT ........AA.C.............ACCCGAA....G...................CC.. ...GGC........GG.C............CT.....A....A.........CC...CCT Tttg......GG.........G...................AG.....GGC.......GT Tc......TCGAA....GGT.......................GGG...A.......... .CTGGC.................G........ATTGGGACTAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........G.................................. ............................................................ ........................................................... > .........................GAUUCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GG.............................AUcccu....G. ................................G........................... ..CAGCUUGC.U.G......................................Ucgggg.. ............U....G............AG............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAAUGC.GUGA.CCAA.CC..................U .G.......................................................CC. .C.....U....................GUGC............................ .ACC.GGAAUAGC.U.C.C...........UGG.AA.ACGG.G................. ................U........................................... .............................................G.G............ .................................................UAAUACC.... ...................................GGAUGC................... .....................UC..................................... ............................................................ ...................................C........................ ............................................................ .....AUCGCA.......UGGU...................................... .................................................GGGGUG..... .........GG.....AAAUGC.......UUUU........................... ............................................................ ...............................G............................ ......CGGC.....AU........................................... ...............................G............................ ..................GG.......A.......U........................ GGGAUGGGG.....UCG.CGUC...................................... ..C..................UAUCAGCU...UG.UUGGCGG.GGUGAUGGC..CCACCA AGG.CGUUGAC..GGGUAGCCGGCC.........UG.AGAG..GGUGC..CCG...GCCA CAUU.GG.ACUGAGAUACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GCGGGAUGG...A...GG.CC.........UUC.GGGUUG UAAACC..........................G.CUU.........U...U......... ....................................................GUUcaagg gcaaggcacgguuucggccgU......GU............................... ...UG................................................AG..... .....................................................U...... .............GGA..................UUG....................... ............................................................ ............................................................ ............................................................ ............................................................ ................................................U.U..CGAA..U .......AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUAUCCGGAUUUAUUGGGCGU..AAAGGG.CU.C.GUAGG...... ........C.GGU.................UCG.............UCGCG.UCc.GG.. ....................UGUG.......AAAG.......UCC.Auc.GCCUAA.Cg. ...G.........UG........G.........AUC........U...G........... ......................CGCC...G..................GG....UACGGG CGG...............G.CUG....GA..GU..G....CG.............GU... AGGGG..AGA..CGGGAAUUC......CC.....................GGUGUAACGG UGG..AAUGUGUA.GAU.AUCG.GG.AAGAACACCA.AUGGCGAA............GGC AGGUCU.C.UGG..GCCGUC..ACUGACGCU....GAG.GAGCGAAACGGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGG....AUGC.......... ....UGGAU........................G.......U...G.G.GGC........ CC..............................UUU.......C........CACGGG... ....................Uc.....................C................ ...C...GU........GUCGG.......AGCC..AACGCGU..........UAAGC..A UC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGAAAU UGACGGGGG.CCC.GCACA.AG.C..GCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UGUGCC.........G....... ............GA................................UC............ ....................GC.....C................................ .......GUGGAGAC..A..CG..G................................... ............................................................ ......................UU............................U....... .....CCCUUC..G..........GG............................G..... ...................CC.........................G.G..U........ ..............UCA.CAGG.UGGUGCAUGGUCGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCGC...CGCAUG......U....UGC..C .AG.C.G...GGU.....................G.AU............G.CCGGGA.. A.CUCAUGUG............GG.ACCGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..AG..AUCAUgccccucac.....GCCAG.GG CUUCAC.GCAUGCUACAAU.GGC.CG..G.UACAAGccg..................... ............................................UGGCGAC.......Ac gguGACG........UGGgGCGGAU......CGCUG......A.AAA..C..CG.G.U.C UC.A....GUUCGGAUCGCAGUCUGCAACUCGACUGCGUGAAGG.CGGAGUCGCUAGUAA UCGCGGAUCAG.C.AACG.CCGCGG.....UGAAUGCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAAGUCAUGAAA......GUG.............................GG. ........UAGC.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............C.G.........A.........CC...C.. ..........U.....UG..UG.GG.................G.....GGA.......GC ....C..GUCUAA....GGUGA......................G...ACUC........ ....................GUGAUU.........GGGACUAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG...................CUG......GA U............CACCUCCUUUCU................................... ........................................................... > ....................AGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU........GA...................A........... .........G.....C.......................C.................... ..CUUC......GGG.....G..........................UG........... ..............GA...U........................................ ......................................................CAGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAAUC..................U .G.......................................................CC. ......UC..............UG............A......................C .U.CUGGGAUAAC..CA.CG...........GG.AA.ACGG.U................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GACAUA.................................. .......................................U..GGCCGAGUGGUCU..... ............................................................ ............................................................ ....................GU...................................... .................................................GCG........ ..U.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGUC.....A........................................... ...............................GA........................... ...................G.......A.......U........................ GAG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGCGAA.AGC................CU...GAC....GC.A GCGAC.GCCGC.GU......GAGGGAUG...AA...GG.CC.........UUC.GGGUCG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCGA.............................G.. ............................................................ ............................................................ ..........................................A................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................CUG.............UCGCG.UCU.GC.. ....................UGUG.......AAA.......ACC.UAG.GGCUUAA.C.. ..U..C.......UG........GG.........CG........U...G........... ......................CA.G..UG..................GG....UACGGG CAG...............G.CU....AGA..GU..G....CG.............GU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCCGUA..ACUGACGCU....GAG.GAGCGAAAGCAUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GGC........ ...............U.....C.........AUU........C........CACGA.... .....G..............UU.....................C................ .U.....GC........GCCGC.......AGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UG.............G....... ............GA................................U............. ........GAAA.......AC.....UC......G.......................U. ...........AGAGAUA..CG..G.G................................. ............................................................ ............................................................ ..........G..UCCGCA....AGG............................GCguc. ............................................................ ..............UCA.CAGG.UGGUGCAUGGUUGUCGCCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCCAUG......U....UGC..C .AG.C....A.....C.....G.U.........U.AUG......G...U.....GGGG.. A.CUCAUGGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUUCAC.GCAUGCUACAAU.GGC.CA..G.UACAA.AG................GGC... ......U.G..............CG........A......G..ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....A..A.AAA.GCU..G.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GA.U.......GG.C............CU.....A....A.........CC...CGU .A........AG.........G.G.................AG.....GGA.......GU ....C..GUCGAA....GGUG......................GG...A........... CU.................GGCGAUU.........AGGACGAAGUCG.NAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CAC............................................ ........................................................... > ..UUUUC......AUUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CUGCUUUugUGGG.....G..........................YGC.......... ...............UC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAACC..................U .G.......................................................CC. .C.....U..............UG............A......................C .UU.UGGGAUAAC.U.U.C...........AGG.AA.ACUG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AGG....A............ GCUCC....................................................... ......................................................U..... .......................G.................................... ..................................................CU........ ........GCA.......UGGU...................................... .................................................GGGG....... GUU.........G...GAAAGUU..................................... .....................U...................................... .......................C......GG............................ ......CGGU.....U............................................ ..............................GG............................ ..................GG.......A.......U........................ GG.....A.....CUCG.CGGC...................................... ....................UUAUCAGCU...UG.UUGGUGG.GGUAGUGGCU..UACCA AGG.CUUUGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..ACCG...GCCA CAUUGGG.ACUGAGAUACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGNGGAAUA UUG.....C...ACAAUGGGCGGA.AGC................CU...GA.U...GC.A GCAAC.GCCGC.GU......GCGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................G.CUU.........U............. ...................................................CG....... .....................C......C............................... ...UGU................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCGU.............................G.. ............................................................ ............................................................ ..........................................A................. ......GU..GACGGU............................AAUG.G..GUAAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUGAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAUUUAUUGGGCGU..AAAGGG.CU.C.GUAGG...... .........UGGU.................UGA.............UCGCG.UCG.G... .........A..........AGUG.......UAA.......UCU.UGG.GGCUUAA.C.C .....C.......UGA........G.........CG........U...G........... ......................CUU...UC..................G..A..UACGGG UUGA................CU....UGA..G..G....AAG.............GU... AGGGG..NGAA..UGGAAUUC......CU.....................GGUGGAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCAG.UGGCGAA............GGC NGUUCU.C.UGG..GCCUUUC..CUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGCUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGGUGGG....UAC.......... ....UAGGU........................G.......U...G.G.GG........U CC..............................AUU.......C........CACGGG... ....................UU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCUU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UG.............G....... ........................AUcgggAGUG.......................... .....................C............U....CAG............AG.AUG ..................G........................GU............... ..................................GUGCCucUUUUGGGGU.......... ............................................................ ............................................................ ....................C.........................G.G..U........ ..............UCA.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UUCACUG......U....UGC..C .AG.C....A.....C.....G.U.........U.AUG......G...U.....GGGG.. A.CUCAGUGGA............G.ACCGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCAC.GCAUGCUACAAU.GGCU.G..G.UACA.GAGA................G.... ....UG..G..............CG........Agc........C.....UG.UGA.G.. ......GG........UGAGCGAAU......CUC.G....G...AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCUCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGNCUUGU..ACACAC CGCCCGUCAAGUCAUGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CCG..... ..........U.....UG..UG.GG.................G.....GGA.......GC ....C..GUCGAA....GGUG......................GG...A........... CU.................GGUGAUU.........AGGACUAAGNNG.UAACAA.GGNAG CNG.UA.CCGG.AAG..........GA................................. U............CACCUCCUUUCU................................... ........................................................... > ....UUCU.....AC.GGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUU............GCAAGUC.....G AGC.....G........GU..................AAG.................... .........G.....C................A.....................CUUCGG ..........U.........G..........................UAC.......... ...............AC..............G............................ .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUGA.G.UAAUC..................U .G.......................................................CC. .C.....U..............U......C......A......................C .U.CUGGGAUAAG..CACUG........................................ .......GA................................................... .......................................AAggguGUC............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................GACgcacU................................ ............................................................ ............................................................ .........................CACGCAUGUGauguguguggA.............. .....................A..................ACUUUUGUG........... ............................................................ ............................................................ ............................................................ ............................................................ .......GGUG................................................. ..............................GG............................ ..................GG.......A.......U........................ GUG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CUUCGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....G...ACAAUGGGCGGA.AGC................CU...GA.UC...C.A GCAAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GU............................... ...AuC................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCGN................................ ............................................................ ............................................................ .........................................NcgUGUGNGUG........ ......GU..GACGGU............................AGGUA..C.AGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGGG.CU.C.GUAGG...... .........UGGU.................UUG.............UCGCG.UCG.GG.. ....................AGUG.......AAA.......ACAC.UG.GGCUUAA.C.C ...G.........AGU........G.........C......U..U...G........... ......................CUU...UC..................G..A..UACGGG CAGA................CU....UGA..G..GC....A.............UUG... AGGGG..AGAA..CGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGUUCU.C.UGGC..AAUGU..UCUGACGCU....GAG.GAGCGAAAGUGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CACCGUAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GGC........ CN..............................AUU.......C........CACGGG... ....................UU.....................C................ ...C...GU........GCCGC.......AGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UA..................... ...................C....ACCcugccgC.......................... .....................C............U....CAG............AG.AUG ..................G........................GGc.............. ............................................................ ....................................................UUCUUUUG N.................................N......................... ....................NGG................................UGU.. ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCUAUG......U....UGC..C .AG.C....A.....C.....G.UCCUUCGGG...AUG......G...U.....GGGG.. A.CUCAUAGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCAC.GCAUGCUACAAU.GGC.CG..G.UACAA.AG................GGC... ......U.G..............CG........AU........CCC.....G.UGA.G.. ......GG........GGAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUNA UCCGAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGNNCGUCANGUCACGAAA......GU..........................C...GGC ........AA.C.............ACCCGAA....G...................CNA. ....G.U.......GG.C............CU.....A....A.........CC.....A ccuug...........UG..UG.GG.................G.....GGA.......GC .U.....GUCGAA....GGUG......................GGG.............. CU.................GGCGAUU.........GGGACGAAGUCGgUAACAA.GGUAG CCG.UA.CCGG.AAG..........GUG................................ ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGTGCTTcACACATGCAA.GT....C.....G AAC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CgcttgcGG...GT................................ACTCG....... ............................................................ ........................................................AGTG GCG.....AACGGGTGA....GTAACAC.GTG.GGT.AACCT.................. .G.......................................................CC. .CCCatC......................TCTGGGATAACcgTTGGAAACGGC....... ............................................................ ...............G............................................ .............................................G.CTAATACC..... ..GGAT...................................................... ........................................ACGACCattgCCTGCATGGG TGA..................................TGGTGG.....AAAG........ .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTgcgg ttg......................................................... ............................................................ ............................................................ ............................................................ .......................................................GGGAG GGG..........CCCG.CGGC...................................... ..CT..................ATCAGC.TGGTT...GGTGG.GGTGATGGC..CTACCA AGG.CGTTGAC..GGGTAGCCGGCCT.........G.AGAG..GGCGGtcggt.....CA CATTGGG.ACTGAGAtACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATT TTGCACAAT........GGGCGCA.AGC................CT...GAT....GC.A GCGAC.GCCGC.GT......GAGGGATG...A...CGG.CTT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TT........ ....................ATCCACcac............................... ............................................................ .......................................................G.... ............................................................ ..................A....AGGCCAggtattcgcctg.G................. ............................................................ ............................................................ ............................................................ ...............................TTGACG.G....TAGtggtT...GAAT.. .......AAGCGCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAAgAC.............GT AGGGCGCGAG..CGTTGTCCGGATTTA..TTGGGCGTAAAGGG.CT.C.GTAGG...... ........C.GGT.................T......GAttgcgtcc.........GCC. ...........GT..........G.......AAAGG.......CCt.C.GGCTTAA.C.C ...G........G.G........GTT.........TT...........G........... ......................CGGTG.....................G..AT..ACGGG tcGA................CTT....GA..Ggcaat...................T... AGGGG..AGAT..CGGAATTCTACG..........T.................GTAGCGG TG..AAATGCGCA.GATATG.T.GG.AGGAACACCGG.TGGCGAA............GGC GGATCT..CTGGGattg......TT..CTGACGCTGAG.GAGCGAAAGCATGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCAT.GCTGTAAACGGTGGGCGCTAGGTGT....... ...............................................G.GG.....GTca cgttggttga...........................................T...... .......TCT.................................................. ...............GTGCCGT.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGCGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCTAG........................................... ....GTTTGACATCAC............................................ .........................CC............................G.... ........GAAACCTCTA...................GAGATAGA............... GGc....CTCTT................................................ ............................................................ ............................................................ .......C.................................................... .......................................GGACT..G.GGT.....G... ................A.CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTAT...CCcGTGTT..........GC..C .AG.C....ATTCAGT.....................................TGGGG.. A.CTCACGGGA............G.ACTGCC.G..GGGTT....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGAgGTCAA....GTCATCATGCCCCTTATGT.CTAG.GG CTTCACG.CATGCTACAtT.GGC.CG..GT.ACA.GCG................GGT.T. ........G..............CG........AT........ACC.....GT.GA.G.. ......GT........GGAGCGAAT......CCCTGT.......AAA.GC..CG.G.T.C Ttg.....GTTCGGATTcGAGTCTGCAACTCGACTCgATGAAGGT.GGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATGCGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCATGAAA......GTT.............................GGC ........AA.C.............ACCCGAA....G...................CCT. ....GC........GG.C............CT.....A....A.........CCGGTTta cc.........G.........G...................AG.....GGAGT....... G......GTCGAA....GGT.......................GGGG............. .CTGGC.................G........ATTAGGACGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGC............................... ............................................................ ........................................................... > ........................UGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AGC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CUUC......GGG.....G..........................UAC.......... ...............UC..............G............................ .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUGA.GCAA.CC..................U .........................................................CC. .C.....C..............U......AGg...........................C .UU.UGGGAUAAC..CCU............CGG.AA.ACGG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GAAU.AU.U................ ............................................................ ............................................................ ....................................ACUgcugGCCGCAUGG........ ............................................................ ......................CUG...G............................... ..........................................U..G.....G........ ..U.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGCC.....U........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CUCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUGAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGGA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCGCC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAGAC.............GU AGGGCGCGAG..CGUUGUCCGGAUUUAUUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GG.............C....UUG.............UCGCG.UCGA.C.. ....................UGUG.......AAA.......ACCC.GC.GGCUCAA.C.. ..UG......C...G........GG.........CC........U...G........... ......................CA.G..UC..................G..A..UACGGG CAG...............G.CU....AGA..GU......UCG.............GU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCCGAU..ACUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCUGUAAACGUUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG.....G... ....................GCCUcuccggu.....................U....... .................................CC........C................ .U.....GU........GCCGC.......AGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUGC.GGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UCG.................... .........................CC............................G.... ........GAAA.......UCC............U...CCAG............AG.AUG ..................G........................GGG.............. ............................................................ .......................GU................................... ......CCUUC..G..........GG............................G..... ...................CC.........................G.G..U....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUCG...UUCgAUG......U....UGC..C .AG.C.G........C.....G.U.........U.AUG......G........CGGGG.. A.CUCAUcGAA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCAC.GCAUGCUACAAU.GGC.CG..G.UACAA.UG................GGC... ......U.G..............CG........AU........ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....A..A.AAA.GC..CG.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCAGGUCACGAAA......GU..........................C...GGC ........AA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............C.....CA....A.........CC...CGU .A........AG.........G.G.................AG.....GGA.......GC ....C..GUCGAA....GGUG......................GGG.............. CU.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG................................................. ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AGC.....G........GT..................AAG.................... .........G.....C.......................C.................... ..CTTtcgGGG...GT................................AC.......... ...............AC..............G............................ .......................................................AGC.G GCG.....AACGGGTGA....GTAACAC.GTG.GGTG.ACCT.................. .G.......................................................CC. .CTCAGC......................TCTGGGATAAGCCTGGGAAACTGG....... ............................................................ ...............GT........................................... ...............................................CTAATACC..... ..GGAT...................................................... ........................................ATGACCTtcCAT......CG ...........................CATGGTG.GGGGGTGG.....AAAG........ .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTC... ............................................................ ......................................GGCT.................. ..................................GG........................ ................................G........................... ..................GAT....................................... GGG..........CCCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTGATGGC..CTACCA AGG.CGACGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCGCAAT........GGGCGGA.AGCN................T...GAC....GC.A GCGAC.GCCGC.GT......GGGGGATG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TCGacc.... ............................................................ ....GG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCGTG............................... ............................................................ ............................................................ ..........................................A................. ......G.........................TGACG.G....TACCG.GT..AGAA... ...G...AAGCACC..................G........................... ............GCCAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGTGCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GGT.............G....T......GT.......CGCGT.CG.GTC. ...........GT..........G.......AAA.......ACTt.GG.GGCTTAA.CT. .....CT.......GA........GC.........TT...........G........... ......................CGGT...C..................G..AT..ACGGG CATc...............AC.TG...GA..GTT......CG.............G.C.. AGGGG..AGA..CTGGAATTCCTGG..........T.................GTAGCGG TG..AAATGCGCA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGGTCT..CTGGG......CCGA..TACTGACGCTGAG.GAGCGAAAGCGTGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGGTGGGCGCTAGGTGT....... ...............................................G.GG.....G... ....................GCCA.TT...............C........CACGGT... ......CTCT.................................................. ...............GTGCCGC.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGTGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCTGG........................................... ....GTTTGACATG.............................................. ............................................................ ...CACTaGACGCC...................GGtgGAGATATc..............G GTT......................................................... ............................................................ .......................................CC.CTTGTGG........... ............................................................ ..........................................CT..G.GTG......... .......TG.........CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGTTCC...ATGTT..........GC..C .AG.C.G...GGTTAT..................................G.CCGGGG.. A.CTCATGGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGCCCCTTATGT.CCAG.GG CTTCACA.CATGCTACAAT.GGC.CtA..T.ACA.GAG................GGC.T. ........G..............CG........A......G..ACC.....GC.GA.G.. ......GT........GGAGCGAAT......CCCTTAAAGTA...........G.G.T.C TC.A....GTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTT.GGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCACGAAA......GTT.............................GGT ........AA.C.............ACCCGAA....G...................CC.. ...GAC........GG.C............CT.....A....A.........CC...CCG TA........AG.........G...................AG.....GGAGT....... T......GTCGAA....GGT.......................GGG...A.......... .CTGGC.................G........ATTGGGACGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGC............................... ............................................................ ........................................................... > ......................TTTGATCCT............................. ..GGCTCAG.GACGAACGCTGG.CGG..CGTGCTTAACACATGCAA.GT....C.....G AGC.....G........GT..................AAG.................... .........G.....C.......................CT................... ...TTC..GGG...GT................................AC.......... ...............AC..............G............................ .......................................................AGC.G GCG.....AACGGGTGA....GTAACAC.GTG.GGTG.ACCT.................. .G.......................................................CC. .CTCAGC......................TCTGGGATAAGCCTGGGAAACTGG....... ............................................................ ...............GT........................................... ...............................................CTAATACC..... ..GGAT...................................................... ........................................ATGACCTctCAT......CG ...........................CATGGTG.GGTGGTGG.....AAAG........ .................TT......................................... ............................................................ ............................................................ ............................................................ ............................................................ .....................................................TTTC... ............................................................ ......................................GGCT.................. ..................................GG........................ ................................G........................... ..................GAT....................................... GGG..........CCCG.CGGC...................................... ..CT..................ATCAGC.TTGTT...GGTGG.GGTGATGGC..CTACCA AGG.CGACGAC..GGGTAGCCGGCCT.........G.AGAG..GGCG..ACCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCGCAAT........GGGCGGA.AGC................CT...GAC....GC.A GCGAC.GCCGC.GT......GGGGGATG...A...CGG.CCT.........TC.GGGT.. ............................................................ ......................TGTAAACCTCTT................TCG....... .....................C......C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCGTG............................... ............................................................ ............................................................ ..........................................A................. ......G.........................TGACG.G....TACCT.Ggat..AA... ...G...AAGCACC..................G........................... ............GCCAACTAC..GTGCCAGCAGCCGCGGTAACAC.............GT AGGGTGCGAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGAG.CT.C.GTAGG...... ........C.GGTC.................T......GT.......CGCGT.CG.GTC. ...........GT..........G.......AAA.......ACCtgc..AGCTTAA.CTG T.............G........GGC.........TT...........G........... ......................CGGT...C..................G..AT..ACGGG CAT...............GAC.TG...GA..GTT......CG.............G.C.. AGGGG..AGA..CTGGAATTCCTGG..........T.................GTAGCGG TG..AAATGCGCA.GATAT.CA.GG.AGGAACACCGG.TGGCGAA............GGC GGGTCT..CTGGG......CCGA..TACTGACGCTGAG.GACCGAAAGCGTGGGGAGCGA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGTTGGGCGCTAGGTGT....... ...............................................G.GG.....G... ....................GCCA.TT...............C........CACGGT... ......CTCT.................................................. ...............GTGCCGC.......AGCT..AACGCATT..........AAGC..G CC.............CCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCATGTGGATTAATT.CGA.TGCAACGCG .AAGAACCTTA.CCTGG........................................... ....GTTTGACATG.............................................. ............................................................ ...CACcagacatccCTA...................GAGATAGgGC............. .TT......................................................... ............................................................ .......................................CC.CTTGTGGt.......... ............................................................ ...........................................T..G.GTG......... .......TG.........CAGGT.GGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTCGTTCC...ATGTT..........GC..C .AG.C.G...GGTTAT..................................G.CCGGGG.. A.CTCATGGGA............G.ACTGCC.G..GGGTC....AACT.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAA....GTCATCATGCCCCTTATGT.CCAG.GG CTTCACA.CATGCTACAAT.GGC.Ca..GT.ACA.GAG................GGC.T. ........G..............CG........A......G..ACC.....GT.GA.G.. ......GT........GGAGCGAAT......CTCTT........AAA.GCT..G.G.T.C TC.A....GTTCGGATCGGGGTCTGCAACTCGACCCCGTGAAGTT.GGAGTCGCTAGTAA TCGCAGATCAG.C.AACG.CTGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACGTCACGAAA......GTT.............................GGT ........AA.C.............ACCCGAA....G...................CC.. ...GAC........GG.C............CT.....A....A.........CC...CCT T.......GTGG.........G...................AG.....GGAGT....... T......GTCGAA....GGT.......................GGG...A.......... .CTGGC.................G........ATTGGGACGAAGTCGT.AACAA.GGTAG CCGT.A.CCGG.AAG..........GTGCGGCTGGATCACtcct................ ............................................................ ........................................................... > guggggguuuuUGUUUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CUUC......GGG.....G..........................UAC.......... ...............UC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACGC.GUG.GG.UGAUC..................U .G.......................................................CC. .C.....U....................GC......A......................C .UU.UGGAAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GAAU.AGG....A............ .........................................CC................. ............................................................ ............................................................ .............................................AcggUCU........ ........GCA.......UGGAu....UG............................... ..........................................U..G.....G........ ..U.........G...GAAAGC.......UUUU........................... ............................................................ ...............................G............................ ......CGGUG.....U........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGA.GGUUACGGCU..CACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..UCCG...GCCA CACUGGG.ACUGAGAUACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................CG....... .....................C......C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.G..GAGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... .........UGGU.................UUG.............UCGCG.UuGU.... .........UC..........GUG.......AAA.......ACUC.AC.AGCUUAA.C.. ..UG.........UG........GG.........CG........U...G........... ......................CG.GG..C..................G..A..UACGGG CAGA................CUG....GA..GU......AC.............UG.C.. AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCAGUA..ACUGACGCU....GAG.GAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGGG....UAC.......... ....UAGGU........................G.......U...G.G.G..UU...... ...............U.....CC..........UU.......C........CUuGGG... ....................AU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UG..................... ...................C....A.CA...........................G.... ........GACGCC...................GG....CAG............AG.AUG UC......................G.....................G............. ............................................................ .......................U............................U....... .....CCCUUG..U..................GG.......................... .........................Ccu....................G..U....G... ................UGCAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCUCAUG......U....UGC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGG.. U.CUCGUGAGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCACA.CAUGCUACAAU.GGC.CG..G.UACAA.AG................GGC... ......U.G..............CG........AU........GCC.....G.UGA.G.. ......G........UGGAGCGAAU......CC.....UU..UCAAA.GC..CG.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...CCU UG........UG.........G.G.................AG.....GGA.......GC ....C..GUCGAA....GGUG......................GG...AU.......... .C.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG...................CUG......GU U............CACCUCCUUUCU................................... ........................................................... > ............................CCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAANUC.....G AAC.....G........GU..................AAG.................... .........G.....C.......................C.................... ..CUUUCG....GGG.....G..........................UAC.......... ...............AC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UGACC..................U GG.......................................................CC. ......U..............GU......AcG............................ ..UC.GGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GACC.................................... .......................................U.................... ............................................................ ......................UCUCCUGCAUGGG......................... ..................................................G......... ...............................G..U.......U..G.....G........ ..U.........G...GAAAGC.......UUUU........................... ............................................................ ...............................G............................ ......CGGU.....AC........................................... ...............................A............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GU............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCUA..C.AGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAUUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................UUG.............UCGCG.UCGU.C.. ....................UGUG.......AAA.......ACCC.G.AGGCUUAA.C.C .........UC...G........GG.........CC........U...G........... ......................CA.GG..C..................G..A..UACGGG CAGA................CU....UGA..GU......AC.............UGU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GCAGUA..ACUGACGCU....GAG.GAGCGAAAGCGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGGG....UAC.......... ....UAGGU........................G.......U...G.G.G..UU...... ...............U.....CC..........UU.......C........CACGGG... ....................AU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UA.........UAGAG....... ............GA................................UC............ ....................GC.....C......G....CAG............AG.AUG UGGU........................................U............... ............................................................ ............................................................ ..........................Ugccuugugccuuc.................... ..................................................UA.....U.. ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCUCAUG......U....UGC..C .AG.C....A.....C.....G.U.........U.AUG......G...U.....GGGG.. A.CUCGUGAGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCACA.CAUGCUACAAU.GGCG...CG.UACA.GAG................GGC... ......U.G..............CG........AU........ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....U..U.AAA.GC.GC..G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...CCU UG........UG.........G.G.................AG.....GGA.......GC .U.....GUCGAA....GGUG......................GG...AU.......... .U.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....Ggu...................... ............................................................ ........................................................... > ..............................U.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GA..................AAG.................... .........G.....C.......................C.................... ..CAGCUUGC.U.GG.....G..........................UAC.......... ...............UC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UGAUC..................U .G.......................................................CC. .C.....C..............UG............A......................C .UU.UGGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GAAU.AU.U................ ......................CAUU.................................. .......................................U.................... ............................................................ ......................UUCCUCGCAUGGGGAu...................... ............................................................ ..........................................U.......UG........ ..U.........G...GAAAGC.......UUUU........................... ............................................................ ...............................G............................ ......CGGU.....U............................................ ..............................GG............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................A......GC............................... ...UcC................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................AGGA.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCAAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................UUG.............UCGCG.UCGU.C.. ....................UGUG.......AAA.......UUC.UGC.AGCUUAA.C.. ..UGca.................GG.........CG........U...G........... ......................CA.GG..C..................G..A..UACGGG CAGA................CU....UGA..GU......AC.............A.UC.. AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GUAGUA..ACUGACGCU....GAG.GAGCGAAAGCGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGGG....UAC.......... ....UAGGU........................G.......U...G.G.G..UU...... ...............U.....CAU.......UU..................CACGGA... ....................AU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UA..................... ...................C....ACCAG.AcgC.......................... ...................A.............GU....CAG............AG.AUG ..................Gcu.........................G............. ............................................................ .......................U............................U....... .....CCCUUG..U..................GGU......................... ....................UGG................................UGU.. ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUGUA......U....UGC..C .AG.C.G...GGUU......................AU............G.CCGGGG.. A.CUuGCAGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCACA.CAUGCUACAAU.GGCU.G..G.UACA.GAG................GGC... ......U.G..............CG........A......G..ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....U..U.AAA.GC..CA.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...C.. ..........U.....UG..UG.G.................AG.....GGA.......GC .U.....GUCGAA....GGUG......................GG...AU.......... .C.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUG................................ ............................................................ ........................................................... > ............................................................ ..............AACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.U........GA...................A........... .........G.....C.......................C.................... ...AGCUUGC.U..G.....G..........................UG........... ..............GA...UU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UGAUC..................U .G.......................................................CC. .C.....C..............A......A......A......................C .UU.UGGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GAAU.AU.................. ....................GACCgauA................................ ............................................................ ............................................................ .........................CUCGCAUGGG......................... ............................................................ ..............................UG..U.......U..G.....G........ ..U.........G...GAAAGC.......UC............................. ............................................................ .......................C......GG............................ ......CGGU.....UU........................................... ...............................G............................ ..................GG.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGCA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................C........ ....................AC......C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCGA................................ ............................................................ ............................................................ .........................................AA................. ......GU..GACGGU............................ACCU.G..GAGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................UUG.............UCGCG.UCGU.... .........UC..........GUG.......AAA.......ACU.UGG.GGCUUAA.C.. ..U..C....C...AA........G.........CG........U...G........... ......................CG.GG..C..................G..A..UACGGG CAGA................CU....UGA..GU......AC.............U.AC.. AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GUAGUA..ACUGACGCU....GAG.GAGCGAAAGCGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGGG....UAC.......... ....UAGGU........................G.......U...G.G.G..UUC..... .....................CUU.......UU..................CACGGG... ....................AU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UA..................... ...................C....ACCAG.AAAG.......................... .....................CC..................................... .............................................AUAGAGAUAUGGC.. ............................................................ ............................................................ ...CCCCCUUG..U..................GGU......................... ....................UGG................................UGU.. ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUGUG......U....UGC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGG.. A.CUCGCAGGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCACA.CAUGCUACAAU.GGC.CG..G.UACA.GAG................GGC... ......U.G..............CG........AU........ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....U..U.AAA.GC..CG.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............C.....CA....A.........CC...CCU UG........UG.........G.G.................AG.....GGA.......GC ....C..GUCGAA....GGUG......................GG...AU.......... .U.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG................................................. ............................................................ ........................................................... > .................................G.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GU..................AAGC..CC............... .CC......................................................... ....UUCG....GGG.....G..........................UAC.......... ...............AC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UAAUC..................U .G.......................................................CC. .C.....U....................GC......A......................C .UUC.GGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GA...................................... ............................................................ ............................................................ ......................ACUCCUGC.............................. .......CGCA.......UGGU...................................... .................................................GGGG....... GUU.........G...GAAAGUU..................................... .....................UUU.................................... ............................................................ ......CGGUG.....C........................................... ...............................A............................ ..................GG.......A.......U........................ GAG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGAA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GGGGGAUG...A...CGGU.C.........UUC.GGAUUG UAAACC..........................C.CUU.........U............. ...................................................C........ ....................A......GU............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.G.C.AGAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... ........C.GGU.................UUG.............UCACG.UCGU.C.. ....................UGUG.......AAA.......UCCC.UC.GGCUUAA.C.C ...G........G.G........GG.........CG........U...G........... ......................CA.GG..C..................G..A..UACGGG CAGA................CU....UGA..GU......AC.............U.AC.. AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GUAGUA..ACUGACGCU....GAG.GAGCGAAAGCAUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGGUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG........U CC..............................UU........C........CACGGAC.. .....................U.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUAG........................................... ....GCUUGA.....C...A.................UA.........UA....C..... .........................AGGACGA............................ .............C...................GG....CAG............AG.AUG UC......................G................................... ............................................................ ......................UU............................U....... .....CCCUUG..U..................GG.......................... .........................CUU.....................GUA.....U.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUG...UCUCAUG......U....UGC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGG.. A.CUCGUGAGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUAG.GG CUUCACA.CAUGCUACAAU.GGCU.A..G.UACA.GAG................GGC... ......U.G..............CG........AU........ACC.....GC.GA.G.. ......G........UGGAGCGAAU......CCC.....U..U.AAA.GCU..G.G.U.C UC.A....GUUCGGAUUGGGGUCUGCAACUCGACCCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...C.. ..........U.....UG..UG.G.................AG.....GGA.......GC ....C..GUCGAA....GGUG......................GG...AU.......... .C.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........G.................................. ............................................................ ........................................................... > auacg..........UGGAGAGUUUGAUNCU.Ga.......................... ....CUCAG.GACGAAacncucugncgnCGUGCUUA....ACACAU.GCAAGUC.....G AA..........................N...................NNNA....AAGG c..............C.......................C.................... ..CUGCUUNC.AGGG.....G..........................UAC.......... ...............UC..............G............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UGAUC..................U .G.......................................................CC. .C.....U..............U......C......A......................C .UUC.GGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AGG....A............ .........................................CC................. ............................................................ ............................................................ .............................................A.............. .....................A..................UCUUUAGUGUG......... ...............................G..U.......U..G.....G........ ..U.........G...GAAAGUU..................................... .....................UUUU................................... ............................................................ ......CGGUG................................................. ..............................GA............................ ..................GG.......A.......U........................ GAG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGA.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGUGG..ACG...GCCA CAUUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGGA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................CG....... .....................C......U............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....AGCC................................. ..UUcg...................................................... ............................................................ ...................................................G........ ......GU..GACGGU............................ACCU.G..GAUAA... ...G...AAGCACC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CU.C.GUAGG...... .........UGGU.................UUG.............UCGCG.UCGU.C.. ....................UGUG.......AAA.......UUCC.GG.GGCUUAA.C.. ..U..C....C...G........GG.........CG........U...G........... ......................CA.GG..C..................G..A..UACGGG CAAA................CUG....GA..GU..G....C.............UGU... AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UGG..AAUGCGCA.GAU.AUCA.GG.AGGAACACCG.AUGGCGAA............GGC AGGUCU.C.UGG..GCAGUU..ACUGACACU....GAG.GAGCGAAAGCAUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGGUGGG....CGC.......... ....UAGGU........................G.......U...G.G.GG........A ...............U......UU.......UU..................CACGAU... ....................UU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAGC..G CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GCUUGA.....C...A.................UA..................... ...................C....ACC............................G.... ........GAUCGC.......U............G....CAG............AG.AUG U......................AG................................... ............................................................ ......................UU............................U....... .....CCCUUC..G..........GG............................G..... ...................CUGG................................UGU.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GUAACGAGCGCAACCCUUG...UCUUGUG......U....UGC..C .AG.C....A.....C.....G.U.........UG.UG......G...U.....GGGG.. A.CUCACAAGA............G.ACUGCC.G..G..GGUUAAC...UC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCACA.CAUGCUACAAU.GGU.CG..A.UACA.GUG................GG.... ....U.U.G..............CG........AU........GCC.....G.UGA.G.. ......G........UGGAGCUAAU......CCC.....UG...AAA.GU..CG.G..CC UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCGCGUCAUGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CCA. ....G.U.......GG.C............CU.....A....Aacuuguu.......... .........................................AG.....GGA.......GC .U.....GUCGAA....GGUG......................GG...AU.......... .C.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............C.......... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AGC.....G........GU..................AAG.................... .........G.....C.......................C.................... ..CUUC......GGG.....G..........................UAC.......... ...............AC..............G............................ .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUG.GG.UGAUC..................U .G.......................................................CC. ......UC....................GU......A......................C .UUC.GGGAUAAG..CCU.G...........GG.AA.ACU..G................. ...............G............................................ .............................................GUC............ .................................................UAAUACC.... ...................................GGAU.AU.................. ....................GACC.................................... .......................................U.................... ............................................................ ......................UCgg.................................. .......AUGCA...........UG..UCUG............................. ...........................................AgG.....G........ ..U.........G...GAAAGAU..................................... .....................UUAU................................... ............................................................ ......CGGU.....AC........................................... ...............................GA........................... ...................G.......A.......U........................ GGG..........CCCG.CGGC...................................... ..C..................UAUCAGCU...UG.UUGGUGG.GGUAAUGGC..CUACCA AGG.CGACGAC..GGGUAGCCGGCC.........UG.AGAG..GGCG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGGCGAA.AGC................CU...GA.U...GC.A GCGAC.GCCGC.GU......GAGGGAUG...A...CGG.CC.........UUC.GGGUUG UAAACC..........................U.CUU.........U............. ...................................................CG....... ......................A.....C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AGCG................................. ............................................................ .........C.................................................. .........................................AA................. ......GU..GACGGU............................ACCU.GU..AGAA... ...G...AAGCACC..................G........................... ............GCCAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGUGCGAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CU..UGUAGG...... ........C.GGU.................UCG.............UCGCG.UCGc.... .........UC..........GUG.......AAA.......ACU.UGG.GGCUCAA.C.C .....C....Ca...A........G.........C......U..U...G........... ......................CG.GG..C..................G..A..UACGGG CGGU................CU....AGA..GU......AC.............U.UC.. AGGGG..AGA..CUGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGCA.GAU.AUCA.GG.AGGAACACCGG.UGGCGAA............GGC GGGUCU.C.UGG..GAAGUA..ACUGACGCU....GAGA.AGCGAAAGCGUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGGUGGG....UAC.......... ....UAGGU........................G.......U...G.G.G..UU...... ...............U.....CC..........UU.......C........CACGGG... ....................AU.....................C................ ...C...GU........GCCG.......UAGC..UAACGCAU..........UAAG..UA CC.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGCGGAGCAUG.UGGAUUAAUUCGAU.GCAACGCG .AAGAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UA..................... ...................C....ACC............................G.... ........GAAACC.......U............G....CAG............AG.AUG U......................AG...................G............... ............................................................ ............................................................ ...CCCCCUUG..U..................GGU....................C.... .....................GG................................UGU.. ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCUUAUG......U....UGC..C .AG.C.G........C.....G.U.........A.AUG......G........CGGGG.. A.CUCGUGAGA............G.ACUGCC.G..G..GGUCAAC...UC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCCAG.GG CUUCACA.CAUGCUACAAU.GGC.CG..G.UACA.GAG................GGC... ......U.G..............CG........AU........ACC.....G.UGA.G.. ......G........UGGAGCGAAU......CCC.....U..U.AAA.GC..CG.G.U.C UC.A....GUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAG.UUGGAGUCGCUAGUAA UCGCAGAUCAG.CAA.CG.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGAAA......GU..........................C...GG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...C.. ..........U.....UG..UG.G.................AG.....GGA.......GC ....C..GUCGAA....GGUG......................GG...AU.......... .C.................GGCGAUU.........GGGACGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGC............................... ............................................................ ........................................................... > gcu......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ........UCN.UAGA...UU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUG.GGC.AACC..................U ........................................A................CC. .C.....A..............U......A......A......................G C.G.GGGGAUAAC.A.............GUUGG.AA.ACGG.C................. ................U........................................... .............................................G.C............ .................................................UAAcACC.... ...................................GCAU.AA.................. ....................G.CU........GUACA....................... ........................................AUACG............... ............................................................ ............................................................ .............................C.............................. .............................AUG..U.......UAAGUAca.......... ................GU......AAAGAUGG.......CCU.................. ............................CUUA............................ .........AC....A.AAGCUAU.........CA......................... ............................................................ ........................CU...UAU............................ ..................GG.......A.......U........................ GGG..........CCCG.CGUC...................................... ..UG..................AUUAGCU...AG.UUGGUAG.GGUAGUGGC..CUACNA AGG.CAACGA..UCAGUAGCCGGCC.........UG.AGAG..GGUGG..ACG...GCCA CACUGGG.ACUGAGACACG.GCCN..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUaGGGGAA.ACC................CU...GAC....GC.A GCGAC.GCCGC.GU......GAGCGAAG...AA...GG.CC.........UUA.GGGUUG UAAAGC..........................U.CU.........GU...UG........ ............................................................ ......................U.....N............................... ...AGGGAA.....G..................AA...................GA.... ...AC.......................U...UAAGUGAG.........AAUAUUG.... ............................................................ ..................U....UUAAGAG.............................. ............................................................ ..........UGA............................................... ............................................................ ............CGGU............................ACCUU.A..C..UAGA .......AAGCCCC..................G........................... ............GCUNACUAC.G.UGCCAGCAGCCGCGGUNAGAC.............GG UNGGGGCNAG..CGUUGUCCGGAAUUACUGGGCGU..AAAGAG.CA.C.GUAGG...... ........C.GGA.................UA.............UUUAAG.UCA.G... .........A..........UGUG.......AAAG.......NACG.C.AGCUCNA.C.. ..UG......C...G........GNG...............U..U...G........... ......................CAU...U..................UG..A..AACUGG GUAU................CU....UGA..G..G....NC.............AGG... AGAGGG..CNG..UGGAAUUC......CU.....................GGUGUAGCGG UG..AAAUGCGUA.GAA.AUCA.GG.AGGAACACnAG.UGGCGAA............GGC GACUG.U.CUGGA..CUGACC..CUGACGCU....GAG.GUGCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUAC.......... ....UAGGU........................G.......UA....G.G..A...G... ....................GU.A.......U.CGA.....CC........CC....... ....................UU.....................C................ .U.....GU........GCCGC.......AGC..UAACGCAA..........UAAG..UA UC.............CCGCCUGGGGAGUACGGUCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUNAUUCGAN.NNAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UACG..................................................... ........GAUU.......UC.....UAUG.........................A.AAG U......................AGAA..............AGUG............... ............................................................ ......CC...............U............................U....... .....CG.................GGA...........................G..... ...................C.GUA........................G..A....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUGC...UAUUAG......U....UGCU.. .A.AC....A..........U..U.........A.AUG.A........U.....GAG..C A.CUCUAAUG............GG.ACUGCCUG....UG..ACAA..GC.AG........ ...GAGGA.A.GGUA.GGGAUGACGUC..A..AAUCAUCAUGCCCUUUAUG.AUCUG.GG CUACACA.CGUGCUACNAU.GGAU.G..G.UACAAGAG................GGC... ......A.Gu..............G........AA........GCC.....G.UGA.G.. ......G........UGAAGCGAAU......CUC.....A..A.AAA.GC..CA..UU.C UC.N....GUUCGGAUUGCAGUCUGCNACUCGACUGCAUGAAG.UCGGAAUCGCUAGUAA UCGCGAAUCAG..NA.CNU.CNCGG.....UGAAUGCGUUCCCGGGCNUUGU..ACACAC CGCNCGUCACACCACGAAA......GU..........................C...GGC ........AA.C.............ACCCGAA....G...................CC.. ...GG.Uc........ACU.................CA....A.........CUCG..CA AG........AGaga..................................GA.......GC ....C..GUCCAA....GGUG......................GGG...U.......... .U.................Gguga.................................... ............................................................ ............................................................ ........................................................... > ............................................................ ..........GGUGAACGCUGG.CGG..CGCGCUUA....AUGCAU.GCAAGUC.....G AAC.....G.......U.G......................................... .CC......................................................... ....UUCG....G.......G.................................C..... ...............................AAG....U..................... ...........................................................G GCAG.....ACGGCUGA....GUAACGC.GUGA.G.UAAC...................A caccc....................................................... ............................................................ ...................................U.UCGG.U................. ...............G............................................ .............................................Gggu........... ............................................................ ............................................................ ............................................................ ............................................................ ..........AUA....GCCUCGG.................................... ............................................................ ............GA.......A..................ACUG.AGgg.UAAUC.CCGC AUACGAUCCCAgugccuUG..........................G.............. ...............UGUUG........................................ ............................................................ .....................................GGAUGAAAGCCUU.......... ..................................................CGGG...... ............CGCCG.............GA............................ ........................................................GGAG uGG..........CUCG.CGUC...................................... ..C..................UAUCAGGU...AG.UUGGUGA.GGUAACGGCU..CACCA AG.CCGAUGAC..GGGUAGCUGG...U....CUUAG.AGG..A..CG..AUCA...GCCA GAGGGGG.ACUGAGACACG.GCCCCC..AC..U.CCUACGGGAGGCAGCAGCAGGGAAUU UUG.....GG...CAAUGGACGAA.AG................UCU...GAC.C...C.A GCGAC.GUCGC.GU......GGGGGAUG...AA...GGU..........UcUA.GGACUG UAAACC..........................C.CUU.........U...UCcg...... ............................................................ ................................................AGGGAAGAG... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......GAAGGACGGU............................ACCUCG..G.GAA..U .......AAGCUCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGAGCGAG..CGUUACCCGGAAUUACUGGGCGU..AAAGAG.CA.C.GUAGG...... ........C.GGU.................UGG.............AUAAG.UCUC.C.. ....................UGUG.......AAAG.......CUC.CC.GGCUCAA.C.. ..U...........G........GGAGAGGUC............................ ............................AG..................GggA..UACUAU UcGA................CUC....GA..G..GG....C.............UGU... AGAGG..UAAG..CGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AGGAACACCAGC.GGCGAAA............GC GGCUUA.C.UGG..GCAGUgC..CUGACGCU....GAG.GUGCGAGAGCGUGGGGAGCAA ACUGGAUUAGAUACCCAGGUAGUCCA.CGCCCUAAACGAUGA....AUAC.......... ....UAGAUA...............................UA....G.GG.....G... ....................GU.A.......U.CGA.....CC........CC....... .................................CC........C................ .U.....GU........GUCGC.......AGC..UAACGCGA..........UAAG..UA UU.............CCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAA...AGGAAU UGACGGGG..CCC.GCACA.AG.C.GGUGGAGCGUG.UGGUUUAAUUCGAU.GCUAAGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UGA.................... ........UUGU................................................ .........AGUA............................................... ............................................................ .................................GGAACCCG.AAAGGGUGA......... ..CGAUccAGGGGUAACU.......................................... .......C..................U.....GGA.....................AGC. ...............................................UU..U........ ...............CA.CAGG.UGCUGCAUGGCUGUCGUCAGCUCGUGCCGUGAGGUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCGUUAG......U....UACA.. .........................................................U.. U.CUCUAACGA............G.ACAGCCU..CUcaC..AAG...G..AG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGGCCCUUAUG.UCCUG.GG CUACACA.CACGCUACAAU.GGC.CG..G.UACAA.UG................GG.... ....UC..G..............CG........AA........GCC.....GC.GA.G.. ......G........CGGAGCCAAU......CCC.....ACCA.AAG..C..C..GG.CC CC.A....GUUGGGAUUGCAGGCUGCAACUCGCCUGCAUGAACG.UGGAAUCGCUAGUAA CCGCAGGUCAG.C.AC.A.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACGUCAUGGAA......G..........................CC...Gag aacg......................AUUGAA....GU...................C.. ...GC.U.......G.A............GCU.....A....A.........CC...CGC .A........AG.........G.G.................AG.....GCA.......GG ....C..GCCGA....GGucG......................GG...UU.......... .U.................GGUGACU.........GGGACGAAGUCG.UAACAA.GGUAG CUG.UA.CCGG.AAG..........G.................................. ............................................................ ........................................................... > ................................GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GA........GA...................AC.......... ...................................................UUUCUUCGG ..........AAU...........................................G... ...........U.....UCUU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACGC.GUA.GGC.AACC..................U ........................................N................CC. .C.....C..............U......C......U......................G .UU.GGGGACAA.CA.UU............C.CGAAAG.GG.A................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GAAU..................... .......GA...........GAuccucu................................ ............................................................ UU.......................................................... .............................C.............................. .......CGCA.......UGGA...................................... .................................................GAG........ ..A.........G...GAUG....AAAGAUGG.......CCU.................. ............................CUAC............................ ...U.........UGU.AAGCUAU.........C.......................... .......GCC.....A............................................ ..............................GAA........................... ...................G.......A.......U........................ GGG..........CCUG.CGUC...................................... ..UG..................AUUAGCU...NG.UAGGUGA.GGUAACGGCU..CACCU AGG.CGAUGA..UCAGUAGCCGG...U....CUGAG.AGG..A..UG..AACG...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UUC.....CG...CAAUGGACGAA.AG................UCU...GAC....G.GA GCAAC.GCCGC.GU......GAGUGAUG...AA...GG.CC.........UUC.GGGUUG UAAAAC..........................U.CU.........GU...UG........ ............................................................ ......................U.....C............................... ...AG........GG..................ACGA....................... ............................................................ ............................................................ ............................................................ ...................AAGCACCG.....AUCUAUAA...................U A......................................CAUUUUGG.U........... .......................G...................................U .......U..GACGGU............................ACCU.GA..CGA.... G..G...AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGAG.CA..UGUAGG...... ........C.GG.................GCU.............UUUAAG.UC.CG... .........AC..........GUG.......AAA.......AUGC.GG.GGCUUAA.C.C .....C....C...GU.................AUg............G........... ......................CGU...UG..................G..A..UACUGG AAGU................CU....UGA..GU..G....C.............AGG... AGAGG..AAAG..GGGAAUUC......CCA.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUUG.GG.AGGAACACCAG.UGGCGAA............GGC GCCU.UU.CUGGA..CUGUG..UCUGACGCU....GAGA.UGCGAAAGCCAGGGUAGCAA ACGGGAUUAGAUACCCCGGUAGUCCUG.GCCGUAAACGAUGGG....UAC.......... ....UAGGU........................G.......UA....G.G..A...G... ....................GU.A.......U.CGA.....CC........CC....... ....................UU.....................C................ .U.....GU........GCCGG.......AGU..UAACGCAA..........UAAG..UA CC.............CCGCCUGGGGAGUACGAUCGCAAGAUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UU.............G....... ........................A....................G.............. .........UGAAAGA......C...............CCAG............AG.AUG ..................G........................GUcccc........... ............................................................ ..............................U............................. ..........................U.CUUCGGA.....................AGC. ...............................................AcGAA.....A.. ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCCUAUG......U....UAC..C .AG.C....A.....C.....G.U.........A.AUG......G...U.....GGGG.. A.CUCAUAGGA............G.ACUGCCAG..GG....A.UAAC.C.UG........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UCUUG.GG CUACACA.CGUACUACAAU.GGU.CG..GCAACAA.AG................GGC... ......A.G..............CG........AA........GCC.....GC.GA.G.. ......G........CGGAGCCAAU......CCC.....AG...AAAC.C..CG..A.CC CC.A....GUUCGGAUCGCAGGCUGCAACCCGCCUGCGUGAAG.UUGGAAUCGCUAGUAA UCGCAGGUCAG.C.AU.A.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......GU.............................UGG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......G.AgA............U.....A....A.........CC.....U .U........U.....U...AG.G.................AGUC.....A.......GC .U.....GUCUAA....GGUG......................GGG.............. CC.................GAUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UU.CGAGAACG............................................. ............................................................ ........................................................... > .........................GAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CAUGCCUA....ACACAU.GCAAGUC.....G AAC.....G........GA........GAgcggaaguUUCG.......AU.......... ................................G......G...A........AGC..... ............................................................ .................UCUU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUG.GAC.AACC..................U ........................................A................CCg g.............................AG....A......................G .UG.GGGGAUAAC.A.............GUC.CGAAAG.GG.C................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AAC...GUUCcuga...... ........A...........GGACAUCCUUcagg.......................... ............................................................ ............................................................ ............................................................ ............................................................ ..........................................................AA C...C............AAAGG.......AGC............................ .....................AAU.................................... ............................................................ ...C..CGCU.....UU........................................... ...............................CC........................... ..................GA.......UG............................... .....GGU.....CCA..CGUC...................................... ..CG..................AUUAGCU...AG.UUGGUAG.GGUAAAGGC..CUACCA AGG.CGACGA..UCGGUAGCCGGCC.........UG.AGAG..GGUG..AACG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUC UUC.....CG...CAAUGGGCGAA.AGC................CU...GAC....G.GA GCAAU.GCCGC.GU......GGGGGAUG...AA...GGU.C.........UUC.GGAUUG UAAACC..........................Cuugucuu.................... ......................................................CG.... ............................................................ ....G........GG..................AA...................G..... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ....................AAGU...............................U...U .......U..GACGGU............................ACCC.GA.G.GA.... G..G...AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGGGCAAG..CGUUGUCCGGAAUGACUGGGCGU..AAAGCG.CG..UGCAGG...... ........C.GGA.................CA.............UGUAAG.UCU.G... .........AG..........GUG.......AAAG.......CU.UGG.AGCUCAA.C.. ..U..C....C...GA.................AACg...........G........... ......................CCU...UG..................G..A..AACUGG AUGU................CU....UGA..GA..G....A.............UGG... AGAGG..AUAG..CGGAAUUC......CC.....................GGUGUAGCGG UG..AAAUGCGUA.GAU.AUCG.GG.AGGAACACCCG.UGGCGAA............GGC GGCU.AU.CUGGA..CAUUA..UCUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAGGU........................G.......UU....G.GG.....G... ....................GU.A.......U.CGA.....CC........CC....... .................................CC........C................ .....G.GU........GCCGC.......AGU..UcACGCAA..........UAAGC..A CU.............CCGCCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GuUGGAGCAUG.UGGUUUAAUUCGAC.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UC.C................... ...UCU......GA................................Auccg....A.... ..........................................................U. ...........AGAGAUAGCG...GA....................G............. ...................................UG....................... .....CCC...............U............................U....... .....CG.................GG............................GAG... ..................CAG..A........................G..A....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UCCCUAG......U....UGC..C .AG.C.G.............AG.Ag...........AGU..............CGGGG.. A.CUCUAGGGA............G.ACUGCC.C..GGGAcg....AC.CG.G........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.UCUUG.GG CUACACA.CGUGCUACAAU.GGG.CG..G.UACAA.ACC................G.... ....A.A.G..............CG........AA........GCC.....G.AGA.G.. ......G........UGGAGCGAACCg......G.....AG...AAA.GC..CG..UU.C CC.A....GUUCGGAUUGCUCUCUGCAACUCGAGAGCAUGAAGG.CGGAAUCGCUAGUAA UCGCGGGUCAG.C.AU.A.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAAA......GU..........................C...GGC ........AA.C.............ACCCGAA....GU...................C.. ...GG.U.......G.A............GGU.....A....A.........CC.....U .U........Uc........AG.G.................AGC.....CA.......GC ....C..GCCGAA....GGUG......................GGG...U.......... .C.................GAUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > nnNNNNUA.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G.......A.A........Gc...................AUNN....AAGA C..................................NRGA....UUNY........UUCGG ..........RAU...........................................G... ...........A.....AGucnnuuaUGNCUG............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUG.GG.UAACC..................U .G.......................................................CC. ......UC..............A......C......A......................C .AG.GGGGAUAGC.A.............GUUGG.AA.ACGG.C................. ................U........................................... .............................................G.............. ................................................AUAAUACC.... ...................................GCAU.AA.................. ....................G.Cgcac.............A................... ............................................G............... NA.......................................................... .............................C.............................. .......CGCA.......UGGU..................ACAG.UGUGAAAAACUCCGg ug.......................................................... ............................................................ ............................................................ ...............................GUG.......................... ................U........................................... ...............................GA........................... ...................G.......A.......U........................ GG.....A.....CCCG.CGUC...................................... ..UG..................AUUAGCUGG....UUGGCAG.GGUAACGGC..CUACCA AGG.CAACGA..UCAGUAGCCGACC.........UG.AGAG..GGUG..ACCG...GCCA CAUUGGG.ACUGAGACACG.GCCC..NGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....C...ACAAUGGAGG.................AAACUCU...GA.U...GC.A GCGAC.GCCGC.GU......GAGUGAAG...AA...GUN..........AUUC.GuUAUG UAAAGC..........................U.CUA.........U............. ...................................................C........ ....................A......GC............................... ...AGG................................................G..... .....................................................AAG.... ............................................................ ..................A....U.................................... ............................................................ ............................................................ ..........................................A................. ......GU..GACGGU............................ACCU.GA..CUAA... ...G...AAGCUCC..................G........................... ............GCUAAAUAC.G.UGCCAGCAGCCNCGGUAAUAC.............GU AUGGAGCNAG..CGUUAUCCGGAUUUACUGGGUGU..AAAGGGA.G..UGUAGG...... .........UGG.............C....AUC.............ACAAG.UCA.G... .........A..........AGUG.......AAAG.......CCC.GG.GGCUCAA.C.C .....C....C...GN.................NAC........U...G........... ......................CUU...U..................UG..A..AACUGU GGA...............G.CU....NGA..GU..G....C.............AGG... AGAGGC..AAG..UGGAAUUC......CUA.....................GUGUAGCGG U..NAAAUGCGUA.GAU.AUUA.GG.AGGAACACCAG.UGGCGAA............GGC GGCU.UG.CUGGA..CUGUA..ACUGACACU....GAG.GCUCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....AUAC.......... ....UAGGU........................G.......UC....G.GG.....GCUC A..................................UAAGAGCU................. .....................U.....................C................ .....G.GU........GCCGC.......AGC..AAACGCAA..........UAAG..UA UU.............CCRCCUGGGGAGUACGUUCGCAAGAAUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACR.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....UCUUGA.....C...A.................UC.C................... ...UCC.........................UUG.......................... .....................CC...............Cgguc................. .................................................AGUAAUGUGAC CU.......................................................... .............................UU............................. ..........................U.CUUCGGA.....................Aca. ...................AG..A........................G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UUCUUAG......U....AGC..C .AG.C....A..........U..U.........U.AAG......G...U.....GGG..C A.CUCUAGGAA............G.ACUGCCAG..GG....A.UAAC.C.UG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCNUNAUG.ACUUG.GG CUACACA.CGUGCUACAAU.GGCG.U..A.AACAA.AGU................G.... ....A.A.G..............CG........A......G..A................ .......GUGUGagcuNAAGCAAAU......CAC.....A..A.AAAU.AA.C..G.U.C UC.A....GUUCGGAUUGUAGUCUGCAACUCGACUACAUGAAGC.UGGAAUCGCUAGUAA UCGCGAAUCAG..AAU.GU.CGCGG.....UGAAUACGUUCCCNnGUCUUGU..ACACAC NGCncgunACNCCAUGGGA......GU..........................C...GG. ........AAA.............UGCCCGAA....GU...................C.. ...GG.UNA........C............CU.....A....A.........CG...... .......................................AAA......GAAGGA...... .......GCCN.......................CCGAAGGCAGGU.............. ............................................................ ............................................................ ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGCGCTTAACACATGCAA.GT....C.....G AGC.....GAtga.....................................AATCTT.... ................................GacagatC.................... ..CTTC..GGG...GTgaagataagatggaTT............................ ............................................................ .......................................................AGC.G GCGG.....ACGGGTGA....GTAACAC.GTGA.GT.AACCT.................. .G.......................................................CCT tagacA..TT.................................................. .....GGGATAG.C.Ct.CG...........GG.AA.ACCG.G................. ...............GAT.......................................... ................................................TAATACCA.... ............................................................ ............................................................ ....AAT..................................................... ...........GAAAtcatag....................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................GTGCCC......... ........................................Atgcactaatgatcaaaact ccggtggtcta.............................................A... ..................GAT....................................... GG.....A.....CTCG.CGTCC..................................... ...C..................ATTAGC.TAGTT...GGTGA.GGTAACGGC..CCACCA AGG.CGACGAT..GGGTAGCCGGCCT.........G.AGAG..GGTG..AACG...GCCA CATTGGA.ACTGAGAAACG.GTCC..AAACT...CCTACGGGAGGCAGCAGTGGGGAATA TTGCACAAT........GGAgggaact.................CT...GAT....GC.A GCGAC.GCCGC.GT......GAACGATG...AA...GG.CTT.........TC.GaGTC. ............................................................ .......................GTAAAGTTCTTTTATAt................GGGA AGA......................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .........................TA.A...TGACG.G....TACCAT.A..AGAA..A .......AAGCCCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGGGCTAG..CGTTGTCCGGAATCAC..TGGGCGTAAAGGGTt..C.GCAGG...... ........C.GGA.................AAt.............GCAAGT.CA.G... .........ATGTa.................AAAG.......GC.AGT.AGCTTAA.CTa ctgtaa..........................................G........... ......................CATTT.....................G..A..AACTGC AtA............T....CTT....GA..Gaaga...................GT... AGAGGT..AAG..TGGAATTTtTAG..........T.................GTAGCGG TG..AAATGCGTA.GATATT.AA.A.AAGAATACCGG.TGGCGAA............GGC GACTTA..CTGGG......CTCATT..CTGACGCTGAG.GAACGAAAGCGTGGGTAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCTGTAAACGATGAGTGCTAGGTatcggaata a.....T..................................................... ........................................................TC.. .........G.................................................. ...............GTGCCGC.......AGTT..AACACATT..........AAGCA.. CT.............CCGCCTGGGGAGTACGtGCGCAAGCATGAAACTCAA...AGGAAT TGACGGGG.ACCC.GCACA.AG.CA.GCGGAGCATGTGGTTTAATT.CGAA.GCAACGCG .AAGAACCTTA.CCAGG........................................... ....GCTTGACAT.........................A..................... ...................Ctg....AGGA...C.......................... ...........CGGTaTA...................GAGATATaccct........... ....CT..TCTT................................................ ............................................................ ............................................................ .......C.................................................... .......................................GGAAGCctcaA.......... .......T........A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TCaGTTAAGTCtG.GCAACGAGCGCAACCCCTAT...CTTTAGTT..........AC..C .AG.C....ATTTcgga....................................TGGGG.. A.CTCTAAAGA............G.ACTGCC.Ga..T.G.AT.AAA.T.C.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCtaTATGC.CCTG.GG CTACACA.CGTGCTACAAT.GGAa.GA..T.ACAA.AG................GG.... ....A.A.G..............CG........A......G..ATAGT............ .................GAtattaagccaaCCTC.....A..A.AAA.Gtct..T..T.C TC.A....GTTCGGATTGTACTCTGCAACTCGAGTACATGAAGat.GGAGTTGCTAGTAA TCGCAGATCAG.C.AT.G.CTGCGGT.....GAATGCGTTCCCGGGTCTTGT..ACACAC CGCCCGTCACACCATGGAA......G..........................CTtgta.. .AT......................ACCCGAA....G...................CCT. ....GC........GAG.............CG.....A....A.........CCTT.... ..........AG.........G.G.................AAGCA..GCA.......G. ........TCGAA....GGTAGGA..........................Ta........ ............................GGTGACTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AT.CGGAAGG............................................. ............................................................ ........................................................... > ............................................................ ................CGCUGG.CGGN..GUGnUUA....ACACAU.GCAAGU.....UG UGC.....GA........G...AA................AGUU...............A CCUUCGG..G.............................................UAAC. .............AAGUA......A.................AgcA.............. ............................................................ ............................................................ GCG.....AACGGGUGA....GUAACGC.GUAA.G.UAAUC..................U ........................................A................CC. ......UU..............U......A......A......................G .U.CUGGGAUAA.CU.C............UU.CGAAAG.AG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ..................................AGAUA.UAC................. .....................UC..................................... ............................................................ ...................................C........................ ............................................................ .....UUg.................................................... .........................................................GGA G..................G....AAAGAUGGUAUUACU.AU.................. ............................................................ ..........U................................................. .......GCU.....UA........................................... ...............................AA........................... ...................G.......A.......U........................ GAG..........CUUG.CGUC...................................... ..CC..................AUUAGCU...AG.UUGGUGA.GaUAACAGCU..CACCA AGG.CAACGA..UGGGUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCUGCAGUGGGGAAUC UUC.....CG...CAAUGGGCGAA.AGC................CU...GAC....G.GA GCAAC.GCCGC.GU......GAGUGAUG...AA...GG.CC.........UUA.GGGUCG UAAAGC..........................U.CU.........GU............. ...................................................C........ ....................U.U.....U............................... ...AG........GG..................AA...................GA.... ...AC.......................AC.............................. ............................................................ ..........................U......................UUAGUAGAG.A A.....U.UACUGC.............................................. ............................................................ ....................UAGA...............................A...U .......U..GACGGU............................ACCUU.U....AA..A G..G...AAGCCCC..................G........................... ............GCUAAUUAC.G.UGCCAGCAGCCGUGGUAACAC.............GU AAGGGGCUAG..CGUUGUCCGGAAUUACUGGGCGUg..AAGGGU.A.C.GCAGG...... ........C.GGU.................CU.............AGCAAG.UCAA.G.. ....................AGUG.......AAA.......ACC.AUC.GGCUCAA.C.C .........N...AU........G.........AAG........U...G........... ......................CUU...U..................UG..A..AACUGU AAGA................CU....UGA..GA..C....C.............AAG... AGGGG..AAGA..UGGAAUUC......CU.....................GGUGUAGUGG UG..AAAUACGUA.GAU.AUCA.GG.AAGAAUACCA.NUGGCGAAA............GC AGUC.UU.CUGGC..UUGAC..UCUGACcCU....GAG.GUACGAAAGCUAGGGUAUCAA ACGGGAUUAGAUACCCCGGUAGUCCUA.NCUGUAAACGCUGG....AUAC.......... ....UAGGU........................G.......UU....G.G..A...G... ....................GU.UCAAcuc...........CU................. .....................U.....................C................ .....G.GU........GCCG.......UAGU..UAACGCUU..........UAAG..UA UC.............CCGCCUGGGGAUUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACAc.G.C.GGCGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAG............................................ ...AACUUGA.....C...A.................UC.C............C...... ...UGUGAUC..GU................UC............................ ...................UU.....UAAC.........................A.A.G aacuuuuc........................................C........... ..........................................UUU............... .......................UGGAACACa............................ ............................................................ .....................G..........................A..U....G... ................A.CAGG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGUAACCCCUA...UUCUUAG......U....UGC..C .AG.C....A..........UG.U.........AGU.G.A........U.....GGGG.. A.CUCUAAGAA............G.ACUGCC.GCggaagcaac....G.C.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCAUCAUGCCCCUUAUG.UUCUG.GG CUACACA.CGUGCUACAAU.GGUU.U..A.UACA.GAG................GGG... ......A.G..............CG........AA........GCC.....GC.AA.G.. ......G........UGGAGCAAAU......CCC.......CA.AAA.G.U..A.G.ACC UC.A....GUUCGGAUUGCAGAuUGCAACUCaUCUGCAUGAAGC.UGGAGUCGCUAGUAA UCGUGGAUCAG..AAU.G.CCACGG.....UGAAUCCGUUCUCGGGCCUUGU..ACACAC CGCCCGUCACACCACCCGA......GU.............................UGGG G.........GC.............ACCAGAA....GU...................CAC u........................................................... .............................GACCUAACUUUUA......GAAGGAaGU... .......GCCGAA....GGUGU......................GC.............. Ccgau......................A.AGG...GGGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUAA.................................... ........................................................... > ..................AGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AAC.....G........GUCUACcucgac...........UGAU...............A CCUUCGG..G.............................................UUGac gaCGAGAUCUA................................................. .......G...........AU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACAC.GUGA.U.UAAUC..................U .G......................................U................CC. ......UCA...........................A......................C .U.CUGGGAUAAC..CUG.G............CGAAAG.UC.G................. ...............G............................................ .............................................G.C............ .................................................UAAcCCC.... ...................................GGAU.AA.................. ....................G.CU........GAgag....................... ............................................................ ............................................................ ............................................................ ........UG..U...........GGCAUCACAcaaucagAA.................. ..................................A.......A..G.....G........ ..U.........G...GUUU........................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .UG..........CCAUC.GUuugaggaggaguucgcgg..................... .UAG..................AUUAGCU...AGc.UGGUGA.GGUAAUGGCU..CACCA gggcaaca.A..UCUAUUGCUGG...U....CUGAG.AGG..A..CG..AUCA...GUCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGgaggAGUGGGGAAUC UUC.....C...ACAAUGGGCGAA.AGC................CU...GA.U...G.GA GCAAC.GCCGC.GU......GAGUGAAG...A...CGGU.C.........UUC.GGAUUG UAAAGC..........................U.CU.........GU............. ...................................................C........ .............................................CUUAGGGAAGAACCG U....GGAU.....G..................UA...................GU.... ...UC.......................A...AUGACAUcc................... ............................................A............... ............................................................ ............................................................ ............................................................ ........................C...............................C... .......U..GACGGU............................ACCU.GU.G.GA.... G..G...AAGCACU..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGAGUGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGGGU.A.C.GCAGG...... ........C.GGA.................UA.............AUCAAG.UCAA.G.. ..........C..........GUG.......AAAGGug........UC.GGCUUAA.C.C ...G.........ACA........G.........AC........U...G........... ......................CGU...U..................UG..A..AACUGA UUAU................CU....UGA..GU..G....U.............AA.C.. AGAGG..AGAG..UGGAAUUC......CUA.....................GUGUAGUGG UG..AAAUACGUA.GAU.AUUA.GG.AAGAACACCAG.UGGCGAA............GGC GACUC.U.CUGG..GUUAAC..ACUGACGCU....GAG.GUACGAAAGCUGGGGGAGCGA ACGGGAUUAGAUACCCCGGUAGUCCCA.GCCGUAAACGCUGG....AUAC.......... ....UAGGU........................G.......UU....G.G..A...G... ....................GU.UCGA........AU..............CC....... ....................UU.....................C................ .A.....GU........GCCGG.......AGU..UAACGCAU..........UAAG..UA UC.............CCGCCUGGGGAAUACGAUCGCAAGAUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCGaG........................................... ....AAUUGA.....C...A.................UC.C............C...... ......GUGACc................................................ ...........A.......UC.....UAUG.........................A.AAG U......................AGAGUU.........UGA................... CACU........................................................ ............................................................ ............................................................ ..........UUGUgucACAC.........................G.G..A....G... ................A.CAGG.UGGUGCAUGGAUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UUCUUAG......U....UGC..C .AG.C.G.............AG.U.........A.AUGU..............CGGGG.. A.CUCUAAGAA............G.ACUGCC.G..G.UG.AA.A...GUC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AGUCCUCAUGCCCUUUAUA.UCUCG.GG CUACACA.CGUGCUACAAU.GGUU.G..G.UACA.GAG................GGG... ......A.G..............CA........A......G..ACC.....GC.GA.G.. ......G........UGGAGCAAAA......CC.....UU..U.AAAA.C..CA..A.CC CC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGUAUGAAG.UUGGAAUCGCUAGUAA UCGCAGGUCAG.C.AU.A.CUGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAAuCGA......GU.............................UGG. ........AUGC.............ACCAGAA....GU...................CAU CUgcgga..................................................... .....................................................U...... .......GCCAAA....GGUGU......................G...UCc......... ..GGCAAG.................A.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UA.CCGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUU...................................... ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AGC.....G........GAC........................................ ...............C................UUC......................... ............G.......G....................................... ............................................................ .........GGUC..........................................AGC.G GCGG.....ACGGGUGA....GUAACAC.GUG.GG.UAAUC..................U .G.......................................................CC. .C.....A..............A......C......U......................G .ACC.GGAAUAACG..C.C...........UGG.AA.ACGG.G................. ................U........................................... .............................................G.C............ .................................................UAAUGCC.... ...................................GGAU.AGGCancgag.......... ............................................................ ............................................................ ............................................................ .......................C.................................... ............A...........GGCAUC.............................. .............................U...............GcucgcU........ ...........GG...GAAAGG.......UGC............................ .....................AAAUgc................................. ......................A..................................... ...C..CGCAG................................................. ..............................AU............................ ..................GG.......AG............................... GAG..........CCCG.CGGC...................................... ..GC..................AUUAGCUG...G.UUGGUGG.GGUAACGGCU..CACCA AGG.CGACGA..UGCGUAGCCGACC.........UG.AGAG..GGUGG..ACG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....CG...CAAUGGGCGCA.AGC................CU...GAC....G.GA GCAAC.GCCGC.GU......GAGCGAAG...AA...GG.CC.........UUC.GGGUUG UAAAGC..........................U.CA.........GU............. ...................................................C........ ....................Acuc.........................GGGAAGAGcgg ..............................................CAAGGGGAG..... .....................................................U...... .............GGA..................AAGCCCC................... .........................UUGAG.............................. ............................................................ ..........AGA............................................... ............................................................ ............CGGU............................ACCGAG...AGA.... G..G...AAGCCCC..................G........................... ............GCUAACUAC.G.UGCCAnnAGCCGCGGUAAUAC.............GU AGGGGGCAAG..CGUUGUCCGGAAUCACUGGGCGU..AAAGCGU.G.C.GUAGG...... ........C.GGU.................UGC.............GUGUG.UCC.GG.. ..........G..........GUG.......AAAG.......UCC.AG.GGCUCAA.C.C .....C.......UG........GG.........A......A..U...G........... ......................CCU...UG..................G..A..AACUGC GUAA................CU....UGA..GU..G....C.............UGG... AGAGGC..AAG..GGGAAUUC......CGC.....................GUGUAGCGG UGG..AAUGCGUA.GAU.AUG.CGG.AGGAAUACCAG.UGGCGAA............GGC GCCU.UG.CUGGA..CAGUG..ACUGACGCU....GAG.GCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAGGU........................G.......UU....G.GG.....G... ....................G....GU........A.....CCA.......CC....... .................C...U.....................C................ .A.....GU........GCCG.......AAGGAAACC..CAA..........UAAGC..A CU.............CCGCCUGGGGAGUACGGUCGCAAGACUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....GCUUGA.....C...A.................UC.C............CCCugac ga.......................................................... .....................C.....C......G....CAG............AG.AUG ....................CG..G................................... ............................................................ ......................UU............................U....... .....CCCUUC..G..........GG............................G..... ...................CAGG.......................G.G..A....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...AACUGUG......U....UAC..C .AG.C....A.....C.....G.U.......G...AAG......G...U.....GGGG.. NACUCACAGUU............G.ACUGCC.G..G.CG.UA.A...GUC.G........ ...GAGGA.A.GGCG.GGGAUGACGUC..A..AAUCAUCAUGCCCUUUAUG.UCCUG.GG CUACACA.CGUGCUACAAU.GGG.CG..G.UACAA.CG................GG.... ....A.A.G..............CG........A......G..ACC.....GC.GA.G.. ......G........UGGAGCAAAC......CCC.....UG...AAA.GC..CG..UU.C GU.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAGC.CGGAAUUGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUCCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAGA......GU..........................C...GGC ........AA.C.............ACCCGAA....GU...................C.. ...GG.U.......GG.............GGU.....A....A.........CC...CGU cagggg....................................GC.....CA.......GC ....C..GCCGAA....GGUG......................GGG...U.......... .U.................GAUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGCG.....G.............CU......... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCTGG.CGG..CGTGCCTAATACATGCAA.GT....C.....G AGC.....G........GA..................Atcgatg................ ..........................................G.........AG.TGCTT GCACTCCTgagaT.................TT............................ ............................................................ .......................................................AGC.G GCGG.....ACGGGTGA....GTAACAC.GTA.GGC.AACCT.................. .G.......................................................CC. .CTCAagaCT.................................................. .....GGGATAA.CT.A.C...........CGG.AA.ACGG.T................. ................A........................................... .............................................G.CTAATACCRgata ..GGAT...................................................... ........................................ATTtgg.....CTGCATGGc ygaata..................................TGG.....AAAGGC...... ...................GGagcaa.................................. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......................T.................CT.................. ..................................GTCACTTg.................. ...............................AG........................... ..................GAT....................................... GGG..........CCTG.CGGC...................................... ..GC..................ATTAGC.TAGTT...GGTGG.GGTAATGGC..CTACCA AGG.CGACGAT..GCGTAGCCGACCT.........G.AGAG..GGTG..AACG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTAGGGAATC TTCCGCAAT........GGACGAA.AGT................CT...GAC....G.GA GCAAC.GCCGC.GT......GAGTGATG...AA...GGTTTTCGGA...........TC. ............................................................ .......................GTAAAGCTCTG................TTGc...... ............................C............................... ...AG........GG..................AA...................GA.... ...ACGcc.................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................AGAGAGAGTAACTGCT ctttgGG.........................TGACG.G....TACCT.GA.G...AAGA .......AAGCCCC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGGGGCAAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGCG.CG.C.GCAGG...... ........C.GGT.................TCTT......T.......AAGT.CT.GG.. ..........TGTtt.................AA.......ACCC.GG.AGCTTAA.CTt cgggacgcac.................................................. .........................TG.....................G..A..AACTGG GGGA................CTT....GA..GT..G....C.............AGA... AGAGG..AGAG..TGGAATTCCACG..........T.................GTAGCGG TG..AAATGCGTA.GATATG.T.GG.AGGAACACCAG.TGGCGAA............GGC GACTCT..CTGGG......CTGTA..ACTGACGCTGAG.GCGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGAATGCTAGGTGTTAG.... ..GG........................................................ ......................................................Gtttcg ataccct.TG.................................................. ...............GTGCCG.......AAGTT..AACACATT..........AAGCAT. .T.............CCGCCTGGGGAGTACGGTCGCAAGACTGAAACTCAA...AGGAAT TGACGGGG.ACCC.GCACA.AG.CA.GTGGAGTATGTGGTTTAATT.CGAA.GCAACGCG .AAGAACCTTA.CCAGGT.......................................... .....CTTGACATC........................C.CTTTGACC............ ............................................................ ............CCTCTA...................GAGATAGA............... GGTTT....................................................... ............................................................ ........................................C.CTTC.............. ........................GG............................G..... .................ACAG..A......................G.G..A....G... ................A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGAT...CTTAGTT..........GC..C .AG.C....A.....C.....GTGAA......TGG..................TGGG..C A.CTCTAAGGT............G.ACTGCC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATG.ACCTG.GG CTACACA.CGTACTACAAT.GGCT.G..GT.ACAA.CG................GG.... ....A.A.G..............CG........AA........GCC.....GC.GA.G.. ......GT........GGAGCCAAT......CCT.....A..A.AAA.GC..CA.G.T.C TC.A....GTTCGGATTGCAGGCTGCAACTCGCCTGCATGAAGT.CGGAATTGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGTCTTGT..ACACAC CGCCCGTCACACCACGAGA......GTTTa.............................C ........AA.C.............ACCCGAA....GT...................C.. ...GGT........G.GGG............T.....A....A.........CCG..... ..............C.A...AG.G.................AGC.....CA.......GC ....C..GCCGAA....GGT.......................GGG....T......... ..A.................GATG........ATTGGGGTGAAGTCGT.AACAA.GGTAG CCGT.AT.CGGAAGGtgc.......................................... ............................................................ ........................................................... > ............................................................ ..........GACGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AGC.....G..................................CACAGAA........G. ................................G......G...AG.........CUUGC. ........................U..........................CCNGGac.. ............................................................ ....................................GUGAGC.................G GCGG.....AUGGGUGA....GUAACAC.GUG.GGC.AACC..................U .G.......................................................CC. ......U..............GU......A......A......................G .A.CNGGGAUAA.CU.U.CG...........GG.AA.ACCG.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AA.UCCCucg.......... .....C...................................................... ............................................................ .A.......................................................... .............................C.............................. .......CGCA.......UGGU...................................... .................................................GCG........ ..A.........G...GUUG....AAAGAUGGUUUCGGCCAU.................. ............................................................ ............................................................ ......CACU.....UA........................................... ...............................CA........................... ...................G.......A.......U........................ GGG..........CCCG.CGG....................................... .UGC..................AUUAGUUAG....UUGGCGG.GGUAANGGC..CCACCA AGA.CCGCGA..UGCAUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....C...ACAAUGGACGAA.AG................UCU...GA.U...G.GA GCAAC.GCCGC.GU......GAGCGAAG...AA...GGU..........UUUC.GGAUCG UAAAGC..........................U.CU.........GU...UGcc...... ............................................................ .............................GGA...................GAAGAACGA Gugcc................................................AG..... .....................................................A...... .............GGA..................AAUGCUgg.................. ............................................................ ............................................................ ...........................UG........................C...... ..........................................U................. ......GU..GACGGU............................AUCC.G..GC..CAGA .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGCG.CG.C.GCAGG...... ........C.GG.............C....UUC.............UUAAG.UCU.G... .........A..........UGUG.......AAA.......UCU.UGC.GGCUCAA.C.C ...GC....A....A..................AAGGU...................... ......................CAU...UG..................G..A..AACUGG GGA...............G.CU....UGA..GU..G....C.............AGA... AGAGG..AGAG..UAGAAUUC......CAC.....................GUGUAGCGG UG..AAAUGCGUA.GAG.AUGU.GG.AGGAAUACCAG.UGGCGAA............GGC GGCUC.U.CUGGU..CUGUU..ACUGACGCU....GAG.GUGCGAAAGCAUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGAUGA....AUGC.......... ....UAGGU........................G.......UUAGG.G.GG.....G... ...............U.....CC..........AA.......C........CC....... .................C...UU..................................... .A.....GU........GCUG.......AAGU..UAACACAU..........UAAGC..A UU.............CCGCCUGGGGAGUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UCU......GACAAgNC....U....AG............................. ............................................................ .......................AGAU..............AGGccG............. ............................................................ .......................U............................U....... .....CCCCUUCGG..........GG............................G..... .................ACAG..A........................G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...AUCUUAG......U....UGC..C .AG.C....A..........U..U.........A.A.G.U........U.....GGG..C A.CUCUAAGGU............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.AUCUG.GG CUACACA.CGUGCUACAAU.GGG.CG..G.UACAA.AG................GGC... ......A.G..............CG........AA........ACC.....GC.AA.G.. ......G........UCAAGCCAAU......CCC.....A..U.AAA.GC..CGC...CC CC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAGC.CGGAAUUGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUCCGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAGA......GU.............................UUG. .......UAA.C.............ACCCGAA....GU...................C.. ...GG.U.......G.U............GGg.....A....A.........CC.....U .U........U.....A...UG.G.................AcC.....CA.......GC ....C..GCCGAA....GGUG......................GG...A........... CAA.................AUGAUU.........GGGGUGAAGUCG.UAACAA...... ............................................................ ............................................................ ........................................................... > ...........................UCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AGC.....G........GACUUUca................................... ......................................AG...A........AGCUUGC. .................U......U.................UUU.............G. ..............................AAAG....UU.................... .......................................................AGC.G GCGG.....ACGGGUGA....GUAACAC.GUG.GGC.AACC..................U .G.......................................................CC. ......U..............Gcaa..................................G .A.CGGGGAUAAC.U.C.CG...........GG.AA.ACCG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AA.UA............... .....................................UC..................... .........................................................UUC .....................................................CU..... .............UCGCAUGA....................................... .......................AG...G............................... ..........................................Aa................ ............................................................ ............................................................ .....................................GGUUGAAAGGC............ ....................................................GG...... ............CGCAAGCUGCCGCU...UgCA........................... ...................G.......A.......U........................ GGG..........CCCG.CGGC...................................... ..GC..................AUUAGCU...AG.UUGGUGA.GGUAACGGCU..CACCA AGG.CGACGA..UGCGUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....CG...CAAUGGACGAA.AG................UCU...GAC....G.GC GCAAC.GCCGC.GU......GAGCGAAG...AA...GGU.C.........UUC.GGAUCG UAAAGC..........................U.CU.........GU...UG........ ............................................................ ......................U.....C............................... ...AG........GG..................AA...................GA.... ...AC.......................A...AGu......................... ........................................ACCGUUCgaac......A.. .GGGCGG................UAC.................................. ............................................................ ............................................................ ..........................................................CU .......U..GACGGU............................ACCU.GA..C..CAGA .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGCG.CG.C.GCAGG...... ........C.GGU.................CUC.............UUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.AC.GGCUCAA.C.C ...G.........UG........G.........AGGGU...................... ......................CAU...UG..................G..A..AACUGG GAGA................CU....UGA..GU..G....C.............AGA... AGAGG..AGAG..CGGAAUUC......CAC.....................GUGUAGCGG UG..AAAUGCGUA.GAG.AUGU.GG.AGGAACACCAG.UGGCGAA............GGC GGCUC.U.CUGGU..CUGUA..ACUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAAGU........................G.......UUA.....Gagggcuucc. ...............................A..........C........CC....... ....................UUU..................................... .A.....GU........GCUGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGGG..CC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUANUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UUCGcUAC......CUC....U....AG............................. ............................................................ .......................AGAU..............AGAGGG............. ............................................................ .......................U............................U....... .....CCCCUUCGG..........GG............................G..... .................ACgG..A........................G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...ACCUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAAGGU............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.ACCUG.GG CUACACA.CGUGCUACAAU.GGAU.G..G.UACAA.AG................GG.... ....UC..G..............CG........AA........ACC.....GC.GA.G.. ......G........UGGAGCUAAU......CCC.....A..A.AAAA.C..CA..UU.C UC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAGC.CGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACGAGA......GU.............................UUGC ........AA.C.............ACCCGAA....GU...................C.. ...GG.U.......G.A............GGU.....A....A.........CC...CUU .AC........G.........G.G.................AGC.....CA.......GC ....C..GCCGAA....GGUG......................GGG.............. CA.................GAUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGCG.....G.............CU......... ............................................................ ........................................................... > U...UU.......UAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AGC.....GAACggac............................................ .....................................GAG...A........AGCUUGC. .................U......U..........................C........ ........UCUg...................AUG....UU.................... .......................................................AGC.G GCGG.....ACGGGUGA....GUAACAC.GUG.GA.UAACC..................U ........................................A................CC. ......UA..............U......A......A......................G .A.CUGGGAUAA.CU.U.CG...........GG.AA.ACCG.G................. ................A........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AA.UA............... .....................................UUUU................... ............................................G............... AA.......................................................... .............................C.............................. .......CGCA.......UGGU..................UCAAAAGUGAAAGACggucu ............................................................ ............................................................ ............................................................ .........................................................UGC UGUCA...CU.....UA........................................... ...............................UA........................... ...................G.......A.......U........................ GG.....AU.....CCG.CGC....................................... .UGC..................AUUAGCU...AG.UUGGUAA.GGUAACGGCU..UACCA AGG.CAACGA..UGCAUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....CG...CAAUGGGCGAA.AGC................CU...GAC....G.GA GCAAC.GCCGC.GU......GAGUGAUG...AA...GGU.C.........UUC.GGAUCG UAAAAC..........................U.CU.........GU...U......... ............................................................ ....................A.U.....U............................... ...AG........GG..................AA...................GA.... ...AC.......................A...UAUGUGU..................... ............................................................ ...........................................................A AGUAA....................................................... .........CUGUgcaca.......................................... .......................U..................................CU .......U..GACGGU............................ACCUA.A....UCAGA .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGCG.CG.C.GUAGG...... ........C.GGU.................UU.............UUUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.AC.GGCUCAA.C.C ...G.........UG........G.........AGGGU...................... ......................CAU...UG..................G..A..AACUGG AAAA................CU....UGA..GU..G....C.............AGA... AGAGG..AAAG..UGGAAUUC......CAU.....................GUGUAGCGG UG..AAAUGCGCA.GAG.AUAU.GG.AGGAACACCAG.UGGCGAA............GGC GACU.UU.CUGGU..CUGUA..ACUGACGCU....GAU.GUGCGAAAGCGUGGGGAUCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAAGU........................G.......UUA.....GG.....G... ....................G....GU........UUCCG..C........CC....... .................C...UU..................................... .A.....GU........GCUGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAA............................................ ...AUCUUGA.....C...A.................UC.C................... ...UUU......GACaACUC....U....AG............................. ............................................................ .......................AGAU..............AGAG............... ............................................................ ......CC...............U............................U....... .....CCCCUUCGG..........GG............................G..... .................ACA..AA........................G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...AgCUUAG......U....UGC..C .A.UC....A..........U..U.........A.A.G.U........U.....GGG..C A.CUCUAAGUU............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACaUC..A..AAUCAUCAUGCCCCUUAUG.AUUUG.GG CUACACA.CGUGCUACAAU.GGA.CA..A.UACAA.AG................GGC... ......A.G..............CG........AA........ACC.....GC.GA.G.. ......G........UCAAGCAAAU......CCC.....A..U.AAA.G.UU...GUU.C UC.A....GUUCGGAUUGUAGUCUGCAACUCGACUACAUGAAGC.UGGAAUCGCUAGUAA UCGUAGAUCAG.C.AU.G.CUACGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCACGAGA......GU.............................UUG. .......UAA.C.............ACCCGAA....G...................CC.. ...GG.U.......GGa.............GU.....A....A.........CC.....U .U........U.....U...AG.G.................AGC.....CA.......GC ....C..GUCGAA....GGUG......................GG...A........... CAA.................AUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAU.CGG.AAG..........GUGCG.....G.............CUG......GA U............CACCUCCUUUCU................................... ........................................................... > .............N...NAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AGC.....GAAC.............................................UGA C..................................UUGAG...A........AGCUUGC. .................U......U..........................C........ ........UCA.AUGAC................G....UU.................... .......................................................A.... GCGG.....ACGGGUGA....GUAACAC.GUG.GG.UAACC..................U ........................................A................CC. ......UU..............A......U......A......................G .UU.UGGGAUAAC.U.C.CG...........GG.AA.ACCG.G................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GAAU.AA.................. ....................GUgau................................... ............................................................ ...................................................UUCU..... .............UCGCAUGA....................................... .......................AG..UG............................... ..........................................A.......AUCUGG..AA AGA...............................................CGGUUUCGgc ..........................................UGU............... ............................................................ ............................................................ ......................CGCU...AUA............................ ..................GG.......A.......U........................ GG.....A.....CCCG.CGGC...................................... ..GC..................AUUAGCU...AG.UUGGUGA.GGUAACGGCU..CACCA AGG.CAACGA..UGCGUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....C...ACAAUGGACGAA.AG................UCU...GA.U...G.GA GCAAC.GCCGC.GU......GAGUGAAG...AA...GGA..........UUUC.GGUUCG UAAAAC..........................U.CU.........GU...UG........ ............................................................ ......................U.....A............................... ...AGGGAA.....G..................AAY........................ ..AAGU...................................................... ......................................AGC..............GUA.. .GUAAcuggcgu...........UAC.................................. ............................................................ ............................................................ ..........................................................CU .......U..GACGGU............................ACCUU.A....UUAGA .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUGUCCGGAAUUAUUGGGCGU..AAAGCG.CG.C.GCAGG...... .........UGGU.................UC.............UUUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.CC.GGCUCAA.C.C ...G........G.G........G.........AGGGU...................... ......................CAU...UG..................G..A..AACUGG GGAA................CU....UGA..GU..G....C.............AGA... AGAGG..AUAG..UGGAAUUC......CAA.....................GUGUAGCGG UG..AAAUGCGUA.GAG.AUUU.GG.AGGAACACCAG.UGGCGAA............GGC GACU.NU.CUGGU..CUGUA..ACUGACACU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAAGU........................G.......UU....G.GG.....G... ....................G....GU........UUCCG..C........CC....... .................C...U.....................C................ .A.....GU........GCUGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGUCGCAAGACUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC.C............C...... ...ACU......GACC............................................ .............................GCU..A......................... ........UGGAGAC..Au........................AG............... ............................................................ ......C...............UU............................U....... .....CCCUUC..G..........GG............................G..... .................ACAG..U......................G.G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCCUUAG......U....UGC..C .A.UC....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCUAGGGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.ACCUG.GG CUACACA.CGUGCUACAAU.GGA.CG..A.UACAA.AC................GG.... ....U.U.G..............CC........AA........CCC.....GC.GA.G.. ......GG........GGAGCCAAU......CCG.....A..U.AAA.G.U.C..GUU.C UC.A....GUUCGGAUUGUAGGCUGCAACUCGCCUACAUGAAGC.CGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCACAAGA......GU.............................UUG. .......UAA.C.............ACCCGAA....GN...................C.. ...GG.U.......GG.............GGU.....A....A.........CC...CUU .U........UG.........G.G.................AGCU.....A.......GC ....C..GUCGAA....GGUG......................GG...AU.......... .A.................GAUG..................................... ............................................................ ............................................................ ........................................................... > ............................................................ .............GAACGCTGG.CGG..CGTGCCTAATACATGCAA.GT....C.....G AGC.....G........GA..................Act.................... ...............................GAA.......AG.........AGCTTG.. ...CTCCTTcagT.................TT............................ ............................................................ .......................................................AGC.G GCGG.....ACGGGTGA....GTAACAC.GTG.GGC.AACCT.................. .G.......................................................CC. .CTGCAga......................TC............................ .....GGGATAA.CT.C.CG...........GG.AA.ACCG.GT................ ............................................................ .............................................G.CTAATACC..... ..GAATAgttttttg.............CCCCT....................CCtgggg cgaaac...................................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ......................................................GG..AA AGA...............................................CGGTTTC... ............................................................ ......................................GGCT.................. ..................................GTCACTGC.................. ...............................AG........................... ..................GAT....................................... GGG..........CCCG.CGGC...................................... ..GC..................ATTAGC.TAGTT...GGTGG.GGTAATGGC..CCACCA AGG.CSACGAT..GCGTAGCCGACCT.........G.AGAG..GGTG..ATCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTAGGGAATC TTCCGCAAT........GGACGCA.AGT................CT...GAC....G.GA GCAAC.GCCGC.GT......GAGTGACG...AA...GGTTTTCGGA...........TC. ............................................................ .......................GTAAAACTCTG................TTGTg..... ............................................................ ...AG........GG..................AA...................GA.... ...AC.......................A...AGC......................... ............................................................ ................................Atcatctaactaatggtg.......... ............................................................ ............................................................ ............................................................ ....CC.........................TTGACG.G....TACCTC.A..C..CAGA .......AAGCCAC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGTGGCAAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGCG.CG.C.GCAGG...... ........C.GGTCc.................CT......T.......AAGT.CT.G... .........ATGT..........G.......AAAG.......CCC.AC.GGCTCAA.C.C ...G..T.......G........G.........AGGGT...................... ......................CATTG.....................G..A..AACTGG GGGA................CTT....GA..GT..G....C.............AGA... AGAGG..AAAG..TGGAATTCCATG..........T.................GTAGCGG TG..AAATGCGTA.GAGATG.T.GG.AGGAACACCAG.TGGCGAA............GGC GACTTT..CTGGT......CTGTA..ACTGACGCTGAG.GCGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGAGTGCTAAGTGTTAG.... ..GG........................................................ ......................................................GGTTT. ...........................................C................ ...C...GCCCCTTAGTGCTGC.......AGCT..AACGCATT..........AAGCA.. CT.............CCGCCTGGGGAGTACGGCCGCAAGGCTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAA.GCAACGCG .AAGAACCTTA.CCAGGT.......................................... .....CTTGACATC........................C.CGct..........GACCGC ............................................................ ....................Ctaggagactag.......................GCT.. .TT......................................................... ............................................................ .......................................CC.CTTC.............. ........................GG............................GGACAg ..............................................C.GGT.....G... ................A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGAT...CTTAGTT..........GC..C .AG.C....ATTCAGT.....................................TGGG..C A.CTCTAAGGT............G.ACTGCC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATG.ACCTG.GG CTACACA.CGTGCTACAAT.GGA.CG..GT.ACAA.AG................GGC... ......A.G..............CC........AA........CCC.....GC.GA.G.. ......GG........GGAGCCAAT......CCC.....AG...AAAA.C..CGT..T.C TC.A....GTTCGGATTGCAGGCTGCAACTCGCCTGCATGAAGC.CGGAATCGCTAGTAA TCGTGGATCAG.C.AT.G.CCACGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGAGA......GTTT.............................GT ........AA.C.............ACCCGAA....GT...................C.. ...GGT........GAGG.............T.....A....A.........CC...CTT GT...................G.G.................AGC.....CA.......GC ....C..GCCGAA....GGT.......................GGG...A.......... .C.................GGATG........ATTGGGGTGAAGTCGT.AACAA...... ............................................................ ............................................................ ........................................................... > ............................................................ .............................GTGCCTAATACATGCAA.GT....C.....G AAC.....G.......A.Atgacctta................................. ........G.................................G.........AGCTTG.. ...CTCCTTTGGtcGTT........................................... ............................................................ ........................................................AGTG GCGG.....ACGGGTGA....GTAACAC.GTG.GGC.AACCT.................. .G.......................................................CCT gtaagA..TT.................................................. .....GGGATAA.CT.C.CG...........GG.AA.ACCG.G................. ................A........................................... .............................................G.CTAATACC..... ..GAATAataatcagct........................................... .........................................................CCG ...........................CATGGagcgggTTT.G.....AAAGGC...... ...................GGC...................................... ............................................................ ............................................................ ............................................................ ............................................................ ......................................................TTC... ............................................................ ......................................GGCT.................. ..................................GTCACTTac................. ............................................................ .................AGAT....................................... GGG..........CCCG.CGGT...................................... ..GC..................ATTAGC.TAGTT...GGTGG.GGTAAAGGC..CTACCA AGG.CGACGAT..GCATAGCCGACCT.........G.AGAG..GGTG..ATCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACTt...CTACGGGAGGCAGCAATAGGGAAAC TTCCGCAAT........GGACGAA.AGT................CT...GAC....G.GA GCAAC.GCCGC.GT......GTGTGAAG...AA...GGTTTTCGGA...........TC. ............................................................ .......................GTAAAGCACTG................TTGTT..... ............................................................ ...AG.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....ACAAGGATa............................ ............................................................ ............................................................ ................................................AGAGTAACTGCT tgTCCC.........................TTGACG.G....TATCTA.A..C..CAGA .......AAGCCAC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGTGGCAAG..CGTTGTCCGGAATTA..TTGGGCGTAAAGCG.CG.C.GCAGG...... ........C.GGT.................TTCT......T.......AAGT.CT.G... .........ATGT..........G.......AAAG.......CCC.CC.GGCTTAA.C.C ...G........G.G........G.........AGGGT...................... ......................CATTG.....................G..A..AACTGG GAGA................CTT...AGA..GT..G....C.............AGA... AGAGG..AGAG..TGGAATTCCATG..........T.................GTAGCGG TG..AAATGCGTA.GATATA.T.GG.AGGAACACCAG.TGGCGAA............GGC GACTCT..CTGGT......CTGTA..ACTGACGCTGAG.GCGCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGAGTGCTAAGTGTTAG.... ..GG........................................................ ......................................................GGTTT. ...........................................C................ ...C...GCCCCTTAGTGCTGC.......AGCT..AACGCATT..........AAGCA.. CT.............CCGCCTGGGGAGTACGACCGCAAGGTTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAA.GCAACGCG .AAGAACCTTA.CCAGGT.......................................... .....CTTGACATC........................C..TTTGACCA........... ............................................................ .............CTCTGGA.............GA....CAG............AGCT.. .TT......................................................... ............................................................ .......................................CC.CTTC.............. ........................GG............................GGACAA A................................................GT.....G... ................A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTGAT...TTTAGTT..........GC..C .AG.C....ATTTAGT.....................................TGGG..C A.CTCTAAAGT............G.ACTGCC.G..GT.G...C.AA.GCC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATG.ACCTG.GG CTACACA.CGTGCTACAAT.GGAt.GA..T.ACAA.AG................GGTCGC g.................................A........ACC.....GC.GA.G.. ......GT........GAAGCTAAT......CCC.....ATAAAatca......T..T.C TC.A....GTTCGGATTGTAGGCTGCAACTCGCCTACATGAAGC.CGGAATCGCTAGTAA TCGCGGATCAG.C.AT.G.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGAGA......GTTT.............................GT ........AA.C.............ACCCGAA....GT...................C.. ...GGT.........AGGG............T.....A....A.........CCTTTa.. .T...................G.G.................AGC.....C.......... ............................................................ ............................................................ ............................................................ ............................................................ ........................................................... > NN.UUUCA.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACNAACGCUGG.CGG..CAUGCCUA....AUACAU.GCAAGUC.....G AGC.....GAAC.............................................AGA u...............................GA.......AG.........UGCUUGC. .................ACUUc...................................... .............UGAC................G....UU.................... .......................................................AGC.G GCG.....AACGGGUGA....GUAACAC.GUAA.Gg.AAUC..................U ........................................A................CC. ......UA..............U......A......A......................G C.G.GGGGAUAAC.A.UU............CGG.AA.ACGG.G................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.UA............... .....................................UC..................... .........................................................UUC UU.......................................................... .............................C.............................. .......CGCA.......UGGA..................A................... ............................................................ ............................................................ ............................................................ ......................................GAAGAUUGAAAGAcGGCUCUGC UGUCA...CU.....UA........................................... ...............................UA........................... ...................G.......A.......U........................ GAC..........CUUG.CGG....................................... .UGC..................AUUAGUU...AG.UUGGUGG.GGUAAUGGC..CUACCA AGA.CGAUGA..UGCAUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....CG...CAAUGGGCGAA.AGC................CU...GAC....G.GA GCAAU.GCCGC.GU......GAGUGAAG...AA...GG.CC.........UUC.GGGUCG UAAAAC..........................U.CU.........GU...U......... ............................................................ ....................A.U.....A............................... ...AG.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....ACAA......................AUUGUAGAG.U A.....ACUGCUACA...G.UC...................................... .............................U.............................. ............................................................ .......U..GACGGU............................AUCUU.A....UCAGA .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCNAG..CGUUGUCCGGAUUUAUUGGGCGU..AAAGGGA.G.C.GCAGG...... .........UGGU.................UUC.............UUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.AC.GGCUUAA.C.C ...G.........UG........G.........AGGGU...................... ......................CAU...UG..................G..A..AACUGG GAAA................CU....UGA..GU......AC.............AGA... AGAGG..AAUG..UGGAACUC......CAU.....................GUGUAGCGG UGG..AAUGCGUA.GAU.AUAU.GG.AAGAACACCAG.UGGCGAA............GGC GACA.UU.CUGGU..CUGUU..ACUGACACU....GAG.GCUCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAGGU........................G.......UU....G.G..A...G... ....................G....GU........UUCCG..C........CC....... ....................UU.....................C................ .A.....GU........GCCGC.......AGU..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGG.ACC.NGCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.NNAACGCG .AAGAACCUUA.CCAAG........................................... ....UCUUGA.....C...A.................UC.C................... ...UUU......GACCACCC....U....AG............................. ............................................................ .......................AGAU..............AGGGN.............. ............................................................ ......................UU............................U....... .....CCCUUC..G..........GG............................G..... .................ACA..AA........................G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCNN.CAACGAGCGCAACCCCUA...UUAUUAG......U....UGC..C .AG.C....A..........U..U.........U.A.G.U........U.....GGG..C A.CUCUAAUGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAGCAUGCCCCUUAUG.ACUUG.GG CUACACA.CGUGCUACAAU.GGAU.G..G.UACAA.CGA................G.... ....UC..G..............CA........AA........CCC.....GC.GA.G.. ......GG........CAAGCAAAU......CUC.....U..U.AAA.GC..CA..UU.C UC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAGC.CGGAAUCGCUAGUAA UCGUGGAUCAG.C.A.CG.CCACGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGNNCGUCACACCACGAGA......GU.............................UUG. .......UAA.C.............ACCCGAA....GU...................C.. ...GG.U.......G.A............GGU.....A....A.........CC.....U .U........U.....A...UG.G.................AGC.....CA.......GC ....C..GCCGAA....GGUG......................GG...A........... CA.................GAUGAUU.........GGGG.......G.UAAC........ ....................................A.............AG......GA U............CACCUCCUUUCU................................... ........................................................... > uc..AAAU.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAGCcacaG..................................CGA..AA.......... ................................G......G...UG.........CUUGC. ........................A..........................CCUU..... ........UCA.A....G............UG............................ .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUG.GAC.AACC..................U .G.......................................................CC. ......UC..............A......Aggc........................... ..U.GGGGAUAAC.A.UU............UGG.AA.ACAG.A................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GAAU.AA.A................ ............................................................ ............................................................ ....................................ACUUAG.................. ...........UGUCGCAUGACAC....................AAA............. .GUUAAAAggc................................................. ............................................................ ...............................GC........UUCGGCGUcac........ ............................................................ ............................................................ .........C.....UA........................................... ...............................GA........................... ...................G.......A.......U........................ GG.....AU.....CCG.CGG....................................... .UGC..................AUUAGUU...AG.UUGGUGG.GGUAAAGGC..CUACCA AGA.CAAUGA..UGCAUAGCCGA.....G..UUGAG.AGAC....UG..AUCG...GCCA CAUUGGG.ACUGAGACACG.GCCC..AAAC..U.CCUACGGGAGGCUGCAGUAGGGAAUC UUC.....C...ACAAUGGGCGAA.AGC................CU...GA.U...G.GA GCAAC.GCCGC.GU......GUGUGAUG...AA...GG.C.........UUUC.GGGUCG UAAAGC..........................A.CU.........GU...UG........ ............................................................ ......................U.....A............................... ...UGGGAA.....G..................AAC........................ ............................................................ ................................AGCUAGA..............AUA.... GGAAAUGA.......UUuuag....................................... ............................................................ .............................U.............................. ............................................................ .......UU.GACGGU............................ACCAU.A..C..CAGA .......AAGGGAC..................G........................... ............GCUAAAUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AUGUCCCGAG..CGUUAUCCGGAUUUAUUGGGCGU..AAAGCGA.G.C.GCAGA...... ........C.GGU.................UU.............AUUAAG.UCU.G... .........A..........UGUG.......AAAG.......CCC.GG.AGCUCAA.C.. ..U..C....C...G........G.........NA......UG.....G........... ......................CAU...UG..................G..A..AACUGG UUAA................CU....UGA..GU..G....C.............AGU... AGAGG..UAAG..UGGAACUC......CAU.....................GUGUNGCGG UGG..AAUGCGUA.GAU.AUAU.GG.AAGAACACCAG.UGGCGAA............GGC GGCU.UA.CUGGA..CUGCA..ACUGACGUU....GAG.GCUCGNAAGUGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CACCGUAAACGAUGA....ACAC.......... ....UAGGU........................G.......UUAGGA............. ....................G....GU........UUCCG..C........C........ ...................................................UCUUA...G ....UGCC.....N..............AAGC..UAACGCAU..........UAAG..UG UU.............CCGCCUGGGGAGUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UUU......GA................AGcu....................UU.... ..........................................................U. ...........AGAGAUAG....A.AG..............UGU................ ............................................................ .................U.......................................... .......C..................U.CUUCGGA...................G..... .................ACA..AA........................G..U....G... ................A.CAGG.UGGUGCAUGGUCGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UUGUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.A........U.....GGG..C A.CUCUAGCGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGCG.GGGACGACGUC..AG..AUCAUCAUGCCCCUUAUG.ACCUG.GG CUACACA.CGUGCUACAAU.GGCG.U..A.UACAA.CGA................G.... ....U.U.G..............CC........AA........CCC.....GC.GA.G.. ......GG........UGAGCUAAU......CUC.....U..U.AAA.GUA.C..G.U.C UC.A....GUUCGGAUUGUAGUCUGCAACUCGACUACAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.A.CG.CCGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UUG. ........UAA.............UGCCCAAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC.....U .U........U.....U...AG.G.................AA.....GGA.......GC ....C..GUCUAA....GGC......................AGG...A........... CA.................GAUGACc.........GGGG.......G.UAACAA.GGAA. ..............................C..................CUG......GA U............CACCUCCUUUCU................................... ........................................................... > ..................AGAGUUUGAUNNU.GG.......................... ....CUCAG.GAUGAACGCCGG.CGGU..GUGCCUA....AUACAU.GCAAGUC.....G UAC.....G......CA..Cuggcccaacugauu......G.......AU.......... ................................G......G...UG.........CUUGC. ........................A..........................CCUGauuga cgauggaucaccA....G............UG............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAACAC.GUA.GG.UAACC..................U .G.......................................................CC. .C.....C...................GG.......A......................G C.G.GGGGAUAAC.A.UU............UGG.AA.ACAG.A................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AAC................. .....................AACa................................... ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .................AAAGC...................................... ............................................................ ..........................CGCAUGGCUU...UUGUUUGAAAGAuggcuuugg cuaucacu..C.....U........................................... ...............................G............................ ..................GG.......A.......U........................ GG.....A.....CCUG.CGG....................................... .UGC..................AUUAGCU...AG.UUGGUAA.GGUAACGGCU..UACCA AGG.CGAUGA..UGCAUAGCCGA.....G..UUGAG.AGAC....UG..AUCG...GCCA CAAUGGA.ACUGAGACACG.GUCC..AUAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....C...ACAAUGGGCGCA.AGC................CU...GA.U...G.GA GCAAC.GCCGC.GU......GAGUGAAG...AA...GGGuuucggc...........UCG UAAAGC..........................U.CU.........GU...UG........ ............................................................ ......................U.....UGGA...................GAAGAACGU Gcg......................................................... ............................................................ ............................................................ ..............................UG......................AGAG.U A.....ACUGUUCNC............................................. ............................G........................C...... ..........................................A................. ......GU..GACGGU............................AUCCA.A..C..CAGA .......AAGUCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUAUCCGGAUUUAUUGGGCGU..AAAGCGA.G.C.GCAGG...... ........C.GGU.................UGC.............UUAGG.UCU.G... .........A..........UGUG.......AAAG.......CC.UUC.GGCUUAA.C.C ...G.........AA........G.........AAG........U...G........... ......................CAUC...G..................G..A..AACcGG GCGA................CU....UGA..GU..G....C.............AGA... AGAGG..ACAG..UGGAACUC......CAU.....................GUGUAGCGG UGG..AAUGCGUA.GAU.AUAU.GG.AAGAACACCAG.UGGCGAA............GGC GGCUG.U.CUGGU..CUGCA..ACUGACGCU....GAG.GCUCGAAAGCAUGGGUAGCGA ACAGGAUUAGAUACCCUGGUAGUCCAU.GCCGUAAACGAUGAG....UGC.......... ....UAGGU........................G.......UU....G.G..A...G... ....................G....GU........UUCCG..C........CC....... ....................UU.....................C................ .A.....GU........GCCGG.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGACCGCAAGGUUGAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCUACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC...................UU gcgcuaa..................................................... .....................CC..................................... .............................................UUAGAGAUAAGGCgU U........................................................... ........................N................................... ......CCUUC..G..........GG............................G..... .................ACgc..A........................A..U....G... ................A.CAGG.UGGUGCAUGGUCGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCU.GCAACGAGCGCAACCCUUG...UUACUAG......U....UGC..C .AG.C....A..........U..U.........A.A.G.U........U.....GGG..C A.CUCUAGUGA............G.ACUGCC.G..G.UG.A.CAAA..CC.G........ ...GAGGA.A.GGUG.GGGACGACGUC..AG..AUCAUCAUGCCCCUUAUG.ACCUG.GG CUACACA.CGUGCUACAAU.GGA.CG..G.UACAA.CGA................G.... ....UC..G..............CA........A......G..CUC.....GC.GA.GA. .......G........UAAGCUAAU......CUC.....U..U.AAA.GC..C..GUU.C UC.A....GUUCGGACUGUAGGCUGCAACUCGCCUACAcGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UUG. ........UAAc.............GCCCAAA....GU...................C.. ...GG.U.......GG.C............CU.....A....A.........CC.....U .U........U.....A...UG.G.................AG.....GGA.......GC ....C..GCCUAA....GGcG......................GG...A........... CA.................GAUGACU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGAGAgCC............UGCG.....G.............CUG......GA U............CACCUCCUUUNU................................... ........................................................... > ..................AGAGUUUGAUCAU.GG.......................... ....CUCAG.GACGAACnCUGG.CGG..CAUGCCUA....AUACAU.GCAAGUC.....G AAC.....G......CU.UCuuucc........................UAU....U... ........................................GAG.........UGCUUGC. .................ACUC...........GACUGGAaagA..G.............. ...............................G............................ .......................................................AGU.G GCGG.....ACGGGUGA....GUAACAC.GUG.GG.UAACC..................U .G.......................................................CC. .C.....A..............U......A......A......................G .UG.GGGGAUAAC.A.UU............CGG.AA.ACGG.A................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.UUC.............. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ...............UGAUUGC...................................... ............................................................ ..........................CGCAUGNGAACGGAUGAAAGGUGGcuucg..... ............................................................ .................GCUGCCGCU...UAU............................ ..................GG.......A.......U........................ GG.....A.....CCCG.CGGC...................................... ..GU..................AUUAGCU...AG.UUGGUGA.GGUAAUGGCU..CACCA AGG.CAAUGA..UACGUAGCCGACC.........UG.AGAGN..GUG..AUCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUC UUC.....CG...CAAUGGACGNA.AG................UCU...GAC....G.GA GCAAU.GCCGC.GU......GAGUGAAG...AA...GGU..........UUUC.GGAUCG UAAAAC..........................U.CU.........GU...UG........ ............................................................ ......................U.....U............................... ...AG.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....ACAAGGAUG......................AGAG.U A.....ACUGCUcau............................................. ............................................................ .......................CC...............................C... .......U..GACGGU............................AUCUA.A..C..CAGA .......AAGCCAU..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGAUGGCAAG..CGUUGUCCGGAUUUAUUGGGCGU..AAAGCGA.G.C.GCAGG...... ........C.GGU.................UC.............UUUAAG.UCU.G... .........A..........UGUG.......AAAG.......ACC.CC.AGCUCAA.C.. ..UG........G.G........G.........AAGGU...................... ......................CAU...UG..................G..A..AACUGG AGAA................CU....UGA..GU..G....C.............AGA... AGAGG..AGAG..UGGAAUUC......CAU.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUAU.GG.AGGAACACCAG.UGGCGAA............GGC GACUC.U.CUGGU..CUGUA..ACUGACGCU....GAG.GCUCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....UGC.......... ....UAAGU........................G.......UU....G.GG.....G... ....................G....GU........UUCCG..C........CC....... .................C...U.....................C................ .A.....GU........GCUGC.......AGC..UAACGCAU..........UAAGC..A CU.............CCGCCUGGGGAGUACGGCCGCAAGGCUGAAACUCAA...AGGAAU UGACGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UC.C................... ...UUU......GACCACUC....U....AG............................. ............................................................ .......................AGAU..............AGAG............... ............................................................ ......C...............UU............................U....... .....CCCUUC..G..........GG............................G..... .................ACA..AA........................G..U....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCCUA...UUAUUAG......U....UGC..C .AG.C....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUAGUGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.ACCUG.GG CUACACA.CGUGCUACAAU.GGAU.G..G.UACAA.CGA................G.... ....UC..G..............CA........A......G..AUC.....GC.GA.G.. ......G........UCAAGCUAAU......CUC.....U..U.AAA.GC..CA..UU.C UC.A....GUUCGGAUUGCAGGCUGCAACUCGCCUGCAUGAAGC.CGGAAUCGCUAGUAA UCGCGGAUCAG..AA.CG.CCGCGG.....UGAAUACGUUCCCGGGUCUUGU..ACACAC CGCCCGUCACACCACGAGA......GU.............................UUG. .......UAA.C.............ACCCGAA....GU...................C.. ...GG.U.......G.A............GGU.....A....A.........CC...CUU .U........UG.........G.G.................AGC.....CA.......GC ....C..GCCUAA....GGUG......................GG...AU.......... .A.................GAUAAUU.........GGGGUGAAGUCG.UAACAA.GGUAA CC.......................................................... ............................................................ ........................................................... > ..................AGAGTTTGATCCT............................. ..GGCTCAGAGACGAACGCTGccgc...CGTGCCTAATAtATGCAA.GT....C.....G AAC.....G......C.......................................Ttctt tttccACCG.................................G.........AGCTTG.. ...CTCCacCGG.........................................A...... ...AAAAGA......................G............................ .......................................................AAGTG GCG.....AACGGGTGA....GTAACAC.GTG.GGT.AACCT.................. .G.......................................................CC. .Cat.........................C......A......................G .AA.GGGGATAA.CAc.T.T...........GG.AA.ACAG.GT................ ............................................................ .............................................G.CTAATACCcgtat aacaatc..................................................... .........................................G............AAACCG ...........................CATGGTTTtgaTTT.G.....AAAGGC...... ...................GCTTtcggg................................ .......................................TG................... ............................................................ ............................................................ ............................................................ ........................................................TCGC Tgat........................................................ ............................................................ ............................................................ ................................G........................... ..................GAT....................................... GG.....A.....CCCG.CGGT...................................... ..GC..................ATTAGC.TAGTT...GGTGA.GGTAACGGCT..CACCA AGG.CCACGAT..GCATAGCCGACCT.........G.AGAG..GGTG..ATCG...GCCA CATTGGAct.AGAGACACG.GGCCaaAAACT...CCTACGGGAGGCAGCAGTGAGGggaa tct..............GCGCGCA.AGtggacgAAG........CT...GAC....GCGA GCAAC.G.CGC.GT......GAGTGAAG...AA...GGGTTTCGGA............C. ............................................................ .......................GTAAAACTCTG................TTGTT..... ............................................................ ...AG.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....ACAAGGAT............................. ............................................................ ............................................................ ...............................................GAGAGTAACTGtt caTCCC.........................TTGACG.G....TATCTA.A..C..CAGA .......AAGCCAC..................G........................... ............GCTAcCTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGTGGCAAC..CGTTGTCCGGATTTA..TTGGcCGTAAAGCGA.G.C.GCAGG...... ........C.GGT.................TTCT......T.......AAGT.CT.G... .........ATGT..........G.......AAAG.......CCC.CC.GGCTCAA.C.C ...G........G.G........G.........AGGGT...................... ......................CATTG.....................G..A..AACTGG GAGA................CTT....GA..GT..G....C.............AGA... AGAGG..AGAG..TGGAATTCCATG..........T.................GTAGCGG TG..AAATGCGTA.GATATA.T.GG.AGGAACACCAG.TGGCGAA............GGC GGCTCT..CTGGT......CTGTA..ACTGACGCTGAG.GCTCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGAGTGCTAAGTGTTgga... ...G........................................................ ......................................................GGTTT. ...........................................C................ ...C...GCCCTTCAGTGCTGC.......AGCT..AACGCATT..........AAGCA.. CT.............CCGCCTGGGGAGTACGACCGCAAG.TTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAA.GCAACGCG aAAGAACCTTA.CCAGGT.......................................... .....CTTGACATC........................C..TTTGACCA........... ............................................................ .............CTCTA...................GAGATAGA............... Gcttc....................................................... ............................................................ .......................................CC.CTTC.............. ........................GG............................GGGCAA A................................................GT.....G... ................A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCTTATTG...TTAGTT..........GC..C .AT.C....ATTCAGT.....................................TGGG..C A.CTCTAGCaagactt.............CC.G..GT.G.A.CAAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATG.ACCTG.GG CTACACA.CGTGCTACAAT.GGGAa...GT.ACAA.CGA................GT... .............................................TGCG......AA... ......GTcgcgaggctAAGCTAAT......CTCTT........AAA.GCTtc....T.C TC.A....GTTCGGATTGCAGGCTGCAACTCGCCTGCATGAAGC.CGGAATCGCTAGTAA TCGCGGATCAG.C.A.CG.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCC.GTCACACCACGAGA......GTTT.............................GT ........AA.C.............ACCCGAA....GT...................C.. ...GGT.........AGG.............T.....A....A.........CCTTT... .T...................G.G.................AGC.....CA........C ....C..GCCTAA....GGT.......................GGG...AT......... ..A.................GATG........ATTGGGGTGAAGTCGT.AACAA.GGTAA CC.......................................................... ............................................................ ........................................................... > ..................AGAGTTTGATNNT............................. ..GGCTCAG.GACGAACGCTGG.CGG..CGTGCCTAATACATGCAA.GTa.........G AAC.....G......C.......................................T.... ................................GaagacttT...........AGCTTG.. ...CTAGAgtt.........G....................................... .......G...........AA..........GAGtt........................ ............................................................ GCG.....AACGGGTGA....GTAACGC.GTA.GGT.AACCT.................. .G.......................................................CCT aTT.................................A......................G T.G.GGGGATAA.CT.AT.T...........GG.AA.ACG.AT................. ................A........................................... .............................................G.CTAATACC..... ..GCATAAtagtgtttaacacatgttagagacttaaaagatgcaatt............. ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ ............................................................ .............................................GCATCACTagtA... ..................GAT....................................... GG.....A.....CCTGCGTTgt..................................... ......................ATTAGC.TAGTT...GGTGG.GGTAACGGC..CTACCA AGG.CGACGATa..CATAGCCGACCT.........G.AGAG..GGTG..ATCG...GCCA CACTGGG.ACTGAGACACG.GCCC..AGACT...CCTACGGGAGGCAGCAGTAGGGAATC TTCgGCAAT........GGGGGCA.ACC................CT...GAC.C....GA GCAAC.GCCGC.GT......GAGTGAAG...AA...GGTTTTCGGA...........TC. ............................................................ .......................GTAAAGCTCTG................TTGT...... ............................A............................... ...AG.............................A...................G..... .....................................................AAG.... ............................................................ ..................A....ACgtgtgtgagagtggaaagttcacac.......... ............................................................ ............................................................ ..........................................A................. ......G.........................TGACG.G....TAactt.A..C..CAGA .......AAGGGAC..................G........................... ............GCTAACTAC..GTGCCAGCAGCCGCGGTAATAC.............GT AGGTCCCGAG..CGTTGTCCGGATTTA..TTGGGCGTAAAGCGA.G.C.GCAGG...... ........C.GGT.................TTa......AT.......AAGT.CT.G... .........Aagtt.................AAAG.......GC.AGT.GGCTTAA.C.C attgttcgct.................................................. ........................TTG.....................G..A..AACTGT TAAA................CTT....GA..GT..G....C.............AGA... AGGGG..AGAG..TGGAATTCCATG..........T.................GTAGCGG TG..AAATGCGTA.GATATA.T.GG.AGGAACACCGG.TGGCGAAA............GC GGCTCT..CTGGT......CTGTA..ACTGACGCTGAG.GCTCGAAAGCGTGGGGAGCAA ACAGGATTAGATACCCTGGTAGTCCA.CGCCGTAAACGATGAGTGCTAGGTGTTAG.... ..Gccctttccgggg............................................. ............................................................ ............................................................ ...........CTTAGTGCCGC.......AGCT..AACGCATT..........AAGCA.. CT.............CCGCCTGGGGAGTACGACCGCAAGGTTGAAACTCAA...AGGAAT TGACGGGGG.CCC.GCACA.AG.C.GGTGGAGCATGTGGTTTAATT.CGAA.GCAACGCG .AAGAACCTTA.CCAGGT.......................................... .....CTTGACATC........................C.CGATgctatt.......... ............................................................ ..............TCTA...................GAGATAGAaagt........... .....T..TCTT................................................ ............................................................ ............................................................ .......C.................................................... .......................................GGAAcATC.GGT.....G... ................A.CAGGT.GGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGT TGGGTTAAGTCCC.GCAACGAGCGCAACCCCTATTG...TTAGTT..........GC..C .AT.C....ATTCAGT.....................................TGGG..C A.CTCTAGCGA............G.ACTGCC.G..GT.G.AT.AAA..CC.G........ ...GAGGA.A.GGTG.GGGATGACGTCAAA....TCATCATGCCCCTTATG.ACCTG.GG CTACACA.CGTGCTACAAT.GGTT.G..GT.ACAA.CGA................GTC.. ........G..............CA........A......G..CCggtgac......... ......GG........CAAGCAAAT......CTCTT........AAA.GC..CA..AT.C TC.A....GTTCGGATTGTAGGCTGCAACTCGCCTACATGAAGT.CGGAATCGCTAGTAA TCGCGGATCAG.C.A.CG.CCGCGGT.....GAATACGTTCCCGGGCCTTGT..ACACAC CGCCCGTCACACCACGAGA......GTTT.............................GT ........AA.C.............ACCCGAA....GT...................C.. ...GGT........GAGG.............T.....A....A.........CCTTT... .T..................AG.G.................AGC.....CA.......GC ....C..GCCTAA....GGT.......................GGG...A.......... .CA.................GATG........ATTGGGGTGAAnTCGT.AACAA.GGTAN CCGT.AT.CGG.AAG..........GTGCGGCTGGATCACCTCCTTT............. ............................................................ ........................................................... > ..................AGAGUUUGAUCCU.GC.......................... ....CUCAG.GAUGAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAC.....G.......A.AC........................................ ...............C................A.....................CUUCGG ..........U.........G....................................... .......G...........UU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUACGA.UAACC..................U .G.......................................................CC. .C.....U..............A......A......Aacuc................... ....GAGGAUAAC.A.C.CG...........GGgAA.ACUG.G................. ................U........................................... .............................................G.C............ .................................................UAAUAC..... ..................................UGGAU.AGG....AUGUUAggau... ....................GA.....UU................UUCUUAC........ ............................................................ ............................................................ ............................................................ ............................................................ ...........................................AUU.............. ............................................................ ..............UAAAGAUU....................AAU............... ............................................................ ......CGGU.....UU........................................... ...............................UA........................... ...................G.......AG............................... .....GGGU.....CUuuCGGC...................................... ..GC..................AUUAGUU...AGUUUGGUGG.GGUAAAGGC..CUccca acaCCGAUGA..UGCGUUGgcccggcU....UUGAG.AGG..U..CUUUUUCG...GCCA CAUUGGGgACUGAGAAcuguGCCC..AAAC..UcCUUACGGGAGGCAGCAGUGGGGAAUU UUC.....GccaA.AUUGGGGGAA.ACC................CU...GAC.C....GA CCAAC.GCCGC.GU......GAACGAAG...AA...GUU.C.........UUC.GGAAUG UAAg..........................GUU.CUU.........U...UA........ ............................................................ ......................U.....A............................... ...UGGGAA.....G..................AAA........................ ..AAC.......................UC.............................. ............................................................ ..........................A......................AAAuugg.... ............................................................ ............................................................ ............................................................ ............CGGU............................ACCAU.A..UGAA..U .......AAcCCCC..................G........................... ............GCUAACUAU.G.UGCCAGCAcCCGCGGUAAUACA.............U AGGGGGCGAG..CGUUAUCCGGAUUUACUGGGCGU..AAAGGGU.G.C.GUAGG...... .........UGGU.................UA.............AACAAG.UUUC.... .........UG..........GUG.......UAAG.......UgC.AG.UGCUCAA.CGC .........U..G...........UG...............A..U...G........... ......................CUAg...G..................A..A..AACUGU UUA...............G.CU....AGA..GU..G....AG.............A.C.. AGAGGC..AAG..UGGAAUUC......CAU.....................GUGUAGCGG U..AAAAUGCGUAA.AU.AUAU.GG.AGGAACACCAG.UGGCGAA............GGC GGCU.UG.CUGG..GUCUAU..ACUGACACU....GAU.GCACGAAAGCGUGGaGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGAG....AAC.......... ....UAAGU........................G.......UU....G.GC......... .....................................CC..................... .UCAGGG..............U.....................C................ .A.....GU........GCUGC.......AGU..UAACGCAU..........UAAG..UU CU.............CCGCCUGAGUAGUACGUACGCAAGUAUGAAACUCAA...AGGAAU UGACGGGAC.CCC.GCACA.AG.C.GGUGGAUCAUG.UUGUUUAAUUCGAA.GAUACACG .AAAAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UA..................... ...................C....UCUGcaaugg.......................... ....................C.....UUAG.........................A.AAU AAG............................U............................ .Ucgga...................................................... ............................................................ ........................GGU................................. .................UAAC..A........................G..A...UGU.. ................A.CAGG.UGGUGCACGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UUGCUAG......U....UAC..C .A.UCA...A..........U..U.........A.A.G.U........U.....GGGG.. A.CUCUAGCGA............G.ACUGCCAG..G.UG.AU.AAA..UUUG........ ...GAGGA.A.GGUG.GGGAUGACcgucaaucAAUCAUC...CCCCUUAUG.ACCUG.Gc cuccAAA.CGUGAUACAAU.Gucugauacca..AA.AGA................G.... ....A.A.G..............CG........AU........G................ .......GGuugacCCGGAGCGAAU......CUC.....A..U.AAA.GU..CA.G.U.C UC.A....GUUCGGAUUGAAGUCUGCAACUCGACUUCAUGAAG.UUGGAAUCGCUAGUAA UCGCGAAUCAG.C.AU.GU.CGCGG.....UGAAUACGUUCUCGGGGUUUGU..ACACAC CGCCCGUCAAACCACGAAA......GUGa.............................GC ........AA..............UACCCAAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC...CGU .A........AG.........G.G.................AG.....GGAc.......C ....C..GUCUAA....GGUA......................GGG...U.......... .UC.................AUGAUU.........GGGGUUAAGUCG.UAACAA.GGUAA CCG.UA...................................................... ............................................................ ........................................................... > ..NAAAUU.....U...GAGAGUUcGAUCCU.GG.......................... ....CUCAG.GAUNAAnGCCGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAC.....G.......A.G......................................... .CU...................................................CUUCGG ..........A................................................. .......G.......Cc........................................... ......................................................CAGU.G GCG.....UACGGGUGA....GUAACAC.GUU.GG.UAACC..................U .G.......................................................CC. .C.....UC....................C......A......................G .ACC.GGAAUAC.CAg.A.G...........AGAAA.U.C.UC................. ................U........................................... .............................................G.C............ .................................................UAAUGCC.... ...................................GGAUGAC.................. ....................GUCAUA.................................. .......................................U..GGUCGCAA.......... ..............................G.....ACC..................... ...........Ucu.............................................. ............................................................ ............................................................ ...............U............................................ ..........................GACCAAAGGcggcaacugccg............. ............................................................ ......CGCUG................................................. ..............................AA............................ ..................GG.......A.......U........................ GG.....A.....CCUG.CGUC...................................... ..GC..................AUUAGCU...AG.UUGGCGG.GaUAAUGGC..CCACCA AGG.CGAgGA..UGCGUAGCCGA.....G..CUGAG.AGGC......UNAACG...GCCA CAUUGGG.ACUGAGACACG.GCCC..NGAC..U.CCUACGGGAGGCAGCAGUAGGGAgua uuu.....GG...CAAUGGGGGAA.ACC................CU...GAC.C....GA GCAAC.GCCGC.GU......GUGUGAUG...AA...GG.CC.........UUC.GGGUCG UAAAAC..........................A.CU.........GUgauUC........ ............................................................ ......................U.....C............................... ...UG........GG..................AAAC........UCAUGGGGAG..... .....................................................U...... .............GGA..................AAGCCUCAUGacugaccggac..... ....UAUUAGAAAGCAA........................................... ............................................................ ............................................................ ............................................................ ............................................................ .............CU............................................. ............GCUAACUAC.G.UGCCAGCAGCAGCGGUAAUAC.............GU AGGUUGCAAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGAGU.G..AGCAGG...... ........C.GG.............C....UU.............UGCNAGc.CG.GG.. ..........G..........GUC.......AAAG.......GC.AG.UGGCUUAA.C.C .........A...UU........G.........UUCguc..................... .................................................CCCGGAACUGC AUG...............G.CU....AGA..GU..G....C.............UGG... AGAGGC..AAG..CGGAACUC......CACA.....................UGUAGCGG UG..AAAUGCGCA.GAU.AUGU.GG.AAGAACACCAG.UGGCGAA............GGC GGCU.UG.CUAGA..CAGUA..ACUGACGCUC....AGU.CACGAAAGCGUGGGGAGCAA AUAGGCUUAGAUACCCUAGUAGUCCA.CGCCGUAAACGUUGAGgacc............. .....AGGU........................G.......UC....G.GG.....G... ....................GC.........AUA........C........CUCGGCGcc a........................................................... .....................C.......AGC..UAACGCAU..........UgAG..UC CU.............CCGCCUGGGUACUACGUUCGCAAGAAUAAAACUUAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GUGGAGCAUG.UGGUUUAAUUCGNU.GCUACGCG g.AAAACCUUA.CCUGG........................................... ....GUUUGA.....C...A.................UC...................UU CUCAAagg.........CCC....U....AG............................. ............................................................ .......................AGAU..............AGGGAGAUAG......... .........................................UUAUGGGAAUG........ ............................................................ ............................................................ ......................Aac................................... ....................GG.UGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCCN.CAACGAGCGCAACCCCCG...UCUUCAG......U....UGC..C .A.UC....A..........U..UC..........A.G.U........U.....GGG..C A.CUCUGGAGA............G.ACUGCC.G...ACGc.A.A...GUC.G........ ...GAGGA.A.GAUG.GGGAUGACGUC..A..AGUCAUCACGCCYCUUAUGC.CCAG.GG CGACACA.CGUGCUACAAU.GGU.CG..G.UACAA.CGC................G.... ....U.U.G..............CG........A........CACC.....GC.GA.G.. ......G........UGAAGCGGAU......CGCUG......A.AAg..C..CG..A.CC CC.A....GUACGGAUCGGAGUCUGCAAUUCGACUCCGUGAAGC.CGGAAUUGCUAGUAA UCGCGGAUCAG.CAUU.G.CCGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC UGCCCGUCACACCAUGAGA......G..........................CC...GGC ........Aa.G.............GCCCGAAag.......................C.. ...GU.UU.......GU.............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GAC.......GG ....C..GUCUAA....GGC......................AGGgC............. .CN.................GNNAUN.........GGG...................... ............................................................ ............................................................ ........................................................... > N...NA.......AAUGGAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUGG.CGG..CGUGCCUA....AUACAU.GCAAGUC.....G AAC.....G.......A.A........GUGA............AG....A.......... ................................G......G...AG.........CUUGC. ........................U..........................CCUUGG... ...........A.....ACUU....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAAUACA.UAA.GC.AACC..................U .G.......................................................CC. ......UC....................GA......U......................G C..CUGGGAUAA.CAG.A.GGGAAAC.............U.UC................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AC.................. ....................GU.....UA................AUCUAAGA....... ......................................CA.................... ............................................................ ......................UC....................UUA............. .GAUUAAUUAAAGA.......UGGGAUACAUcac.......................... ............................................................ ............................................................ ............................................................ ............................................................ .........A.....AC........................................... ...............................GA........................... ...................G.......A.......U........................ GGG..........CUUau.GGC...................................... ..GC..................AUUAGUU...AG.UUGGUAA.GGUAACGGCU..UACCA AGA.CGAUGA..UGCGUAGCCGACC.........UG.AGAG..GGUG..ACCG...GCCA CACUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAGGGAAUU UUC.....GG...CAAUGGGGGAA.ACC................CU...GAC.C....GA GCAAC.GCCGC.GU......GAGUGAAG...A...CGG.CC.........UUC.GGGUUG UAAAGC..........................U.CU.........GU...UG........ ............................................................ ......................U.....A............................... ...AGGGAA.....G..................AACg....................... ......AUAGGAAGagg........................................... ............................................................ .........GAAUGCUUCU....UA................................... ............................................................ .............................U.............................. ............................................................ .......AU.GACGGU............................ACCUU.A..C..CAGA .......AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGGGA.G.C.GCAGG...... ........C.GGU.................UU.............AUCAAG.UUUAUGGU UAAAgu.....................................UC.GG.GGCUUAA.C.C .....C....C...GN........G................A..U...G........... ......................CCA...U..................AG..A..AACUGG UAGA................CU....AGA..GU..G....C.............AGG... AGAGG..UUAG..UGGAAUUC......CAU.....................GUGUAGCGG U..AAAAUGCGUA.GAU.AUAU.GG.AGGAACACCAG.UGGCGAA............GGC GGCU.AA.CUGGC..CUGUA..ACUGACGCU....GAG.GCUCGAAAGCGUGGGGAGCAA AUAGGAUUAGAUACCCUAGUAGUCCA.CGCCGUAAACGAUGG....AUAC.......... ....UAAGU........................G.......UU....G.G..A...Gaa. ............................................................ ...................AUU.....................C................ .A.....GU........GCUG.......UAGU..UAACGCAA..........UAAG..UA UC.............CCGCCUGGGGAGUAUGCGCGCAAGCGUAAAACUCAA...AGGAAU UGACGGGGG.CC.NGCACA.AG.C.GGUGGAGUAUG.UGGUUUAAUUCGAA.NCAACGCG .AAGAACCUUA.CCAGG........................................... ....UCUUGA.....C...A.................UA..................... ...................Ccgcgc....AAAAG.......................... .....................C............A....CAG............AG.AUG UGUAAUAGUUAU................................................ ............................................................ ............................................................ .........................Gg..............................C.. .....................G..........................G..A.....U.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUG...UCUUUAG......U....UAC..C .AG.C....A..........U..U.........A.A.G.U........U.....GGGG.. A.CUCUAAAGA............G.ACUGCC.G..G.UG.AU.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUG.AUCUG.GG CUACACA.CGUACUACAAU.GGCG.U..A.UACA.GAG................GGC... ......A.G..............CG........AA........GC.....AGCGAU.... ......G........CGGAGCGAAU......CUC.....AG...AAA.GUA.C..G.U.C UC.A....GUUCGGAUUGGAGUCUGCAACUCGACUCCAUGAAG.UCGGAAUCGCUAGUAA UCGCGGAUCAG..AAU.G.CCGCGG.....UGAAUACGUUCUCGGGCNUUGU..ACACAC CGCCCGUCAAACCAUGAGA......GU.............................UGG. .......UAA..............UACCCGAA....G...................CC.. ...GG.U.......GG.C............CU.....A....A.........CC.....U .Aguu.......UAC.U...AG.G.................AG.....GGA.......GC ....C..GUCGAA....GGU......................AGG...AU.......... .C.................GAUGAUU.........GGGG..................... ............................................................ ............................................................ ........................................................... > ..UUUUAA.....U...GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUGAACGCUGG.CGG..CAUGCCUA....AUACAU.GCAAGUC.....G AAC.....G........GG.............................U........... ...................GCUUG.................................... .................................................CG......... ..............CC....N....................................... .......................................................AGU.G GCG.....AACGGGUGA....GUAACAC.GUAU.C.UAAUC..................U ........................................A................CC. .C.....A..............U......U......A......................G C.G.GGGGAUAAC.A.............GUUGG.AA.AUG.AC................. ................U........................................... .............................................G.............. ................................................AUAAUACC.... ...................................GCAU.AC.................. ....................GACAUU.................................. .......................................U.................... ............................................................ ......................UC.................................... ............U...........GGCAUC.............................. .............................A...............G.............. ...............AGAAUGUU..................................... .....................AAAAGGUCCGUUU.GG....................... ......................AU.........CA......................... ............................................................ ........................CU...AAU............................ ..................GG.......A.......U........................ GAG.....G.....AUG.CGGC...................................... ..GU..................AUUAGUU...AG.UUGGUGG.GGUAAUGGC..CUACCA AGA.CAAUGA..UACGUAGCCGA...A....CUGAG.AGG..U..UG..AUCG...GCCA CAUCGGG.ACUGAGACACG.GCCCG..AAC..U.CCUACGGGAGGCAGCAGUAGGGAAUU UU.....UC...ACAAUGGGCGAA.AGC................CU...GA.U...G.GA GCAAU.GCCGC.GU......GACUGAAG...A...CGGU.C.........UUC.GGAUUG UAAAAg..........................U.CU.........GU...UG........ ............................................................ ......................U.....A............................... ...AGGGAA.....G..................AAC........................ ............................................................ ................................AGUAAGU..............AUA.... GGAAAUGA.......UACU....UA................................... ............................................................ .............................U.............................. ............................................................ .......UU.GACGGU............................ACCUU.A..C..CAGA .......AAGCCAC..................G........................... ............GCUAACUAU.G.UGCCAGCAGCCGCGGUAAUACA.............U AGGUGGCNAG..CGUUAUCCGGAUUUAUUGGGCGU..AAAGCGU.G.C.GCAGA...... ........C.GGU.................UU.............AACAAG.UUU.GG.. ..........G..........GUC.......AAA.......UCC.UGG.AGCUCAA.C.. ..U..C....C...A........GG.........UUC...........G........... ......................CCU...UG..................A..A..AACUGU UAA...............G.CU....AGA..GU..G....U.............AGG... AAAGG..UcGA..UGGAAUUC......CAU.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUAU.GG.AGGAACACCAG.UGGCGAA............GGC GGUCgA.C.UGGC..CUAUC..ACUGACGUUU....AG.GCACGNAAGCGcaGGGAGCAA AUAGGAUUAGAUACCCUAGUAGUCUA.CGCCGUAAACGAUGAG....UAC.......... ....UAAGU........................G.......Ucgg............... ............................................................ .....................ACUAAGU..........UCG................... .......GU........GCUGC.......AGC..UAACGCAU..........UAAG..UA CU.............CCGCCUGAGUAGUAUGCUCGCAAGAGNGAAACUCAA...AGGAAU UGNnGGGG.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCAAG........................................... ....GCUUGA.....C...A.................UC.C................... ...AGUGcAAAGCU.....GUAGAA....A.............................. ...............................U..A....CAG............UG...G AGGU........................................U............... ............................................................ ............................................................ ..........................A................................. .................ACA..UU........................G..A....G... ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGCCGUGAGGUGU UUGGUUAAGUCCA.GUAACGAGCGCAACCCUUGC...UGUUAG......U....UA...C .UC.C....A..........U..U.........A.A.G.U........UaGA.....U.. A.CUCUAACA............GG.ACUGCuAG....UG..U.AA..GC.U.A....... ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAGCAUGCCCCUUAUA.UCUUG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACAA.ACA................G.... ....U.U.G..............CGaucucguaA......G..A................ .......G........GGAGCUAAU......CUG.....A..A.AAA.GC..C..GAU.C UC.A....GUUCGGAUUGAGGGCUGCAACUCGCCCUCAUGAAGC.CGGAAUCGCUAGUAA UCGCGAAUCAG.CAAU.GU.CGCGG.....UGAAUACGUUCUCGGGUCUUGU..ACACAC CGCCCGUCACACCAUGAGA......GU.............................UGAU AAUACCAgc......................A....GU...................C.. ...GG.UAU.......U.............CU.....A....A.........CCG..... ..............C.A...AG.G.................AG.....GAA.......GC ....C..GCCCAA....GGU......................AGG...AU.......... .U.................GAUGAUUA...........G.......G.UAAC........ ....................................A.............AG......GU AUCCGGAACGGAUCACCUCCUUUCUN.................................. ........................................................... > cgcAAUCA.....U...GAGAGUUUGAUCCUa.G.......................... ....CUCAG.GAUGAACGCUAG.CUGU..GUGCUUA....AUACAU.GCAUUU......G AAC.....G........GG.............................AUAg........ ..............................UAUUUUAGU....UUUAcu........... ............................................................ ..........A.AAGU...AU....................................... .......................................................UGUuu uaguagcaAAUGGGUGA....GUAACAC.GUAC.C.UAACC..................U ........................................A................CC. ......UU..............U......U............................GG .A.CUGGGAUAAC..CAU............UGG.AA.ACAG.U................. ...............G............................................ .............................................G.C............ .................................................UAAUACC.... ...................................GGAU.AU.AA............... .....................................UAAAaauuc.............. ............................................................ ............................................................ ............................................................ ............................AC.............................. .............................AUG..A.......AUUU.............. ............................................................ ..............UUAUGAAA....................AggagC............ ............................................................ .....................GAAA................................... .............................AUAA........................... ..................GCUCcaccaA.......AAAAUGGgggugc............ ...........................................................G CAAC..................AUUAGUU...AG.UUGGUAG.GGUAAAGGC..CUACCA AGA.CGAUGA..UGUUUAGCGGGgcc.......AAG.AGG..U..UG..UACC...GCCA CACUGGG.AUUGAGAUACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUAAGGAAUA UUC.....C...ACAAUGaGCGAA.AGCU................U...GA.U...G.GA GCGACA.CAGC.GU......GCAGGAUG...AA...GU.C.........UUUA.GGUAUG UAAAC..........................UG.CU.........GU...UG........ ............................................................ ......................U.....A............................... ...AGGGAA.....G..................AAA........................ ..AAAAUUAGGUAGgga....................................AUG.... ............................................................ ..................A....UCUA......................AucU....... ............................................................ ..........UGA............................................... ............................................................ ............CGGU............................ACCUU.A..C..UAGA .......AAGCGAC..................G........................... ............GCAAACUAU.G.UGCCAGCAGCCGCGGUAAUACA.............U AGGUCGCAAG..CGUUAUCCGGAAUUAUUGGGCGU..AAAGCGU.U.C.GUAGG...... .........UUUU.................UUG.............UUAAG.UUUAAGGU UAAAugcuaA..........AGCUCAAC................................ ............................UUuagucc............G........... ......................CUU...U..................AG..A..UACUGG CAAAA.........................................UAGAAUUAUGA... AGAGG..UUAG..CGGAAUUC......CUA.....................GUGgAGUGG UGG..AAUACGUA.GAU.AUUA.GG.AAGAACACCAaUAGGCGAA............GGC AGCUAA.C.UGGU..CAUAU..AUUGACACU....GAG.GGACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....UCAu.......... .......UA........................G......UU.......GG......... ......................UG........Gcag........................ .................................AAGUCACUA.................. .......G...........CGC.......AGC..UAACGCGU..........UAAA..UG AU.............CCGCCUGAGUAGUAUGCUCGCAAGAGUGAAACUUAA...AGGAAU UGACGGGA.ACCC.GCACA.AG.C.GGUGGAGCAUG.UGGUUUAAUUugag.GAUACGCG .UAGAACCUUA.CCCAC........................................... ....UCUUGA.....C...A.................UU..................... ...................C....UCgc................................ .........AAA.......AC.....UA................................ U......................AGAGAU.........A..................... ......................................................UAGCGG AGGCUAA........................................CGAgauu...... ............................................................ .................ACAGA...................................... .......................UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UAGGUUAAGUCCU.GCAACGAGCGCAACCCUUU...UCUUUAG......U....UGCU.. .A.AC....A..........U..U.........A.A.G.U........U.....GaGA.. A.CCCUAGAGA.............UACUGCC.G..G.UG..U.AAA..CC.G........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCUCUUACG.AGUGG.GG CAACACA.CGUGCUACAAU.GGCU.A...CUACAA.AGA................GC... ......A.G..............CA........AA........AC.....AG.UGAU... ......G........UCAAGCUAAU......CUC.....Aa.A.AAA.G.U..A.G.U.C UC.A....GUUCGGAUUGAAGUCUGCAACUCGACUUCAUGAAG.UCGGAAUCGCUAGUAA UCGCAGGUCAG.C.UA.UaCUGCGG.....UGAAUACGUUCUCGGGUUUUGU..ACACAC CGCCCGUCACACCAUGGGA......GU.............................UGG. .......UAA..............UGCCCAAA....GU...................C.. ...GG.U.......G.A........................................... ..........................................................GU .....UA.ACCUC....GGAGAccaUU......GCCUAAGGCAGGA.............. CC.................GAUGACU.........GGGGUGAAGUCG.UAACAA.GGUAU CCc.UA.CGAGAACGugg...........G.....GA.............UG......GA A............CACCUCCUUUCUA.................................. ........................................................... > ..NUUUUU.....A...GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GAUNAACGCUGG.CGG..CGUGCCUA....ACACAU.GCAAGUC.....G AAC.....G........GA........GU...................UAUU....UUGG AA....A.U......C................U.....................CUUCGG ..........A.........G..........................AUGGAAUUca... ..........UA.....ACUU....................................... .......................................................AGU.G GCGG.....ACGGGUGA....GUAACGC.GUGA.GCAAUC...................U .G.......................................................CC. ......UU..............U......A............................GG .UG.GGGGAUAA.CAG.U............CGG.AA.ACGG.C................. ................U........................................... .............................................G.C............ .................................................UAAUACC.... ...................................GCAU.AA.UACG............. .....................................U..........UUUG........ .......................................GGGGCA............... ....................................UCC..................... ...........Uugaaac.......................................... ............................................................ ..................G......................................... ...UC............AAAGAU..................................... .....................UUAU....................U.............. ............................................................ .......GCC.....UU........................................... ...............................UA........................... ...................G.......A.......U........................ GAG..........CUCG.CGUC...................................... ..UG..................AUUAGCUGG....UUGGCGG.GGNAACGGC..CCACCA AGG.CGACGA..UCAGUAGCCGG...A....CUGAG.AGG..U..UG..AACG...GCCA CAUUGGG.ACUGAGACACG.GCCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGGGAA.ACC................CN...GAC....GC.A GCAAC.GCCGC.GU......GAUUGAAG...AA...GG.CC.........UUC.GGGUUG UAAAG..........................AU.CUU.........U...AA........ ............................................................ ......................U.....C............................... ...AGG................................................G..... .....................................................ACG.... ............................................................ ..................A....AU................................... ............................................................ .............................U.............................. ............................................................ .......UU.GACGGU............................ACCU.GA..AGAA..U .......AAGCUCC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGGAGCAAG..CGUUAUCCGGAUUUACUGGGUGU..AAAGGG.CG.C.GCAGN...... ........C.GGG.................NCG.............GcAAG.UUG.GG.. ....................AGUG.......AAA.......UCNG.GG.GGCUUAA.C.C .....C....Cc...........G.........AAC........U...G........... ......................CUU...UC..................A..A..AACUGC UGGU................CU....UGA..GU..G....A.............UGG... AGAGGC..AGG..CGGAAUUC......CGU.....................GUGUAGCGG UG..AAAUGCGUA.GAU.AUA.CGG.AGGAACACCAG.UGGCGAA............GGC GGCC.UG.CUGGA..CAUUA..ACUGACGCU....GAG.GCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGG....AUAC.......... ....UAGGU........................G.......U...G.G.G..A...G... ....................G..U.......AUUGA.....CC........CC....... ....................UU.....................C................ ...C...GU........GCCGC.......AGU..UAACACAA..........UAAG..UA UC.............CCACCUGGGGAGUACGGCCGCAAGGUUGAAACUCAA...AGGAAU UGACGnnnG.CCC.GCACA.AG.CA.GUGGAGUAUG.UGGUUUAAUUCGAA.NNAACGCG .AAGAACCUUA.CCAGG........................................... ....NCUUGA.....C...A.................UC.C............C...... ......GGUGACCG..U.CC....U....AG............................. ............................................................ .......................AGAU..............AGGac.............U U........................................................... ........................N................................... ......CCUUC..G..........GGN.CAACGGU...................G..... .................ACAGN...................................... .......................UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGNUUAAGUCCC.GCAACGAGCGCAACCCUUAcggUUAGUUG......A....UACG.. ............................................................ ......CAAGAucacucuagccGG.ACUGCC.G...UUG.AC.AAA..AC.G........ ...GAGGA.A.GGUG.GGGACGACGU..NN..AAUCAUCAUGCCCCNUAUG.ACCUG.GG CUACACA.CGUACUACAAU.GGCA.GUCA.UACA.GAG................GG.... ....A.A.G..............CA........AA........AUC.....GC.GA.G.. ......G........UGGAGCAAAU......CCC.....U..A.AAA.GCU..G...U.C CC.A....GUUCAGAUUGCAGGCUGCAACCCGCCUGCAUGAAG.UCGGAAUUGCUAGUAA UCGCGGAUCAG.C.AU.G.CCGCGG.....UGAAUACGUUCCCGGGNNUUGU..ACACAC CGCCCGUCACACCAUGAGA......G..........................CC...GUC ........AA..............UACCCGAA....GU...................CC. ....G.UA.......G.C............CU.....A....A.........CCG..... ..............C.A...AG.GG.................G.....GGC.......GC G......GCCGAA....GGU......................AGGGGUgguaau...... ............................................................ ............................................................ ............................................................ ........................................................... > .................GAGAGUUUGAUCCU.GG.......................... ....CUCAG.GACGAACGCUGG.CGG..CGUGCUUA....ACACAU.GCAAGUC.....G AGC.....GAUGAagCU.UC........................................ ...............C................UUC......................... ............G.......G....................................... .......G...........AA..........GUGga..UU.................... .......................................................AGC.G GCGG.....ACGGGUGA....GUAACACAGUG.GGC.AACC..................U .G.......................................................CC. ......UC..............A......A......A......................G .AG.GGGAAUAG.C.CCU............C.CGAAAG.G.................... ............................................................ ............................................................ ............................................AGGAUUAAUACC.... ...................................GCAU.AA.A..G............. .....................................U..........UAAG........ .......................................GUUUCG............... ............................................................ ............................................................ .............................C.............................. .............................AUG..A.......AA..........CUUUAA C...C............AAAGG.......AGu............................ ...........................AAUCU............................ ............................................................ .......GCU.....UU........................................... ...............................GA........................... ...................G.......A.......U........................ GGG..........CCCG.CGCC...................................... ..CC..................AUUAGCU...Au.UUGGUAA.GGUAAUGGCU..UACCA AGG.CGACGU..AGGGUAGCCGACC.........UG.AGAG..GGUG..AUCG...GCCA CAUUGGA.ACUGAGACACG.GUCC..AGAC..U.CCUACGGGAGGCAGCAGUGGGGAAUA UUG.....CG...CAAUGGGGGAA.ACC................CU...GAC....GC.A GCAAC.GCCGC.GU......GGGUGAUG...AA...GGU..........UUUC.GGAUCG UAAAACCC............................Ug........U...UU........ ............................................................ ......................U.....C............................... ...UGG................................................G..... .....................................................ACG.... ............................................................ ..................A....UA................................... ............................................................ .............................A.............................. ............................................................ .......U..GACGGU............................ACCA.GA.G.GA.... G..G...AAGCCAC..................G........................... ............GCUAACUAC.G.UGCCAGCAGCCGCGGUAAUAC.............GU AGGUGGCAAG..CGUUGUCCGGAUUUACUGGGCGU..AAAGGGU.G.C.GUAGG...... ........C.GGA.................UGC.............UUAAG.UGA.G... .........A..........UGUG.......AAA.......UACC.U.AAGCUUAA.C.. ..U......U...AG........GG.........GC........U...G........... ......................CAU...U..................UC..A..AACUGG GCAU................CU....AGA..GU......AC.............AGG... AGAGGG..AAA..CGGAAUUC......CUA.....................GUGUAGCGG UG..AAAUGCGUA.GAGgAUUA.GG.AAGAACACCAG.UGGCGAA............GGC GGUU.U.CCUGGA..CUGUA..ACUGACGCA....GAG.GCACGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUGGUAGUCCA.CGCCGUAAACGAUGA....AUAC.......... ....UAGGU........................G.......UA....G.G..A...G... ....................G....GUcc......AA..............CC....... ....................UU.....................C................ .U.....GU........GCCGC.......AGU..UAACACAU..........UAAG..UA UU.............CCGCCUGGGGAGUACGGUCGCAAGACUAAAACUCAA...AGGAAU UGACGGGGG.CCC.GCACA.AG.CA.GCGGAGCAUG.UGGUUUAAUUCGAA.GCAACGCG .AAGAACCUUA.CCUAG........................................... ....ACUUGA.....CcAUCCU...................................... ...UCU......GACCUCUC....U....U.............................. ...............................A..A....CUG............AG...G A............................AG............................. ............................................................ ....................................................U....... .....CCCUUC..G..........GG............................G..... .................ACAGG..........................G..A.....U.. ................A.CAGG.UGGUGCAUGGUUGUCGUCAGCUCGUGUCGUGAGAUGU UGGGUUAAGUCCC.GCAACGAGCGCAACCCUUA...UUAUUAG......U....UGCU.. .AC.C...............A..U.........U.AAG.U........U.....GAG..C A.CUCUAAUGA............G.ACUGCCUG..GG....Ug.AAC.C.AG........ ...GAGGA.A.GGUG.GGGAUGACGUC..A..AAUCAUCAUGCCCCUUAUGCUCUAG.GG CUACACA.CGUGCUACAAU.GGU.CG..G.UACA.GAGA................G.... ....AC..G..............CA........A......G..ACC.....GC.GA.G.. ......G........UGGAGCAAAU......CUC.....A..A.AAA..C..CG..AU.C CC.A....GUUCGGAUUGCAGGCUGAAACUCGCCUGCAUGAAGC.CGGAGUUGCUAGUAA UCGCAAAUCAG..AAU.GU.UGCGG.....UGAAUACGUUCCCGGGCCUUGU..ACACAC CGCCCGUCACACCAUGAGA......GU.............................UGGC ........AA.C.............ACCCGAA....GU...................CC. ....G.U.......G.A............GGU.....A....A.........CCG..... ..........U.....A...AG.G.................AGC.....CA.......GC G......GCCGAA....GGUG......................GGG...U.......... .UA.................AUGAUU.........GGGGUGAAGUCG.UAACAA.GGUAG CCG.UAGGAGAACC............UGCG.....G.............CUG......GA U............CACCUCC........................................ ...........................................................